Cited by 107Malaria Research and ControlHemoglobinopathies and Related DisordersBlood groups and transfusion

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Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

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Gong, Lauren, Parikh, Sunil, Rosenthal, Philip J, Greenhouse, Bryan·2013·Malaria Journal

DOI 10.1186/1475-2875-12-317PMC PMC3847285

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Abstract

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been proposed, and it is likely that multiple complex mechanisms are responsible for the observed protection. Increased evidence for an immune component of protection as well as novel mechanisms, such as enhanced tolerance to disease mediated by HO-1 and reduced parasitic growth due to translocation of host micro-RNA into the parasite, have recently been described. A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria.

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Figure 1 Model of mechanisms by which sickle cell trait may protect against malaria.CC BY · PubMed Central

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The pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,804
Common West African HLA antigens are associated with protection from severe malaria
Hill, A. V. S., Allsopp, C. E. M., Kwiatkowski, D. P., Anstey, N. M., Twumasi, P., Rowe, P. A., Bennett, S., Brewster, D., McMichael, A. J., & Greenwood, B. M. (1991) · Nature · doi:10.1038/352595a0 · Cited by 1,573
Abnormal human haemoglobins
Clegg, J. B., Naughton, M. A., & Weatherall, D. J. (1966) · Journal of Molecular Biology · doi:10.1016/s0022-2836(66)80052-9 · Cited by 1,495
Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection
ALLISON, A. C. (1954) · BMJ · doi:10.1136/bmj.1.4857.290 · Cited by 1,297
Pathogenesis and Treatment of Sickle Cell Disease
Bunn, H. F. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709113371107 · Cited by 1,154 · cited 1×
“Heterozygotes for sickle haemoglobin (HbAS) have sickle cell trait and are generally asymptomatic [10].”
Background
Immunity to malaria: more questions than answers
Langhorne, J., Ndungu, F. M., Sponaas, A., & Marsh, K. (2008) · Nature Immunology · doi:10.1038/ni.f.205 · Cited by 908
Disease and Evolution
Haldane, J. B. S. (2006) · Springer eBooks · doi:10.1007/0-387-28295-5_9 · Cited by 748
Protective effects of the sickle cell gene against malaria morbidity and mortality
Aidoo, M., Terlouw, D. J., KOLCZAK, M. S., McElroy, P. D., ter Kuile, F. O., Kariuki, S., Nahlen, B. L., Lal, A. A., & Udhayakumar, V. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08273-9 · Cited by 701
Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis
Piel, F. B., Patil, A. P., Howes, R. E., Nyangiri, O. A., Gething, P. W., Williams, T. N., Weatherall, D. J., & Hay, S. I. (2010) · Nature Communications · doi:10.1038/ncomms1104 · Cited by 629 · cited 1×
“The high prevalence of HbS in sub-Saharan Africa and some other tropical areas is almost certainly due to the protection against malaria afforded to heterozygotes [1-3,5].”
Background
An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration.
Turner, G. D. H., Morrison, H., Jones, M., Davis, T. M. E., Looareesuwan, S., BULEY, I. D., Gatter, K. C., Newbold, C., Pukritayakamee, S., & Nagachinta, B. (1994) · PubMed Central · Cited by 596
Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells
Hoffmann, P. R., deCathelineau, A. M., Ogden, C. A., Leverrier, Y., Bratton, D. L., Daleke, D. L., Ridley, A. J., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108080 · Cited by 541
Human cerebral malaria: association with erythrocyte rosetting and lack of anti-rosetting antibodies
Carlson, J., Helmby, H., Wahlgren, M., Carlson, J., Helmby, H., Wahlgren, M., Hill, A., Brewster, D., & Greenwood, B. M. (1990) · The Lancet · doi:10.1016/0140-6736(90)93174-n · Cited by 447
Antibodies to blood stage antigens of Plasmodium falciparum in rural Gambians and their relation to protection against infection
Marsh, K., Otoo, L., Hayes, R. J., Carson, D. C., & Greenwood, B. M. (1989) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(89)90478-1 · Cited by 446
Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia
Boas, F. E., Forman, L., & Beutler, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3077 · Cited by 405
Haemoglobin C protects against clinical Plasmodium falciparum malaria
Modiano, D., Luoni, G., Sirima, B. S., Simporé, J., Verra, F., Konaté, A., Rastrelli, E., Olivieri, A., Calissano, C., Paganotti, G. M., et al. (2001) · Nature · doi:10.1038/35104556 · Cited by 381
Genome-wide and fine-resolution association analysis of malaria in West Africa
Jallow, M., Teo, Y. Y., Small, K. S., Rockett, K. A., Deloukas, P., Clark, T. G., Kivinen, K., Bojang, K., Conway, D. J., Pinder, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.388 · Cited by 380
Enhanced phagocytosis of ring-parasitized mutant erythrocytes: a common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait
Ayi, K., Turrini, F., Piga, A. G., & Arese, P. (2004) · Blood · doi:10.1182/blood-2003-11-3820 · Cited by 359
In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes.
