The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
BLAST+: architecture and applications
Open accessAbstract
Background: Sequence similarity searching is a very important bioinformatics task. While Basic Local Alignment Search Tool (BLAST) outperforms exact methods through its use of heuristics, the speed of the current BLAST software is suboptimal for very long queries or database sequences. There are also some shortcomings in the user-interface of the current command-line applications. Results: We describe features and improvements of rewritten BLAST software and introduce new command-line applications. Long query sequences are broken into chunks for processing, in some cases leading to dramatically shorter run times. For long database sequences, it is possible to retrieve only the relevant parts of the sequence, reducing CPU time and memory usage for searches of short queries against databases of contigs or chromosomes. The program can now retrieve masking information for database sequences from the BLAST databases. A new modular software library can now access subject sequence data from arbitrary data sources. We introduce several new features, including strategy files that allow a user to save and reuse their favorite set of options. The strategy files can be uploaded to and downloaded from the NCBI BLAST web site. Conclusion: The new BLAST command-line applications, compared to the current BLAST tools, demonstrate substantial speed improvements for long queries as well as chromosome length database sequences. We have also improved the user interface of the command-line applications.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“In response to frequent requests from the user community since the AlphaFold DB launch, we have made significant strides to implement a sequence-based similarity search feature. We have incorporated the Basic Local Alignment Search Tool (BLAST) (21) into our Google Cloud Platform infrastructure to achieve this.”
From AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences (2024) · cites this paper as [21]
In the citing paper
“When searching the NR database using NCBI BLAST28, we found no bacterial hits for the human AIM2 gene.”
From Clustering predicted structures at the scale of the known protein universe (2023) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480
Initial sequencing and comparative analysis of the mouse genome
Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187
A Greedy Algorithm for Aligning DNA Sequences
Zhang, Z., Schwartz, S., Wagner, L., & Miller, W. (2000) · Journal of Computational Biology · doi:10.1089/10665270050081478 · Cited by 5,459
NCBI BLAST: a better web interface
Johnson, M., Zaretskaya, I., Raytselis, Y., Merezhuk, Y., McGinnis, S., & Madden, T. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn201 · Cited by 4,207
Self-citationDatabase indexing for production MegaBLAST searches
Morgulis, A. O., Coulouris, G., Raytselis, Y., Madden, T., Agarwala, R., & Schäffer, A. A. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn322 · Cited by 1,395
Self-citationSchäffer, A. A. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.14.2994 · Cited by 1,375
[33] Analysis of compositionally biased regions in sequence databases
Wootton, J. C., & Federhen, S. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66035-2 · Cited by 745
A Fast and Symmetric DUST Implementation to Mask Low-Complexity DNA Sequences
Morgulis, A. O., Gertz, E. M., Schäffer, A. A., & Agarwala, R. (2006) · Journal of Computational Biology · doi:10.1089/cmb.2006.13.1028 · Cited by 498
Flagged first, then by citations
Research works printed but not linked: 8
- NCBI C toolkit[http://www.ncbi.nlm.nih.gov/IEB/ToolBox/SDKDOCS/INDEX.HTML]
- NCBI BLAST web site[http://blast.ncbi.nlm.nih.gov/Blast.cgi]
