Identification of the collagen type 1 alpha 1 gene (COL1A1) as a candidate survival-related factor associated with hepatocellular carcinoma
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BACKGROUND: Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death especially among Asian and African populations. It is urgent that we identify carcinogenesis-related genes to establish an innovative treatment strategy for this disease. METHODS: Triple-combination array analysis was performed using one pair each of HCC and noncancerous liver samples from a 68-year-old woman. This analysis consists of expression array, single nucleotide polymorphism array and methylation array. The gene encoding collagen type 1 alpha 1 (COL1A1) was identified and verified using HCC cell lines and 48 tissues from patients with primary HCC. RESULTS: Expression array revealed that COL1A1 gene expression was markedly decreased in tumor tissues (log2 ratio -1.1). The single nucleotide polymorphism array showed no chromosomal deletion in the locus of COL1A1. Importantly, the methylation value in the tumor tissue was higher (0.557) than that of the adjacent liver tissue (0.008). We verified that expression of this gene was suppressed by promoter methylation. Reactivation of COL1A1 expression by 5-aza-2'-deoxycytidine treatment was seen in HCC cell lines, and sequence analysis identified methylated CpG sites in the COL1A1 promoter region. Among 48 pairs of surgical specimens, 13 (27.1%) showed decreased COL1A1 mRNA expression in tumor sites. Among these 13 cases, 10 had promoter methylation at the tumor site. The log-rank test indicated that mRNA down-regulated tumors were significantly correlated with a poor overall survival rate (P = 0.013). CONCLUSIONS: Triple-combination array analysis successfully identified COL1A1 as a candidate survival-related gene in HCCs. Epigenetic down-regulation of COL1A1 mRNA expression might have a role as a prognostic biomarker of HCC.
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In three breast cancer tissues, H&E regions corresponding to tumor tissue showed high similarity with bulk RNA-seq data from tumor biopsies, which include tumor-related markers such as COL1A1 and ACTB.
“In three breast cancer tissues, H&E regions corresponding to tumor tissue showed high similarity with the bulk RNA-seq data from tumor biopsies, which include tumor-related markers such as COL1A1 (ref. 38) and ACTB39 (Fig. 3b and Supplementary Fig. 5).”
From A visual–omics foundation model to bridge histopathology with spatial transcriptomics (2025) · cites this paper as [38]
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Jemal, A., Bray, F., Ferlay, J., Ward, E., & Forman, D. (2011) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20107 · Cited by 54,708 · see citing works
El-Serag, H. B. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1001683 · Cited by 3,529 · see citing works
Decitabine improves patient outcomes in myelodysplastic syndromes
Kantarjian, H. M., Issa, J. J., Rosenfeld, C. S., Bennett, J. M., Albitar, M. X., DiPersio, J. F., Klimek, V. M., Slack, J. L., de Castro, C., Ravandi, F., et al. (2006) · Cancer · doi:10.1002/cncr.21792 · Cited by 1,530 · see citing works
Hotary, K. B., Allen, E. D., Brooks, P. C., Datta, N. S., Long, M. W., & Weiss, S. J. (2003) · Cell · doi:10.1016/s0092-8674(03)00513-0 · Cited by 677 · see citing works
Over- and under-expressed microRNAs in human colorectal cancer
Mori (2009) · International Journal of Oncology · doi:10.3892/ijo_00000233 · Cited by 349 · see citing works
Huang, J., Wang, Y., Guo, Y., & Sun, S. (2010) · Hepatology · doi:10.1002/hep.23660 · Cited by 342 · see citing works
Zeller, C., Dai, W., Steele, N. L., Siddiq, A., Walley, A. J., Wilhelm-Benartzi, C. S., Rizzo, S., van der Zee, A. G. J., Plumb, J. A., & Brown, R. E. (2012) · Oncogene · doi:10.1038/onc.2011.611 · Cited by 281 · see citing works
Genome-wide screen of promoter methylation identifies novel markers in melanomaPreprint