Schroit, A. J., Madsen, J. W., & Tanaka, Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89189-x · Cited by 349
Sickle Cell Trait and the Risk ofPlasmodium falciparumMalaria and Other Childhood Diseases
Williams, T. N., Mwangi, T., Wambua, S., Alexander, N. D. E., Kortok, M., Snow, R. W., & Marsh, K. (2005) · The Journal of Infectious Diseases · doi:10.1086/430744 · Cited by 349
Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis
Taylor, S. M., Parobek, C. M., & Fairhurst, R. M. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70055-5 · Cited by 347
Sickle Hemoglobin Confers Tolerance to Plasmodium Infection
Ferreira, A., Marguti, I., Bechmann, I., Jeney, V., Chora, Â., Palha, N. R., Rebelo, S., Henri, A., Beuzard, Y., & Soares, M. P. (2011) · Cell · doi:10.1016/j.cell.2011.03.049 · Cited by 340
Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency
Cappadoro, M., Giribaldi, G., O'Brien, E., Turrini, F., Mannu, F., Ulliers, D., Simula, G., Luzzatto, L., & Arese, P. (1998) · Blood · doi:10.1182/blood.v92.7.2527 · Cited by 339
Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria
Pasvol, G., Weatherall, D. J., & Wilson, R. J. (1978) · Nature · doi:10.1038/274701a0 · Cited by 323
Identification of a Platelet Membrane Glycoprotein as a Falciparum Malaria Sequestration Receptor
Ockenhouse, C. F., Tandon, N. N., Magowan, C., Jamieson, G. A., & Chulay, J. D. (1989) · Science · doi:10.1126/science.2467377 · Cited by 310
Erythrocytic mechanism of sickle cell resistance to malaria.
Friedman, M. J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.4.1994 · Cited by 304
α + -Thalassemia protects children against disease caused by other infections as well as malaria
Allen, S. J., O’Donnell, A., Alexander, N. D. E., Alpers, M. P., Peto, T., Clegg, J. B., & Weatherall, D. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14736 · Cited by 303
Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance
LaMonte, G., Philip, N., Reardon, J., Lacsina, J. R., Majoros, W., Chapman, L., Thornburg, C. D., Telen, M. J., Ohler, U., Nicchitta, C. V., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.06.007 · Cited by 290
Heritability of Malaria in Africa
Mackinnon, M. J., Mwangi, T. W., Snow, R. W., Marsh, K., & Williams, T. N. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020340 · Cited by 277
Band 3/Complement-mediated Recognition and Removal of Normally Senescent and Pathological Human Erythrocytes
Arese, P., Turrini, F., & Schwarzer, E. (2005) · Cellular Physiology and Biochemistry · doi:10.1159/000089839 · Cited by 275
Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum–parasitized erythrocytes: a role for CD36 in malarial clearance
McGilvray, I. D., Serghides, L., Kapùs, A., Rotstein, O. D., & Kain, K. C. (2000) · Blood · doi:10.1182/blood.v96.9.3231 · Cited by 266
Abnormal haemoglobins in the Sudan savanna of Nigeria
Fleming, A. F., Storey, J., Molineaux, L., Iroko, E. A., & Attai, E. D. E. (1979) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034983.1979.11687243 · Cited by 251
Hemoglobins S and C Interfere with Actin Remodeling in Plasmodium falciparum –Infected Erythrocytes
Cyrklaff, M., Sanchez, C. P., Kilian, N., Bisseyé, C., Simporè, J., Frischknecht, F., & Lanzer, M. (2011) · Science · doi:10.1126/science.1213775 · Cited by 249
Impaired cytoadherence of Plasmodium falciparum -infected erythrocytes containing sickle hemoglobin
Cholera, R., Brittain, N. J., Gillrie, M. R., Lopera-Mesa, T. M., Diakité, S. A. S., Arie, T., Krause, M. A., Guindo, A., Tubman, A., Fujioka, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711401105 · Cited by 249
INCREASED SICKLING OF PARASITISED ERYTHROCYTES AS MECHANISM OF RESISTANCE AGAINST MALARIA IN THE SICKLE-CELL TRAIT