- NCBI C++ toolkit documentation[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=toolkit]
- Implementing a BlastSeqSrc[http://www.ncbi.nlm.nih.gov/IEB/ToolBox/CPP_DOC/doxyhtml/_impl_blast_seqsrc_howto.html]
- BLAST+ Command Line Applications User Manual[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=helpblast]
- Reference assembly for Human genome build 36.1[http://www.ncbi.nlm.nih.gov/genome/guide/human/release_notes.html#b36]
- NCBI SRA Software Development Kit[http://www.ncbi.nlm.nih.gov/Traces/sra/sra.cgi?cmd=show&f=software&m=software&s=software]
- PUBLIC DOMAIN NOTICE for NCBI[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=toolkit&part=toolkit.fm#A3]
Cited by
Sorted by citations
Items 901–1,000 of 1,061
Single-cell copy number variant detection reveals the dynamics and diversity of adaptation
Lauer, S. L., Avecilla, G., Spealman, P., Sethia, G., Brandt, N., Levy, S. F., & Gresham, D. (2018) · PLoS Biology · doi:10.1371/journal.pbio.3000069 · Cited by 123
Ouyang, Y., & Norton, J. M. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.02278-19 · Cited by 127
Streamlining CRISPR spacer-based bacterial host predictions to decipher the viral dark matter
Dion, M. B., Plante, P.-L., Zufferey, E., Shah, S. A., Corbeil, J., & Moineau, S. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab133 · Cited by 123
gutSMASH predicts specialized primary metabolic pathways from the human gut microbiota
Andreu, V., Augustijn, H. E., Chen, L., Zhernakova, A., Fu, J., Fischbach, M. A., Dodd, D., & Medema, M. H. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01675-1 · Cited by 123
Schwarz, E. M., Hu, Y., Antoshechkin, I. A., Miller, M. M., Sternberg, P. W., & Aroian, R. V. (2015) · Nature Genetics · doi:10.1038/ng.3237 · Cited by 122
Fitzpatrick, M. A., Ozer, E. A., & Hauser, A. R. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.01818-15 · Cited by 122
Introducing difference recurrence relations for faster semi-global alignment of long sequences
Suzuki, H., & Kasahara, M. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2014-8 · Cited by 122
Staphylococcus aureus viewed from the perspective of 40,000+ genomes
Petit, R. A., & Read, T. D. (2018) · PeerJ · doi:10.7717/peerj.5261 · Cited by 122
Sepp, S., Davison, J., Jairus, T., Vasar, M., Moora, M., Zobel, M., & Öpik, M. (2018) · Molecular Ecology · doi:10.1111/mec.14924 · Cited by 122
mlDEEPre: Multi-Functional Enzyme Function Prediction With Hierarchical Multi-Label Deep Learning
Zou, Z., Tian, S., Gao, X., & Li, Y. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00714 · Cited by 122
Interspecific hybridization facilitates niche adaptation in beer yeast
Gallone, B., Steensels, J., Mertens, S., Dzialo, M. C., Gordon, J., Wauters, R., Theßeling, F. A., Bellinazzo, F., Saels, V., Herrera‐Malaver, B., et al. (2019) · Nature Ecology & Evolution · doi:10.1038/s41559-019-0997-9 · Cited by 122
Thermal stratification and fish thermal preference explain vertical eDNA distributions in lakes
Littlefair, J. E., Hrenchuk, L. E., Blanchfield, P. J., Rennie, M. D., & Cristescu, M. E. (2020) · Molecular Ecology · doi:10.1111/mec.15623 · Cited by 122
Villanueva, L., von Meijenfeldt, F. A. B., Westbye, A. B., Yadav, S., Hopmans, E. C., Dutilh, B. E., & Damsté, J. S. S. (2020) · The ISME Journal · doi:10.1038/s41396-020-00772-2 · Cited by 122
Genome and transcriptome mechanisms driving cephalopod evolution
Albertin, C. B., Medina-Ruiz, S., Mitros, T., Schmidbaur, H., Sánchez, G., Wang, Z. Y., Grimwood, J., Rosenthal, J. J. C., Ragsdale, C. W., Simakov, O., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29748-w · Cited by 122
Yan, Q., Li, S., Yan, Q., Huo, X., Wang, C., Wang, X., Sun, Y., Zhao, W., Yu, Z., Zhang, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.04.043 · Cited by 127
