The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Frailty, fitness and late-life mortality in relation to chronological and biological age
Open accessAbstract
BACKGROUND: People age at remarkably different rates, but how to estimate trajectories of senescence is controversial. METHODS: In a secondary analysis of a representative cohort of Canadians aged 65 and over (n = 2914) we estimated a frailty index based on the proportion of 20 deficits observed in a structured clinical examination. The construct validity of the index was examined through its relationship to chronological age (CA). The criterion validity was examined in its ability to predict mortality, and in relation to other predictions about aging. From the frailty index, relative (to CA) fitness and frailty were estimated, as was an individual's biological age. RESULTS: The average value of the frailty index increased with age in a log-linear relationship (r = 0.91; p < 0.001). In a Cox regression analysis, biological age was significantly more highly associated with death than chronological age. The average increase in the frailty index (i.e. the average accumulation of deficits) amongst those with no cognitive impairment was 3 per cent per year. CONCLUSIONS: The frailty index is a sensitive predictor of survival. As the index includes items not traditionally related to adverse health outcomes, the finding is compatible with a view of frailty as the failure to integrate the complex responses required to maintain function.
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Cites
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Accumulation of Deficits as a Proxy Measure of Aging
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“While this is of interest, and served as the basis of further inquiry [27] we are not making a claim to have definitively calculated the PBA.”
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Self-citationA brief clinical instrument to classify frailty in elderly people
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Cited by
Frailty in relation to the accumulation of deficits
Rockwood, K., & Mitnitski, A. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.7.722 · Cited by 3,076
Self-citationPrevalence of frailty in community-dwelling older persons: a systematic review
Collard, R. M., Boter, H., Schoevers, R. A., & Oude Voshaar, R. C. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2012.04054.x · Cited by 3,073
Frailty: An Emerging Research and Clinical Paradigm--Issues and Controversies
Bergman, H., Ferrucci, L., Guralnik, J., Hogan, D. B., Hummel, S., Karunananthan, S., & Wolfson, C. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.7.731 · Cited by 1,134
The I.A.N.A. task force on frailty assessment of older people in clinical practice
Van Kan, G. A., Rolland, Y., Bergman, H., Morley, J. E., Kritchevsky, S. B., & Vellas, B. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982161 · Cited by 1,099
Levine, M. E. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gls233 · Cited by 892
Metadata
- Authors
- Mitnitski, A. B., Graham, J. E., Mogilner, A. J., & Rockwood, K.
- Venue
- BMC Geriatrics
- Published
- 2002-02-27
- Volume
- 2
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1471-2318 (ISSN-L)
- OpenAlex
- W1502716447
- Cited by
- 709
- References
- 36
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- gold
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