The effectiveness of cognitive behavioral therapy on the quality of life of patients with inflammatory bowel disease: multi-center design and study protocol (KL!C- study)
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Background: Inflammatory Bowel Disease (IBD) patients report poorer quality of life (QoL) and more anxiety and depressive symptoms than controls from the general population. Cognitive behavioral therapy (CBT) is effective for anxiety and depression, but questionable in case of co-morbidity with IBD. Therefore, an adapted new CBT specifically designed for IBD patients was developed. The objective of this study is to evaluate the effectiveness of adapted CBT on QoL. Methods/design: IBD patients with a poor level of mental QoL (score less than or equal to 23 on the mental health scale of SF-36) will be randomly assigned to the experimental (n = 40) or waiting-list control condition (n = 40). The experimental condition will then immediately start CBT. The waiting-list control condition will wait 3,5 months before CBT begins with pre- and post assessments. Both conditions will complete a baseline and follow-up assessment following CBT and a mid-treatment assessment. The primary outcome is IBD-specific QoL (IBDQ). Secondary outcomes are generic QoL (SF-36) and anxiety and depression complaints (HADS, CES-D). Additionally, we will examine the working mechanism of the psychological intervention by investigating the impact of the intervention on illness-related cognitions, attitudes, coping styles and their associations with outcome. Data will be analysed on an intention to treat (ITT) as well as treatment completer basis (greater than or equal to five sessions followed). Discussion: If found effective, this IBD-specific CBT is a first step to enhance poor QoL in IBD patients and possibly, other gastroenterological diseases. By enhancing IBD patients’ QoL, we may also improve their mental and physical health, and lower unnecessary health care consumption. Trial registration number: NTR (TC = 1869)
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Over 60% of adult IBD patients attending a tertiary care centre with co-morbid anxiety and/or depressive symptoms did not receive adequate care.
“A recent Dutch study (n=231) showed that over 60% of adult IBD patients attending a tertiary care centre with co-morbid anxiety and/or depressive symptoms did not receive adequate care (12).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [12]
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“In case of depression the therapist will stimulate behavioral change by helping patients to become more active by increasing mood independent potential pleasurable (reinforcing) activities in their lives (behavior activation) [19-21].”
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“Results from a recent meta-analysis of psychological interventions for treatment of IBD showed that current psychological treatment is not effective among IBD patients [15].”
BackgroundInfluentialBennebroek Evertsz', F., Thijssens, N. A. M., Stokkers, P. C. F., Grootenhuis, M. A., Bockting, C. L. H., Nieuwkerk, P. T., & Sprangers, M. A. G. (2012) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2011.07.006 · Cited by 131 · see citing works
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“Additionally, CD patients report a poorer quality of life and more anxiety symptoms than UC patients [49,50].”
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Mikocka-Walus, A., Knowles, S. R., Keefer, L., & Graff, L. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000620 · Cited by 567 · see citing works
Bennebroek Evertsz', F., Sprangers, M. A. G., Sitnikova, K., Stokkers, P. C. F., Ponsioen, C. Y., Bartelsman, J. F. W. M., van Bodegraven, A. A., Fischer, S., Depla, A. C. T. M., Mallant, R. C., et al. (2017) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000227 · Cited by 84 · see citing works
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- Authors
- Evertsz’, F. B., Bockting, C. L., Stokkers, P. C., Hinnen, C., Sanderman, R., & Sprangers, M. A.
- Affiliations
- University of Groningen (NL)
- Sint Lucas Andreas Hospital (NL)
- University Medical Center Groningen (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- BMC Psychiatry
- Published
- 2012-12
- Volume
- 12
- Issue
- 1
- Pages
- 227-227
- ISSN
- 1471-244X (ISSN-L)
- PMC
- PMC3570397
- OpenAlex
- W2084589932
- Cited by
- 30
- References
- 9
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 2
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Psychiatry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Pure Amsterdam UMC (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Funders
- Maag Lever Darm Stichting
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Keywords
- cognitive behavioral therapy, inflammatory bowel disease, quality of life, anxiety, depression, coping styles, psychological intervention, gastroenterological diseases, waitlist control
- MeSH terms
- Adaptation, Psychological, Adult, Anxiety, Attitude to Health, Clinical Protocols, Cognition, Depression, Humans, Quality of Life, Inflammatory Bowel Diseases, Cognitive Behavioral Therapy
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