Thorpe, P., Cock, P., & Bos, J. I. B. (2016) · BMC Genomics · doi:10.1186/s12864-016-2496-6 · Cited by 121
Armitage, A. D., Taylor, A., Sobczyk, M. K., Baxter, L. A., Greenfield, B. P. J., Bates, H. J., Wilson, F. M., Jackson, A. C., Ott, S., Harrison, R. J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30335-7 · Cited by 121
Lactobacilli Have a Niche in the Human Nose
Boeck, I. D., van den Broek, M. F. L., Allonsius, C. N., Spacova, I., Wittouck, S., Martens, K., Wuyts, S., Cauwenberghs, E., Jokicevic, K., Vandenheuvel, D., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107674 · Cited by 121
Barchi, L., Rabanus‐Wallace, M. T., Prohens, J., Toppino, L., Padmarasu, S., Portis, E., Rotino, G. L., Stein, N., Lanteri, S., & Giuliano, G. (2021) · The Plant Journal · doi:10.1111/tpj.15313 · Cited by 121
Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species
Uchiyama, J., Akiyama, M., Hase, K., Kumagai, Y., & Kim, Y. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110479 · Cited by 121
Tesson, F., Planel, R., Egorov, A. A., Georjon, H., Vaysset, H., Brancotte, B., Néron, B., Mordret, E., Atkinson, G. C., Bernheim, A., et al. (2024) · Peer Community Journal · doi:10.24072/pcjournal.470 · Cited by 120
Li, J., Tai, C., Deng, Z., Zhong, W., He, Y. O., & Ou, H. (2016) · Briefings in Bioinformatics · doi:10.1093/bib/bbw141 · Cited by 120
Nakajima, A., Kaga, N., Nakanishi, Y., Ohno, H., Miyamoto, J., Kimura, I., Hori, S., Sasaki, T., Hiramatsu, K., Okumura, K., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700248 · Cited by 120
Garrido‐Sanz, D., Redondo‐Nieto, M., Guirado, M., Jiménez, Ó. P., Millán, R., Martín, M., & Rivilla, R. (2019) · Genes · doi:10.3390/genes10060456 · Cited by 120
Quigley, K. M., Willis, B. L., & Bay, L. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-08179-4 · Cited by 120
Liao, B., Shen, X., Li, X., Guo, S., Chen, S., Meng, Y., Liang, Y., Ding, D., Bai, J., Zhang, D., et al. (2022) · Molecular Plant · doi:10.1016/j.molp.2022.05.013 · Cited by 120
Venus flytrap carnivorous lifestyle builds on herbivore defense strategiesPreprint
Bemm, F., Becker, D., Larisch, C., Kreuzer, I., Escalante‐Pérez, M., Schulze, W. X., Ankenbrand, M. J., de Weyer, A.-L. V., Krol, E., Al‐Rasheid, K. A. S., et al. (2016) · Genome Research · doi:10.1101/gr.202200.115 · Cited by 120
Identification of candidate long non-coding RNAs in response to myocardial infarction
Zangrando, J., Zhang, L., Vausort, M., Maskali, F., Marie, P., Wagner, D. R., & Devaux, Y. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-460 · Cited by 119
Nowrouzi, A., Penaud‐Budloo, M., Kaeppel, C., Appelt, U., Guiner, C. L., Moullier, P., Kalle, C. V., Snyder, R. O., & Schmidt, M. (2012) · Molecular Therapy · doi:10.1038/mt.2012.47 · Cited by 119
Gandini, C. L., & Sanchez-Puerta, M. V. (2017) · Scientific Reports · doi:10.1038/srep43402 · Cited by 119
DNA methylation footprints during soybean domestication and improvement
Shen, Y., Zhang, J., Liu, Y., Liu, S., Liu, Z., Duan, Z., Wang, Z., Zhu, B., Guo, Y., & Tian, Z. (2018) · Genome biology · doi:10.1186/s13059-018-1516-z · Cited by 119
De novo design of a non-local β-sheet protein with high stability and accuracy
Marcos, E., Chidyausiku, T. M., McShan, A. C., Evangelidis, T., Nerli, S., Carter, L. P., Nivón, L. G., Davis, A. L., Oberdorfer, G., Tripsianes, K., et al. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0141-6 · Cited by 119
Genome-wide association analysis of stalk biomass and anatomical traits in maize
Mazaheri, M., Heckwolf, M., Vaillancourt, B., Gage, J. L., Burdo, B., Heckwolf, S., Barry, K., Lipzen, A., Ribeiro, C. B., Kono, T. J. Y., et al. (2019) · BMC Plant Biology · doi:10.1186/s12870-019-1653-x · Cited by 119
