A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron™) injection to treat fractures
Open accessAbstract
BACKGROUND: We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts. METHODS: Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable. RESULTS: The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment. CONCLUSION: Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple studies have shown that both ASCs and BM-MSCs can promote bone tissue reconstruction in sites of bone loss with and without multifunctional biomaterials.
“Multiple studies have shown that both ASCs and BM-MSCs can promote bone tissue reconstruction in sites of bone loss with and without multifunctional biomaterials (ceramic, biodegradable polymers, and composite materials) that have been designed to guide bone regeneration [39,90,91,92].”
From Mesenchymal Stem/Stromal Cells: Immunomodulatory and Bone Regeneration Potential after Tumor Excision in Osteosarcoma Patients (2023) · cites this paper as [90]
The Methods describe injecting bone-marrow-derived cultured osteoblasts mixed with fibrin into fracture sites, and the Discussion reports more rapid callus formation in the treated group (no page numbers supplied). This supports a related claim about cell-assisted bone healing, but the paper does not study ASCs or directly test BM-MSCs, nor does it evaluate the listed ceramic, polymer, or composite biomaterials. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Cell and Molecular Biology of Fracture Healing
Einhorn, T. A. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00003 · Cited by 1,280 · see citing works
Bone regeneration by implantation of purified, culture‐expanded human mesenchymal stem cells
Bruder, S. P., Kurth, A. A., Shea, M., Hayes, W. C., Jaiswal, N., & Kadiyala, S. (1998) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100160202 · Cited by 761 · see citing works
Ahlmann, E. R., Patzakis, M. J., Roidis, N. T., Shepherd, L. E., & Holtom, P. D. (2002) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200205000-00003 · Cited by 661 · see citing works
Formation of Bone and Cartilage by Marrow Stromal Cells in Diffusion Chambers in Vivo
Ashton, B. A., Allen, T., Howlett, C. R., Eaglesom, C. C., Hattori, A., & Owen, M. E. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198009000-00040 · Cited by 597 · see citing works
Natural History of Posterior Iliac Crest Bone Graft Donation for Spinal Surgery
Robertson, P. A., & Wray, A. C. (2001) · Spine · doi:10.1097/00007632-200107010-00018 · Cited by 220 · see citing works
Wilkinson, A. G., Sherlock, D. A., & Murray, G. D. (2002) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.84b5.0840716 · Cited by 141 · see citing works
Walker, N. A., Denegar, C. R., & Preische, J. (2007) · PubMed Central · Cited by 75 · see citing works
Determination of bone volume by osteocyte population
Vashishth, D., Gibson, G., Kimura, J. H., Schaffler, M. B., & Fyhrie, D. P. (2002) · The Anatomical Record · doi:10.1002/ar.10114 · Cited by 67 · see citing works
Stem Cell Therapy in Bone Repair and Regeneration
Zaidi, N., & Nixon, A. J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1402.074 · Cited by 62 · see citing works
The socio-economical impact of paediatric fracture clinic appointments
Morris, M. W. J., & Bell, M. J. (2006) · Injury · doi:10.1016/j.injury.2005.12.010 · Cited by 50 · see citing works
Volumetric Change of the Graft Bone After Intertransverse Fusion
Kim, K.-W., Ha, K.-Y., Moon, M.-S., Kim, Y.-S., Kwon, S.-Y., & Woo, Y.-K. (1999) · Spine · doi:10.1097/00007632-199903010-00003 · Cited by 45 · see citing works
COMPARATIVE STUDY OF THE EFFECT OF ULTRASOUND AND ELECTROSTIMULATION ON BONE HEALING IN RATS1
Zorlu, Ü., Tercan, M., Özyazgan, İ., Taşkan, I., Kardas, Y., Balkar, F., & Öztürk, F. (1998) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/00002060-199809000-00013 · Cited by 36 · see citing works
Autologous Chondrocyte Implantation
Riegger‐Krugh, C., McCarty, E. C., Robinson, M., & WEGZYN, D. A. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31815cb228 · Cited by 34 · see citing works
Kim, S.-J., Jang, J.-D., & Lee, S. (2007) · Cytotechnology · doi:10.1007/s10616-007-9084-1 · Cited by 27 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Bone regeneration: current concepts and future directions
Dimitriou, R. I., Jones, E., McGonagle, D., & Giannoudis, P. V. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-66 · Cited by 2,024 · see citing works
Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair
Agarwal, R., & Garcı́a, A. J. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.03.013 · Cited by 785 · see citing works
Strategies for controlled delivery of growth factors and cells for bone regeneration
Vo, T. N., Kasper, F. K., & Mikos, A. G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.016 · Cited by 670 · see citing works
Bone fracture healing: Cell therapy in delayed unions and nonunions
Gómez‐Barrena, E., Rosset, P., Lozano, D., Stanovici, J., Ermthaller, C., & Gerbhard, F. (2014) · Bone · doi:10.1016/j.bone.2014.07.033 · Cited by 423 · see citing works
Tissue Engineering and Cell-Based Therapies for Fractures and Bone Defects
Perez, J. R., Kouroupis, D., Li, D. J., Best, T. M., Kaplan, L., & Correa, D. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00105 · Cited by 390 · see citing works
Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?
