Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

The pathogenic basis of malaria

Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,804

Common West African HLA antigens are associated with protection from severe malaria

Hill, A. V. S., Allsopp, C. E. M., Kwiatkowski, D. P., Anstey, N. M., Twumasi, P., Rowe, P. A., Bennett, S., Brewster, D., McMichael, A. J., & Greenwood, B. M. (1991) · Nature · doi:10.1038/352595a0 · Cited by 1,573

Abnormal human haemoglobins

Clegg, J. B., Naughton, M. A., & Weatherall, D. J. (1966) · Journal of Molecular Biology · doi:10.1016/s0022-2836(66)80052-9 · Cited by 1,495

Protection Afforded by Sickle-cell Trait Against Subtertian Malarial Infection

ALLISON, A. C. (1954) · BMJ · doi:10.1136/bmj.1.4857.290 · Cited by 1,297

Pathogenesis and Treatment of Sickle Cell Disease

Bunn, H. F. (1997) · New England Journal of Medicine · doi:10.1056/nejm199709113371107 · Cited by 1,154 · cited 1×

Immunity to malaria: more questions than answers

Langhorne, J., Ndungu, F. M., Sponaas, A., & Marsh, K. (2008) · Nature Immunology · doi:10.1038/ni.f.205 · Cited by 908

Disease and Evolution

Haldane, J. B. S. (2006) · Springer eBooks · doi:10.1007/0-387-28295-5_9 · Cited by 748

Protective effects of the sickle cell gene against malaria morbidity and mortality

Aidoo, M., Terlouw, D. J., KOLCZAK, M. S., McElroy, P. D., ter Kuile, F. O., Kariuki, S., Nahlen, B. L., Lal, A. A., & Udhayakumar, V. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08273-9 · Cited by 701

Global distribution of the sickle cell gene and geographical confirmation of the malaria hypothesis

Piel, F. B., Patil, A. P., Howes, R. E., Nyangiri, O. A., Gething, P. W., Williams, T. N., Weatherall, D. J., & Hay, S. I. (2010) · Nature Communications · doi:10.1038/ncomms1104 · Cited by 629 · cited 1×

An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration.

Turner, G. D. H., Morrison, H., Jones, M., Davis, T. M. E., Looareesuwan, S., BULEY, I. D., Gatter, K. C., Newbold, C., Pukritayakamee, S., & Nagachinta, B. (1994) · PubMed Central · Cited by 596

Iron in infection and immunity

Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359

Parasitic Protozoa and Interactions with the Host Intestinal Microbiota

Burgess, S. L., Gilchrist, C. A., Lynn, T. C., & Petri, W. A. (2017) · Infection and Immunity · doi:10.1128/iai.00101-17 · Cited by 161

Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor

Balderston, S., Taulbee, J. J., Celaya, E., Fung, K., Jiao, A., Smith, K., Hajian, R., Gasiūnas, G., Kutanovas, S., Kim, D., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00706-z · Cited by 170

Activated Neutrophils Are Associated with Pediatric Cerebral Malaria Vasculopathy in Malawian Children

Feintuch, C. M., Saidi, A., Seydel, K. B., Chen, G., Goldman-Yassen, A. E., Mita-Mendoza, N. K., Kim, R. S., Frenette, P. S., Taylor, T. E., & Daily, J. P. (2016) · mBio · doi:10.1128/mbio.01300-15 · Cited by 103

Extreme Competence: Keystone Hosts of Infections

Martin, L. B., Addison, B., Bean, A. G. D., Buchanan, K. L., Crino, O. L., Eastwood, J. R., Flies, A. S., Hamede, R., Hill, G. E., Klaassen, M., et al. (2019) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2018.12.009 · Cited by 70

Genome-wide identification of cancer/testis genes and their association with prognosis in a pan-cancer analysis

da Silva, V. L., Fonseca, A. F., da Fonsêca, M. M., da Silva, T. E., Coelho, A. C., Kroll, J. E., de Souza, J. E. S., Stransky, B., de Souza, G. A., & SOUZA, S. J. D. (2017) · Oncotarget · doi:10.18632/oncotarget.21715 · Cited by 57

Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats

Bielitza, M., Belorgey, D., Ehrhardt, K., Johann, L., Lanfranchi, D. A., Gallo, V., Schwarzer, E., Mohring, F., Jortzik, E., Williams, D. L., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6047 · Cited by 42

Genetic diseases conferring resistance to infectious diseases

Withrock, I. C., Anderson, S. J., Jefferson, M. A., Schmidt-McCormack, G. R., Mlynarczyk, G. S. A., Nakama, A., Lange, J. K., Berg, C. A., Acharya, S., Stock, M. L., et al. (2015) · Genes & Diseases · doi:10.1016/j.gendis.2015.02.008 · Cited by 41

Malaria parasites and red cell variants

Taylor, S. M., & Fairhurst, R. M. (2014) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000039 · Cited by 41

Characterizing the pathogenicity of genetic variants: the consequences of context

Ciesielski, T. H., Sirugo, G., Iyengar, S. K., & Williams, S. M. (2024) · npj Genomic Medicine · doi:10.1038/s41525-023-00386-5 · Cited by 46

Novel Insights Into the Protective Role of Hemoglobin S and C AgainstPlasmodium falciparumParasitemia

Mangano, V. D., Kaboré, Y., Bougouma, E. C. C., Verra, F., Sepúlveda, N., Bisseyé, C., Santolamazza, F., Avellino, P., Tiono, A. B., Diarra, A., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv098 · Cited by 38

Eryptosis as a New Insight in Malaria Pathogenesis

Scovino, A. M., Totino, P. R. R., & Morrot, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.855795 · Cited by 28

Turf wars: exploring splenomegaly in sickle cell disease in malaria‐endemic regions

Tubman, V. N., & Makani, J. (2017) · British Journal of Haematology · doi:10.1111/bjh.14592 · Cited by 28

Associations between Red Cell Polymorphisms and Plasmodium falciparum Infection in the Middle Belt of Ghana

Amoako, N., Asante, K. P., Adjei, G. O., Awandare, G. A., Bimi, L., & Owusu‐Agyei, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112868 · Cited by 27

Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models

Ndungu, F. M., Marsh, K., Fegan, G., Wambua, J., Nyangweso, G. M., Ogada, E. A., Mwangi, T., Nyundo, C., Macharia, A., Uyoga, S. M., et al. (2015) · BMC Medicine · doi:10.1186/s12916-015-0422-4 · Cited by 26

Stroke and stroke prevention in sickle cell anemia in developed and selected developing countries

Bhattacharya, P., Sarmah, D., Dave, K. R., Goswami, A., Watanabe, M., Wang, X., Kalia, K., Plesnila, N., Yavagal, D. R., & Alvarez, O. A. (2021) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2021.117510 · Cited by 26

An in vitro erythrocyte preference assay reveals that Plasmodium falciparum parasites prefer Type O over Type A erythrocytes

Theron, M., Cross, N., Cawkill, P., Bustamante, L. Y., & Rayner, J. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-26559-2 · Cited by 25

Increased Susceptibility to Plasmodium falciparum in Infants is associated with Low, not High, Placental Malaria Parasitemia

Yunga, S. T., Fouda, G. G., Sama, G., Ngu, J. B., Leke, R. G. F., & Taylor, D. W. (2018) · Scientific Reports · doi:10.1038/s41598-017-18574-6 · Cited by 24

Mistargeting of a truncated Na-K-2Cl cotransporter in epithelial cells

Koumangoye, R. B., Omer, S., & Delpire, E. J. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00130.2018 · Cited by 21

Epigenetics and Malaria Susceptibility/Protection: A Missing Piece of the Puzzle

Arama, C., Quin, J. E., Kouriba, B., Farrants, A. Ö., Troye‐Blomberg, M., & Doumbo, O. K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01733 · Cited by 20

Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical Implications

Aschenbrenner, D., Ye, Z., Zhou, Y., Hu, W., Brooks, I., Williams, I., Capitani, M., Gartner, L., Kotlarz, D., Snapper, S. B., et al. (2022) · Journal of Clinical Immunology · doi:10.1007/s10875-022-01366-7 · Cited by 21

Comparative study of clinical presentation and hematological indices in hospitalized sickle cell patients with severe Plasmodium falciparum malaria

Purohit, P., Mohanty, P. K., Patel, S., Das, P., Panigrahi, J., & Das, K. (2017) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2017.08.013 · Cited by 19

Genetic Basis of Adaptation and Maladaptation via Balancing Selection

Gupta, M. K., & Vadde, R. (2019) · Zoology · doi:10.1016/j.zool.2019.125693 · Cited by 16

Stage-dependent fate of Plasmodium falciparum-infected red blood cells in the spleen and sickle-cell trait-related protection against malaria

Diakité, S. A. S., Ndour, P. A., Brousse, V. A. M., Gay, F., Roussel, C., Biligui, S., Dussiot, M., Prendki, V., Lopera-Mesa, T. M., Traoré, K., et al. (2016) · Malaria Journal · doi:10.1186/s12936-016-1522-0 · Cited by 17

Influence of the sickle cell trait on Plasmodium falciparum infectivity from naturally infected gametocyte carriers

Maffo, C. N., Bayibéki, A. N., Abate, L., Makinde, O. S., Feufack-Donfack, L. B., Sarah-Matio, E. M., Bouopda-Tuedom, A. G., Taconet, P., Moiroux, N., Awono‐Ambene, P., et al. (2023) · BMC Infectious Diseases · doi:10.1186/s12879-023-08134-x · Cited by 15

The scope of clinical morbidity in sickle cell trait

Tantawy, A. A. G. (2014) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2014.08.008 · Cited by 15

Sickle Cell Anemia: History and Epidemiology

Piel, F. B., & Williams, T. N. (2016) · Springer eBooks · doi:10.1007/978-3-319-06713-1_2 · Cited by 15

Treating sickle cell disease in resource-limited sub-Saharan Africa: recent strategies and recommendations in addressing the gaps for the provision of evidence-based management

Brito, M., Ginete, C., Ofakunrin, A. O. D., Diaku-Akinwumi, I., & Inusa, B. P. D. (2025) · Expert Review of Hematology · doi:10.1080/17474086.2025.2500599 · Cited by 15

Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study

Mpimbaza, A., Walakira, A., Ndeezi, G., Katahoire, A., Karamagi, C., Nsobya, S. L., Tukwasibwe, S., Asua, V., & Rosenthal, P. J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203229 · Cited by 14

Comparative analysis of asexual and sexual stage Plasmodium falciparum development in different red blood cell types

Amoah, L. E., Acquah, F. K., Nyarko, P., Cudjoe, E., Donu, D., Ayanful‐Torgby, R., Sey, F., Williamson, K. C., & Awandare, G. A. (2020) · Malaria Journal · doi:10.1186/s12936-020-03275-9 · Cited by 14

The impact of reduced incidence of malaria and other mosquito-borne diseases on global population

Gooch, E. (2016) · Journal of Development Economics · doi:10.1016/j.jdeveco.2016.10.003 · Cited by 13

Influence of blood group, Glucose-6-phosphate dehydrogenase and Haemoglobin genotype on Falciparum malaria in children in Vihiga highland of Western Kenya

Ahmed, J. S., Guyah, B., Sang, D., Webale, M. K., Shaviya, N., Munde, E. O., & Ouma, C. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05216-y · Cited by 13

Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study

Kakande, E. R., Greenhouse, B., Bajunirwe, F., DRAKELEY, C. J., Nankabirwa, J. I., Walakira, A., Nsobya, S. L., Katureebe, A., Rek, J. C., Arinaitwe, E., et al. (2020) · Malaria Journal · doi:10.1186/s12936-020-3105-3 · Cited by 13

Entire expressed peripheral blood transcriptome in pediatric severe malarial anemia