Horizontal transfer and evolution of transposable elements in vertebrates
Zhang, H., Peccoud, J., Xu, M.-R.-X., Xiao-gu, Z., & Gilbert, C. (2020) · Nature Communications · doi:10.1038/s41467-020-15149-4 · Cited by 119
Cai, L., Arnold, B., Xi, Z., Khost, D. E., Patel, N., Hartmann, C. B., Sugumaran, M., Sasirat, S., Nikolov, L. A., Mathews, S., et al. (2021) · Current Biology · doi:10.1016/j.cub.2020.12.045 · Cited by 119
Carreté, L., Ksiezopolska, E., Pegueroles, C., Gómez-Molero, E., Saus, E., Iraola-Guzmán, S., Loska, D., Bader, O., Fairhead, C., & Gabaldón, T. (2018) · Current Biology · doi:10.1016/j.cub.2017.11.027 · Cited by 118
The Caulobacter crescentus phage phiCbK: genomics of a canonical phage
Gill, J. J., Berry, J. D., Russell, W. K., Lessor, L. E., Escobar-Garcia, D. A., Hernández, D. A., Kane, A. A., Keene, J. L., Maddox, M., Martin, R., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-542 · Cited by 118
Pauli, D., Andrade-Sánchez, P., Carmo‐Silva, E., Gazave, É., French, A. N., Heun, J. T., Hunsaker, D. J., Lipka, A. E., Setter, T. L., Strand, R. J., et al. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.023515 · Cited by 118
Structural and regulatory diversity shape HLA-C protein expression levels
Kaur, G., Gras, S., Mobbs, J. I., Vivian, J. P., Cortés, A., Barber, T. R., Kuttikkatte, S. B., Jensen, L. T., Attfield, K. E., Dendrou, C. A., et al. (2017) · Nature Communications · doi:10.1038/ncomms15924 · Cited by 118
Roach, M. J., Johnson, D. L., Bohlmann, J., van Vuuren, H. J. J., Jones, S. J. M., Pretorius, I. S., Schmidt, S. A., & Borneman, A. R. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007807 · Cited by 118
The Predominant Oral Microbiota Is Acquired Early in an Organized Pattern
Sulyanto, R. M., Thompson, Z. A., Beall, C. J., Leys, E. J., & Griffen, A. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-46923-0 · Cited by 118
Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS
Reddy, B. G., Bavi, N., Lu, A. P., Park, Y., & Perozo, E. (2019) · eLife · doi:10.7554/elife.50486 · Cited by 118
BTN3A3 evasion promotes the zoonotic potential of influenza A viruses
Pinto, R. M., Bakshi, S., Lytras, S., Zakaria, M. K., Swingler, S., Worrell, J. C., Herder, V., Hargrave, K. E., Varjak, M., Cameron-Ruiz, N., et al. (2023) · Nature · doi:10.1038/s41586-023-06261-8 · Cited by 118
The complete sequence and comparative analysis of ape sex chromosomes
Makova, K. D., Pickett, B. D., Harris, R. S., Hartley, G. A., Čechová, M., Pál, K., Nurk, S., Yoo, D., Li, Q., Hebbar, P., et al. (2024) · Nature · doi:10.1038/s41586-024-07473-2 · Cited by 118
Akpınar, B. A., Kantar, M., & Budak, H. (2015) · Functional & Integrative Genomics · doi:10.1007/s10142-015-0453-0 · Cited by 118
Ford, M. J., Hempelmann, J. A., Hanson, M. B., Ayres, K. L., Baird, R. W., Emmons, C. K., Lundin, J. I., Schorr, G. S., Wasser, S. K., & Park, L. K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0144956 · Cited by 118
The maternal and early embryonic transcriptome of the milkweed bug Oncopeltus fasciatus
Ewen‐Campen, B., Shaner, N. C., Panfilio, K. A., Suzuki, Y., Roth, S., & Extavour, C. G. M. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-61 · Cited by 117
Identification of Novel Zoonotic Activity of Bartonella spp., France
Vayssier‐Taussat, M., Moutailler, S., Féménia, F., Raymond, P., Croce, O., Scola, B. L., Fournier, P., & Raoult, D. (2016) · Emerging infectious diseases · doi:10.3201/eid2203.150269 · Cited by 117
Gerth, M., & Bleidorn, C. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.241 · Cited by 117
Genome-wide identification of tissue-specific long non-coding RNA in three farm animal species
Kern, C., Wang, Y., Chitwood, J. L., Korf, I. F., Delany, M. E., Cheng, H. H., Medrano, J. F. F., Eenennaam, A. L. V., Ernst, C. W., Ross, P. J., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-5037-7 · Cited by 117