Oryan, A., Kamali, A., Moshiri, A., & Eslaminejad, M. B. (2017) · Cells Tissues Organs · doi:10.1159/000469704 · Cited by 361 · see citing works
Mechanisms of bone repair and regeneration
Deschaseaux, F., Sensebé, L., & Heymann, D. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.07.002 · Cited by 322 · see citing works
Prospective Review of Mesenchymal Stem Cells Differentiation into Osteoblasts
Garg, P., Mazur, M. M., Buck, A. C., Wandtke, M. E., Liu, J., & Ebraheim, N. A. (2017) · Orthopaedic Surgery · doi:10.1111/os.12304 · Cited by 190 · see citing works
The role of stem cells in fracture healing and nonunion
Fayaz, H. C., Giannoudis, P. V., Vrahas, M. S., Smith, R. M., Moran, C., Pape, H. C., Krettek, C., & Jupiter, J. B. (2011) · International Orthopaedics · doi:10.1007/s00264-011-1338-z · Cited by 160 · see citing works
Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology
Gómez‐Barrena, E., Rosset, P., Müller, I., Giordano, R., Bunu, C., Layrolle, P., Konttinen, Y. T., & Luyten, F. P. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01265.x · Cited by 149 · see citing works
Osteogenic Differentiation in Healthy and Pathological Conditions
Valenti, M. T., Carbonare, L. D., & Mottes, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms18010041 · Cited by 135 · see citing works
Rosset, P., Deschaseaux, F., & Layrolle, P. (2014) · Orthopaedics & Traumatology Surgery & Research · doi:10.1016/j.otsr.2013.11.010 · Cited by 134 · see citing works
Beheshtizadeh, N., Gharibshahian, M., Pazhouhnia, Z., Rostami, M., Zangi, A. R., Maleki, R., Azar, H. K., Zalouli, V., Rajavand, H., Farzin, A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113431 · Cited by 98 · see citing works
Advances in Regenerative Orthopedics
Evans, C. H. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.04.027 · Cited by 97 · see citing works
Giannotti, S., Trombi, L., Bottai, V., Ghilardi, M., D’Alessandro, D., Danti, S., Dell'Osso, G., Guido, G., & Petrini, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073893 · Cited by 96 · see citing works
Hernigou, P., Homma, Y., Flouzat–Lachaniette, C.-H., Poignard, A., Chevallier, N., & Rouard, H. (2013) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.m.00261 · Cited by 95 · see citing works
Treatment of long bone defects and non-unions: from research to clinical practice
Berner, A., Reichert, J. C., Müller, M. B., Zellner, J., Pfeifer, C., Dienstknecht, T., Nerlich, M. L., Sommerville, S. M. M., Dickinson, I. C., Schütz, M. A., et al. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1184-8 · Cited by 91 · see citing works
Recent biological trends in management of fracture non-union
Emara, K. M. (2015) · World Journal of Orthopedics · doi:10.5312/wjo.v6.i8.623 · Cited by 91 · see citing works
The roles of immune cells in bone healing; what we know, do not know and future perspectives
El‐Jawhari, J. J., Jones, E., & Giannoudis, P. V. (2016) · Injury · doi:10.1016/j.injury.2016.10.008 · Cited by 87 · see citing works
Mechanism of Action of Mesenchymal Stem Cells (MSCs): impact of delivery method
Bagno, L., Salerno, A. G., Balkan, W., & Hare, J. M. (2021) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2022.2016695 · Cited by 85 · see citing works
Ramezankhani, R., Torabi, S., Minaei, N., Madani, H., Rezaeiani, S., Hassani, S., Gee, A. P., Dominici, M., Silva, D. N., Baharvand, H., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.547653 · Cited by 70 · see citing works
