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Cited by 1,003

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice

Open access
Johansen, Jeanette Schultz, Harris, Alex K, Rychly, David J, Ergul, Adviye·2005·Cardiovascular Diabetology
DOI 10.1186/1475-2840-4-5
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Abstract

Cardiovascular complications, characterized by endothelial dysfunction and accelerated atherosclerosis, are the leading cause of morbidity and mortality associated with diabetes. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. Overproduction and/or insufficient removal of these free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids. Despite overwhelming evidence on the damaging consequences of oxidative stress and its role in experimental diabetes, large scale clinical trials with classic antioxidants failed to demonstrate any benefit for diabetic patients. As our understanding of the mechanisms of free radical generation evolves, it is becoming clear that rather than merely scavenging reactive radicals, a more comprehensive approach aimed at preventing the generation of these reactive species as well as scavenging may prove more beneficial. Therefore, new strategies with classic as well as new antioxidants should be implemented in the treatment of diabetes.

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Metadata

Authors
Johansen, J. S., Harris, A. K., Rychly, D. J., & Ergul, A.
Venue
Cardiovascular Diabetology
Publisher
Springer Science and Business Media LLC
Published
2005-04-29
Volume
4
Issue
1
Pages
5-5
ISSN
1475-2840 (ISSN-L)
DOI
10.1186/1475-2840-4-5
OpenAlex
W2097815597
Cited by
1,003
References
10
FWCI
11.39
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice. https://app.cochat.ai/papers/10.1186/1475-2840-4-5
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Johansen, J. S., Harris, A. K., Rychly, D. J., & Ergul, A. (2005). Oxidative stress and the use of antioxidants in diabetes: Linking basic science to clinical practice. Cardiovascular Diabetology. https://doi.org/10.1186/1475-2840-4-5

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.