The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Acinetobacter baumannii invades epithelial cells and outer membrane protein A mediates interactions with epithelial cells
Open accessAbstract
Background: Acinetobacter baumannii is a nosocomial pathogen of increasing importance, but the pathogenic mechanism of this microorganism has not been fully explored. This study investigated the potential of A. baumannii to invade epithelial cells and determined the role of A. baumannii outer membrane protein A (AbOmpA) in interactions with epithelial cells. Results: A. baumannii invaded epithelial cells by a zipper-like mechanism, which is associated with microfilament- and microtubule-dependent uptake mechanisms. Internalized bacteria were located in the membrane-bound vacuoles. Pretreatment of recombinant AbOmpA significantly inhibited the adherence to and invasion of A. baumannii in epithelial cells. Cell invasion of isogenic AbOmpA- mutant significantly decreased as compared with wild-type bacteria. In a murine pneumonia model, wild-type bacteria exhibited a severe lung pathology and induced a high bacterial burden in blood, whereas AbOmpA- mutant was rarely detected in blood. Conclusion: A. baumannii adheres to and invades epithelial cells. AbOmpA plays a major role in the interactions with epithelial cells. These findings contribute to the understanding of A. baumannii pathogenesis in the early stage of bacterial infection.
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Cites
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Self-citationDiscrimination Between Intracellular Uptake and Surface Adhesion of Bacterial Pathogens
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Cited by
Lee, C.-R., Lee, J. H., Park, M., Park, K. S., Bae, I. K., Kim, Y. B., Cha, C.-J., Jeong, B. C., & Lee, S. H. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00055 · Cited by 1,016
Self-citationNie, D., Hu, Y., Chen, Z., Li, M., Hou, Z., Luo, X., Mao, X., & Xue, X. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-0617-7 · Cited by 316
Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung
Wang, N., Ozer, E. A., Mandel, M. J., & Hauser, A. R. (2014) · mBio · doi:10.1128/mbio.01163-14 · Cited by 234
“baumannii is thought to be an extracellular pathogen, although recent reports indicate that it can invade the intracellular compartment (26).”
BackgroundMortensen, B. L., & Skaar, E. P. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00095 · Cited by 99
Uppuluri, P., Lin, L., Alqarihi, A., Luo, G., Youssef, E. G., Alkhazraji, S., Yount, N. Y., Ibrahim, B. A., Bolaris, M. A., Edwards, J. E., et al. (2018) · PLOS Pathogens · doi:10.1371/journal.ppat.1007056 · Cited by 57
Metadata
- Authors
- Choi, C. H., Lee, J. S., Lee, Y. C., Park, T. I., & Lee, J. C.
- Venue
- BMC Microbiology
- Published
- 2008-12
- Volume
- 8
- Issue
- 1
- Pages
- 216-216
- ISSN
- 1471-2180 (ISSN-L)
- OpenAlex
- W1964799586
- Cited by
- 279
- References
- 22
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Choi, C. H., Lee, J. S., Lee, Y. C., Park, T. I., & Lee, J. C. (2008). Acinetobacter baumannii invades epithelial cells and outer membrane protein A mediates interactions with epithelial cells. BMC Microbiology. https://doi.org/10.1186/1471-2180-8-216
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