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Clinical significance of Polycomb gene expression in brain tumors

Crea, Francesco, Hurt, Elaine M, Farrar, William L·2010·Molecular Cancer
DOI 10.1186/1476-4598-9-265PMC PMC2958980
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Abstract

Polycomb group (PcG) proteins are crucial for neural cancer stem cell (NCSC) self-renewal. However, the relative expression levels of PcG genes in different subtypes of brain tumors, their prognostic role and their effects on cellular pathways have not been investigated. For this purpose, we queried the Oncomine database and found that 4 PcG genes (EZH2, RBBP7, SUZ12, YY1) are specifically expressed in brain tumors. EZH2 expression increases with tumor grade in adult and pediatric brain tumors, and is a poor prognostic factor. In glioblastoma, EZH2 inhibits differentiation, and activates cancer-, cell cycle- and cellular movement-related genes. In keeping with previously published data, our results suggest that EZH2 is both a prognostic factor and a promising therapy target in brain tumors.

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Metadata

Authors
Crea, F., Hurt, E. M., & Farrar, W. L.
Venue
Molecular Cancer
Publisher
Springer Science and Business Media LLC
Published
2010-09-30
Volume
9
Issue
1
ISSN
1476-4598
DOI
10.1186/1476-4598-9-265
PMC
PMC2958980
Cited by
70
References
1
Language
en

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