Cited by 114Garlic and Onion StudiesLipoproteins and Cardiovascular HealthBotanical Studies and Applications

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The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease

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Sobenin, Igor A, Pryanishnikov, Valentin V, Kunnova, Lyudmila M, Rabinovich, Yevgeny A, Martirosyan, Danik M, Orekhov, Alexander N·2010·Lipids in Health and Disease

DOI 10.1186/1476-511x-9-119PMC PMC2972277

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Abstract

The double-blinded placebo-controlled randomized study has been performed in 51 coronary heart disease (CHD) patients to estimate the effects of time-released garlic powder tablets Allicor on the values of 10-year prognostic risk of acute myocardial infarction (fatal and non-fatal) and sudden death, with the respect of secondary CHD prevention. It has been demonstrated that 12-month treatment with Allicor results in the significant decrease of cardiovascular risk by 1.5-fold in men (p < 0.05), and by 1.3-fold in women. The above results were equitable also in terms of relative risks. The main effect that played a role in cardiovascular risk reduction was the decrease in LDL cholesterol by 32.9 mg/dl in men (p < 0.05), and by 27.3 mg/dl in women. Thus, the most significant effects were observed in men, while in women the decrease of cardiovascular risk appeared as a trend that might be due presumably to the insufficient sample size. Since Allicor is the remedy of natural origin, it is safe with the respect to adverse effects and allows even perpetual administration that may be crucial for the secondary prevention of atherosclerotic diseases in CHD patients.

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Authors: Sobenin, I. A., Pryanishnikov, V. V., Kunnova, L. M., Rabinovich, Y. A., Martirosyan, D. M., & Orekhov, A. N.
Affiliations: Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
Corresponding author: Sobenin, Igor A
ORCID: Sobenin, Igor A
Pryanishnikov, Valentin V
Martirosyan, Danik M
Orekhov, Alexander N
Venue: Lipids in Health and Disease
Publisher: Springer Science and Business Media LLC
Published: 2010
Volume: 9
Issue: 1
Pages: 119
ISSN: 1476-511X (ISSN-L)
DOI: 10.1186/1476-511x-9-119
PMC: PMC2972277
OpenAlex: W2028736925
Cited by: 114
References: 35
Citations by year: 2026: 3 · 2025: 9 · 2024: 6 · 2023: 8 · 2022: 13 · 2021: 10 · 2020: 6 · 2019: 7 · 2018: 8 · 2017: 2 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 7 · 2012: 5
FWCI: 6.52
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Lipids in Health and Disease (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Agricultural and Biological Sciences › Plant Science › Botanical Studies and Applications
Keywords: coronary artery disease, cardiovascular risk, secondary prevention, acute myocardial infarction, sudden death, LDL cholesterol, sex differences, atherosclerosis
MeSH terms: Adult, Aged, Antioxidants, Coronary Artery Disease, Double-Blind Method, Female, Garlic, Humans, Cholesterol, LDL, Male, Middle Aged, Sex Factors, Tablets, Treatment Outcome

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The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease

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