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Cited by 202Air Quality and Health ImpactsEnvironmental Justice and Health DisparitiesIndoor Air Quality and Microbial Exposure

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Air pollution from traffic and cancer incidence: a Danish cohort study

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Raaschou-Nielsen, Ole, Andersen, Zorana J, Hvidberg, Martin, Jensen, Steen S, Ketzel, Matthias, Sørensen, Mette, Hansen, Johnni, Loft, Steffen, Overvad, Kim, Tjønneland, Anne·2011·Environmental Health
DOI 10.1186/1476-069x-10-67PMC PMC3157417
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Abstract

BACKGROUND: Vehicle engine exhaust includes ultrafine particles with a large surface area and containing absorbed polycyclic aromatic hydrocarbons, transition metals and other substances. Ultrafine particles and soluble chemicals can be transported from the airways to other organs, such as the liver, kidneys, and brain. Our aim was to investigate whether air pollution from traffic is associated with risk for other cancers than lung cancer. METHODS: We followed up 54,304 participants in the Danish Diet Cancer and Health cohort for 20 selected cancers in the Danish Cancer Registry, from enrolment in 1993-1997 until 2006, and traced their residential addresses from 1971 onwards in the Central Population Registry. We used modeled concentration of nitrogen oxides (NO(x)) and amount of traffic at the residence as indicators of traffic-related air pollution and used Cox models to estimate incidence rate ratios (IRRs) after adjustment for potential confounders. RESULTS: NO(x) at the residence was significantly associated with risks for cervical cancer (IRR, 2.45; 95% confidence interval [CI], 1.01;5.93, per 100 μg/m(3) NO(x)) and brain cancer (IRR, 2.28; 95% CI, 1.25;4.19, per 100 μg/m(3) NO(x)). CONCLUSIONS: This hypothesis-generating study indicates that traffic-related air pollution might increase the risks for cervical and brain cancer, which should be tested in future studies.

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Research works printed but not linked: 55

  1. International Agency for Research on Cancer: Diesel and gasoline engine exhausts and some nitroarenes. IARC Monographs on the Evaluation of the Carcinogenicity of Chemicals to Humans. 1989, Lyon: IARC Press, 46:
  2. Nielsen T, Feilberg A, Binderup ML: The variation of street air levels of PAH and other mutagenic PAC in relation to regulations of traffic emissions and the impact of atmospheric processes. Environ Sci Pollut Res Int. 1999, 6: 133-137. 10.1007/BF02987613. · DOI
  3. Oberdorster G, Utell MJ: Ultrafine particles in the urban air: to the respiratory tract--and beyond?. Environ Health Perspect. 2002, 110: A440-A441. 10.1289/ehp.110-a440. · DOI · Paper page
  4. Schmid O, Moller W, Semmler-Behnke M, Ferron GA, Karg E, Lipka J, Schulz H, Kreyling WG, Stoeger T: Dosimetry and toxicology of inhaled ultrafine particles. Biomarkers. 2009, 14 (Suppl 1): 67-73. · DOI
  5. Oberdorster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C: Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol. 2004, 16: 437-445. 10.1080/08958370490439597. · DOI · Paper page
  6. Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdorster G: Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 2006, 114: 1172-1178. 10.1289/ehp.9030. · DOI
  7. Kreyling WG, Semmler-Behnke M, Seitz J, Scymczak W, Wenk A, Mayer P, Takenaka S, Oberdorster G: Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs. Inhal Toxicol. 2009, 21 (Suppl 1): 55-60. · DOI