Luzzatto, L., Nwachuku-Jarrett, E. S., & Reddy, S. (1970) · The Lancet · doi:10.1016/s0140-6736(70)90700-2 · Cited by 233
An Immune Basis for Malaria Protection by the Sickle Cell Trait
Williams, T. N., Mwangi, T., Roberts, D. J., Alexander, N. D. E., Weatherall, D. J., Wambua, S., Kortok, M., Snow, R. W., & Marsh, K. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020128 · Cited by 233
Human red blood cell polymorphisms and malaria
Williams, T. N. (2006) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.06.009 · Cited by 231
Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettes
Udomsangpetch, R., Wåhlin, B., Carlson, J., Berzins, K., Torii, M., Aikawa, M., Perlmann, P., & Wahlgren, M. (1989) · Journal of Experimental Medicine · doi:10.1084/jem.169.5.1835 · Cited by 229
Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria
Fairhurst, R. M., Baruch, D. I., Brittain, N. J., Ostera, G. R., Wallach, J. S., Hoang, H. L., Hayton, K., Guindo, A., Makobongo, M. O., Schwartz, O., et al. (2005) · Nature · doi:10.1038/nature03631 · Cited by 228
Abnormal human haemoglobins. III the chemical difference between normal and sickle cell haemoglobins
Ingram, V. M. (1959) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(59)90183-0 · Cited by 223
Insertion of fluorescent phosphatidylserine into the plasma membrane of red blood cells. Recognition by autologous macrophages.
Tanaka, Y., & Schroit, A. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44422-x · Cited by 220
Reduced microcirculatory flow in severe falciparum malaria: pathophysiology and electron-microscopic pathology
Dondorp, A. M., Pongponratn, E., & White, N. J. (2003) · Acta Tropica · doi:10.1016/j.actatropica.2003.10.004 · Cited by 209
Rosetting of Plasmodium falciparum-infected red blood cells with uninfected red blood cells enhances microvascular obstruction under flow conditions
Kaul, D., Roth, E. J., Nagel, R. L., Rj, H., & Handunnetti, S. (1991) · Blood · doi:10.1182/blood.v78.3.812.812 · Cited by 197
Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S
Agarwal, A., Guindo, A., Cissoko, Y., Taylor, J. G., Coulibaly, D. M., Kone, A. K., Kayentao, K., DJIMDÉ, A. A., Plowe, C. V., Doumbo, O., et al. (2000) · Blood · doi:10.1182/blood.v96.7.2358 · Cited by 192
Both heterozygous and homozygous α+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
Williams, T. N., Wambua, S., Uyoga, S. M., Macharia, A., Mwacharo, J. K., Newton, C. R. J. C., & Maitland, K. (2005) · Blood · doi:10.1182/blood-2005-01-0313 · Cited by 191
TENNIS ELBOW
Mccracken, P., & Sanderman, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92637-3 · Cited by 191
The Pathology of Human Cerebral Malaria
Aikawa, M., Iseki, M., Barnwell, J. W., Taylor, D. W., Oo, M. M., & Howard, R. J. (1990) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1990.43.30 · Cited by 190
Hemoglobin Variants and Disease Manifestations in Severe Falciparum Malaria
May, J., Evans, J. A., Timmann, C., Ehmen, C., Busch, W., Thye, T., Agbenyega, T., & Horstmann, R. D. (2007) · JAMA · doi:10.1001/jama.297.20.2220 · Cited by 184
Rosette Formation in Plasmodium falciparum Isolates and Anti-Rosette Activity of Sera from Gambians with Cerebral or Uncomplicated Malaria
Treutiger, C. J., Hedlund, I., Helmby, H., Carlson, J., Jepson, A., Twumasi, P., Kwiatkowski, D. P., Greenwood, B. M., & Wahlgren, M. (1992) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1992.46.503 · Cited by 178
Cytokines in the Pathogenesis of and Protection against Malaria
Angulo, I., & Fresno, M. (2002) · Clinical and Vaccine Immunology · doi:10.1128/cdli.9.6.1145-1152.2002 · Cited by 176
The fine structure of Plasmodium falciparum and its host erythrocytes in natural malarial infections in man.
