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Anti-viral activity of red microalgal polysaccharides against retroviruses
Open accessAbstract
Red microalgal polysaccharides significantly inhibited the production of retroviruses (murine leukemia virus- MuLV) and cell transformation by murine sarcoma virus(MuSV-124) in cell culture. The most effective inhibitory effect of these polysaccharides against both cell transformation and virus production was obtained when the polysaccharide was added 2 h before or at the time of infection. Although, addition of the polysaccharide post-infection significantly reduced the number of transformed cells, but its effect was less marked than that obtained when the polysaccharide was added before or at the time of infection.The finding that the inhibition of cell transformation by MuSV-124 was reversible after removal of the polysaccharide suggested that microalgal polysaccharides inhibited a late step after provirus integration into the host genome. In conclusion, our findings could support the possibility that the polysaccharide may affect early steps in the virus replication cycle, such as virus absorption into the host cells, in addition to its effect on a late step after provirus integration.
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“Polysaccharides from the fresh water red microalga Porphyridium sp. were more active than those from Porphyridium aerogineum and Rhodella reticulata against murine leukemia virus (MULV) and murine sarcoma virus (MuSV-124) in cell culture [116].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [116]
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“Some microalgal polysaccharides were found to show antiviral activities against retroviruses.”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [116]
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Metadata
- Authors
- Talyshinsky, M. M., Souprun, Y. Y., & Huleihel, M. M.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Huleihel, Mahmoud M
- ORCID
- Huleihel, Mahmoud M
- Venue
- Cancer Cell International
- Published
- 2002-07-05
- Volume
- 2
- Issue
- 1
- Pages
- 8-8
- ISSN
- 1475-2867 (ISSN-L)
- PMC
- PMC140136
- OpenAlex
- W2111203587
- Cited by
- 109
- References
- 39
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 11 · 2021: 17 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 3
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cancer Cell International (publishedVersion)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Keywords
- retroviruses, murine leukemia virus, murine sarcoma virus, antiviral activity, viral life cycle, provirus integration
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