Koga, Y., Pelizzola, M., Cheng, E., Krauthammer, M. O., Sznol, M., Ariyan, S., Narayan, D., Molinaro, A. M., Halaban, R., & Weissman, S. M. (2009) · Genome Research · doi:10.1101/gr.091447.109 · Cited by 196 · see citing works
Ishigami, K., Yoshimitsu, K., Nishihara, Y., Irié, H., Asayama, Y., Tajima, T., Nishie, A., Hirakawa, M., Ushijima, Y., Okamoto, D., et al. (2008) · Radiology · doi:10.1148/radiol.2501071702 · Cited by 188 · see citing works
Identification of Novel Target Genes by an Epigenetic Reactivation Screen of Renal Cancer
de Cáceres, I. I., Dulaimi, E., Hoffman, A. M., Al‐Saleem, T., Uzzo, R. G., & Cairns, P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3365 · Cited by 154 · see citing works
Cicinnati, V. R., Shen, Q., Sotiropoulos, G. C., Radtke, A., Gerken, G., & Beckebaum, S. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-350 · Cited by 128 · see citing works
Andreou, A., Vauthey, J., Cherqui, D., Zimmitti, G., Ribero, D., Truty, M. J., Wei, S. H., Curley, S. A., Laurent, A., Poon, R. T. P., et al. (2012) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-012-2005-4 · Cited by 112 · see citing works
Epigenetic-Based Therapies in Cancer
Song, S., Han, S., & Bang, Y. (2011) · Drugs · doi:10.2165/11596690-000000000-00000 · Cited by 96 · see citing works
Nomoto (2009) · International Journal of Oncology · doi:10.3892/ijo_00000359 · Cited by 96 · see citing works
Hishida, M., Nomoto, S., Inokawa, Y., Hayashi, M., Kanda, M., Okamura, Y., Nishikawa, Y., Tanaka, C., Kobayashi, D., Yamada, S., et al. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1951 · Cited by 88 · see citing works
Self-citationKanda, M., Nomoto, S., Okamura, Y., Hayashi, M., Hishida, M., Fujii, T., Nishikawa, Y., Sugimoto, H., Takeda, S., & Nakao, A. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.20735 · Cited by 86 · see citing works
Self-citationBonazzi, V., Nancarrow, D. J., Stark, M. S., Moser, R. J., Boyle, G. M., Aoude, L. G., Schmidt, C., & Hayward, N. K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026121 · Cited by 85 · see citing works
Murawaki, Y., Koda, M., Okamoto, K., Mimura, K., & Kawasaki, H. (2001) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2001.02515.x · Cited by 82 · see citing works
Lin, Z., & Chuang, W. (2012) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2012.04.001 · Cited by 79 · see citing works
Nomoto, S., Kanda, M., Okamura, Y., Nishikawa, Y., Li, Q., Fujii, T., Sugimoto, H., Takeda, S., & Nakao, A. (2009) · Annals of Surgical Oncology · doi:10.1245/s10434-009-0790-0 · Cited by 75 · see citing works
Self-citationHerranz, M., Martín‐Caballero, J., Fraga, M. F., Ruı́z-Cabello, J., Flores, J. M., Desco, M., Márquez, V. E., & Esteller, M. (2005) · Blood · doi:10.1182/blood-2005-05-2033 · Cited by 72 · see citing works
Surgical Treatment for Hepatocellular Carcinoma
Takayama, T. (2011) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyr016 · Cited by 67 · see citing works
Collagen α1(I) Gene (COL1A1) Is Repressed by RFX Family
Sengupta, P. K., Xu, Y., Wang, L., Widom, R. L., & Smith, B. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413191200 · Cited by 64 · see citing works
Okamura, Y., Nomoto, S., Kanda, M., Hayashi, M., Nishikawa, Y., Fujii, T., Sugimoto, H., Takeda, S., & Nakao, A. (2010) · Annals of Surgical Oncology · doi:10.1245/s10434-010-1273-z · Cited by 60 · see citing works
Self-citationAnderton, J. A., Lindsey, J. C., Lusher, M. E., Gilbertson, R. J., Bailey, S., Ellison, D. W., & Clifford, S. C. (2008) · Neuro-Oncology · doi:10.1215/15228517-2008-048 · Cited by 59 · see citing works
Okamura, Y., Nomoto, S., Kanda, M., Li, Q., Nishikawa, Y., Sugimoto, H., Kanazumi, N., Takeda, S., & Nakao, A. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.08.013 · Cited by 57 · see citing works
Self-citationIdentification of Novel Methylation Markers in Hepatocellular Carcinoma using a Methylation Array
Shin, S. H., Kim, B., Jang, J., Suh, K., & Kang, G. H. (2010) · Journal of Korean Medical Science · doi:10.3346/jkms.2010.25.8.1152 · Cited by 55 · see citing works
Enokida (2009) · International Journal of Oncology · doi:10.3892/ijo_00000289 · Cited by 53 · see citing works