Clinical Impact of Circulating CD34-Positive Cells on Bone Regeneration and Healing
Kuroda, R., Matsumoto, T., Kawakami, Y., Fukui, T., Mifune, Y., & Kurosaka, M. (2013) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2013.0511 · Cited by 67 · see citing works
Bouland, C., Philippart, P., Dequanter, D., Corrillon, F., Loeb, I., Bron, D., Lagneaux, L., & Meuleman, N. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.674084 · Cited by 65 · see citing works
Bone Graft Substitution and Augmentation
Nauth, A., Lane, J. M., Watson, J. T., & Giannoudis, P. V. (2015) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000000464 · Cited by 65 · see citing works
Mesenchymal stem cell implantation in atrophic nonunion of the long bones
Dilogo, I. H., Phedy, P., Kholinne, E., Djaja, Y. P., Kusnadi, Y., Merlina, M., & Yulisa, N. D. (2016) · Bone and Joint Research · doi:10.1302/2046-3758.57.2000587 · Cited by 64 · see citing works
Bone Tissue Engineering Bioreactors: A Role in the Clinic?
Salter, E. K., Goh, B. C. K., Hung, B. P., Hutton, D. L., Ghone, N. V., & Grayson, W. L. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2011.0209 · Cited by 61 · see citing works
Freitas, G. P., Lopes, H. B., Souza, A. T. P., de Oliveira, P. G. F. P., Almeida, A. L. G., de Souza, L. E. B., Coelho, P. G., Beloti, M. M., & Rosa, A. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-50067-6 · Cited by 59 · see citing works
The control of fracture healing and its therapeutic targeting: Improving upon nature
Komatsu, D. E., & Warden, S. J. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22418 · Cited by 57 · see citing works
Zakrzewski, W., Dobrzyński, M., Rybak, Z., Szymonowicz, M. K., & Wiglusz, R. J. (2020) · Nanomaterials · doi:10.3390/nano10061216 · Cited by 56 · see citing works
Essential Components for Ex Vivo Proliferation of Mesenchymal Stromal Cells
Fekete, N., Rojewski, M., Lotfi, R., & Schrezenmeier, H. (2013) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0061 · Cited by 55 · see citing works
Recent advances in bone regeneration using adult stem cells
Zigdon‐Giladi, H. (2015) · World Journal of Stem Cells · doi:10.4252/wjsc.v7.i3.630 · Cited by 54 · see citing works
Scaffold-free cell sheet injection results in bone formation
Akahane, M., Shigematsu, H., Tadokoro, M., Ueha, T., Matsumoto, T., Tohma, Y., Kido, A., Imamura, T., & Tanaka, Y. (2010) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.259 · Cited by 53 · see citing works
Biologic adjuvants for fracture healing
Virk, M. S., & Lieberman, J. R. (2012) · Arthritis Research & Therapy · doi:10.1186/ar4053 · Cited by 49 · see citing works
Wang, J., Wang, H., Wang, Y., Liu, Z., Li, Z., Li, J., Chen, Q., Meng, Q., Shu, W., Wu, J., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.01.055 · Cited by 48 · see citing works
Nanocomposites drug delivery systems for the healing of bone fractures
Chen, J., Ashames, A., Buabeid, M. A., Fahelelbom, K. M., Ijaz, M., & Murtaza, G. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119477 · Cited by 40 · see citing works
Dozza, B., Bella, C. D., Lucarelli, E., Giavaresi, G., Fini, M., Tazzari, P. L., Giannini, S., & Donati, D. M. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21333 · Cited by 32 · see citing works
The Current Role of Stem Cells in Orthopaedic Surgery
Maniar, H. H., Tawari, A., Suk, M., & Horwitz, D. S. (2015) · Malaysian Orthopaedic Journal · doi:10.5704/moj.1511.016 · Cited by 29 · see citing works