Müller, M. C., Praz, C. R., Sotiropoulos, A. G., Menardo, F., Kunz, L., Schudel, S., Oberhänsli, S., Poretti, M., Wehrli, A., Bourras, S., et al. (2018) · New Phytologist · doi:10.1111/nph.15529 · Cited by 117
Valiente-Mullor, C., Beamud, B., Ansari, I., Francés‐Cuesta, C., García‐González, N., Mejía, L., Ruiz-Hueso, P., & Gónzález‐Candelas, F. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008678 · Cited by 117
Insecticide resistance by a host-symbiont reciprocal detoxification
Sato, Y., Jang, S., Takeshita, K., Itoh, H., Koike, H., Tago, K., Hayatsu, M., Hori, T., & Kikuchi, Y. (2021) · Nature Communications · doi:10.1038/s41467-021-26649-2 · Cited by 117
FUSARIUM-ID v.3.0: An Updated, Downloadable Resource for Fusarium Species Identification
Torres-Cruz, T. J., Whitaker, B. K., Proctor, R. H., Broders, K. D., Laraba, I., Kim, H.-S., Brown, D. W., O’Donnell, K., Estrada-Rodríguez, T. L., Lee, Y.-H., et al. (2021) · Plant Disease · doi:10.1094/pdis-09-21-2105-sr · Cited by 117
Pseudofinder: Detection of Pseudogenes in Prokaryotic Genomes
Syberg‐Olsen, M. J., Garber, A. I., Keeling, P. J., McCutcheon, J. P., & Husník, F. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac153 · Cited by 117
TriTrypDB: An integrated functional genomics resource for kinetoplastida
Shanmugasundram, A., Starns, D., Böhme, U., Amos, B., Wilkinson, P. A., Harb, O. S., Warrenfeltz, S. W., Kissinger, J. C., McDowell, M. A., Roos, D. S., et al. (2023) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0011058 · Cited by 117
Tillett, R. L., Wheatley, M. D., Tattersall, E. A. R., Schlauch, K. A., Cramer, G. R., & Cushman, J. C. (2011) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2011.00648.x · Cited by 117
Expanding our view of genomic diversity in C andidatus A ccumulibacter clades
Skennerton, C. T., Barr, J. J., Slater, F. R., Bond, P. L., & Tyson, G. W. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12582 · Cited by 117
Dong, Y., Zhang, X., Xie, M., Arefnezhad, B., Wang, Z., Wang, W., Feng, S., Huang, G., Guan, R., Shen, W., et al. (2015) · BMC Genomics · doi:10.1186/s12864-015-1606-1 · Cited by 116
Functional Sites Induce Long-Range Evolutionary Constraints in Enzymes
Jack, B. R., Meyer, A. G., Echave, J., & Wilke, C. O. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002452 · Cited by 116
Feng, Y., Wicke, S., Li, J., Yu, H., Lin, C., Li, D.-Z., Zhou, T., Huang, W., Huang, L., & Jin, X. (2016) · Genome Biology and Evolution · doi:10.1093/gbe/evw144 · Cited by 116
Frommhagen, M., Mutte, S. K., Westphal, A. H., Koetsier, M. J., Hinz, S. W. A., Visser, J., Vincken, J., Weijers, D., van Berkel, W. J. H., Gruppen, H., et al. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0810-4 · Cited by 116
Neuenkamp, L., Moora, M., Öpik, M., Davison, J., Gerz, M., Männistö, M. K., Jairus, T., Vasar, M., & Zobel, M. (2018) · New Phytologist · doi:10.1111/nph.14995 · Cited by 116
Walburn, J. W., Wemheuer, B., Thomas, T., Copeland, E., O’Connor, W. A., Booth, M. A., Fielder, D. S., & Egan, S. (2018) · Microbial Biotechnology · doi:10.1111/1751-7915.13323 · Cited by 116
Naz, K., Naz, A., Ashraf, S. T., Rizwan, M., Ahmad, J., Baumbach, J., & Ali, A. (2019) · BMC Bioinformatics · doi:10.1186/s12859-019-2713-9 · Cited by 116
A global survey of arsenic-related genes in soil microbiomes
Dunivin, T. K., Yeh, S. Y., & Shade, A. L. (2019) · BMC Biology · doi:10.1186/s12915-019-0661-5 · Cited by 116
Camp, E. F., Edmondson, J., Doheny, A., Rumney, J., Grima, A., HUETE, A. R., & Suggett, D. (2019) · Marine Ecology Progress Series · doi:10.3354/meps13073 · Cited by 117
A high-quality, chromosome-level genome assembly of the Black Soldier Fly ( Hermetia illucens L.)
