The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects
Open accessAbstract
BACKGROUND: Strawberry flavonoids are potent antioxidants and anti-inflammatory agents that have been shown to reduce cardiovascular disease risk factors in prospective cohort studies. Effects of strawberry supplementation on metabolic risk factors have not been studied in obese populations. We tested the hypothesis that freeze-dried strawberry powder (FSP) will lower fasting lipids and biomarkers of oxidative stress and inflammation at four weeks compared to baseline. We also tested the tolerability and safety of FSP in subjects with metabolic syndrome. FSP is a concentrated source of polyphenolic flavonoids, fiber and phytosterols. METHODS: Females (n = 16) with 3 features of metabolic syndrome (waist circumference >35 inches, triglycerides > 150 mg/dL, fasting glucose > 100 mg/dL and < 126 mg/dL, HDL <50 mg/dL, or blood pressure >130/85 mm Hg) were enrolled in the study. Subjects consumed two cups of the strawberry drink daily for four weeks. Each cup had 25 g FSP blended in water. Fasting blood draws, anthropometrics, dietary analyses, and blood pressure measurements were done at baseline and 4 weeks. Biomarkers of oxidative stress and inflammation were measured using ELISA techniques. Plasma ellagic acid was measured using HPLC-UV techniques. RESULTS: Total cholesterol and LDL-cholesterol levels were significantly lower at 4 weeks versus baseline (-5% and -6%, respectively, p < 0.05), as was lipid peroxidation in the form of malondialdehyde and hydroxynonenal (-14%, p < 0.01). Oxidized-LDL showed a decreasing trend at 4 weeks (p = 0.123). No effects were noted on markers of inflammation including C-reactive protein and adiponectin. A significant number of subjects (13/16) showed an increase in plasma ellagic acid at four weeks versus baseline, while no significant differences were noted in dietary intakes at four weeks versus baseline. Thus, short-term supplementation of freeze-dried strawberries appeared to exert hypocholesterolemic effects and decrease lipid peroxidation in women with metabolic syndrome.
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“Since some clinical studies have also found antidiabetic and antihyperlipidemic effects of encapsulated berry supplements, these forms may be suitable for the management of specific metabolic conditions.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [51]
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Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women
Mink, P. J., Scrafford, C. G., Barraj, L. M., Harnack, L., Hong, C.-P., Nettleton, J. A., & Jacobs, D. R. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.895 · Cited by 945
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Cellular Antioxidant Activity of Common Fruits
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Potential Impact of Strawberries on Human Health: A Review of the Science
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Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis
Grattagliano, I., Palmieri, V. O., Portincasa, P., Moschetta, A., & Palasciano, G. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.011 · Cited by 301
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Self-citationBerries: emerging impact on cardiovascular health
Basu, A., Rhone, M., & Lyons, T. J. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00273.x · Cited by 462
“…decreased LDLcholesterol, decreased mass and activity of plasma cholesteryl ester transfer protein in anthocyanin group versus placebo (P < 0.05) Basu et al. (2009)51 Four weeks Baseline and postintervention effects Sixteen women with metabolic syndrome (mean age, 51 ± 9.1 years) None…”
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Metadata
- Authors
- Basu, A., Wilkinson, M., Penugonda, K., Simmons, B., Betts, N. M., & Lyons, T. J.
- Affiliations
- Oklahoma State University (US)
- University of Oklahoma Health Sciences Center (US)
- Corresponding author
- Basu, Arpita
- Venue
- Nutrition Journal
- Published
- 2009-09-28
- Volume
- 8
- Issue
- 1
- Pages
- 43-43
- ISSN
- 1475-2891 (ISSN-L)
- PMC
- PMC2761419
- OpenAlex
- W2130393481
- Cited by
- 164
- References
- 25
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 10 · 2021: 6 · 2020: 14 · 2019: 11 · 2018: 11 · 2017: 16 · 2016: 14 · 2015: 11 · 2014: 14 · 2013: 20 · 2012: 10
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrition Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
- Keywords
- metabolic syndrome, lipid profile, lipid peroxidation, oxidative stress, flavonoids, ellagic acid, cholesterol-lowering effect, LDL cholesterol, malondialdehyde, 4-hydroxynonenal, oxidized LDL, C-reactive protein, adiponectin, dietary supplementation, women, obesity
- MeSH terms
- Adult, Aged, Hypolipidemic Agents, Beverages, Cholesterol, Female, Freeze Drying, Humans, Lipids, Cholesterol, LDL, Middle Aged, Lipid Peroxidation, Metabolic Syndrome, Fragaria
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