Osteogenic Protein-1 Associated with Mesenchymal Stem Cells Promote Bone Allograft Integration
Bella, C. D., Aldini, N. N., Lucarelli, E., Dozza, B., Frisoni, T., Martini, L., Fini, M., & Donati, D. M. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0637 · Cited by 28 · see citing works
Mesenchymal Stem Cell Therapy for Sports Injuries - From Research to Clinical Practice
Looi, Q. H., Eng, S. P., Liau, L. L., Tor, Y. S., Bajuri, M. Y., Ng, M. H., & Law, J. X. (2020) · Sains Malaysiana · doi:10.17576/jsm-2020-4904-12 · Cited by 28 · see citing works
Living scaffolds: surgical repair using scaffolds seeded with human adipose-derived stem cells
Klinger, A. L., Kawata, M., Villalobos, M., Jones, R. B., Pike, S. L., Wu, N., Chang, S., Zhang, P., DiMuzio, P. J., Vernengo, J., et al. (2015) · Hernia · doi:10.1007/s10029-015-1415-0 · Cited by 27 · see citing works
Bone repair with skeletal stem cells: rationale, progress to date and clinical application
Jones, E., Giannoudis, P. V., & Kouroupis, D. (2016) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x16642372 · Cited by 27 · see citing works
Stem cell therapy for fracture non-union: The current evidence from human studies
Thurairajah, K., Briggs, G. D., & Balogh, Z. J. (2021) · Journal of orthopaedic surgery · doi:10.1177/23094990211036545 · Cited by 25 · see citing works
Association of Mesenchymal Stem Cells and Osteoblasts for Bone Repair
Santos, T. D. S., Abuna, R. P. F., Lopes, H. B., Almeida, A. L. G., Beloti, M. M., & Rosa, A. L. (2015) · Regenerative Medicine · doi:10.2217/rme.14.75 · Cited by 25 · see citing works
Phases 1–3 Clinical Trials Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures
Hauzeur, J., & Gangji, V. (2010) · Stem Cells International · doi:10.4061/2010/410170 · Cited by 25 · see citing works
Kassem, M. S. (2013) · PubMed · Cited by 25 · see citing works
Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies
Runzer, C. D. T., Balmayor, E. R., & van Griensven, M. (2026) · Bone Research · doi:10.1038/s41413-025-00487-0 · Cited by 24 · see citing works
Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells
Aasebø, E., Brenner, A. K., Hernandez-Valladares, M., Birkeland, E., Berven, F. S., Selheim, F., & Bruserud, Ø. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115665 · Cited by 24 · see citing works
Yamada, M., Watanabe, J., Ueno, T., Ogawa, T., & Egusa, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205199 · Cited by 24 · see citing works
Apheresis Platelet Rich-Plasma for Regenerative Medicine: An In Vitro Study on Osteogenic Potential
Pulcini, S., Merolle, L., Marraccini, C., Quartieri, E., Mori, D., Schiroli, D., Berni, P., Iotti, B., Bartolomeo, E. D., Baricchi, R., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168764 · Cited by 23 · see citing works
Hixon, K. R., & Miller, A. N. (2022) · Journal of Orthopaedic Research® · doi:10.1002/jor.25277 · Cited by 22 · see citing works
Freitas, G. P., Lopes, H. B., Souza, A. T. P., de Oliveira, P. G. F. P., Almeida, A. L. G., Coelho, P. G., Ferreira, F. U., Covas, D. T., Beloti, M. M., & Rosa, A. L. (2019) · Regenerative Medicine · doi:10.2217/rme-2019-0036 · Cited by 22 · see citing works
Sahu, R. L. (2017) · Revista Brasileira de Ortopedia (English Edition) · doi:10.1016/j.rboe.2017.09.004 · Cited by 21 · see citing works