  8. Peters A, Veronesi B, Calderon-Garciduenas L, Gehr P, Chen LC, Geiser M, Reed W, Rothen-Rutishauser B, Schurch S, Schulz H: Translocation and potential neurological effects of fine and ultrafine particles a critical update. Part Fibre Toxicol. 2006, 3: 13-10.1186/1743-8977-3-13. · DOI
  9. Pope CA, Burnett RT, Thun MJ, Calle EE, Krewski D, Ito K, Thurston GD: Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA. 2002, 287: 1132-1141. 10.1001/jama.287.9.1132. · DOI · Paper page
  10. Nyberg F, Gustavsson P, Jarup L, Bellander T, Berglind N, Jakobsson R, Pershagen G: Urban air pollution and lung cancer in Stockholm. Epidemiology. 2000, 11: 487-495. 10.1097/00001648-200009000-00002. · DOI
  11. Vineis P, Hoek G, Krzyzanowski M, Vigna-Taglianti F, Veglia F, Airoldi L, Autrup H, Dunning A, Garte S, Hainaut P, Malaveille C, Matullo G, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Linseisen J, Boeing H, Trichopoulou A, Palli D, Peluso M, Krogh V, Tumino R, Panico S, Bueno-de-Mesquita HB, Peeters PH, Lund EE, Gonzalez CA, Martinez C, Dorronsoro M, Barricarte A, Cirera L, Quiros JR, Berglund G, Forsberg B, Day NE, Key TJ, Saracci R, Kaaks R, Riboli E: Air pollution and risk of lung cancer in a prospective study in Europe. Int J Cancer. 2006, 119: 169-174. 10.1002/ijc.21801. · DOI · Paper page
  12. Raaschou-Nielsen O, Bak H, Sorensen M, Jensen SS, Ketzel M, Hvidberg M, Schnohr P, Tjonneland A, Overvad K, Loft S: Air pollution from traffic and risk for lung cancer in three Danish cohorts. Cancer Epidemiol Biomarkers Prev. 2010, 19: 1284-1291. 10.1158/1055-9965.EPI-10-0036. · DOI
  13. Raaschou-Nielsen O, Andersen ZJ, Hvidberg M, Jensen SS, Ketzel M, Sørensen M, Loft S, Overvad K, Tjonneland A: Lung cancer incidence and long-term exposure to air pollution from traffic. Environ Health Perspect. 2011, 119: 860-865. 10.1289/ehp.1002353. · DOI
  14. Sapkota A, Gajalakshmi V, Jetly DH, Roychowdhury S, Dikshit RP, Brennan P, Hashibe M, Boffetta P: Indoor air pollution from solid fuels and risk of hypopharyngeal/laryngeal and lung cancers: a multicentric case-control study from India. Int J Epidemiol. 2008, 37: 321-328. 10.1093/ije/dym261. · DOI
  15. Lynge E, Andersen A, Nilsson R, Barlow L, Pukkala E, Nordlinder R, Boffetta P, Grandjean P, Heikkila P, Horte LG, Jakobsson R, Lundberg I, Moen B, Partanen T, Riise T: Risk of cancer and exposure to gasoline vapors. Am J Epidemiol. 1997, 145: 449-458. · DOI
  16. Soll-Johanning H, Bach E, Olsen JH, Tuchsen F: Cancer incidence in urban bus drivers and tramway employees: a retrospective cohort study. Occup Environ Med. 1998, 55: 594-598. 10.1136/oem.55.9.594. · DOI
  17. Boffetta P, Dosemeci M, Gridley G, Bath H, Moradi T, Silverman D: Occupational exposure to diesel engine emissions and risk of cancer in Swedish men and women. Cancer Causes Control. 2001, 12: 365-374. 10.1023/A:1011262105972. · DOI
  18. Tarvainen L, Kyyronen P, Kauppinen T, Pukkala E: Cancer of the mouth and pharynx, occupation and exposure to chemical agents in Finland [in 1971-95]. Int J Cancer. 2008, 123: 653-659. 10.1002/ijc.23286. · DOI
  19. Liu CC, Tsai SS, Chiu HF, Wu TN, Chen CC, Yang CY: Ambient exposure to criteria air pollutants and risk of death from bladder cancer in Taiwan. Inhal Toxicol. 2009, 21: 48-54. 10.1080/08958370802207326. · DOI
  20. Castano-Vinyals G, Cantor KP, Malats N, Tardon A, Garcia-Closas R, Serra C, Carrato A, Rothman N, Vermeulen R, Silverman D, Dosemeci M, Kogevinas M: Air pollution and risk of urinary bladder cancer in a case-control study in Spain. Occup Environ Med. 2008, 65: 56-60. 10.1136/oem.2007.034348. · DOI
  21. Silverman DT, Hoover RN, Mason TJ, Swanson GM: Motor exhaust-related occupations and bladder cancer. Cancer Res. 1986, 46: 2113-2116.
