Antioxidants in wild mushrooms
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Maintenance of equilibrium between free radical production and antioxidant defences (enzymatic and non enzymatic) is an essential condition for normal organism functioning. When this equilibrium has a tendency for the production of free radicals we say that the organism is in oxidative stress. In this situation, excess free radicals may damage cellular lipids, proteins and DNA, affecting normal function and leading to various diseases. In aerobic organisms, the free radicals are constantly produced during the normal cellular metabolism, mainly in the form of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS). Exposition of the organism to free radicals has led to the development of endogenous defence mechanisms to eliminate them. These defences were the response of evolution to the inevitability of ROS production in aerobic conditions. Natural products with antioxidant activity may help the endogenous defence system. In this perspective the antioxidants present in the diet assume a major importance as possible protector agents reducing oxidative damage. Particularly, the antioxidant properties of wild mushrooms have been extensively studied by our research group and by others, and many antioxidant compounds extracted from these sources have been identified, such as phenolic compounds, tocopherols, ascorbic acid, and carotenoids. We will review the compounds identified so far in mushrooms, as well as the mechanism of action involved in their antioxidant properties. Wild mushrooms might be used directly in diet and promote health, taking advantage of the additive and synergistic effects of all the bioactive compounds present.
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Fungi are capable of biosynthesis of vitamin C, but its content in wild and cultivated fungi is generally very low.
“Besides plants and animals, fungi are also capable of biosynthesis of vitamin C. However, its content in both wild and cultivated fungi is generally very low [14,15,16].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [15]
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- Authors
- Ferreira, I., Barros, L., & Abreu, R.
- Affiliations
- Universidade Politécnica de Bragança (PT)
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-04-01
- Volume
- 16
- Issue
- 12
- Pages
- 1543-1560
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2149614870
- Cited by
- 670
- References
- 136
- Citations by year
- 2026: 28 · 2025: 35 · 2024: 30 · 2023: 52 · 2022: 46 · 2021: 55 · 2020: 47 · 2019: 46 · 2018: 31 · 2017: 51 · 2016: 45 · 2015: 51 · 2014: 48 · 2013: 36 · 2012: 25
- FWCI
- 16.59
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- wild mushrooms, antioxidants, oxidative stress, reactive oxygen species, reactive nitrogen species, phenolic compounds, tocopherols, vitamin C, carotenoids, antioxidant defense, dietary antioxidants, bioactive compounds
- MeSH terms
- Agaricales, Antioxidants, Free Radicals, Humans, Models, Biological, Reactive Oxygen Species
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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