Anyona, S. B., Cheng, Q., Wasena, S. A., Osata, S. W., Guo, Y. P., Raballah, E., Hurwitz, I., Onyango, C., Ouma, C., Seidenberg, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48259-4 · Cited by 13

Altered parasite life-cycle processes characterize Babesia divergens infection in human sickle cell anemia

Cursino‐Santos, J. R., Singh, M., Senaldi, E., Manwani, D. G., Yazdanbakhsh, K., & Lobo, C. A. (2019) · Haematologica · doi:10.3324/haematol.2018.214304 · Cited by 12

To prevent or ameliorate severe Plasmodium falciparum malaria, why not evaluate the impact of exchange transfusions of sickle cell trait red blood cells?

Jajosky, R. P., Jajosky, A. N., & Jajosky, P. G. (2017) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2017.11.032 · Cited by 11

Interethnic diversity of the CD209 (rs4804803) gene promoter polymorphism in African but not American sickle cell disease

Noble, J. A., Duru, K. C., Guindo, A., Yi, L., Imumorin, I. G., Diallo, D. A., & Thomas, B. N. (2015) · PeerJ · doi:10.7717/peerj.799 · Cited by 11

Membrane protein carbonylation of Plasmodium falciparum infected erythrocytes under conditions of sickle cell trait and G6PD deficiency

Contreras‐Puentes, N., Rodríguez-Cavallo, E., & Méndez-Cuadro, D. (2018) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2018.11.003 · Cited by 11

Sickle Cell Anemia and Inflammation: A Review of Stones and Landmarks Paving the Road in the Last 25 Years

Dorneles, J., Mayer, A. D. M., & Chies, J. A. B. (2025) · Hematology Reports · doi:10.3390/hematolrep17010002 · Cited by 10

Effect of iron fortification on anaemia and risk of malaria among Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups

Tchum, S. K., Sakyi, S. A., Arthur, F. K. N., Adu, B., Abubakar, L. A., Oppong, F. B., Dzabeng, F., Amoani, B., Gyan, T., & Asante, K. P. (2023) · BMC Nutrition · doi:10.1186/s40795-023-00709-w · Cited by 10

Plasmodium falciparum infection in febrile Congolese children: prevalence of clinical malaria 10 years after introduction of artemisinin‐combination therapies

Etoka‐Beka, M. K., Ntoumi, F., Kombo, M., Deibert, J., Poulain, P., Vouvoungui, C., Kobawila, S. C., & Koukouikila-Koussounda, F. (2016) · Tropical Medicine & International Health · doi:10.1111/tmi.12786 · Cited by 10

Pathophysiology and Perioperative Management of Sickle Cell Disease

Paradowski, K. (2015) · Journal of Perioperative Practice · doi:10.1177/175045891502500602 · Cited by 10

Trained immunity from the perspective of Plasmodium infection

Li, J., Liu, L., Chen, D., Yin, W., & Huang, J. (2023) · European Journal of Immunology · doi:10.1002/eji.202250268 · Cited by 9

Non-S Sickling Hemoglobin Variants: Historical, Genetic, Diagnostic, and Clinical Perspectives

Ahmed, S. G., & Ibrahim, U. A. (2021) · Oman Medical Journal · doi:10.5001/omj.2021.102 · Cited by 9

Elucidating parasite and host-cell factors enabling Babesia infection in sickle red cells under hypoxic/hyperoxic conditions

Beri, D., Singh, M., Rodriguez, M., Barbu-Stevanovic, M., Rasquinha, G., Mendelson, A., An, X., Manwani, D. G., Yazdanbakhsh, K., & Lobo, C. A. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022008159 · Cited by 9

Cross sectional study on prevalence of sickle cell alleles S and C among patients with mild malaria in Ivory Coast

Koui, T. S., Gbessi, E. A., Coulibaly, B., Ako, B., David, C. N., Joly, P., Assi, S.-B., Touré, A. O., & Jambou, R. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3296-7 · Cited by 9