Upregulation of hepatoma-derived growth factor is involved in murine hepatic fibrogenesis
Kao, Y. H., Chen, C., Jawan, B., Chung, Y.-H., Sun, C., Kuo, S.-M., Hu, T., Lin, Y., Chan, H., Cheng, K., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.10.002 · Cited by 50 · see citing works
Misawa, K., Kanazawa, T., Misawa, Y., Imai, A., Endo, S., Hakamada, K., & Mineta, H. (2012) · Cancer Biomarkers · doi:10.3233/cbm-2012-0242 · Cited by 42 · see citing works
Alterations of epigenetics and micro RNA in hepatocellular carcinoma
Saito, Y., Hibino, S., & Saito, H. (2013) · Hepatology Research · doi:10.1111/hepr.12147 · Cited by 42 · see citing works
Hayashi, M., Nomoto, S., Kanda, M., Okamura, Y., Nishikawa, Y., Yamada, S., Fujii, T., Sugimoto, H., Takeda, S., & Kodera, Y. (2011) · Journal of Surgical Oncology · doi:10.1002/jso.22135 · Cited by 39 · see citing works
Self-citationInokawa, Y., Nomoto, S., Hishida, M., Hayashi, M., Kanda, M., Nishikawa, Y., Takeda, S., Fujiwara, M., Koike, M., Sugimoto, H., et al. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s51913 · Cited by 38 · see citing works
Self-citationAttallah, A. M., Mosa, T. E., Omran, M. M., Abo‐Zeid, M., El‐Dosoky, I., & Shaker, Y. (2007) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321810701212088 · Cited by 36 · see citing works
Quinn, M. C. J., Wojnarowicz, P. M., Pickett, A., Provencher, D. M., Mes‐Masson, A., Davis, E. C., & Tonin, P. N. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1797 · Cited by 32 · see citing works
Kanda (2009) · International Journal of Oncology · doi:10.3892/ijo_00000448 · Cited by 32 · see citing works
Dahlman, T., Lammerts, E., Bergström, D., Franzén, Å., Westermark, K., Heldin, N., & Rubin, K. (2001) · International Journal of Cancer · doi:10.1002/ijc.10181 · Cited by 28 · see citing works
Okamura, Y., Nomoto, S., Hayashi, M., Hishida, M., Nishikawa, Y., Yamada, S., Fujii, T., Sugimoto, H., Takeda, S., Kodera, Y., et al. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.07.028 · Cited by 27 · see citing works
Self-citationKoilan, S., Hamilton, D. J., Baburyan, N., Padala, M. K., Weber, K. T., & Guntaka, R. V. (2010) · Oligonucleotides · doi:10.1089/oli.2010.0244 · Cited by 24 · see citing works
Inokawa, Y., Nomoto, S., Hishida, M., Hayashi, M., Kanda, M., Nishikawa, Y., Takeda, S., Sugimoto, H., Fujii, T., Yamada, S., et al. (2013) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-32-65 · Cited by 18 · see citing works
Self-citationThe 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007
Rajasekhar, V. K., Dalerba, P. D., Passegue, E. A., Lagasse, E., & Najbauer, J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0647 · Cited by 17 · see citing works
Bamias, A., Bamia, C., Zagouri, F., Kostouros, E., Kakoyianni, K., Rodolakis, A., Vlachos, G. D., Haidopoulos, D. A., Thomakos, N., Antsaklis, A. J., et al. (2012) · Oncology · doi:10.1159/000341366 · Cited by 17 · see citing works
Xia, X., Cui, Y., Huang, Y., Pan, L., Yang, B., Wang, H., Li, X., Shi, Y., Lu, H., & Zhou, Y. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.07.030 · Cited by 15 · see citing works
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Ma, H., Chang, H., Bamodu, O. A., Yadav, V. K., Huang, T., Wu, A. T. H., Yeh, C., Tsai, S. H., & Lee, W. (2019) · Cancers · doi:10.3390/cancers11060786 · Cited by 212 · see citing works
Identification of COL1A1 and COL1A2 as candidate prognostic factors in gastric cancer
Li, J., Ding, Y., & Li, A. (2016) · World Journal of Surgical Oncology · doi:10.1186/s12957-016-1056-5 · Cited by 199 · see citing works
MiR-129-5p suppresses gastric cancer cell invasion and proliferation by inhibiting COL1A1
Wang, Q., & Yu, J. (2017) · Biochemistry and Cell Biology · doi:10.1139/bcb-2016-0254 · Cited by 127 · see citing works
A visual–omics foundation model to bridge histopathology with spatial transcriptomics
Chen, W., Zhang, P., Tran, T. N., Xiao, Y., Li, S., Shah, V. V., Cheng, H., Brannan, K. W., Youker, K., Lai, L., et al. (2025) · Nature Methods · doi:10.1038/s41592-025-02707-1 · Cited by 118 · see citing works
“38) and ACTB 39 (Fig.”
