Diabetes mellitus and oxidative stress—A concise review

Asmat, Ullah; Abad, Khan; Ismail, Khan

doi:10.1016/j.jsps.2015.03.013

Cited by 1,570Antioxidant Activity and Oxidative StressNitric Oxide and Endothelin EffectsAdvanced Glycation End Products research

Diabetes mellitus and oxidative stress—A concise review

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Asmat, Ullah, Abad, Khan, Ismail, Khan·2016·Saudi Pharmaceutical Journal

DOI 10.1016/j.jsps.2015.03.013PMC PMC5059829

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Abstract

Human body is continuously exposed to different types of agents that results in the production of reactive species called as free radicals (ROS/RNS) which by the transfer of their free unpaired electron causes the oxidation of cellular machinery. In order to encounter the deleterious effects of such species, body has got endogenous antioxidant systems or it obtains exogenous antioxidants from diet that neutralizes such species and keeps the homeostasis of body. Any imbalance between the RS and antioxidants leads to produce a condition known as "oxidative stress" that results in the development of pathological condition among which one is diabetes. Most of the studies reveal the inference of oxidative stress in diabetes pathogenesis by the alteration in enzymatic systems, lipid peroxidation, impaired Glutathione metabolism and decreased Vitamin C levels. Lipids, proteins, DNA damage, Glutathione, catalane and superoxide dismutase are various biomarkers of oxidative stress in diabetes mellitus. Oxidative stress induced complications of diabetes may include stroke, neuropathy, retinopathy and nephropathy. The basic aim of this review was to summarize the basics of oxidative stress in diabetes mellitus.

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Chronic oxidative stress and resultant oxidative damage have been implicated in many human diseases including cardiovascular disease, neurodegenerative diseases, diabetes, cancer, and aging.
“Chronic oxidative stress and the resultant oxidative damage have been implicated in many human diseases including cardiovascular disease, neurodegenerative diseases, diabetes, cancer, and the aging process [18,19,20,21,22].”
From Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease (2022) · cites this paper as [20]

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Authors: Asmat, U., Abad, K., & Ismail, K.
Affiliations: University of Peshawar (PK)
ORCID: Asmat, Ullah
Venue: Saudi Pharmaceutical Journal
Publisher: Springer Science and Business Media LLC
Published: 2016-09
Volume: 24
Issue: 5
Pages: 547-553
ISSN: 1319-0164 (ISSN-L)
DOI: 10.1016/j.jsps.2015.03.013
PMC: PMC5059829
OpenAlex: W1999647730
Cited by: 1,570
References: 46
Citations by year: 2026: 55 · 2025: 90 · 2024: 179 · 2023: 190 · 2022: 254 · 2021: 209 · 2020: 226 · 2019: 170 · 2018: 115 · 2017: 65 · 2016: 12 · 2015: 4 · 2013: 1
FWCI: 6.85
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Saudi Pharmaceutical Journal (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords: diabetes mellitus, oxidative stress, reactive oxygen species, reactive nitrogen species, free radicals, antioxidant defense, lipid peroxidation, glutathione metabolism, vitamin C, superoxide dismutase, catalase, DNA damage, oxidative stress biomarkers, diabetes complications, neuropathy, retinopathy, kidney disease, stroke

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Diabetes mellitus and oxidative stress—A concise review

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