Genetic origin, admixture, and asymmetry in maternal and paternal human lineages in Cuba
Open accessAbstract
Background: Before the arrival of Europeans to Cuba, the island was inhabited by two Native American groups, the Tainos and the Ciboneys. Most of the present archaeological, linguistic and ancient DNA evidence indicates a South American origin for these populations. In colonial times, Cuban Native American people were replaced by European settlers and slaves from Africa. It is still unknown however, to what extent their genetic pool intermingled with and was 'diluted' by the arrival of newcomers. In order to investigate the demographic processes that gave rise to the current Cuban population, we analyzed the hypervariable region I (HVS-I) and five single nucleotide polymorphisms (SNPs) in the mitochondrial DNA (mtDNA) coding region in 245 individuals, and 40 Y-chromosome SNPs in 132 male individuals. Results: The Native American contribution to present-day Cubans accounted for 33% of the maternal lineages, whereas Africa and Eurasia contributed 45% and 22% of the lineages, respectively. This Native American substrate in Cuba cannot be traced back to a single origin within the American continent, as previously suggested by ancient DNA analyses. Strikingly, no Native American lineages were found for the Y-chromosome, for which the Eurasian and African contributions were around 80% and 20%, respectively. Conclusion: While the ancestral Native American substrate is still appreciable in the maternal lineages, the extensive process of population admixture in Cuba has left no trace of the paternal Native American lineages, mirroring the strong sexual bias in the admixture processes taking place during colonial times.
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Latinos across the Americas have differing proportions of Native American, African, and European genetic ancestry, shaped by local historical interactions with migrants brought by the slave trade, European settlement, and indigenous Native American populations.
“Latinos across the Americas have differing proportions of Native American, African, and European genetic ancestry, shaped by local historical interactions with migrants brought by the slave trade, European settlement, and indigenous Native American populations.12–18”
From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [15]
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Experimental — accuracy not yet measuredConsistent with previous studies, Latinos have 13% less European ancestry on the X chromosome than genome-wide, showing proportionally greater European ancestry contributions from males.
“Consistent with previous studies that show a sex bias in admixture in Latino populations,12–18 we estimate 13% less European ancestry on the X chromosome than genome-wide (Table 1), showing proportionally greater European ancestry contributions from males.”
From The genetic ancestry of African Americans, Latinos, and European Americans across the United States (2015) · cites this paper as [15]
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The genetic ancestry of African Americans, Latinos, and European Americans across the United States
Bryc, K., Durand, E. Y., Macpherson, J. M., Reich, D., & Mountain, J. L. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.11.010 · Cited by 712 · see citing works
Origins and genetic legacies of the Caribbean Taino
Schroeder, H., Sikora, M., Gopalakrishnan, S., Cassidy, L. M., Maisano Delser, P., Sandoval Velasco, M., Schraiber, J. G., Rasmussen, S., Homburger, J. R., Ávila-Arcos, M. C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716839115 · Cited by 126 · see citing works
Self-citation
- Authors
- Mendizabal, I., Sandoval, K., Berniell-Lee, G., Calafell, F., Salas, A., Martínez-Fuentes, A., & Comas, D.
- Affiliations
- Universitat Pompeu Fabra (ES)
- Universidade de Santiago de Compostela (ES)
- University of Havana (CU)
- Corresponding author
- Comas, David
- Venue
- BMC Evolutionary Biology
- Published
- 2008-07-21
- Volume
- 8
- Issue
- 1
- Pages
- 213-213
- ISSN
- 1471-2148 (ISSN-L)
- PMC
- PMC2492877
- OpenAlex
- W2087572948
- Cited by
- 121
- References
- 1
- Citations by year
- 2026: 1 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 10
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Evolutionary Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (publishedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Hispana (submittedVersion, cc-by)
- Repositorio institucional da Universidade de Santiago de Compostela (University of Santiago de Compostela) (submittedVersion, other-oa)
- Funders
- Universitat Pompeu Fabra
- Generalitat de Catalunya
- Eusko Jaurlaritza
- Direcció General de Recerca, Generalitat de Catalunya
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Race, Genetics, and Society
- Keywords
- Native American ancestry, Taino, maternal lineage, paternal lineages, Y chromosome, mitochondrial DNA
- MeSH terms
- Cuba, DNA, Mitochondrial, Female, Genetics, Population, Haplotypes, Humans, Male, Phylogeny, Genetic Variation, Polymorphism, Single Nucleotide, Chromosomes, Human, Y, Racial Groups
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