Trager, W. F., Rudzinska, M. A., & BRADBURY, P. C. (1966) · PubMed · Cited by 174
High Immunoglobulin G2 (IgG2) and Low IgG4 Levels Are Associated with Human Resistance toPlasmodium falciparumMalaria
Aucan, C., Traoré, Y., Tall, F. H., Nacro, B., Traoré-Leroux, T., Fumoux, F., & Rihet, P. (2000) · Infection and Immunity · doi:10.1128/iai.68.3.1252-1258.2000 · Cited by 173
The Effect of α +-Thalassaemia on the Incidence of Malaria and Other Diseases in Children Living on the Coast of Kenya
Wambua, S., Mwangi, T., Kortok, M., Uyoga, S. M., Macharia, A., Mwacharo, J. K., Weatherall, D. J., Snow, R. W., Marsh, K., & Williams, T. N. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030158 · Cited by 167
Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S
Agarwal, A., Guindo, A., Cissoko, Y., Taylor, J. G., Coulibaly, D., Kone, A. K., Kayentao, K., DJIMDÉ, A. A., Plowe, C. V., Doumbo, O. K., et al. (2000) · Blood · doi:10.1182/blood.v96.7.2358.h8002358_2358_2363 · Cited by 164
Antigen-Specific Immunosuppression in Human Malaria Due to Plasmodium falciparum
Ho, M., Webster, H. K., Looareesuwan, S., Supanaranond, W., Phillips, R. E., Chanthavanich, P., & Warrell, D. A. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/153.4.763 · Cited by 162
5. Variation of Plasmodium falciparum msp1 block 2 and msp2 allele prevalence and of infection complexity in two neighbouring Senegalese villages with different transmission conditions
Konaté, L., Zwetyenga, J. S. L. G., Rogier, C., Bischoff, E., Fontenille, D., Tall, A., Spiegel, A., Trape, J., & Mercereau‐Puijalon, O. (1999) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(99)90323-1 · Cited by 156
Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria
Chotivanich, K., Udomsangpetch, R., Pattanapanyasat, K., Chierakul, W., Simpson, J. A., Looareesuwan, S., & White, N. J. (2002) · Blood · doi:10.1182/blood.v100.4.1172.h81602001172_1172_1176 · Cited by 155
Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization
Makani, J., Komba, A., Cox, S. E., Oruo, J., Mwamtemi, K., Kitundu, J. A., Magesa, P., Rwezaula, S. S., Meda, E., Mgaya, J., et al. (2009) · Blood · doi:10.1182/blood-2009-07-233528 · Cited by 155
α+-thalassemia protects African children from severe malaria
Mockenhaupt, F. P., Ehrhardt, S., Gellert, S., Otchwemah, R. N., Dietz, E., Anemana, S. D., & Bienzle, U. (2004) · Blood · doi:10.1182/blood-2003-11-4090 · Cited by 149
GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY, SICKLING, AND MALARIA IN AFRICAN CHILDREN IN SOUTH WESTERN NIGERIA
Gilles, H. M., Fletcher, K. A., Hendrickse, R. G., Lindner, R., Reddy, S., & Allan, N. C. (1967) · The Lancet · doi:10.1016/s0140-6736(67)91037-9 · Cited by 145
Reduced Risk of Plasmodium vivax Malaria in Papua New Guinean Children with Southeast Asian Ovalocytosis in Two Cohorts and a Case-Control Study
Rosanas‐Urgell, A., Lin, E., Manning, L. A., Rarau, P., Laman, M., Senn, N., Grimberg, B. T., Tavul, L., Stanisic, D. I., Robinson, L. J., et al. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001305 · Cited by 145
Factors Determining the Heterogeneity of Malaria Incidence in Children in Kampala, Uganda
Clark, T. D., Greenhouse, B., Njama‐Meya, D., Nzarubara, B., Maiteki‐Sebuguzi, C., Staedke, S. G., Seto, E., Kamya, M. R., Rosenthal, P. J., & Dorsey, G. (2008) · The Journal of Infectious Diseases · doi:10.1086/589778 · Cited by 139
Self-citation
Accelerated Clearance of Plasmodium-infected Erythrocytes in Sickle Cell Trait and Annexin-A7 Deficiency