Sickle Cell Trait Induces Oxidative Damage on Plasmodium falciparum Proteome at Erythrocyte Stages

Díaz-Castillo, A., Contreras‐Puentes, N., Alvear, C., Moneriz, C., Rodríguez-Cavallo, E., & Méndez-Cuadro, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225769 · Cited by 8

Genetic resistance to human malaria

Muhammad, I., Abubakar, B., & Muhammad, T. (2022) · Cellular Molecular and Biomedical Reports · doi:10.55705/cmbr.2022.342533.1043 · Cited by 8

Extensive Genomic Variability of Knops Blood Group Polymorphisms is Associated with Sickle Cell Disease in Africa

Duru, K. C., Noble, J. A., Guindo, A., Yi, L., Imumorin, I. G., Diallo, D. A., & Thomas, B. N. (2015) · Evolutionary Bioinformatics · doi:10.4137/ebo.s23132 · Cited by 8

Transfusion‐transmitted malaria masquerading as sickle cell crisis with multisystem organ failure

Maier, C. L., Gross, P. J., Dean, C. L., Chonat, S., Ip, A., McLemore, M. L., Rassi, F. A. E., Stowell, S. R., Josephson, C. D., & Fasano, R. M. (2018) · Transfusion · doi:10.1111/trf.14566 · Cited by 8

Sickle Cell Disease – Current Treatment and New Therapeutical Approaches

de Melo, T. R. F., Ercolin, L. D. R., Chelucci, R. C., Melchior, A. C. B., Lanaro, C., Chin, C. M., & dos Santos, J. L. (2015) · InTech eBooks · doi:10.5772/60515 · Cited by 8

Diagnostic challenges of prolonged post-treatment clearance of Plasmodium nucleic acids in a pre-transplant autosplenectomized patient with sickle cell disease

Luethy, P. M., Murphy, S. C., Seilie, A. M., Xie, Y. L., Lau, C., Tisdale, J. F., Hsieh, M. M., Reinhardt, J. L., Lau, A. F., & Fahle, G. A. (2018) · Malaria Journal · doi:10.1186/s12936-017-2152-x · Cited by 6

Immunoglobulin G responses against falciparum malaria specific antigens are higher in children with homozygous sickle cell trait than those with normal hemoglobin

Bwire, G. M., Majigo, M. V., Makala, R., Nkinda, L., Mawazo, A., Mizinduko, M. M., & Makani, J. (2019) · BMC Immunology · doi:10.1186/s12865-019-0294-z · Cited by 6

Data-driven spatial–temporal framework for exploring the heterogeneity and temporality of sepsis

Qiu, Y., & Zhou, X. Q. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003849 · Cited by 5

Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia

Sambo, M. D. R., Penha‐Gonçalves, C., Trovoada, M. J., Costa, J., Ferrer, R. L., & Coutinho, A. (2015) · Malaria Journal · doi:10.1186/s12936-015-0920-z · Cited by 4

Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism

Onyango, C., Anyona, S. B., Hurwitz, I., Raballah, E., Wasena, S. A., Osata, S. W., Seidenberg, P., McMahon, B. H., Lambert, C. G., Schneider, K. A., et al. (2024) · Pathogens · doi:10.3390/pathogens13100867 · Cited by 3

Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya

Olewe, P., Awandu, S. S., Munde, E. O., Anyona, S. B., Raballah, E. O., Amolo, A. S., Ogola, S., Ndenga, E., Onyango, C., Rochford, R. A., et al. (2023) · BMC Cancer · doi:10.1186/s12885-023-11063-2 · Cited by 3

Pathophysiologic Basis of Haemolysis in Patients with Sickle Cell Disease in Steady State and in Hyperhaemolytic States

Ahmed, S. G., & Ibrahim, U. A. (2023) · Nigerian Journal of Basic and Clinical Sciences. · doi:10.4103/njbcs.njbcs_55_22 · Cited by 3

Novel secretory organelles of parasite origin ‐ at the center of host‐parasite interaction