Baron, M., Drohat, P., Crawford, B., Hornicek, F. J., Best, T. M., & Kouroupis, D. (2023) · Bioengineering · doi:10.3390/bioengineering10101187 · Cited by 19 · see citing works
Jayankura, M., Schulz, A., Delahaut, O., Witvrouw, R., Seefried, L., Berg, B. V., Heynen, G., & Sonnet, W. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02432-4 · Cited by 19 · see citing works
Double-layered cell transfer technology for bone regeneration
Akazawa, K., Iwasaki, K., Nagata, M., Yokoyama, N., Ayame, H., Yamaki, K., Tanaka, Y., Honda, I., Morioka, C., Kimura, T., et al. (2016) · Scientific Reports · doi:10.1038/srep33286 · Cited by 19 · see citing works
Desai, S., & Jayasuriya, C. T. (2020) · Bioengineering · doi:10.3390/bioengineering7030086 · Cited by 17 · see citing works
Systematic review assessing the evidence for the use of stem cells in fracture healing
Mott, A., Mitchell, A. S., McDaid, C., Harden, M., Grupping, R., Dean, A., Byrne, A. K., Doherty, L., & Sharma, H. (2020) · Bone & Joint Open · doi:10.1302/2633-1462.110.bjo-2020-0129 · Cited by 16 · see citing works
Gasson, S. B., Dobson, L. K., Chow, L., DOW, S. W., Gregory, C. A., & Saunders, W. B. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0144 · Cited by 16 · see citing works
Centeno, C. J., Schultz, J. R., & Cheever, M. (2011) · Journal of Bioengineering and Biomedical Sciences · doi:10.4172/2155-9538.s2-007 · Cited by 16 · see citing works
The Potential of microRNAs for Stem Cell-based Therapy for Degenerative Skeletal Diseases
Budd, E., Waddell, S. J., de Andrés, M. C., & Oreffo, R. O. C. (2017) · Current Molecular Biology Reports · doi:10.1007/s40610-017-0076-4 · Cited by 14 · see citing works
Current Modalities for Fracture Healing Enhancement
Chun, Y. S., Lee, D. H., Won, T. G., Kim, Y., Shetty, A. A., & Kim, S. J. (2021) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-021-00399-0 · Cited by 13 · see citing works
Self-citationGiannotti, S., Trombi, L., Bottai, V., Ghilardi, M., D'Alessandro, D., Danti, S., Dell'Osso, G., Guido, G., & Petrini, M. (2013) · PLoS ONE · doi:10.1371/annotation/e4403abb-b80e-43c5-be74-1bdb2c899d1c · Cited by 12 · see citing works
Effectiveness of Weekly Teriparatide Injection in Postmenopausal Patients with Hip Fractures
Lee, S.-Y., Seo, M.-S., & Yoo, J. (2023) · Clinics in Orthopedic Surgery · doi:10.4055/cios22280 · Cited by 12 · see citing works
Self-citationBiomaterials, substitutes, and tissue engineering in bone repair: current and future concepts
Fattahian, H., Mansouri, K., & Mansouri, N. (2017) · Comparative Clinical Pathology · doi:10.1007/s00580-017-2507-2 · Cited by 12 · see citing works
Sotoca, A. M., Roelofs-Hendriks, J., Boeren, S. A., van der Kraan, P. M., Vervoort, J. J. M., van Zoelen, E. J. J., & Piek, E. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.07.027 · Cited by 12 · see citing works
Managing Bone Infections Beyond Systemic Antibiotics: A Scoping Review
Polyzou, E., Gavatha, M., Efthymiou, D., Papageorgiou, D., Ntalaki, E., Stavropoulos, N. A., & Akinosoglou, K. (2026) · Pathogens · doi:10.3390/pathogens15020201 · Cited by 10 · see citing works
Sahu, R. L. (2018) · Revista Brasileira de Ortopedia · doi:10.1016/j.rbo.2017.09.012 · Cited by 10 · see citing works
Park, H. Y., Shetty, A. A., Kim, J. M., Kim, Y. J., Jang, J.-D., Choi, N. Y., Lee, J. H., & Kim, S. J. (2017) · Cells Tissues Organs · doi:10.1159/000455829 · Cited by 9 · see citing works
Self-citationA practical model for economic evaluation of tissue‐engineered therapies