Lang, P. A., Kasinathan, R. S., Brand, V. B., Duranton, C., Lang, C., Koka, S., Shumilina, E. V., Kempe, D. S., Duranton‐Tanneur, V., Akel, A., et al. (2009) · Cellular Physiology and Biochemistry · doi:10.1159/000257529 · Cited by 131
Sickling Rates of Human as Red Cells Infected in Vitro with Plasmodium falciparum Malaria
Roth, E. F., Friedman, M. J., Ueda, Y., Tellez-Nagel, I., Trager, W., & Nagel, R. L. (1978) · Science · doi:10.1126/science.360396 · Cited by 122
Sickle Cell Trait Is Associated with a Delayed Onset of Malaria: Implications for Time‐to‐Event Analysis in Clinical Studies of Malaria
Crompton, P. D., Traoré, B., Kayentao, K., Doumbo, S., Ongoïba, A., Diakité, S. A. S., Krause, M., Doumtabé, D., Koné, Y., Weiss, G. E., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/592224 · Cited by 121
Influence of Hemoglobin E Trait on the Severity of Falciparum Malaria
Hutagalung, R., Wilairatana, P., Looareesuwan, S., Brittenham, G. M., Aikawa, M., & Gordeuk, V. R. (1999) · The Journal of Infectious Diseases · doi:10.1086/314561 · Cited by 108
Hemoglobinopathies: slicing the gordian knot of plasmodium falciparum malaria pathogenesis.
Taylor, S. M., Cerami, C., & Fairhurst, R. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003327 · Cited by 103
Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth
Kreuels, B., Kreuzberg, C., Kobbe, R., Ayim‐Akonor, M., Appiah–Thompson, P., Thompson, B., Ehmen, C., Adjei, S., Langefeld, I., Adjei, O., et al. (2010) · Blood · doi:10.1182/blood-2009-09-241844 · Cited by 103
Cellular immune responses to Plasmodium falciparum antigens in Gambian children during and after an acute attack of falciparum malaria.
Riley, E. M., Andersson, G., Otoo, L. N., Jepsen, S. V., & Greenwood, B. M. (1988) · PubMed Central · Cited by 95
The Sickle Cell Trait Is Associated with Enhanced Immunoglobulin G Antibody Responses toPlasmodium falciparumVariant Surface Antigens
Cabrera, G., Cot, M., Migot‐Nabias, F., Kremsner, P. G., Deloron, P., & Luty, A. J. F. (2005) · The Journal of Infectious Diseases · doi:10.1086/429832 · Cited by 91
Higher resistance to Plasmodium falciparum infection in patients with homozygous sickle cell disease in western Kenya
Aluoch, J. R. (1997) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1997.d01-322.x · Cited by 89
Haemoglobin C and S Role in Acquired Immunity against Plasmodium falciparum Malaria
Verra, F., Simporè, J., Warimwe, G. M., Tetteh, K. K. A., Howard, T., Osier, F. H. A., Bancone, G., Avellino, P., Blot, I., Fegan, G., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000978 · Cited by 88
Hemoglobin C and Resistance to Severe Malaria in Ghanaian Children
Mockenhaupt, F. P., Ehrhardt, S., Cramer, J. P., Otchwemah, R. N., Anemana, S. D., Goltz, K., Mylius, F., Dietz, E., Eggelte, T. A., & Bienzle, U. (2004) · The Journal of Infectious Diseases · doi:10.1086/422847 · Cited by 88
Immune Responses to Asexual Blood-Stages of Malaria Parasites
Yazdani, S. S., Mukherjee, P., Chauhan, V. S., & Chitnis, C. E. (2006) · Current Molecular Medicine · doi:10.2174/156652406776055212 · Cited by 87
Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait
Gong, L., Maiteki‐Sebuguzi, C., Rosenthal, P. J., Hubbard, A., DRAKELEY, C. J., Dorsey, G., & Greenhouse, B. (2012) · Blood · doi:10.1182/blood-2011-08-371062 · Cited by 87
Self-citation
Sickle cell disease in the Balovale District of Northern Rhodesia.
