The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Smoking and Lung Cancer: The Role of Inflammation
Open accessAbstract
Worldwide over 1 million people die due to lung cancer each year. It is estimated that cigarette smoking explains almost 90% of lung cancer risk in men and 70 to 80% in women. Clinically evident lung cancers have multiple genetic and epigenetic abnormalities. These abnormalities may result in activation of oncogenes and inactivation of tumor-suppressor genes. Chronic inflammation, which is known to promote cancer, may result both from smoking and from genetic abnormalities. These mediators in turn may be responsible for increased macrophage recruitment, delayed neutrophil clearance, and increase in reactive oxygen species (ROS). Thus, the pulmonary environment presents a unique milieu in which lung carcinogenesis proceeds in complicity with the host cellular network. The pulmonary diseases that are associated with the greatest risk for lung cancer are characterized by abundant and deregulated inflammation. Pulmonary disorders such as chronic obstructive pulmonary disease (COPD)/emphysema are characterized by profound abnormalities in inflammatory and fibrotic pathways. The cytokines and growth factors aberrantly produced in COPD and the developing tumor microenvironment have been found to have deleterious properties that simultaneously pave the way for both epithelial–mesenchymal transition (EMT) and destruction of specific host cell–mediated immune responses. Full definition of these pathways will afford the opportunity to intervene in specific inflammatory events mediating lung tumorigenesis and resistance to therapy.
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Cites
1 retracted
Regulation of Cyclooxgenase-2 mRNA Stability by Taxanes
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RetractedThe Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
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The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
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Epithelial-mesenchymal transition and its implications for fibrosis
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Huber, M. A., Kraut, N., & Beug, H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.001 · Cited by 1,821
Epithelial–mesenchymal transitions in development and pathologies
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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
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The International Epidemiology of Lung Cancer: Geographical Distribution and Secular Trends
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Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
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Brown, D. W., Anda, R. F., Felitti, V. J., Edwards, V. J., Malarcher, A. M., Croft, J. B., & Giles, W. H. (2010) · BMC Public Health · doi:10.1186/1471-2458-10-20 · Cited by 391
A Collaborative Federated Learning Framework for Lung and Colon Cancer Classifications
Hossain, M. M., Islam, M. R., Ahamed, M. F., Ahsan, M., & Haider, J. (2024) · Technologies · doi:10.3390/technologies12090151 · Cited by 44
Psychological Symptom Trajectories and Non–Small Cell Lung Cancer Survival: A Joint Model Analysis
Andersen, B. L., McElroy, J. P., Carbone, D. P., Presley, C. J., Smith, R. M., Shields, P. G., & Brock, G. N. (2022) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001027 · Cited by 37
Electronic Cigarette Use during Pregnancy: Is It Harmful?
Vilcassim, M. J. R., Stowe, S., Majumder, R., Subramaniam, A., & Sinkey, R. G. (2023) · Toxics · doi:10.3390/toxics11030278 · Cited by 30
Metadata
- Authors
- Walser, T., Cui, X., Yanagawa, J., Lee, J. M., Heinrich, E., Lee, G., Sharma, S., & Dubinett, S. M.
- Venue
- Proceedings of the American Thoracic Society
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-12-01
- Volume
- 5
- Issue
- 8
- Pages
- 811-815
- ISSN
- 1546-3222 (ISSN-L)
- 1943-5665
- OpenAlex
- W1969574651
- Cited by
- 379
- References
- 75
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Walser, T., Cui, X., Yanagawa, J., Lee, J. M., Heinrich, E., Lee, G., Sharma, S., & Dubinett, S. M. (2008). Smoking and Lung Cancer: The Role of Inflammation. Proceedings of the American Thoracic Society. https://doi.org/10.1513/pats.200809-100th
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