Tan, T., Peh, G. S. L., Finkelstein, E. A., & Mehta, J. S. (2015) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1292 · Cited by 8 · see citing works
Extracorporeal human bone-like tissue generation
Rosenberg, N., & Rosenberg, O. (2012) · Bone and Joint Research · doi:10.1302/2046-3758.1.1.2000007 · Cited by 6 · see citing works
Korzh, M., Vorontsov, P., Vishnyakova, I., & Samoilova, К. (2018) · ORTHOPAEDICS TRAUMATOLOGY and PROSTHETICS · doi:10.15674/0030-598720181105-116 · Cited by 6 · see citing works
da Rocha, L. R., Dias, R. B., Fernandes, M. B. C., Prinz, R. A. D., Eirado, T. P., Costa, I. D. S., Monteiro, M. J., da Silva, C. E. R., dos Santos, C. T., & Fogagnolo, F. (2023) · Injury · doi:10.1016/j.injury.2023.05.008 · Cited by 5 · see citing works
Bone Tissue Engineering – A Field For New Medicinal Products?
Lewandowska-Szumieł, M., & Wójtowicz, J. (2011) · Current Pharmaceutical Biotechnology · doi:10.2174/138920111798376941 · Cited by 5 · see citing works
The use of biological augments in fracture healing: where is the evidence?
Barkham, B., Khan, H., & Trompeter, A. J. (2021) · Orthopaedics and Trauma · doi:10.1016/j.mporth.2021.07.004 · Cited by 3 · see citing works
Cellular therapies for bone repair: current insights
Rodham, P. L., Khaliq, F., Giannoudis, V., & Giannoudis, P. V. (2024) · Journal of Orthopaedics and Traumatology · doi:10.1186/s10195-024-00768-0 · Cited by 3 · see citing works
(ii) Stem cell research in orthopaedic and trauma surgery
Kim, S.-J., & Shetty, A. A. (2011) · Orthopaedics and Trauma · doi:10.1016/j.mporth.2011.04.001 · Cited by 3 · see citing works
Self-citationReichert, J. C., Nöth, U. A., Berner, A., & Hutmacher, D. W. (2016) · Springer eBooks · doi:10.1007/978-3-319-28386-9_9 · Cited by 3 · see citing works
Frontiers in Spinal Neurosurgery
Wang, J. J., Wang, G., Lv, X., Sun, Z., & Mahapure, K. S. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1000270 · Cited by 2 · see citing works
Stem Cell Research in Orthopaedic and Trauma Surgery
Kim, S.-J., & Shetty, A. A. (2014) · Springer eBooks · doi:10.1007/978-3-642-41921-8_18 · Cited by 2 · see citing works
Self-citationSaputra, R. A., Arsa, W., & Sakti, Y. M. (2025) · European Journal of Medical and Health Sciences · doi:10.24018/ejmed.2025.7.2.2278 · Cited by 1 · see citing works
Hong, Y., & Hao, G. G. (2025) · Journal of Genetic Engineering and Biotechnology · doi:10.1016/j.jgeb.2025.100638 · Cited by 1 · see citing works
Aptamer-Mediated Selective Protein Affinity to Improve Scaffold Biocompatibility
Parisi, L., Galli, C., Elviri, L., Bianchera, A., Lagonegro, P., Lumetti, S., Manfredi, E., & Macaluso, G. M. (2016) · InTech eBooks · doi:10.5772/63265 · Cited by 1 · see citing works
Application of Stem Cells in Treatment of Bone Diseases: Pre-clinical and Clinical Perspectives
Sadat‐Ali, M. (2021) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-030-78101-9_8 · Cited by 1 · see citing works
Osteogenic Cells and Microenvironment of Early Bone Development and Clinical Implication
Kim, K., & Lee, C. C. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1002037 · Cited by 1 · see citing works
Intrinsic and Extrinsic Methods for Augmenting Fracture Healing in the Hand and Wrist
Borole, A., Trubiano, J., Viqueira, M., Kalahasti, K., Stamos, T., Kirschenbaum, D., & Katt, B. M. (2024) · Cureus · doi:10.7759/cureus.74972 · Cited by 1 · see citing works
Design and Application of Biomaterials to Regulate Microenvironment for Bone Regeneration