BEET, E. A. (1946) · PubMed · Cited by 75
Morbidity from malaria and immune responses to defined Plasmodium falciparum antigens in children with sickle cell trait in The Gambia
Allen, S. J., Bennett, S., Riley, E. M., Rowe, P. A., Jakobsen, P., O’Donnell, A., & Greenwood, B. M. (1992) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(92)90083-o · Cited by 73
Population genetic studies in the Congo. I. Glucose-6-phosphate dehydrogenase deficiency, hemoglobin S, and malaria.
Motulsky, A. G., Vandepitte, J., & Fraser, G. R. (1966) · PubMed · Cited by 64
α-Thalassemia Impairs the Cytoadherence of Plasmodium falciparum-Infected Erythrocytes
Krause, M., Diakité, S. A. S., Lopera-Mesa, T. M., Amaratunga, C., Arie, T., Traoré, K., Doumbia, S., Konate, D. S., Keefer, J. R., Diakité, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037214 · Cited by 63
Effects of red blood cell potassium and hypertonicity on the growth ofPlasmodium falciparum in culture
Ginsburg, H., Handeli, S., Friedman, S., Gorodetsky, R., & Krugliak, M. (1986) · Parasitology Research · doi:10.1007/bf00931146 · Cited by 59
Suppression of Parasite‐Specific Response in Plasmodium falciparum Malaria. A Longitudinal Study of Blood Mononculear Cell Proliferation and Subset Composition
Theander, T. G., Bygbjerg, I. C., Andersen, B. J., Jepsen, S. V., Kharazmi, A., & Ødum, N. (1986) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1986.tb02071.x · Cited by 59
Longitudinal study of Plasmodium falciparum infection and immune responses in infants with or without the sickle cell trait
Hesran, J. L., Personne, I., Personne, P., Fiévet, N., Dubois, B., Beyeme, M., Boudin, C., Cot, M., & Deloron, P. (1999) · International Journal of Epidemiology · doi:10.1093/ije/28.4.793 · Cited by 59
IMMUNOADSORBENT ISOLATION OF ANTIGENS FROM THE CULTURE MEDIUM OF IN VITRO CULTIVATEDPLASMODIUM FALCIPARUM
Jepsen, S. V., & Andersen, B. J. (1981) · Acta Pathologica Microbiologica Scandinavica Section C Immunology · doi:10.1111/j.1699-0463.1981.tb02671.x · Cited by 46
Influence of haemoglobins S and C on predominantly asymptomatic Plasmodium infections in northern Ghana
Danquah, I., Ziniel, P. D., Eggelte, T. A., Ehrhardt, S., & Mockenhaupt, F. P. (2010) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2010.08.001 · Cited by 46
Red blood cell polymorphisms in relation to Plasmodium falciparum asymptomatic parasite densities and morbidity in Senegal
Migot‐Nabias, F., Pelleau, S., Watier, L., Guitard, J., Toly‐Ndour, C., Araujo, C. D., Ngom, M., Chevillard, C., Gaye, O., & Garcia, A. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.03.021 · Cited by 45
HOST POLYMORPHISMS AND THE INCIDENCE OF MALARIA IN UGANDAN CHILDREN
Parikh, S., Dorsey, G., & Rosenthal, P. J. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.71.750 · Cited by 44
Self-citation
Impaired cell-mediated immunity in Plasmodium falciparum-infected patients with high-parasitemia and cerebral malaria
Brasseur, P., Agrapart, M., Ballet, J.-J., Druilhe, P., Warrell, M. J., & Tharavanis, S. (1983) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(83)90054-5 · Cited by 43
Plasmodium Falciparum Malaria and Human Red Cells. II. Red Cell Genetic Traits and Resistance Against Malaria
Guggenmoos-Holzmann, I., Bienzle, U., & Luzzatto, L. (1981) · International Journal of Epidemiology · doi:10.1093/ije/10.1.16 · Cited by 43
Hemoglobin S and C Heterozygosity Enhances Neither the Magnitude nor Breadth of Antibody Responses to a Diverse Array of Plasmodium falciparum Antigens
