The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria
Open accessAbstract
Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been proposed, and it is likely that multiple complex mechanisms are responsible for the observed protection. Increased evidence for an immune component of protection as well as novel mechanisms, such as enhanced tolerance to disease mediated by HO-1 and reduced parasitic growth due to translocation of host micro-RNA into the parasite, have recently been described. A better understanding of relevant mechanisms will provide valuable insight into the host-parasite relationship, including the role of the host immune system in protection against malaria.
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“As a consequence, the balance between damaging prooxidative molecules such as free heme or iron and antioxidative factors such as carbon monoxide (CO) and bilirubin is shifted towards cytoprotection (Cholera et al., 2008;Ferreira et al., 2011;Gong et al., 2013;Jeney et al., 2014).”
From Iron in infection and immunity (2020) · cites this paper as Gong et al., 2013
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Citations
Cites
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“Heterozygotes for sickle haemoglobin (HbAS) have sickle cell trait and are generally asymptomatic [10].”
BackgroundImmunity to malaria: more questions than answers
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Protective effects of the sickle cell gene against malaria morbidity and mortality
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Cited by
Sorted by citations
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359
Parasitic Protozoa and Interactions with the Host Intestinal Microbiota
Burgess, S. L., Gilchrist, C. A., Lynn, T. C., & Petri, W. A. (2017) · Infection and Immunity · doi:10.1128/iai.00101-17 · Cited by 161
Balderston, S., Taulbee, J. J., Celaya, E., Fung, K., Jiao, A., Smith, K., Hajian, R., Gasiūnas, G., Kutanovas, S., Kim, D., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00706-z · Cited by 170
Feintuch, C. M., Saidi, A., Seydel, K. B., Chen, G., Goldman-Yassen, A. E., Mita-Mendoza, N. K., Kim, R. S., Frenette, P. S., Taylor, T. E., & Daily, J. P. (2016) · mBio · doi:10.1128/mbio.01300-15 · Cited by 103
Extreme Competence: Keystone Hosts of Infections
Martin, L. B., Addison, B., Bean, A. G. D., Buchanan, K. L., Crino, O. L., Eastwood, J. R., Flies, A. S., Hamede, R., Hill, G. E., Klaassen, M., et al. (2019) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2018.12.009 · Cited by 70
Metadata
- Authors
- Gong, L., Parikh, S., Rosenthal, P. J., & Greenhouse, B.
- Affiliations
- University of California, San Francisco (US)
- Yale University (US)
- Corresponding author
- Greenhouse, Bryan
- Venue
- Malaria Journal
- Published
- 2013-09-11
- Volume
- 12
- Issue
- 1
- Pages
- 317-317
- ISSN
- 1475-2875 (ISSN-L)
- PMC
- PMC3847285
- OpenAlex
- W2156643348
- Cited by
- 105
- References
- 108
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 6
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Malaria Journal (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Doris Duke Charitable Foundation (2011043)
- National Institutes of Health
- U.S. Public Health Service (U19 A1089674)
- National Institute of Allergy and Infectious Diseases (K23AI076614, U19AI089674)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Keywords
- sickle cell trait, falciparum malaria, malaria prevention, host-parasite interactions, host immune response, heme oxygenase-1, host genetic polymorphisms
- MeSH terms
- Humans, Sickle Cell Trait, Malaria, Falciparum, Host-Pathogen Interactions
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