A portrait of single and multiple HPV type infections in Brazilian women of different age strata with squamous or glandular cervical lesions
Open accessAbstract
Background: Cervical cancer ranks third in prevalence and fourth as cause of death in women worldwide. In Brazil, 17,540 women were diagnosed in 2012 with the disease. Persistent infection with high-risk HPV types is a necessary condition for the development of pre-invasive and invasive cervical neoplasia. Currently, over 100 HPV types have been identified, but HPV16 and 18 are recognized as the mayor culprits in cervical carcinogenesis. Our objective was to assess the relationships between single- (ST) and multiple-type (MT) HPV infections with patients’ age and lesion pathological status. Methods: 328 patients with either squamous or glandular intraepithelial or invasive cervical lesion were selected. All subjects were tested for HPV genotypes with reverse hybridization for 21 high- (hr-HPV) and 16 low-risk (lr-HPV) probes. Prevalence of ST and MT HPV infections was compared across histological types and age strata. Results: 287 (87%) women had at least one HPV type detected and 149 (52%) had MT infections. The most prevalent HPV type was HPV16, present in 142 cases (49% of all HPV-positive cases), followed by HPV58, 52, 31, 35 and 33. HPV18, in single or multiple infections, occurred in 23 cases (8% of hr-HPV cases). Almost all glandular lesions were associated with HPV16 and 18 alone. Multiple infections were significantly more prevalent in squamous than in glandular lesion for HPV16 and 18 (P = 0.04 and 0.03 respectively). The prevalence of MT infections followed a bimodal distribution; peaking in women younger 29 years and in those aged 50 to 59. Conclusions: Our data indicate that prevention strategies for pre-invasive and invasive squamous lesions should be focused on HPV16 and a few alpha-9 HPV types. It is clear to us that in young women, prophylaxis must cover a large amalgam of HPV types beyond classic HPV16 and 18.
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The pattern of multiple infections in women without cancer corroborates with previous studies.
“In women without cancer multiple infections were most frequently observed in the age group 36–45 years and lowest in >55 years age group which corroborates with previous studies [25, 29].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [29]
The Results (page unavailable) report that multiple-type HPV infections were most prevalent in women under 29, not those aged 36–45. They do report a decline in women aged 60 or older, which broadly supports the older-age part of the pattern. The reported age pattern is not specific to women without cancer. (LLM, conf=0.86)
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- Authors
- Resende, L. S. D. A., Rabelo-Santos, S. H., Sarian, L. O., Alves, R. R. F., Ribeiro, A. A., Zeferino, L. C., & Derchain, S.
- Affiliations
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Universidade Federal de Goiás (BR)
- Corresponding author
- Derchain, Sophie
- ORCID
- Venue
- BMC Infectious Diseases
- Published
- 2014-04-22
- Volume
- 14
- Issue
- 1
- Pages
- 214-214
- ISSN
- 1471-2334 (ISSN-L)
- PMC
- PMC4020319
- OpenAlex
- W2048224389
- Cited by
- 23
- References
- 26
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 1
- FWCI
- 2.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Infectious Diseases (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, cc-by)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo (12/15059-8)
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Keywords
- human papillomavirus, multiple HPV infection, HPV16, HPV 18, high-risk HPV, low-risk HPV, cervical intraepithelial neoplasia, age distribution, HPV genotyping, cervical cancer prevention, Brazilian women
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Brazil, Uterine Cervical Dysplasia, Uterine Cervical Neoplasms, DNA, Viral, Female, Genotype, Humans, Middle Aged, Prevalence, Age Distribution, Papillomaviridae, Papillomavirus Infections, Young Adult, Coinfection
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