Generalovic, T. N., McCarthy, S., Warren, I. A., Wood, J. M. D., Torrance, J., Sims, Y., Quail, M. A., Howe, K., Pipan, M., Durbin, R. M., et al. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab085 · Cited by 116
Completion of the gut microbial epi-bile acid pathway
Doden, H. L., Wolf, P. G., Gaskins, H. R., Anantharaman, K., Alves, J. M. P., & Ridlon, J. M. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1907271 · Cited by 117
Chloranthus genome provides insights into the early diversification of angiosperms
Guo, X., Fang, D., Sahu, S. K., Yang, S., Guang, X., Folk, R. A., Smith, S. A., Chanderbali, A. S., Chen, S., Liu, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26922-4 · Cited by 116
The Ubiquitous Human Skin Commensal Staphylococcus hominis Protects against Opportunistic Pathogens
Severn, M. M., Williams, M. R., Shahbandi, A., Bunch, Z. L., Lyon, L. M., Nguyen, A., Zaramela, L. S., Todd, D. A., Zengler, K., Cech, N. B., et al. (2022) · mBio · doi:10.1128/mbio.00930-22 · Cited by 116
Veenstra, J. A. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.06.013 · Cited by 116
Biller, S. J., McDaniel, L. D., Breitbart, M., Rogers, E., Paul, J. H., & Chisholm, S. W. (2016) · The ISME Journal · doi:10.1038/ismej.2016.134 · Cited by 116
Computational Predictions Provide Insights into the Biology of TAL Effector Target Sites
Grau, J., Wolf, A., Reschke, M., Bonas, U., Posch, S., & Boch, J. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002962 · Cited by 115
Fagerlund, A., Langsrud, S., Schirmer, B. C., Møretrø, T., & Heir, E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151117 · Cited by 115
PPARgene: A Database of Experimentally Verified and Computationally Predicted PPAR Target Genes
Li, F., Zhang, M., Li, Y., Liu, Y., Cui, Q., & Wang, N. (2016) · PPAR Research · doi:10.1155/2016/6042162 · Cited by 115
Haddad, S., Shin, S., Lemmon, A. R., Lemmon, E. M., Švácha, P., Farrell, B. D., Ślipiński, A., Windsor, D. M., & McKenna, D. D. (2017) · Systematic Entomology · doi:10.1111/syen.12257 · Cited by 115
Winter, D. J., Ganley, A. R. D., Young, C. A., Liachko, I., Schardl, C. L., Dupont, P., Berry, D., Ram, A., Scott, B., & Cox, M. P. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007467 · Cited by 115
Krebs, S. J., Kwon, Y. D., Schramm, C. A., Law, W. H., Donofrio, G. C., Zhou, K. H., Gift, S. K., Dussupt, V., Georgiev, I. S., Schätzle, S., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.008 · Cited by 115
TCR3d: The T cell receptor structural repertoire database
Gowthaman, R., & Pierce, B. G. (2019) · Bioinformatics · doi:10.1093/bioinformatics/btz517 · Cited by 115
PhyloFisher: A phylogenomic package for resolving eukaryotic relationships
Tice, A. K., Žihala, D., Pánek, T., Jones, R. E., Salomaki, E. D., Nenarokov, S., Burki, F., Eliáš, M., Eme, L., Roger, A. J., et al. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001365 · Cited by 116
Tumescheit, C., Firth, A. E., & Brown, K. A. (2022) · PeerJ · doi:10.7717/peerj.12983 · Cited by 115
Soil health is associated with higher primary productivity across Europe
Romero, F., Labouyrie, M., Orgiazzi, A., Ballabio, C., Panagos, P., Jones, A., Tedersoo, L., Bahram, M., Guerra, C. A., Eisenhauer, N., et al. (2024) · Nature Ecology & Evolution · doi:10.1038/s41559-024-02511-8 · Cited by 115
The last common ancestor of animals lacked the HIF pathway and respired in low-oxygen environments
Mills, D. B., Francis, W. R., Vargas, S., Larsen, M., Elemans, C. P., Canfield, D. E., & Wörheide, G. (2018) · eLife · doi:10.7554/elife.31176 · Cited by 114
Phylostratigraphic Bias Creates Spurious Patterns of Genome Evolution
Moyers, B. A., & Zhang, J. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu286 · Cited by 114
A giant virus infecting green algae encodes key fermentation genes
Schvarcz, C. R., & Steward, G. F. (2018) · Virology · doi:10.1016/j.virol.2018.03.010 · Cited by 114
Bacterial Community Composition and Dynamics Spanning Five Years in Freshwater Bog Lakes
