Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats
Open accessAbstract
BACKGROUND: Obesity is a multifactor disease associated with cardiovascular disorders such as hypertension. Recently, gut microbiota was linked to obesity pathogenesisand shown to influence the host metabolism. Moreover, several factors such as host-genotype and life-style have been shown to modulate gut microbiota composition. Exercise is a well-known agent used for the treatment of numerous pathologies, such as obesity and hypertension; it has recently been demonstrated to shape gut microbiota consortia. Since exercise-altered microbiota could possibly improve the treatment of diseases related to dysfunctional microbiota, this study aimed to examine the effect of controlled exercise training on gut microbial composition in Obese rats (n = 3), non-obese Wistar rats (n = 3) and Spontaneously Hypertensive rats (n = 3). Pyrosequencing of 16S rRNA genes from fecal samples collected before and after exercise training was used for this purpose. RESULTS: Exercise altered the composition and diversity of gut bacteria at genus level in all rat lineages. Allobaculum (Hypertensive rats), Pseudomonas and Lactobacillus (Obese rats) were shown to be enriched after exercise, while Streptococcus (Wistar rats), Aggregatibacter and Sutturella (Hypertensive rats) were more enhanced before exercise. A significant correlation was seen in the Clostridiaceae and Bacteroidaceae families and Oscillospira and Ruminococcus genera with blood lactate accumulation. Moreover, Wistar and Hypertensive rats were shown to share a similar microbiota composition, as opposed to Obese rats. Finally, Streptococcus alactolyticus, Bifidobacterium animalis, Ruminococcus gnavus, Aggregatibacter pneumotropica and Bifidobacterium pseudolongum were enriched in Obese rats. CONCLUSIONS: These data indicate that non-obese and hypertensive rats harbor a different gut microbiota from obese rats and that exercise training alters gut microbiota from an obese and hypertensive genotype background.
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Exercise appears to be able to enrich microbiota diversity.
“Exercise appears to be able to enrich microbiota diversity [20–25]”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [24]
Other than a positive correlation between exercise and Lactobacillus, no other taxa consistently increase in relative abundance in regularly exercised mice or rats.
“Other than a positive correlation between exercise and Lactobacillus [73, 86, 87], there are no other taxa that consistently increase in relative abundance in regularly exercised mice or rats.”
From The athletic gut microbiota (2020) · cites this paper as [86]
Bacterial abundance of Clostridiaceae and Bacteroidaceae families and Ruminoccocus genus were negatively associated with blood lactate levels in exercised animals, whereas a positive association was reported for Oscillospira genus.
“The bacterial abundance of Clostridiaceae and Bacteroidaceae families and Ruminoccocus genus were negatively associated with blood lactate levels in exercised animals, whereas a positive association was reported for Oscillospira genus [86].”
From The athletic gut microbiota (2020) · cites this paper as [86]
Several other murine studies demonstrated increased alpha diversity in animals that exercised vs. those that were sedentary.
“Several other studies using murine-based models also demonstrated increased alpha diversity in animals that exercised vs. those that were sedentary [73, 74, 86, 87].”
From The athletic gut microbiota (2020) · cites this paper as [86]
Regular forced exercise differentially affected microbiota richness whether rats were obese-hypertensive or normal.
“For example, regular forced exercise differentially affected microbiota richness whether they were obese-hypertensive or normal rats [86].”
From The athletic gut microbiota (2020) · cites this paper as [86]
Previous studies failed to identify differences in the gut microbiota between WKY and SHR and L-NAME hypertension.
“Previous studies failed to identify differences in the gut microbiota between WKY and SHR36, and L-NAME hypertension37.”
From Gut Dysbiosis Is Linked to Hypertension (2015) · cites this paper as [36]
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References 63 · Cited by 293
- Authors
- Petriz, B. A., Castro, A. P., Almeida, J. A., Gomes, C. P., Fernandes, G. R., Kruger, R. H., Pereira, R. W., & Franco, O. L.
- Affiliations
- Universidade Católica de Brasília (BR)
- Universidade de Brasília (BR)
- Venue
- BMC Genomics
- Published
- 2014-06-21
- Volume
- 15
- Issue
- 1
- Pages
- 511-511
- ISSN
- 1471-2164 (ISSN-L)
- PMC
- PMC4082611
- OpenAlex
- W2007185474
- Cited by
- 293
- References
- 63
- Citations by year
- 2026: 9 · 2025: 15 · 2024: 17 · 2023: 23 · 2022: 37 · 2021: 35 · 2020: 26 · 2019: 35 · 2018: 28 · 2017: 31 · 2016: 18 · 2015: 18 · 2014: 1
- FWCI
- 9.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Genomics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by)
- RIUnB Institutional Repository (University of Brasília) (submittedVersion, cc-by)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Apoio à Pesquisa do Distrito Federal
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- exercise training, gut microbiota, obesity, hypertension, spontaneously hypertensive rats, obese rats, fecal microbiota, bacterial diversity, Clostridiaceae, Bacteroidaceae, Oscillospira, Ruminococcus, blood lactate, Streptococcus, Bifidobacterium, Pseudomonas, Lactobacillus, Aggregatibacter
- MeSH terms
- Animals, Hypertension, Obesity, Physical Conditioning, Animal, Gastrointestinal Tract, Rats, Microbiota
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