He, B., Lin, X., Tian, F., Yu, W., & Qiao, B. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26182 · Cited by 116 · see citing works
Hua, X., Wang, Y., Jia, P., Xiong, Q., Hu, Y., Chang, Y., Lai, S., Xu, Y. J., Zhao, Z., & Song, J. (2020) · BMC Medicine · doi:10.1186/s12916-019-1469-4 · Cited by 114 · see citing works
Aspects of the Epigenetic Regulation of EMT Related to Cancer Metastasis
Nowak, E., & Bednarek, I. A. (2021) · Cells · doi:10.3390/cells10123435 · Cited by 110 · see citing works
Angel, P. M., Comte‐Walters, S., Ball, L. E., Talbot, K. M., Mehta, A. S., Brockbank, K. G. M., & Drake, R. R. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00713 · Cited by 102 · see citing works
Jiang, K., Liu, H., Xie, D., & Xiao, Q. (2019) · Oncology Letters · doi:10.3892/ol.2019.9952 · Cited by 87 · see citing works
Thangavelu, P. U., Krenács, T., Dray, E. V., & Duijf, P. H. G. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0290-6 · Cited by 79 · see citing works
Zhang, R., Ma, M., Lin, X.-H., Liu, H.-H., Chen, J., Chen, J., Gao, D.-M., Cui, J.-F., Ren, Z.-G., & Chen, R.-X. (2018) · BMC Cancer · doi:10.1186/s12885-018-4820-9 · Cited by 68 · see citing works
Regulatory effects of COL1A1 on apoptosis induced by radiation in cervical cancer cells
Liu, S., Liao, G., & Li, G. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0443-5 · Cited by 67 · see citing works
Chen, C., Chung, T., Wu, C., Ng, K., Yu, J., Tsai, C.-H., Chang, Y., Liang, Y. J., Tsui, K., & Chen, Y. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.051524 · Cited by 64 · see citing works
Filliol, A. A., & Schwabe, R. F. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1685539 · Cited by 58 · see citing works
Yin, Y., Du, L., Li, X., Zhang, X., & Gao, Y. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27896 · Cited by 56 · see citing works
Manjubaashini, N., Purushothaman, B., & Balakumar, S. (2024) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2024.115702 · Cited by 52 · see citing works
Mann, S. N., Hadad, N., Holte, M. N., Rothman, A. R., Sathiaseelan, R., Mondal, S. A., Agbaga, M., Unnikrishnan, A., Subramaniam, M., Hawse, J. R., et al. (2020) · eLife · doi:10.7554/elife.59616 · Cited by 50 · see citing works
Benlebna, M., Balas, L., Bonafos, B., Pessemesse, L., Vigor, C., Grober, J., Bernex, F., Fouret, G., Paluchová, V., Gaillet, S., et al. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108361 · Cited by 49 · see citing works
Mitochondrial DNA plasticity is an essential inducer of tumorigenesis
Lee, W., Cain, J. E., Cuddihy, A. R., Johnson, J., Dickinson, A., Yeung, K.-Y., Kumar, B., Johns, T. G., Watkins, D. N., Spencer, A. G., et al. (2016) · Cell Death Discovery · doi:10.1038/cddiscovery.2016.16 · Cited by 40 · see citing works
Identification of hub genes and outcome in colon cancer based on bioinformatics analysis
Yang, W., Ma, J., Zhou, W. J., Li, Z., Zhou, X., Cao, B., Zhang, Y., Liu, J., Yang, Z., Zhang, H., et al. (2018) · Cancer Management and Research · doi:10.2147/cmar.s173240 · Cited by 38 · see citing works
Atia, M. M., Abdel-Tawab, H. S., Mostafa, A., & Mobarak, S. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-12406-y · Cited by 37 · see citing works
miR-133b Suppresses Invasion and Migration of Gastric Cancer Cells via the COL1A1/TGF-β Axis
Guo, Y., Lu, G., Mao, H., Zhou, S., Tong, X., Wu, J., Sun, Q., Xu, H., & Fang, F. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s249667 · Cited by 36 · see citing works
Wu, W., Zhu, Y., Long, F., Luo, L., Deng, Q., Wu, J.-L., Ouyang, S., & Tang, D. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103457 · Cited by 34 · see citing works
Lv, J., Guo, L., Wang, J.-H., Yan, Y., Zhang, J., Wang, Y., Yu, Y. P., Huang, Y., & Zhao, H. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i2.233 · Cited by 33 · see citing works
High expression of collagen 1A2 promotes the proliferation and metastasis of esophageal cancer cells
Li, G., Jiang, W., Kang, Y., Yu, X., Zhang, C., & Yu, F. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-7867 · Cited by 33 · see citing works
Min, S., Lee, Y., Hong, J., Park, T. J., Woo, H. G., Kwon, S. M., & Yoon, G. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04370-8 · Cited by 33 · see citing works
