CoChat
Sign Up
Cited by 292Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromePsychosomatic Disorders and Their Treatments

The Relationship of Inflammatory Bowel Disease Type and Activity to Psychological Functioning and Quality of Life

Open access
Graff, Lesley A., Walker, John R., Lix, Lisa, Clara, Ian, Rawsthorne, Patricia, Rogala, Linda, Miller, Norine, Jakul, Laura +3 more·2006·Clinical Gastroenterology and Hepatology
DOI 10.1016/j.cgh.2006.09.027
Open this paper in CoChat — free accountOpen PDF

Abstract

Background & aims We aimed to assess the relationship of disease type and disease activity with psychological functioning and quality of life (QOL) in a population-based cohort of patients with recently diagnosed inflammatory bowel disease (IBD).Methods A total of 388 individuals diagnosed within 7 years were recruited from a population-based registry of IBD patients for the Manitoba IBD Cohort Study. Participants completed a clinical interview and standardized self-report measures of positive and negative psychological functioning, and QOL. Disease activity was determined by symptom self-report over the prior 6 months; Harvey-Bradshaw or Powell-Tuck disease activity indices also were used. Disease type was determined through chart verification.Results Seventy-four percent of Crohn's disease and 66% of ulcerative colitis participants had active disease during the previous 6 months. Multivariate regression showed that those with active disease had higher levels of distress, health anxiety, and perceived stress, lower social support, well-being and mastery, and poorer disease-specific QOL, relative to those with inactive disease. Disease type was not contributory to psychological functioning or QOL. Pain anxiety (fear of pain) and pain-specific catastrophizing were not associated with disease activity, after controlling for other psychological variables. Participants with either active or inactive disease had suboptimal general QOL.Conclusions Ulcerative colitis and Crohn's disease participants were not differentiated in their psychological profiles. Given the strong association between disease-specific QOL, psychological functioning, and disease activity, it is important to be aware of related difficulties in patients with active IBD. There is a continued impact on QOL by the disease, even when it is inactive.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cgh.2006.09.027

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Self-report measures have the advantages of being quick and easy to administer, low in cost, nonintrusive, reasonably consistent over time, and strongly related to important clinical outcomes.

    “Self-report measures have the advantage of being quick and easy to administer, low in cost, nonintrusive, reasonably consistent over time, and relate strongly to important clinical outcomes 13 .”

    From The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity (2009) · cites this paper as [13]

  • Of 15 studies with applicable data, 11 reported significantly higher rates or levels of anxiety in active IBD compared to inactive IBD.

    “Of the remaining 15, 11 reported significantly higher rates or levels of anxiety in participants with active IBD compared to those with inactive IBD (n=13,585) (4, 18, 20, 27, 29, 31, 38, 41, 42, 44, 45).”

    From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [4]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

4 of the 94 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. Stewart SH, Watt MC. Assessment of health anxiety. In: Asmund- son GJG, Taylor S, Cox BJ, eds. Health anxiety. John Wiley & Sons Ltd., 2001:95-131.
  2. Hadjistavropoulos HD, Owens K, Hadjistavropoulos T, et al. Hy- pochondriasis and health anxiety among pain patients. In: As- mundson GJG, Taylor S, Cox BJ, eds. Health anxiety: clinical and research perspectives on hypochondriasis and related disorders. London: Wiley, 2001:298 -323.
  3. Masse R, Poulin C, Dassa C, et al. Elaboration and validation of a tool to measure psychological well-being: WBMMS. Can J Public Health 1998;89:352-357.
  4. Hollingsworth H. A modified step-down procedure for multivariate analysis of variance: an example. American Statistical Associa- tion Proceedings of the Social Statistics Section. Alexandria, VA: American Statistical Association; 1982.
  5. Derogatis LR, Cleary PA. Confirmation of the dimensional struc- ture of the SCL-90: a study in construct validation. J Clin Psychol 1977;33:981-989.

Cited by

Sorted by citations

Related

Authors
Graff, L. A., Walker, J. R., Lix, L., Clara, I., Rawsthorne, P., Rogala, L., Miller, N., Jakul, L., McPhail, C., Ediger, J., & Bernstein, C. N.
Affiliations
University of Manitoba (CA)
Corresponding author
Graff, Lesley A.
ORCID
Venue
Clinical Gastroenterology and Hepatology
Publisher
Elsevier BV
Published
2006-12
Volume
4
Issue
12
Pages
1491-1501.e1
ISSN
1542-3565 (ISSN-L)
DOI
10.1016/j.cgh.2006.09.027
OpenAlex
W2013139593
Cited by
292
References
94
Citations by year
2026: 3 · 2025: 9 · 2024: 8 · 2023: 14 · 2022: 14 · 2021: 16 · 2020: 12 · 2019: 17 · 2018: 18 · 2017: 13 · 2016: 15 · 2015: 18 · 2014: 21 · 2013: 21 · 2012: 19
FWCI
7.34
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Gastroenterology and Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
inflammatory bowel disease, Crohn's disease, ulcerative colitis, disease activity, psychological functioning, quality of life, distress, health anxiety, perceived stress, social support, pain catastrophizing, pain-related anxiety, well-being, mastery
MeSH terms
Adaptation, Psychological, Adolescent, Adult, Aged, Aged, 80 and over, Anxiety, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Quality of Life, Retrospective Studies, Severity of Illness Index, Stress, Psychological, Inflammatory Bowel Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review