Linz, A. M., Crary, B. C., Shade, A. L., Owens, S. M., Gilbert, J. A., Knight, R. D., & McMahon, K. D. (2017) · mSphere · doi:10.1128/msphere.00169-17 · Cited by 114
Garcia, A. K., McShea, H. S., Kolaczkowski, B., & Kaçar, B. (2020) · Geobiology · doi:10.1111/gbi.12381 · Cited by 116
Trace Metal Substitution in Marine Phytoplankton
Morel, F. M. M., Lam, P. J., & Saito, M. A. (2020) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev-earth-053018-060108 · Cited by 116
Donkey genomes provide new insights into domestication and selection for coat color
Wang, C., Li, H., Guo, Y., Huang, J., Sun, Y., Min, J., Wang, J., Fang, X., Zhao, Z., Wang, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19813-7 · Cited by 115
Li, G., Panday, S. K., & Alexov, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020606 · Cited by 114
Ballesteros, J. A., Santibáñez‐López, C. E., Baker, C. M., Benavides, L. R., Cunha, T. J., Gainett, G., Ontano, A. Z., Setton, E. V. W., Arango, C. P., Gavish‐Regev, E., et al. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac021 · Cited by 114
LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations
Zhao, L., Liu, L., Feng, C., Qin, Y., Xiao, J., Zhang, Z., & Ma, L. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac999 · Cited by 115
Origin and evolution of the bread wheat D genome
Cavalet-Giorsa, E., González-Muñoz, A., Athiyannan, N., Holden, S., Salhi, A., Gardener, C., Quiroz-Chávez, J., Rustamova, S. M., Elkot, A. F., Patpour, M., et al. (2024) · Nature · doi:10.1038/s41586-024-07808-z · Cited by 114
Chan, C. X., Yang, E. C., Banerjee, T., Yoon, H. S., Martone, P. T., Estevez, J. M., & Bhattacharya, D. (2011) · Current Biology · doi:10.1016/j.cub.2011.01.037 · Cited by 113
Yazawa, T., Kawahigashi, H., Matsumoto, T., & Mizuno, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062460 · Cited by 113
Liu, H., Lamm, M. S., Rutherford, K., Black, M. A., Godwin, J., & Gemmell, N. J. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0044-8 · Cited by 113
TENOR: Database for Comprehensive mRNA-Seq Experiments in Rice
Kawahara, Y., Oono, Y., Wakimoto, H., Ogata, J., Kanamori, H., Sasaki, H., Mori, S., Matsumoto, T., & Itoh, T. (2015) · Plant and Cell Physiology · doi:10.1093/pcp/pcv179 · Cited by 113
Comprehensive classification of the PIN domain-like superfamily
Matelska, D., Steczkiewicz, K., & Ginalski, K. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx494 · Cited by 113
Plant host habitat and root exudates shape fungal diversity
Hugoni, M., Luis, P., Guyonnet, J. P., & Haichar, F. E. Z. (2018) · Mycorrhiza · doi:10.1007/s00572-018-0857-5 · Cited by 113
Metadata
- Authors
- Camacho, C., Coulouris, G., Avagyan, V., Ma, N., Papadopoulos, J., Bealer, K., & Madden, T. L.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Madden, Thomas L
- ORCID
- Madden, Thomas L
- Venue
- BMC Bioinformatics
- Published
- 2009-12
- Volume
- 10
- Issue
- 1
- Pages
- 421-421
- ISSN
- 1471-2105 (ISSN-L)
- PMC
- PMC2803857
- OpenAlex
- W2142678478
- Cited by
- 22,074
- References
- 15
- Citations by year
- 2026: 2652 · 2025: 2909 · 2024: 2584 · 2023: 2213 · 2022: 2114 · 2021: 2164 · 2020: 1780 · 2019: 1400 · 2018: 1093 · 2017: 979 · 2016: 725 · 2015: 518 · 2014: 412 · 2013: 241 · 2012: 144
- FWCI
- 36.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Bioinformatics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health
- U.S. National Library of Medicine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Physical Sciences › Mathematics › Theoretical Computer Science › Algorithms and Data Compression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fractal and DNA sequence analysis
- Keywords
- BLAST, sequence similarity searching, chunking, command-line tool, software performance optimization, user interface
- MeSH terms
- Software, Sequence Alignment, Computational Biology, Databases, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review