Bekić, V., & Kilian, N. (2023) · BioEssays · doi:10.1002/bies.202200241 · Cited by 3

Human red blood cell polymorphisms prevalent in Colombian population and its protective role against malaria

Contreras‐Puentes, N., & Amador, A. A. (2018) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2018.08.001 · Cited by 3

Determinants and modifiers of bleeding phenotypes in haemophilia-A: General and tropical perspectives

Ibrahim, U. A., & Ahmed, S. G. (2017) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2017.10.004 · Cited by 3

Anemia de células falciformes

Chaves, W. G., Amador, D., & Sánchez, J. M. M. (2014) · Revista Repertorio de Medicina y Cirugía · doi:10.31260/repertmedcir.v23.n3.2014.715 · Cited by 3

Natural killer cell antibody‐dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission

Tukwasibwe, S., Lewis, S. N., Taremwa, Y., van der Ploeg, K., Press, K. D., Ty, M., Nankya, F., Musinguzi, K., Nansubuga, E., Bach, F. A., et al. (2024) · Clinical & Translational Immunology · doi:10.1002/cti2.70005 · Cited by 2

Azadirachta indica (A. Juss.) and Curcuma longa (L.) modulate immunoglobulin and cytokine levels in Plasmodium berghei-infected mice

Olanlokun, J. O., & Olorunsogo, O. O. (2021) · Comparative Clinical Pathology · doi:10.1007/s00580-021-03272-7 · Cited by 2

Developmental Biology of Black Skin, Hair, and Nails

Tang, N., Heath, C. R., & Silverberg, N. B. (2015) · Springer eBooks · doi:10.1007/978-1-4614-6654-3_2 · Cited by 2

Inherited Hemoglobin Disorders

Munshi, A. (2015) · InTech eBooks · doi:10.5772/59742 · Cited by 3

Opioid dependence among people with haemophilia in a low-resource tropical setting: prevalence and risk factors in northern Nigeria

Ahmed, S. G., Ibrahim, U. A., & Kagu, M. B. (2019) · The Journal of Haemophilia Practice · doi:10.17225/jhp00132 · Cited by 2

Haemoglobin phenotypes and the risk of asymptomatic malaria parasitemia among blood donors in northwest Nigeria: clinical implications in the practice of tropical transfusion medicine

Kani, K. M., Ibrahim, Z., Habeeb, A., Ibrahim, U. A., & Ahmed, S. G. (2021) · African Journal of Clinical and Experimental Microbiology · doi:10.4314/ajcem.v22i2.10 · Cited by 2

Sickle Cell Retinopathy

Lim, J. I. (2022) · Springer eBooks · doi:10.1007/978-3-030-42634-7_29 · Cited by 1

Association between sickle cell trait and Plasmodium falciparum infection: evidence for age-specific protection in a cross-sectional study in Guinea-Bissau

Silva, R., Rodrigues, A., Arez, A. P., & Medeiros, M. M. (2025) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2025.108135 · Cited by 1

From Protective Factors to Mechanisms: Charting the Neurobiology of Schizophrenia Resilience

Bittner, R. A., Barnes-Scheufler, C. V., Reif, A., & Qubad, M. (2026) · Schizophrenia Bulletin · doi:10.1093/schbul/sbag146 · Cited by 1

Immunological Perspectives of sub-Saharan Populations under Prophylaxis against Malaria

Bwire, G. M., & Mwambete, K. D. (2019) · Immunology and Inflammation Diseases Therapy · doi:10.31579/2637-8876/013 · Cited by 1

A doença falciforme como factor protector contra a Malária

Chimuco, K. S. M. (2023) · Revista Angolana de Ciências da Saúde / Angolan Journal Of Health Sciences · doi:10.54283/racsaude.v3i2.2023.p4-9 · Cited by 1

Teaching developmental biology to drive social change: Pedagogy that challenges biologically deterministic views on phenotypic variation

Paxson, J. A. (2025) · Developmental Biology · doi:10.1016/j.ydbio.2025.03.004 · Cited by 1

