The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity – a common inflammatory phenotype?
Open accessAbstract
Chronic Obstructive Pulmonary Disease (COPD) is and will remain a major cause of morbidity and mortality worldwide. The severity of airflow obstruction is known to relate to overall health status and mortality. However, even allowing for common aetiological factors, a link has been identified between COPD and other systemic diseases such as cardiovascular disease, diabetes and osteoporosis. COPD is known to be an inflammatory condition and neutrophil elastase has long been considered a significant mediator of the disease. Pro-inflammatory cytokines, in particular TNF-α (Tumour Necrosis Factor alpha), may be the driving force behind the disease process. However, the roles of inflammation and these pro-inflammatory cytokines may extend beyond the lungs and play a part in the systemic effects of the disease and associated co-morbidities. This article describes the mechanisms involved and proposes a common inflammatory TNF-α phenotype that may, in part, account for the associations.
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Cited by
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Pulmonary-intestinal cross-talk in mucosal inflammatory disease
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Smoking and Lung Cancer: The Role of Inflammation
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Metadata
- Authors
- Sevenoaks, M. J., & Stockley, R. A.
- Venue
- Respiratory Research
- Published
- 2006-05-02
- Volume
- 7
- Issue
- 1
- Pages
- 70-70
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- OpenAlex
- W1963333787
- Cited by
- 241
- References
- 11
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sevenoaks, M. J., & Stockley, R. A. (2006). Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity – a common inflammatory phenotype? Respiratory Research. https://doi.org/10.1186/1465-9921-7-70
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