  22. Kogevinas M, 't Mannetje A, Cordier S, Ranft U, Gonzalez CA, Vineis P, Chang-Claude J, Lynge E, Wahrendorf J, Tzonou A, Jockel KH, Serra C, Porru S, Hours M, Greiser E, Boffetta P: Occupation and bladder cancer among men in Western Europe. Cancer Causes Control. 2003, 14: 907-914. · DOI
  23. Guo J, Kauppinen T, Kyyronen P, Heikkila P, Lindbohm ML, Pukkala E: Risk of esophageal, ovarian, testicular, kidney and bladder cancers and leukemia among Finnish workers exposed to diesel or gasoline engine exhaust. Int J Cancer. 2004, 111: 286-292. 10.1002/ijc.20263. · DOI
  24. Bosetti C, Boffetta P, La Vecchia C: Occupational exposures to polycyclic aromatic hydrocarbons, and respiratory and urinary tract cancers: a quantitative review to 2005. Ann Oncol. 2007, 18: 431-446. · DOI
  25. Sjodahl K, Jansson C, Bergdahl IA, Adami J, Boffetta P, Lagergren J: Airborne exposures and risk of gastric cancer: a prospective cohort study. Int J Cancer. 2007, 120: 2013-2018. 10.1002/ijc.22566. · DOI
  26. Ji J, Granstrom C, Hemminki K: Occupational risk factors for kidney cancer: a cohort study in Sweden. World J Urol. 2005, 23: 271-278. 10.1007/s00345-005-0007-5. · DOI
  27. Boeglin ML, Wessels D, Henshel D: An investigation of the relationship between air emissions of volatile organic compounds and the incidence of cancer in Indiana counties. Environ Res. 2006, 100: 242-254. 10.1016/j.envres.2005.04.004. · DOI
  28. Crouse DL, Goldberg MS, Ross NA, Chen H, Labreche F: Postmenopausal breast cancer is associated with exposure to traffic-related air pollution in Montreal, Canada: A case-control study. Environ Health Perspect. 2010, 118: 1578-1583. 10.1289/ehp.1002221. · DOI
  29. Barregard L, Holmberg E, Sallsten G: Leukaemia incidence in people living close to an oil refinery. Environ Res. 2009, 109: 985-990. 10.1016/j.envres.2009.09.001. · DOI
  30. Visser O, van Wijnen JH, van Leeuwen FE: Residential traffic density and cancer incidence in Amsterdam, 1989-1997. Cancer Causes Control. 2004, 15: 331-339. · DOI
  31. Tjonneland A, Olsen A, Boll K, Stripp C, Christensen J, Engholm G, Overvad K: Study design, exposure variables, and socioeconomic determinants of participation in Diet, Cancer and Health: a population-based prospective cohort study of 57,053 men and women in Denmark. Scand J Public Health. 2007, 35: 432-441. 10.1080/14034940601047986. · DOI
  32. Storm HH, Michelsen EV, Clemmensen IH, Pihl J: The Danish Cancer Registry--history, content, quality and use. Dan Med Bull. 1997, 44: 535-539.
