The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease
Open accessAbstract
The double-blinded placebo-controlled randomized study has been performed in 51 coronary heart disease (CHD) patients to estimate the effects of time-released garlic powder tablets Allicor on the values of 10-year prognostic risk of acute myocardial infarction (fatal and non-fatal) and sudden death, with the respect of secondary CHD prevention. It has been demonstrated that 12-month treatment with Allicor results in the significant decrease of cardiovascular risk by 1.5-fold in men (p < 0.05), and by 1.3-fold in women. The above results were equitable also in terms of relative risks. The main effect that played a role in cardiovascular risk reduction was the decrease in LDL cholesterol by 32.9 mg/dl in men (p < 0.05), and by 27.3 mg/dl in women. Thus, the most significant effects were observed in men, while in women the decrease of cardiovascular risk appeared as a trend that might be due presumably to the insufficient sample size. Since Allicor is the remedy of natural origin, it is safe with the respect to adverse effects and allows even perpetual administration that may be crucial for the secondary prevention of atherosclerotic diseases in CHD patients.
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“Sobenin et al. [110,111] revealed that garlic administration at a dose of 300 and 60 mg/day for 12 months and 12 weeks, respectively decreased TC, TG, and LDL while increased HDL.”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [111]
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Citations
Cites
The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2002) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.288.23.2981 · Cited by 5,664
Assmann, G., Cullen, P., & Schulte, H. (2002) · Circulation · doi:10.1161/hc0302.102575 · Cited by 1,541
Tunstall-Pedoe, H., Kuulasmaa, K., Mähönen, M., Tolonen, H., & Ruokokoski, E. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04021-0 · Cited by 1,444
Intake of Garlic and Its Bioactive Components
Amagase, H., Petesch, B. L., Matsuura, H., Kasuga, S., & Itakura, Y. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.955s · Cited by 1,055
The Chemistry of Garlic and Onions
Block, E. (1985) · Scientific American · doi:10.1038/scientificamerican0385-114 · Cited by 936
A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects
Hata, Y., Yamamoto, M., Ohni, M., Nakajima, K., Nakamura, Y., & Takano, T. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.5.767 · Cited by 508
Kannel, W. B., Neaton, J. D., Wentworth, D. N., Thomas, H. E., Stamler, J., Hulley, S. B., & Kjelsberg, M. O. (1986) · American Heart Journal · doi:10.1016/0002-8703(86)90481-3 · Cited by 502
Cholesterol-Lowering Effect of Garlic Extracts and Organosulfur Compounds: Human and Animal Studies
Yeh, Y.-Y., & Liu, L. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.989s · Cited by 425
A meta-analysis of the effect of garlic on blood pressure
Silagy, C., & Neil, H. A. W. (1994) · Journal of Hypertension · doi:10.1097/00004872-199404000-00017 · Cited by 340
Garlic Shows Promise for Improving Some Cardiovascular Risk Factors
Ackermann, R. T., Mulrow, C. D., Ramirez, G., Gardner, C. D., Morbidoni, L., & Lawrence, V. A. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.6.813 · Cited by 295
Garlic as a Lipid Lowering Agent—A Meta-Analysis
Silagy, C., & Neil, A. (1994) · Journal of the Royal College of Physicians of London · doi:10.1016/s0035-8819(25)00866-9 · Cited by 261
Stamler, J., Dyer, A. R., Shekelle, R. B., Neaton, J. D., & Stamler, R. (2008) · Cardiology · doi:10.1159/000175868 · Cited by 250
Bordia, A., Verma, S. K., & Srivastava, K. C. (1998) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(98)90034-5 · Cited by 249
Multiple Risk Factor Intervention Trial
Eberly, L. E., Stamler, J., Kuller, L. H., & Neaton, J. D. (2014) · doi:10.1002/9781118596005.ch47 · Cited by 206
Garlic reduces plasma lipids by inhibiting hepatic cholesterol and triacylglycerol synthesis
Yeh, Y., & Yeh, S. (1994) · Lipids · doi:10.1007/bf02536728 · Cited by 193
Quantitative Determination of Allicin and Alliin from Garlic by HPLC*
Iberl, B., Winkler, G., Müller, B., & Knobloch, K. (1990) · Planta Medica · doi:10.1055/s-2006-960969 · Cited by 164
Effect of garlic on blood lipids in patients with coronary heart disease
Bordia, A. (1981) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.10.2100 · Cited by 163
Garlic and Garlic-Derived Compounds Inhibit Human Squalene Monooxygenase
Gupta, N. J., & Porter, T. D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.6.1662 · Cited by 157
Multiple inhibitory effects of garlic extracts on cholesterol biosynthesis in hepatocytes
Gebhardt, R. (1993) · Lipids · doi:10.1007/bf02536055 · Cited by 153
Voß, R., Cullen, P., Schulte, H., & Assmann, G. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.6.1253 · Cited by 148
Hypertension and hyperlipidaemia: garlic helps in mild cases.
Auer, W., Eiber, A., Hertkorn, E., Hoehfeld, E., Koehrle, U., Lorenz, A., Mader, F. M., Merx, W., Otto, G., & Schmid-Otto, B. (1990) · PubMed · Cited by 101
Garlic: Empiricism or Science?