Yang, W., Zhao, X., Han, Y., Duan, L., Lü, X., Wang, X., Zhang, Y., Zhou, W. J., Liu, J., Zhang, H., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0854-6 · Cited by 31 · see citing works
Bibaki, E., Tsitoura, E., Vasarmidi, E., Margaritopoulos, G., Trachalaki, A., Koutoulaki, C., Georgopoulou, T., Spandidos, D., Tzanakis, N., & Antoniou, K. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8778 · Cited by 29 · see citing works
Zarzour, R. A., Alshawsh, M. A., Asif, M., Al‐Mansoub, M. A., Mohamed, Z., Ahmad, M., Majid, A. M. S. A., Asmawi, M. Z., Kaur, G., Al-dualimi, D. W., et al. (2018) · Nutrients · doi:10.3390/nu10081057 · Cited by 28 · see citing works
Influence of surface topography on PCL electrospun scaffolds for liver tissue engineering
Gao, Y., & Callanan, A. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00789k · Cited by 29 · see citing works
Shen, L., Xiao, Y., Wu, Q., Liu, L., Zhang, C., & Pan, X. (2019) · Europe PMC (PubMed Central) · Cited by 25 · see citing works
Song, Y., Wang, X., Wang, F., Peng, X., Li, P., Liu, S., & Zhang, D. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01814-1 · Cited by 23 · see citing works
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Baglieri, J., Zhang, C., Liang, S., Liu, X., Nishio, T., Rosenthal, S. B., Dhar, D., Su, H., Cong, M., Jia, J., et al. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.05.019 · Cited by 23 · see citing works
Identity of MMP1 and its effects on tumor progression in head and neck squamous cell carcinoma
Zhang, G., Li, T., Tan, G., Song, Y., Liu, Q., Wang, K., Ai, J., Zhou, Z. Y., & Li, W. (2022) · Cancer Medicine · doi:10.1002/cam4.4623 · Cited by 23 · see citing works
Zhao, W. G., Jiang, X., & Yang, S. (2020) · Cancer Management and Research · doi:10.2147/cmar.s256624 · Cited by 23 · see citing works
Hepatotoxicity assessment of Rhizoma Paridis in adult zebrafish through proteomes and metabolome
Jia, Z., Zhao, C., Wang, M., Zhao, X., Zhang, W., Han, T., Xia, Q., Han, Z., Lin, R., & Li, X.-R. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109558 · Cited by 21 · see citing works
Identification of COL1A1 associated with immune infiltration in brain lower grade glioma
Ren, J., Da, J., & Hu, N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269533 · Cited by 18 · see citing works
MALDI-MSI: A Powerful Approach to Understand Primary Pancreatic Ductal Adenocarcinoma and Metastases
Gonçalves, J. P. L., Bollwein, C., Schlitter, A. M., Kriegsmann, M., Jacob, A., Weichert, W., & Schwamborn, K. (2022) · Molecules · doi:10.3390/molecules27154811 · Cited by 18 · see citing works
Inokawa, Y., Inaoka, K., Sonohara, F., Hayashi, M., Kanda, M., & Nomoto, S. (2016) · Oncology Letters · doi:10.3892/ol.2016.5141 · Cited by 16 · see citing works
Self-citationIdentification of six candidate genes for endometrial carcinoma by bioinformatics analysis
Zhu, Y., Shi, L., Chen, P., Zhang, Y., & Zhu, T. (2020) · World Journal of Surgical Oncology · doi:10.1186/s12957-020-01920-w · Cited by 16 · see citing works
Panneerselvam, J., Mohamed, J. M. M., Annamalai, D., Al‐Serwi, R. H., Ibrahim, A. M., El‐Sherbiny, M., Rajam, A. M., Eldesoqui, M. B., & Mansour, N. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125948 · Cited by 14 · see citing works
Igreja, I. C., Tripská, K., Hroch, M., Hyšpler, R., Tichá, A., Laštůvková, H., Schreiberová, J., Doleželová, E., Eissazadeh, S., Vitverová, B., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239021 · Cited by 14 · see citing works
Search for useful biomarkers in hepatocellular carcinoma, tumor factors and background liver factors
Shimizu, D., Inokawa, Y., Sonohara, F., Inaoka, K., & Nomoto, S. (2017) · Oncology Reports · doi:10.3892/or.2017.5541 · Cited by 13 · see citing works
Self-citationHansdah, K., Singh, N., Bouzid, A., Priyadarshi, S., Ray, C. S., Desai, A., Panda, K. C., Choudhury, J. C., Biswal, N. C., Tekari, A., et al. (2020) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2019.0235 · Cited by 12 · see citing works
Zhang, R., Zhang, L., Yang, M., Huang, L., Chen, G., & Feng, Z. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.8167 · Cited by 12 · see citing works
Patil, A., Salvatori, R., Smith, L., Jenkins, S. M., Cannon, A. C., Hartley, C., Graham, R. P., & Moreira, R. K. (2023) · Histopathology · doi:10.1111/his.15001 · Cited by 11 · see citing works