  33. Jensen SS, Berkowicz R, Hansen SH, Hertel O: A Danish decision-support GIS tool for management of urban air quality and human exposures. Transport Res Part D: Transport Environ. 2001, 6: 229-241. 10.1016/S1361-9209(00)00026-2. · DOI
  34. Raaschou-Nielsen O, Hertel O, Vignati E, Berkowicz R, Jensen SS, Larsen VB, Lohse C, Olsen JH: An air pollution model for use in epidemiological studies: evaluation with measured levels of nitrogen dioxide and benzene. J Expo Anal Environ Epidemiol. 2000, 10: 4-14. 10.1038/sj.jea.7500070. · DOI
  35. Berkowicz R, Ketzel M, Jensen SS, Hvidberg M, Raaschou-Nielsen O: Evaluation and application of OSMP for traffic pollution assessment for large number of street locations. Environ Model Software. 2008, 23: 296-303. 10.1016/j.envsoft.2007.04.007. · DOI
  36. Ketzel M, Wahlin P, Berkowicz R, Palmgren F: Particle and trace gas emission factors under urban driving conditions in Copenhagen based on street and roof level observations. Atmos Environ. 2003, 37: 2735-2749. 10.1016/S1352-2310(03)00245-0. · DOI
  37. Andersen ZJ, Hvidberg M, Jensen SS, Ketzel M, Loft S, Sorensen M, Tjonneland A, Overvad K, Raaschou-Nielsen O: Chronic Obstructive Pulmonary Disease and Long-Term Exposure to Traffic-Related Air Pollution: A Cohort Study. Am J Respir Crit Care Med. 2011, 183: 455-461. 10.1164/rccm.201006-0937OC. · DOI
  38. Dosemeci M, Wacholder S, Lubin JH: Does nondifferential misclassification of exposure always bias a true effect toward the null value?. Am J Epidemiol. 1990, 132: 746-748. · DOI
  39. Schiffman MH, Hildesheim A: Cervical cancer. Cancer Epidemiology and Prevention. Edited by: Schottenfeld D, Fraumeni JF, Jr. 2006, Oxford: Oxford University Press, 1044-1067. · DOI
  40. Bondy ML, Scheurer ME, Malmer B, Barnholtz-Sloan JS, Davis FG, Il'yasova D, Kruchko C, McCarthy BJ, Rajaraman P, Schwartzbaum JA, Sadetzki S, Schlehofer B, Tihan T, Wiemels JL, Wrensch M, Buffler PA: Brain tumor epidemiology: consensus from the Brain Tumor Epidemiology Consortium. Cancer. 2008, 113: 1953-1968. 10.1002/cncr.23741. · DOI
  41. Schmidt LS, Nielsen H, Schmiedel S, Johansen C: Social inequality and incidence of and survival from tumours of the central nervous system in a population-based study in Denmark, 1994-2003. Eur J Cancer. 2008, 44: 2050-2057. 10.1016/j.ejca.2008.06.015. · DOI
  42. Calderon-Garciduenas L, Franco-Lira M, Torres-Jardon R, Henriquez-Roldan C, Barragan-Mejia G, Valencia-Salazar G, Gonzalez-Maciel A, Reynoso-Robles R, Villarreal-Calderon R, Reed W: Pediatric respiratory and systemic effects of chronic air pollution exposure: nose, lung, heart, and brain pathology. Toxicol Pathol. 2007, 35: 154-162. 10.1080/01926230601059985. · DOI
  43. Cruts B, van EL, Tornqvist H, Blomberg A, Sandstrom T, Mills NL, Borm PJ: Exposure to diesel exhaust induces changes in EEG in human volunteers. Part Fibre Toxicol. 2008, 5: 4-10.1186/1743-8977-5-4. · DOI
  44. McKean-Cowdin R, Calle EE, Peters JM, Henley J, Hannan L, Thurston GD, Thun MJ, Preston-Martin S: Ambient air pollution and brain cancer mortality. Cancer Causes Control. 2009, 20: 1645-1651. 10.1007/s10552-009-9412-1. · DOI
  45. Lee YC, Cohet C, Yang YC, Stayner L, Hashibe M, Straif K: Meta-analysis of epidemiologic studies on cigarette smoking and liver cancer. Int J Epidemiol. 2009, 38: 1497-1511. 10.1093/ije/dyp280. · DOI
  46. Danielsen PH, Risom L, Wallin H, Autrup H, Vogel U, Loft S, Moller P: DNA damage in rats after a single oral exposure to diesel exhaust particles. Mutat Res. 2008, 637: 49-55. · DOI
