Cited by 200Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychometric Methodologies and Testing

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The self-reported Montgomery-Asberg depression rating scale is a useful evaluative tool in major depressive disorder

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Fantino, Bruno, Moore, Nicholas·2009·BMC Psychiatry

DOI 10.1186/1471-244x-9-26PMC PMC2701427

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Abstract

BACKGROUND: The use of Patient-reported Outcomes (PROs) as secondary endpoints in the development of new antidepressants has grown in recent years. The objective of this study was to assess the psychometric properties of the 9-item, patient-administered version of the Montgomery-Asberg Depression Rating Scale (MADRS-S). METHODS: Data from a multicentre, double-blind, 8-week, randomised controlled trial of 278 outpatients diagnosed with Major Depressive Disorder were used to evaluate the validity, reliability and sensitivity to change of the MADRS-S using psychometric methods. A Receiver Operating Characteristic (ROC) curve was plotted to identify the most appropriate threshold to define perceived remission. RESULTS: No missing values were found at the item level, indicating good acceptability of the scale. The construct validity was satisfactory: all items contributed to a common underlying concept, as expected. The correlation between MADRS-S and physicians' MADRS was moderate (r = 0.54, p < 0.001) indicating that MADRS-S is complementary rather than redundant to the MADRS. Cronbach's alpha was 0.84, and the stability over time of the scale, estimated on a sub-sample of patients whose health status did not change during the first week of the study, was good (intraclass correlation coefficient of 0.78). MADRS-S sensitivity to change was shown. Using a threshold value of 5, the definition of "perceived remission" reached a sensitivity of 82% and a specificity of 75%. CONCLUSION: Taking account of patient's perceptions of the severity of their own symptoms along with the psychometric properties of the MADRS-S enable its use for evaluative purposes in the development of new antidepressant drugs.

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Figure 1 Receiver Operating Characteristic Curve for Perceived Remission. CO: cut-off value for MADRS-S score.CC BY · PubMed Central

Figure 2 Perceived Response and Perceived Remission at Week 8.CC BY · PubMed Central

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Authors: Fantino, B., & Moore, N.
Affiliations: Centre Hospitalier Universitaire de Bordeaux (FR)
Corresponding author: Fantino, Bruno
Moore, Nicholas
ORCID: Moore, Nicholas
Venue: BMC Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2009-05-27
Volume: 9
Issue: 1
Pages: 26-26
ISSN: 1471-244X (ISSN-L)
DOI: 10.1186/1471-244x-9-26
PMC: PMC2701427
OpenAlex: W2044133982
Cited by: 200
References: 35
Citations by year: 2026: 14 · 2025: 14 · 2024: 23 · 2023: 16 · 2022: 15 · 2021: 13 · 2020: 23 · 2019: 17 · 2018: 17 · 2017: 10 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 7
FWCI: 3.85
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
www.springer.com/tdm (unspecified)
Locations: BMC Psychiatry (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: H. Lundbeck A/S
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
Keywords: Montgomery-Asberg Depression Rating Scale, major depressive disorder, patient-reported outcomes, psychometric properties, construct validity, reliability statistics, sensitivity to change, antidepressant drug development
MeSH terms: Adolescent, Adult, Aged, Ambulatory Care, Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Female, Health Status, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Psychometrics, Surveys and Questionnaires, ROC Curve, Sensitivity and Specificity, Severity of Illness Index, Reproducibility of Results, Multicenter Studies as Topic, Randomized Controlled Trials as Topic, Treatment Outcome, Drug Discovery

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The self-reported Montgomery-Asberg depression rating scale is a useful evaluative tool in major depressive disorder

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