Definition, Scope, and Premises of Human Population Genetics

Templeton, A. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-386025-5.00001-4 · Cited by 1

Estimating Malaria Vaccine Efficacy in the Absence of a Gold Standard Case Definition: Mendelian Factorial Design

Hasegawa, R. B., & Small, D. S. (2020) · Journal of the American Statistical Association · doi:10.1080/01621459.2020.1863222 · Cited by 1

A review of the role of infections in the aetiology of haemolysis in patients with sickle cell diseases: pathogenesis, management, and prevention

Ahmed, S. G., & Ibrahim, U. A. (2022) · African Journal of Clinical and Experimental Microbiology · doi:10.4314/ajcem.v23i4.3 · Cited by 1

Validação da triagem clínica para malária em candidatos à doação de sangue (região não endêmica)

Mazzariol, A. M. M. (2014) · doi:10.11606/t.5.2014.tde-24032014-111125 · Cited by 1

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Chee, R.-I., Zahid, S., & Lim, J. I. (2020) · Retina atlas · doi:10.1007/978-981-15-4075-2_14 · Cited by 1

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Flansburg, C. N. (2014)

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Stern, J. G., & Gaucher, E. A. (2015) · doi:10.7287/peerj.preprints.1293v1

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Anzellini, A. (2016) · Journal of International Crisis and Risk Communication Research

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Hasegawa, R. B., & Small, D. S. (2020) · Figshare · doi:10.6084/m9.figshare.13373997

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Bei, A. K., & Parikh, S. (2019) · Springer eBooks · doi:10.1007/978-3-030-25553-4_12

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Shourove, J. H., & Islam, G. M. R. (2021) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2021.100896

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Veronese, S., & Sbarbati, A. (2022) · Encyclopedia · doi:10.3390/encyclopedia2010008

Faculty Opinions recommendation of Genetic diseases conferring resistance to infectious diseases.

Meyts, I. (2017) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.729105766.793539039

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Lim, J. I. (2021) · Springer eBooks · doi:10.1007/978-3-319-90495-5_29-2

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Mafra, A. E. D. S., Neto, H. J. D. S., de Castro, S. S. B. M., Brito, Á. D. C., Backsmann, Y. L., Martim, S. R., & Figueiredo, E. F. G. (2022) · Research Society and Development · doi:10.33448/rsd-v11i14.36508

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Steffens, N. (2023) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/4116

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Olewe, P., Awandu, S. S., Munde, E. O., Anyona, S. B., Raballah, E. O., Amolo, A. S., Ogola, S., Ndenga, E., Onyango, C., Rochford, R. A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23550272

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Thomas, S., Okodaso, H., Kanjia, K., Khatu, V., Michaud, D. S., Singh, K., Jones, K., Taylor, C., Ikolo, B. T., & Ikolo, F. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1010722

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Loonat, S. B., Naran, N. H., Ramparsad, N., Beringer, N., Moodly, M., Ismail, A., Bronze, M., Faller, G., & Alli, N. A. (2025) · Hemoglobin · doi:10.1080/03630269.2025.2537094

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Maffo, C. N., Bayibéki, A. N., Abate, L., Makinde, O. S., Feufack-Donfack, L. B., Sarah-Matio, E. M., Bouopda-Tuedom, A. G., Taconet, P., Moiroux, N., Awono-Ambéné, P. H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22799959

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Bayoumi, R. (1987) · Medical Hypotheses · doi:10.1016/0306-9877(87)90193-9 · Cited by 38

[page 72] [Hematology Reports 2011; 3:e24] Sickle cell protection frommalaria

(2016)

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Williams, T. N., Mwangi, T., Roberts, D. J., Alexander, N. D. E., Weatherall, D. J., Wambua, S., Kortok, M., Snow, R. W., & Marsh, K. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020128 · Cited by 233

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Eridani, S. (2011) · Hematology Reports · doi:10.4081/hr.2011.e24 · Cited by 47

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Eridani, S. (2014) · DOAJ (DOAJ: Directory of Open Access Journals)