Tan, X., Traoré, B., Kayentao, K., Ongoïba, A., Doumbo, S., Waisberg, M., Doumbo, O. K., Felgner, P. L., Fairhurst, R. M., & Crompton, P. D. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir638 · Cited by 42
THE RELATIONSHIP OF SERUM GAMMA-GLOBULIN CONCENTRATION TO MALARIA AND SICKLING
Edozien, J. C., Boyo, A. E., & Morley, D. C. (1960) · Journal of Clinical Pathology · doi:10.1136/jcp.13.2.118 · Cited by 40
Immunoglobulin M and G antibody responses to Plasmodium falciparum glutamate-rich protein: correlation with clinical immunity in Gambian children
Dziegiel, M. H., Rowe, P. A., Bennett, S. C. J., Allen, S. J., Olerup, O., Gottschau, A., Borre, M. B., & Riley, E. M. (1993) · Infection and Immunity · doi:10.1128/iai.61.1.103-108.1993 · Cited by 40
Cell-mediated immune responses to Plasmodium falciparum purified soluble antigens in sickle-cell trait subjects
Bayoumi, R., Abu-Zeid, Y. A., Abdulhadi, N. H., Saeed, B. O., Theander, T. G., Hviid, L., Ghalib, H. W., Nugud, A. H. D., Jepsen, S. V., & Jensen, J. B. (1990) · Immunology Letters · doi:10.1016/0165-2478(90)90122-7 · Cited by 36
Abnormal haemoglobins in the Sudan savanna of Nigeria
Cornille-Brøgger, R., Fleming, A. F., Kagan, I. G., Matsushima, T., & Molineaux, L. (1979) · Annals of Tropical Medicine and Parasitology · doi:10.1080/00034983.1979.11687244 · Cited by 36
Sickle Cell Trait Protects Against Plasmodium falciparum Infection
Billo, M. A., Johnson, E. S., Doumbia, S., Poudiougou, B., Sagara, I., Diawara, S. I., Diakité, M., Diallo, M., Doumbo, O. K., Tounkara, A., et al. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws323 · Cited by 32
Imbalanced Distribution of Plasmodium falciparum MSP-1 Genotypes Related to Sickle-Cell Trait
Ntoumi, F., Rogier, C., Dièye, A., Trape, J., Millet, P. G., & Mercereau‐Puijalon, O. (1997) · Molecular Medicine · doi:10.1007/bf03401815 · Cited by 31
Specific proliferative response of human lymphocytes to purified soluble antigens from Plasmodium falciparum in vitro cultures and to antigens from malaria patients' sera.
Bygbjerg, I. C., Jepsen, S. V., Theander, T. G., & Ødum, N. (1985) · PubMed Central · Cited by 29
Toxic Heme in Sickle Cells: an Explanation for Death of Malaria Parasites *
Orjih, A. U., Fitch, C. D., & Chevli, R. (1985) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1985.34.223 · Cited by 27
Modulation of the cellular immune response during Plasmodium falciparum infections in sickle cell trait individuals
Abu-Zeid, Y. A., Theander, T. G., Abdulhadi, N. H., Hviid, L., Saeed, B. O., Jepsen, S. V., Jensen, J. B., & Bayoumi, R. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb03048.x · Cited by 26
Impact of red blood cell polymorphisms on the antibody response to Plasmodium falciparum in Senegal
Sarr, J. B., Pelleau, S., Toly‐Ndour, C., Guitard, J., Konaté, L., Deloron, P., Garcia, A., & Migot‐Nabias, F. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2005.12.005 · Cited by 25
Lymphoproliferative Responses to Plasmodium falciparum Antigens in Children With and Without the Sickle Cell Trait
Abu-Zeid, Y. A., Abdulhadi, N. H., Hviid, L., Theander, T. G., Saeed, B. O., Jepsen, S. V., Jensen, J. B., & Bayoumi, R. (1991) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1991.tb01542.x · Cited by 24
Host Genetic Factors in Resistance and Susceptibility to Malaria
Kwiatkowski, D. P., & Luoni, G. (2014) · ASM Press eBooks · doi:10.1128/9781555817558.ch24 · Cited by 22
The sickle cell trait; its clinical significance.