Ding, B., Ye, Z., Yin, H., Hong, X., Feng, S., Xu, J., & Shen, Y. (2023) · Genomics · doi:10.1016/j.ygeno.2023.110703 · Cited by 11 · see citing works
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Inaoka, K., Inokawa, Y., & Nomoto, S. (2015) · Microarrays · doi:10.3390/microarrays4040454 · Cited by 11 · see citing works
Self-citationSun, W., Zhang, Y., Liu, B., Duan, Y., Li, W., & Chen, J. (2021) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/2021/9990305 · Cited by 11 · see citing works
Hishida, M., Inokawa, Y., Takano, N., Nishikawa, Y., Iwata, N., Kanda, M., Tanaka, C., Kobayashi, D., Yamada, S., Nakayama, G., et al. (2015) · Journal of Surgical Research · doi:10.1016/j.jss.2014.12.045 · Cited by 11 · see citing works
Self-citationIdentifying hepatocellular carcinoma-related genes and pathways by system biology analysis
Wang, P., Ouyang, L., Zheng, L., & Wang, Z. (2014) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-014-1119-y · Cited by 10 · see citing works
Jiang, A., Liu, J.-T., Zhao, K., Wu, H., Wang, S., Yan, K., & Yang, W. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.561805 · Cited by 10 · see citing works
Xu, J., Ma, J., Shi, Y., Yin, D., Zhang, Y., Dai, P., Zhao, W., & Zhang, T. (2020) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201900112 · Cited by 10 · see citing works
Tandem mass tag‐based quantitative proteomic analysis of cervical cancer
Aljawad, M. F., Faisal, A. H. M. A., Alqanbar, M. F., Wilmarth, P. A., & Hassan, B. Q. (2022) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.202100105 · Cited by 10 · see citing works
Proteomic Signatures of Thymomas
Wang, L., Branson, O. E., Shilo, K., Hitchcock, C. L., & Freitas, M. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166494 · Cited by 10 · see citing works
Propolis compound inhibits profibrotic TGF-β1/SMAD signalling in human fibroblasts
Randall, L. J., Bajan, S., Tran, T. D., Harvey, R. J., & Russell, F. D. (2025) · Scientific Reports · doi:10.1038/s41598-025-07918-2 · Cited by 9 · see citing works
Macdonald, J. K., Taylor, H. B., Wang, M., DelaCourt, A. T., Edge, C., Lewin, D., Kubota, N., Fujiwara, N., Rasha, F. A., Marquez, C. A., et al. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00099 · Cited by 9 · see citing works
Zhu, M., Gong, J., Zhan, M., Xi, C., Shen, G., & Shen, H. (2021) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2021.100916 · Cited by 9 · see citing works
Castro‐Gil, M. P., Torres‐Mena, J. E., Salgado, R. M., Muñoz-Montero, S. A., Martínez-Garcés, J. M., López‐Torres, C. D., Mendoza-Vargas, A., Gabiño‐López, N. B., Villa‐Treviño, S., del Pozo‐Yauner, L., et al. (2021) · Genomics · doi:10.1016/j.ygeno.2021.11.035 · Cited by 9 · see citing works
Exploring the key genes and pathways in enchondromas using a gene expression microarray
Shi, Z., Zhou, H., Pan, B., Lu, L., Kang, Y., Liu, L., Wei, Z., & Feng, S. (2017) · Oncotarget · doi:10.18632/oncotarget.16700 · Cited by 9 · see citing works
Bioinformatic and experimental analyses of key biomarkers in pancreatic cancer
Ren, T., Xue, X., Wang, X., Zhou, X., & Dang, S.-C. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10794 · Cited by 8 · see citing works
Quah, Y., Chan, J. Y.-L., Park, N., Lee, Y. Y., Lee, E., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S., & Park, S.-C. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00622-7 · Cited by 8 · see citing works
Integrated miRNA-mRNA analysis of Epstein-Barr virus-positive nasopharyngeal carcinoma
Zhu, L., Miao, X. T., & Wang, N. (2015) · Genetics and Molecular Research · doi:10.4238/2015.june.1.20 · Cited by 8 · see citing works
Identification of a Combined RNA Prognostic Signature in Adenocarcinoma of the Lung
He, S.-Y., Xi, W., Wang, X., Xu, C., Cheng, L., Liu, S.-Y., Meng, Q., Li, B., Wang, Y., Shi, H., et al. (2019) · Medical Science Monitor · doi:10.12659/msm.913727 · Cited by 7 · see citing works
Yang, W., Pan, Y., Guan, P., Li, X., & You, C. (2019) · Europe PMC (PubMed Central) · doi:10.12122/j.issn.1673-4254.2019.05.07 · Cited by 7 · see citing works
ZIC5 promotes human hepatocellular carcinoma cell proliferation through upregulating COL1A1
Song, W., Yu, W., Ding, L., Cheng, C., Wu, X., Chen, J., & Zhang, W. (2022) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-22-335 · Cited by 7 · see citing works
A prognostic model based on the COL1A1-network in gastric cancer.
