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Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria
Open accessAbstract
We report the first in vitro and genetic confirmation of Malarone (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two weeks after returning from a 4-week visit to Lagos, Nigeria without prophylaxis, a male patient was given a standard 3-day treatment course of Malarone. Twenty-eight days later the parasitaemia recrudesced. Parasites were cultured from the blood and the isolate (NGATV01) was shown to be resistant to atovaquone and the antifolate pyrimethamine. The cytochrome b gene of isolate NGATV01 showed a single mutation, Tyr268Asn which has not been seen previously.
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Citations
Cited by
Mechanisms of Resistance of Malaria Parasites to Antifolates
Gregson, A., & Plowe, C. V. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.4 · Cited by 499
Antimalarial Drug Resistance: A Threat to Malaria Elimination
Menard, D., & Dondorp, A. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025619 · Cited by 499
Wiesner, J., Ortmann, R., Jomaa, H., & Schlitzer, M. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200200569 · Cited by 428
Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network
Cui, L., Mharakurwa, S., Ndiaye, D., Rathod, P. K., & Rosenthal, P. J. (2015) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.15-0007 · Cited by 305
WALKER, K., & LYNCH, M. (2007) · Medical and Veterinary Entomology · doi:10.1111/j.1365-2915.2007.00674.x · Cited by 279
Metadata
- Authors
- Fivelman, Q. L., Butcher, G. A., Adagu, I. S., Warhurst, D. C., & Pasvol, G.
- Venue
- Malaria Journal
- Published
- 2002-02-08
- Volume
- 1
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1475-2875 (ISSN-L)
- OpenAlex
- W2101397647
- Cited by
- 225
- References
- 0
- FWCI
- 13.66
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fivelman, Q. L., Butcher, G. A., Adagu, I. S., Warhurst, D. C., & Pasvol, G. (2002). Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria. Malaria Journal. https://doi.org/10.1186/1475-2875-1-1
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