  47. Sadauskas E, Danscher G, Stoltenberg M, Vogel U, Larsen A, Wallin H: Protracted elimination of gold nanoparticles from mouse liver. Nanomedicine. 2009, 5: 162-169. · DOI
  48. Lipworth L, Tarone RE, McLaughlin JK: The epidemiology of renal cell carcinoma. J Urol. 2006, 176: 2353-2358. 10.1016/j.juro.2006.07.130. · DOI
  49. Bonner MR, Han D, Nie J, Rogerson P, Vena JE, Muti P, Trevisan M, Edge SB, Freudenheim JL: Breast cancer risk and exposure in early life to polycyclic aromatic hydrocarbons using total suspended particulates as a proxy measure. Cancer Epidemiol Biomarkers Prev. 2005, 14: 53-60. · DOI
  50. Mordukhovich I, Rossner P, Terry MB, Santella R, Zhang YJ, Hibshoosh H, Memeo L, Mansukhani M, Long CM, Garbowski G, Agrawal M, Gaudet MM, Steck SE, Sagiv SK, Eng SM, Teitelbaum SL, Neugut AI, Conway-Dorsey K, Gammon MD: Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors. Environ Health Perspect. 2010, 118: 511-518. · DOI
  51. Michelozzi P, Fusco D, Forastiere F, Ancona C, Dell'Orco V, Perucci CA: Small area study of mortality among people living near multiple sources of air pollution. Occup Environ Med. 1998, 55: 611-615. 10.1136/oem.55.9.611. · DOI
  52. Visser O, van Wijnen JH, van Leeuwen FE: Incidence of cancer in the area around Amsterdam Airport Schiphol in 1988-2003: a population-based ecological study. BMC Public Health. 2005, 5: 127-10.1186/1471-2458-5-127. · DOI
  53. Duarte-Davidson R, Courage C, Rushton L, Levy L: Benzene in the environment: an assessment of the potential risks to the health of the population. Occup Environ Med. 2001, 58: 2-13. 10.1136/oem.58.1.2. · DOI
  54. Borm PJ, Schins RP, Albrecht C: Inhaled particles and lung cancer, part B: paradigms and risk assessment. Int J Cancer. 2004, 110: 3-14. 10.1002/ijc.20064. · DOI
  55. Moller P, Jacobsen NR, Folkmann JK, Danielsen PH, Mikkelsen L, Hemmingsen JG, Vesterdal LK, Forchhammer L, Wallin H, Loft S: Role of oxidative damage in toxicity of particulates. Free Radic Res. 2010, 44: 1-46. 10.3109/10715760903300691. · DOI

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Authors
Raaschou-Nielsen, O., Andersen, Z. J., Hvidberg, M., Jensen, S. S., Ketzel, M., Sørensen, M., Hansen, J., Loft, S., Overvad, K., & Tjønneland, A.
Affiliations
  • Danish Cancer Society (DK)
  • Aarhus University (DK)
  • University of Copenhagen (DK)
ORCID
Venue
Environmental Health
Publisher
Springer Science and Business Media LLC
Published
2011-07-19
Volume
10
Issue
1
Pages
67-67
ISSN
1476-069X (ISSN-L)
DOI
10.1186/1476-069x-10-67
PMC
PMC3157417
OpenAlex
W2120081385
Cited by
202
References
1
Citations by year
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FWCI
6.94
Type
journal article
Language
en
Open access
Licence
Locations
  • Environmental Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • Kræftens Bekæmpelse
  • Forsknings- og Innovationsstyrelsen
  • Danish Agency for Science and Higher Education
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords
traffic-related air pollution, nitrogen oxides, cervical cancer, brain cancer, cancer incidence, ultrafine particles, polycyclic aromatic hydrocarbons, vehicle emissions, residential exposure
MeSH terms
Air Pollutants, Vehicle Emissions, Denmark, Environmental Exposure, Female, Humans, Male, Middle Aged, Neoplasms, Nitrogen Oxides, Residence Characteristics, Cohort Studies, Incidence

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