Aviello, G., Abenavoli, L., Borrelli, F., Capasso, R., Izzo, A. A., Lembo, F., Romano, B., & Capasso, F. (2009) · Natural Product Communications · doi:10.1177/1934578x0900401231 · Cited by 82
Liu, L., & Yeh, Y. (2001) · Lipids · doi:10.1007/s11745-001-0734-4 · Cited by 72
Cardiovascular effects of garlic (Allium sativum): a review.
Ernst, E. K. (1987) · PubMed · Cited by 65
Bordia, A., Verma, S. K., & Srivastava, K. C. (1996) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(96)90099-x · Cited by 62
Direct Anti-atherosclerosis-related Effects of Garlic
Orekhov, A. N., Tertov, V. V., Sobenin, I. A., & Pivovarova, E. M. (1995) · Annals of Medicine · doi:10.3109/07853899509031938 · Cited by 60
Self-citationGarlic preparations for prevention of atherosclerosis
Berthold, H. K., & Sudhop, T. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199812000-00008 · Cited by 43
Blood lipids and coronary heart disease
Gotto, A. M., Assmann, G., Carmena, R., Davignon, J., Fernandex-Cruz, A., Fruchart, J., Kastelein, J. J. P., & Paoletti, R. (2000) · Cited by 15
Pocket guide to prevention of coronary heart disease
Carmena, R., Fruchart, J., OLSSON, A. G., Paoletti, R., Riesen, W., & Tikkanen, M. J. (2003) · Cited by 15
On the Quantitative Determination of Allicin and Alliin from Garlic by HPLC
Iberl, B., Winkler, G., Müller, B., Jansen, H., & Knobloch, K. (1989) · Planta Medica · doi:10.1055/s-2006-962217 · Cited by 14
Andrianova, I. V., Fomchenkov, I. V., & Orekhov, A. N. (2002) · PubMed · Cited by 10
Self-citationAndrianova, I. V., Ионова, В. Г., Demina, E. G., Shabalina, A. A., Karabasova, I. A., Li, L., Te, P., & Orekhov, A. N. (2001) · PubMed · Cited by 5
Self-citationEffect of allicor on platelet aggregationin vitro andex vivo
Andrianova, I. V., Ахнафович, Г. З., Ionova, V. G., & Orekhov, A. N. (1997) · Bulletin of Experimental Biology and Medicine · doi:10.1007/bf02445068 · Cited by 1
Self-citation[Effect of the garlic tablets allicor on thrombocyte aggregation in vitro and ex vivo].
Andrianova, I. V., Ахнафович, Г. З., Ionova, V. G., & Orekhov, A. N. (1997) · PubMed · Cited by 1
Self-citation
Research works printed but not linked: 3
- Ackermann RT Garlic shows promise for improving some cardiovascular risk factors Arch Intern Med 2001 161 813 24 10.1001/archinte.161.6.813 11268223 · DOI · Paper page
- Assmann G Cullen P Schulte H Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Muenster (PROCAM) study Circulation 2002 105 310 5 10.1161/hc0302.102575 11804985 · DOI · Paper page
- Yeh YY Liu L Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies J Nutr 2001 131 989S 93S 11238803
Cited by
Sorted by citations
Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931
The Health Potential of Fruits and Vegetables Phytochemicals: Notable Examples
Rodríguez‐Casado, A. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.755149 · Cited by 267
Allicin and health: A comprehensive review
Salehi, B., Zucca, P., Orhan, İ. E., Azzini, E., Adetunji, C. O., Mohammed, S. A., Banerjee, S., Sharopov, F. S., Rigano, D., Sharifi‐Rad, J., et al. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.03.003 · Cited by 260
Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview
Ansary, J., Forbes-Hernández, T. Y., Gil, E., Cianciosi, D., Zhang, J., Elexpuru-Zabaleta, M., Simal-Gandara, J., Giampieri, F., & Battino, M. (2020) · Antioxidants · doi:10.3390/antiox9070619 · Cited by 217
Andreadou, I., Iliodromitis, E. K., Rassaf, T., Schulz, R., Papapetropoulos, A., & Ferdinandy, P. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12811 · Cited by 213
Metadata
- Authors
- Sobenin, I. A., Pryanishnikov, V. V., Kunnova, L. M., Rabinovich, Y. A., Martirosyan, D. M., & Orekhov, A. N.
- Affiliations
- Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
- Corresponding author
- Sobenin, Igor A
- Venue
- Lipids in Health and Disease
- Published
- 2010
- Volume
- 9
- Issue
- 1
- Pages
- 119
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC2972277
- OpenAlex
- W2028736925
- Cited by
- 114
- References
- 35
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 13 · 2021: 10 · 2020: 6 · 2019: 7 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 7 · 2012: 5
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Botanical Studies and Applications
- Keywords
- coronary artery disease, cardiovascular risk, secondary prevention, acute myocardial infarction, sudden death, LDL cholesterol, sex differences, atherosclerosis
- MeSH terms
- Adult, Aged, Antioxidants, Coronary Artery Disease, Double-Blind Method, Female, Garlic, Humans, Cholesterol, LDL, Male, Middle Aged, Sex Factors, Tablets, Treatment Outcome
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