Liu, S., Chen, L., Zeng, J., & Chen, Y. (2023) · PubMed Central · Cited by 7 · see citing works
Hansen, R. L., & Lange, J. (2013) · PubMed · Cited by 5 · see citing works
Mao, M., Li, Z., Zheng, W., Xia, H., Fei, Z., Yao, Q., & Zheng, R. (2025) · Journal of Neuro-Oncology · doi:10.1007/s11060-025-05132-8 · Cited by 4 · see citing works
Guo, Y., Wang, X., Ning, W., Zhang, H., & Yu, C. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05804-w · Cited by 4 · see citing works
Hu, Y., Hu, Z., Ding, H., Li, Y., Zhao, X., Shao, T. M., & Pan, Y. (2020) · Translational Cancer Research · doi:10.21037/tcr-20-926 · Cited by 4 · see citing works
Wihastyoko, H. Y. L., Soeharto, S., Widjajanto, E., Handono, K., & Pardjianto, B. (2021) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2021.00862 · Cited by 4 · see citing works
Mohamed, A. A., Abo-Amer, Y. E.-E., Aalkhalegy, A., Fathalla, L. A., Elmaghraby, M. B., Elhoseeny, M. M., Mostafa, S. M., El-Abgeegy, M., Khattab, R. A., El-damasy, D. A., et al. (2021) · The Open Biomarkers Journal · doi:10.2174/1875318302111010108 · Cited by 3 · see citing works
Sztolsztener, K., Konstantynowicz-Nowicka, K., Pędzińska‐Betiuk, A., & Chabowski, A. (2023) · Cells · doi:10.3390/cells12182243 · Cited by 3 · see citing works
Alsahli, T. G., Khalid, M., Malik, M. N. H., & Alshammari, S. O. (2025) · Medicina · doi:10.3390/medicina61061048 · Cited by 2 · see citing works
Molecular Profiling of Human Hepatocellular Carcinoma
Budhu, A., & Wang, X.-W. (2016) · Springer eBooks · doi:10.1007/978-3-319-34214-6_5 · Cited by 1 · see citing works
Yang, Y., Dai, E., Wang, S., & Bai, Y. (2020) · DNA and Cell Biology · doi:10.1089/dna.2019.5320 · Cited by 2 · see citing works
The P2X7 Receptor Promotes Intestinal Fibrosis by Modulating the Gut Microbiota and the Inflammasome
Ribeiro, B. E., de Lima, I. S., Souza, K. C. D. S. E., Rosas, S. L. B., Santana, P. T., Amaral, G. R. S., Machado, J. C., de Oliveira, R. P., Leal, C. V., Thompson, C. C., et al. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101718 · Cited by 1 · see citing works
Li, X., Wang, Z., Xie, J., & Zhu, N. (2021) · Research Square · doi:10.21203/rs.3.rs-386986/v1
Wagle, M. M., Rao, A. K., Kabekkodu, S. P., & Mallya, S. P. (2021) · Research Square · doi:10.21203/rs.3.rs-879048/v1
Wagle, M. M., Kedige, A. R., Kabekkodu, S. P., & Mallya, S. (2021) · Research Square · doi:10.21203/rs.3.rs-879048/v2
Causin, R. L., da Silva, L. S., Leal, L. F., Resende, J. C. P., Evangelista, A. F., Matsushita, G. M., Scapulatempo‐Neto, C., Fregnani, J. H. T. G., de Oliveira, M. A., Musselwhite, L. W., et al. (2023) · Cancer Cytopathology · doi:10.1002/cncy.22704
Wagle, M. M., Kedige, A. R., Kabekkodu, S. P., & Mallya, S. (2023) · Asian Pacific Journal of Cancer Prevention · doi:10.31557/apjcp.2023.24.5.1601
Ghosh, S., Datta, R., & Thakur, S. (2024) · Human Gene · doi:10.1016/j.humgen.2024.201357
Effectiveness of a Novel CTGF LNA GapmeR Sequence in Gastric Cancer Cells
Bilecen, D. S. (2024) · Süleyman Demirel Üniversitesi Fen Edebiyat Fakültesi Fen Dergisi · doi:10.29233/sdufeffd.1395816
Boonto, T., & Ariyachet, C. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i7.106795
Song, Y., Wang, X., Wang, F., Peng, X., Li, P., Liu, S., & Zhang, D. (2021) · Figshare · doi:10.6084/m9.figshare.14059482
Song, Y., Wang, X., Wang, F., Peng, X., Li, P., Liu, S., & Zhang, D. (2021) · Figshare · doi:10.6084/m9.figshare.14059476