Brain, P. (1952) · PubMed · Cited by 22
Malaria-induced lymphokines: stimulation of macrophages for enhanced phagocytosis
Ockenhouse, C. F., & Shear, H. L. (1983) · Infection and Immunity · doi:10.1128/iai.42.2.733-739.1983 · Cited by 21
Antibody responses to Plasmodium falciparum: evolution according to the severity of a prior clinical episode and association with subsequent reinfection.
Luty, A. J. F., Ulbert, S., Lell, B., Lehman, L. G., Schmidt‐Ott, R., Luckner, D., Greve, B., Matoušek, P., Schmid, D., Herbich, K., et al. (2000) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2000.62.566 · Cited by 21
The Sickle Cell Trait
Nalbandian, R. M. (1973) · JAMA · doi:10.1001/jama.1973.03230110045013 · Cited by 17
Differential antibody response of Gambian donors to soluble Plasmodium falciparum antigens
Jakobsen, P., Riley, E. M., Allen, S. J., Larsen, S. O., Bennett, S., Jepsen, S. V., & Greenwood, B. M. (1991) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(91)90141-k · Cited by 17
Relationship between Malaria Incidence and IgG Levels to Plasmodium falciparum Merozoite Antigens in Malian Children: Impact of Hemoglobins S and C
Miura, K., Diakité, M., Diouf, A., Doumbia, S., Konate, D. S., Keita, A. S., Moretz, S. E., Tullo, G., Zhou, H., Lopera-Mesa, T. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060182 · Cited by 12
FREQUENCIES OF PERIPHERAL BLOOD MYELOID CELLS IN HEALTHY KENYAN CHILDREN WITH α+ THALASSEMIA AND THE SICKLE CELL TRAIT
Urban, B. C., Shafi, M. J., Cordery, D. V., Macharia, A. W., Lowe, B. S., Marsh, K., & Williams, T. N. (2006) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2006.74.578 · Cited by 12
Relationship of Binding of Immunoglobulin G to Plasmodium falciparum -Infected Erythrocytes with Parasite Endemicity and Antibody Responses to Conserved Antigen in Immune Individuals
Diatta, A.-M., Marrama, L., Tall, A., Trape, J., Dièye, A., Garraud, O., Mercereau‐Puijalon, O., & Perraut, R. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.1.6-11.2004 · Cited by 11

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Authors: Gong, L., Parikh, S., Rosenthal, P. J., & Greenhouse, B.
Affiliations: University of California, San Francisco (US)
Yale University (US)
Corresponding author: Greenhouse, Bryan
ORCID: Parikh, Sunil
Rosenthal, Philip J
Greenhouse, Bryan
Venue: Malaria Journal
Publisher: Springer Science and Business Media LLC
Published: 2013-09-11
Volume: 12
Issue: 1
Pages: 317-317
ISSN: 1475-2875 (ISSN-L)
DOI: 10.1186/1475-2875-12-317
PMC: PMC3847285
OpenAlex: W2156643348
Cited by: 105
References: 108
Citations by year: 2026: 6 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 6
FWCI: 1.14
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Malaria Journal (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: Doris Duke Charitable Foundation (2011043)
National Institutes of Health
U.S. Public Health Service (U19 A1089674)
National Institute of Allergy and Infectious Diseases (K23AI076614, U19AI089674)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Health Sciences › Medicine › Hematology › Blood groups and transfusion
Keywords: sickle cell trait, falciparum malaria, malaria prevention, host-parasite interactions, host immune response, heme oxygenase-1, host genetic polymorphisms
MeSH terms: Humans, Sickle Cell Trait, Malaria, Falciparum, Host-Pathogen Interactions

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Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

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