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Cited by 200Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychometric Methodologies and Testing

The DOI matches its Crossref record; 33 of the 35 references it cites were found in a registry or an index.

The self-reported Montgomery-Asberg depression rating scale is a useful evaluative tool in major depressive disorder

Open access
Fantino, Bruno, Moore, Nicholas·2009·BMC Psychiatry
DOI 10.1186/1471-244x-9-26PMC PMC2701427
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Abstract

BACKGROUND: The use of Patient-reported Outcomes (PROs) as secondary endpoints in the development of new antidepressants has grown in recent years. The objective of this study was to assess the psychometric properties of the 9-item, patient-administered version of the Montgomery-Asberg Depression Rating Scale (MADRS-S). METHODS: Data from a multicentre, double-blind, 8-week, randomised controlled trial of 278 outpatients diagnosed with Major Depressive Disorder were used to evaluate the validity, reliability and sensitivity to change of the MADRS-S using psychometric methods. A Receiver Operating Characteristic (ROC) curve was plotted to identify the most appropriate threshold to define perceived remission. RESULTS: No missing values were found at the item level, indicating good acceptability of the scale. The construct validity was satisfactory: all items contributed to a common underlying concept, as expected. The correlation between MADRS-S and physicians' MADRS was moderate (r = 0.54, p < 0.001) indicating that MADRS-S is complementary rather than redundant to the MADRS. Cronbach's alpha was 0.84, and the stability over time of the scale, estimated on a sub-sample of patients whose health status did not change during the first week of the study, was good (intraclass correlation coefficient of 0.78). MADRS-S sensitivity to change was shown. Using a threshold value of 5, the definition of "perceived remission" reached a sensitivity of 82% and a specificity of 75%. CONCLUSION: Taking account of patient's perceptions of the severity of their own symptoms along with the psychometric properties of the MADRS-S enable its use for evaluative purposes in the development of new antidepressant drugs.

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Figure 1 Receiver Operating Characteristic Curve for Perceived Remission. CO: cut-off value for MADRS-S score.
Figure 1 Receiver Operating Characteristic Curve for Perceived Remission. CO: cut-off value for MADRS-S score.CC BY · PubMed Central
Figure 2 Perceived Response and Perceived Remission at Week 8.
Figure 2 Perceived Response and Perceived Remission at Week 8.CC BY · PubMed Central

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Research works printed but not linked: 5

  1. Committee for Proprietary Medicinal Products: Note for guidance on clinical investigation of medicinal products in the treatment of depression (CPMP/EWP/518/97, Rev 1). 2002, London: EMEA
  2. Beck AT, Steer RA: Beck Depression Inventory Manual. 1993, San Antonio: Psychological Corporation
  3. SAS Institute: SAS/Stat User's Guide version 8.2. 1999, Cary: SAS Institute Inc
  4. Kerlinger FN: Foundation of Behavioral Research. 1964, New York: Holt, Rinehart & Winston
  5. Nunnally JC: Psychometric Theory. 1994, New-York: Mc Graw-Hill, 3

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Metadata

Authors
Fantino, B., & Moore, N.
Affiliations
Centre Hospitalier Universitaire de Bordeaux (FR)
Corresponding author
  • Fantino, Bruno
  • Moore, Nicholas
ORCID
Moore, Nicholas
Venue
BMC Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2009-05-27
Volume
9
Issue
1
Pages
26-26
ISSN
1471-244X (ISSN-L)
DOI
10.1186/1471-244x-9-26
PMC
PMC2701427
OpenAlex
W2044133982
Cited by
200
References
35
Citations by year
2026: 14 · 2025: 14 · 2024: 23 · 2023: 16 · 2022: 15 · 2021: 13 · 2020: 23 · 2019: 17 · 2018: 17 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 7
FWCI
3.85
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Psychiatry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
H. Lundbeck A/S
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
Keywords
Montgomery-Asberg Depression Rating Scale, major depressive disorder, patient-reported outcomes, psychometric properties, construct validity, reliability statistics, sensitivity to change, antidepressant drug development
MeSH terms
Adolescent, Adult, Aged, Ambulatory Care, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Health Status, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Psychometrics, Surveys and Questionnaires, ROC Curve, Sensitivity and Specificity, Severity of Illness Index, Reproducibility of Results, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Treatment Outcome, Drug Discovery

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