Cited by 99Bacterial Genetics and BiotechnologyAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensing

The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host

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Mortensen, Brittany L., Skaar, Eric P.·2013·Frontiers in Cellular and Infection Microbiology

Abstract

Acinetobacter baumannii is a significant contributor to intensive care unit (ICU) mortality causing numerous types of infection in this susceptible ICU population, most notably ventilator-associated pneumonia. The substantial disease burden attributed to A. baumannii and the rapid acquisition of antibiotic resistance make this bacterium a serious health care threat. A. baumannii is equipped to tolerate the hostile host environment through modification of its metabolism and nutritional needs. Among these adaptations is the evolution of mechanisms to acquire nutrient metals that are sequestered by the host as a defense against infection. Although all bacteria require nutrient metals, there is diversity in the particular metal needs among species and within varying tissue types and bacterial lifecycles. A. baumannii is well-equipped with the metal homeostatic systems required for the colonization of a diverse array of tissues. Specifically, iron and zinc homeostasis is important for A. baumannii interactions with biotic surfaces and for growth within vertebrates. This review discusses what is currently known regarding the interaction of A. baumannii with vertebrate cells with a particular emphasis on the contributions of metal homeostasis systems. Overall, published research supports the utility of exploiting these systems as targets for the development of much-needed antimicrobials against this emerging infectious threat.

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Crossref · 10.3389/fcimb.2013.00095

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  • Acinetobacter baumannii encodes several mechanisms to ensure zinc bioavailability.

    “For instance, the nosocomial Gram-negative bacterium Acinetobacter baumannii encodes several mechanisms to ensure zinc bioavailability (Mortensen and Skaar, 2013).”

    From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Mortensen and Skaar, 2013

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Authors
Mortensen, B. L., & Skaar, E. P.
Affiliations
Vanderbilt University (US)
Corresponding author
Skaar, Eric P.
Venue
Frontiers in Cellular and Infection Microbiology
Published
2013
Volume
3
Pages
95-95
ISSN
2235-2988 (ISSN-L)
OpenAlex
W2102877662
Cited by
99
References
123
Citations by year
2026: 9 · 2025: 9 · 2024: 8 · 2023: 11 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 3
FWCI
0.49
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (AI 069233, AI091771, F32AI108192, R01AI069233, R56AI091771, R01AI101171)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
Acinetobacter baumannii, metal homeostasis, iron acquisition, zinc uptake, host-pathogen interaction, bacterial survival in host, antibiotic resistance, antimicrobial drug targets, intensive care unit infections, ventilator-associated pneumonia
MeSH terms
Animals, Biological Transport, Homeostasis, Humans, Metals, Vertebrates, Helicobacter Infections, Acinetobacter baumannii, Microbial Viability, Metabolic Networks and Pathways

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