Wang, X., & Jiang, Y. (2022) · Wiley eBooks · doi:10.1002/9783527837823.ch3 · Cited by 1 · see citing works
Cell Therapy Using Adult Stem Cells in Osteonecrosis and Nonunion Fractures
Hauzeur, J. (2013) · Humana Press eBooks · doi:10.1007/978-1-62703-417-3_14
Santos, T. D. S. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.58.2014.tde-16072014-100408
Aktueller Stand der Stammzelltherapie in Orthopädie und Unfallchirurgie
Randau, T. M., Gravius, S., & Nussler, A. K. (2014) · Zeitschrift für Orthopädie und Unfallchirurgie · doi:10.1055/s-0034-1382867
Methods to Enhance Bone Formation in Distraction Osteogenesis
Song, H., Lee, D. H., Kim, S. J., & Ramanathan, A. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-17097-8_28
Self-citationRéparation osseuse par thérapie cellulaire
Rosset, P. (2013) · Elsevier eBooks · doi:10.1016/b978-2-294-73542-4.00012-7
Endothelial Progenitor Cells, Lnk and Bone Fracture Healing
Matsumoto, T., & Asahara, T. (2013) · CRC Press eBooks · doi:10.1201/b14590-13
Stem Cells in Diseases of Aging
Li, M., & Ikehara, S. (2016) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-29149-9_4
Análise da expressão gênica em larga escala de células-tronco mesenquimais e de osteoblastos
Fideles, S. O. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.58.2019.tde-29082018-135038
Freitas, G. P. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.58.2019.tde-03092019-103652
Davis, A., Guldberg, R. E., & Samsonraj, R. M. (2020) · Journal of Musculoskeletal Research · doi:10.1142/s0218957721400017
Wells, L., Sehgal, K., & Dormans, J. P. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0755-7.00675-8
Cellules souches mésenchymateuses
Rosset, P. (2012) · Springer eBooks · doi:10.1007/978-2-287-99066-3_13
Integrating AI With Tissue Engineering
Malviya, R., Rajput, S., & Vaidya, M. (2024) · Wiley eBooks · doi:10.1002/9781394230914.ch2
- Authors
- Kim, S.-J., Shin, Y.-W., Yang, K.-H., Kim, S.-B., Yoo, M.-J., Han, S.-K., Im, S.-A., Won, Y.-D., Sung, Y.-B., Jeon, T.-S., Chang, C.-H., Jang, J.-D., Lee, S.-B., Kim, H.-C., & Lee, S.-Y.
- Affiliations
- Inje University (KR)
- Yonsei University (KR)
- Konyang University (KR)
- Dankook University Hospital (KR)
- Catholic University of Korea (KR)
- Sewon Cellontech (South Korea) (KR)
- Corresponding author
- Kim, Sang-Bum
- ORCID
- Lee, Soo-Young
- Venue
- BMC Musculoskeletal Disorders
- Published
- 2009-02-12
- Volume
- 10
- Issue
- 1
- Pages
- 20-20
- ISSN
- 1471-2474 (ISSN-L)
- PMC
- PMC2656455
- OpenAlex
- W1973452274
- Cited by
- 111
- References
- 14
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 13 · 2020: 8 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 5 · 2013: 12 · 2012: 5
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Musculoskeletal Disorders (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Korea Health Industry Development Institute
- Topics
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- bone marrow-derived mesenchymal stem cells, long bone fractures, callus formation, cell therapy safety, cell injection
- MeSH terms
- Adolescent, Adult, Aged, Alkaline Phosphatase, Bone Marrow Cells, Bony Callus, Cells, Cultured, Female, Humans, Male, Middle Aged, Osteoblasts, Transplantation, Autologous, Treatment Outcome, Fracture Healing, Cell Transplantation, Cell Culture Techniques, Collagen Type I, Fractures, Bone, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