Quah, Y., Chan, J. Y.-L., Park, N.-H., Lee, Y. Y., Lee, E.-B., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S.-J., & Park, S.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20070891
Quah, Y., Chan, J. Y.-L., Park, N.-H., Lee, Y. Y., Lee, E.-B., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S.-J., & Park, S.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20070903
Quah, Y., Chan, J. Y.-L., Park, N.-H., Lee, Y. Y., Lee, E.-B., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S.-J., & Park, S.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20070894
Quah, Y., Chan, J. Y.-L., Park, N.-H., Lee, Y. Y., Lee, E.-B., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S.-J., & Park, S.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20070876
Quah, Y., Chan, J. Y.-L., Park, N.-H., Lee, Y. Y., Lee, E.-B., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S.-J., & Park, S.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20070888
Quah, Y., Chan, J. Y.-L., Park, N.-H., Lee, Y. Y., Lee, E.-B., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S.-J., & Park, S.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20070885
Quah, Y., Chan, J. Y.-L., Park, N.-H., Lee, Y. Y., Lee, E.-B., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S.-J., & Park, S.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20070882
Quah, Y., Chan, J. Y.-L., Park, N.-H., Lee, Y. Y., Lee, E.-B., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S.-J., & Park, S.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20070867
Song, Y., Wang, X., Wang, F., Peng, X., Li, P., Liu, S., & Zhang, D. (2021) · Figshare · doi:10.6084/m9.figshare.14059479
Quah, Y., Chan, J. Y.-L., Park, N.-H., Lee, Y. Y., Lee, E.-B., Jang, S.-H., Kim, M.-J., Rhee, M. H., Lee, S.-J., & Park, S.-C. (2022) · Figshare · doi:10.6084/m9.figshare.20070870
EVALUATION OF THE EFFECTS OF SULFAMETHOXAZOLE ON ENDOTHELIAL AND FIBROBLAST CELLS
Şen, M. B., Kaçaroğlu, D., & Erikçi, A. (2026) · Ankara Universitesi Eczacilik Fakultesi Dergisi · doi:10.33483/jfpau.1661024
- Authors
- Hayashi, M., Nomoto, S., Hishida, M., Inokawa, Y., Kanda, M., Okamura, Y., Nishikawa, Y., Tanaka, C., Kobayashi, D., Yamada, S., Nakayama, G., Fujii, T., Sugimoto, H., Koike, M., Fujiwara, M., Takeda, S., & Kodera, Y.
- Affiliations
- Nagoya University (JP)
- Corresponding author
- Nomoto, Shuji
- ORCID
- Venue
- BMC Cancer
- Published
- 2014-02-19
- Volume
- 14
- Issue
- 1
- Pages
- 108-108
- ISSN
- 1471-2407 (ISSN-L)
- PMC
- PMC4015503
- OpenAlex
- W2152909439
- Cited by
- 101
- References
- 43
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 17 · 2021: 16 · 2020: 14 · 2019: 10 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Cancer (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22591427)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- hepatocellular carcinoma, COL1A1, promoter methylation, epigenetic silencing, gene downregulation, prognostic factors, overall survival, decitabine, single nucleotide polymorphism array, DNA methylation arrays
- MeSH terms
- Collagen Type I, alpha 1 Chain, Aged, Base Sequence, Female, Carcinoma, Hepatocellular, Humans, Liver Neoplasms, Molecular Sequence Data, Survival Rate, Collagen Type I, Cell Line, Tumor, Genetic Association Studies
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