Potential Health Benefit of Garlic Based on Human Intervention Studies: A Brief Overview
Open accessAbstract
Garlic is a polyphenolic and organosulfur enriched nutraceutical spice consumed since ancient times. Garlic and its secondary metabolites have shown excellent health-promoting and disease-preventing effects on many human common diseases, such as cancer, cardiovascular and metabolic disorders, blood pressure, and diabetes, through its antioxidant, anti-inflammatory, and lipid-lowering properties, as demonstrated in several in vitro, in vivo, and clinical studies. The present review aims to provide a comprehensive overview on the consumption of garlic, garlic preparation, garlic extract, and garlic extract-derived bioactive constituents on oxidative stress, inflammation, cancer, cardiovascular and metabolic disorders, skin, bone, and other common diseases. Among the 83 human interventional trials considered, the consumption of garlic has been reported to modulate multiple biomarkers of different diseases; in addition, its combination with drugs or other food matrices has been shown to be safe and to prolong their therapeutic effects. The rapid metabolism and poor bioavailability that have limited the therapeutic use of garlic in the last years are also discussed.
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Sulphur-containing compounds mainly contained in onion and garlic have shown beneficial effects against cardiovascular diseases, cancer, aging, inflammation, OS, and infection.
“Mainly contained in onion and garlic, they have shown to exert beneficial effects against cardiovascular diseases, cancer, aging, inflammation, OS, and infection, among the others [202,203].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [202]
Alliin, allicin, allyl sulphides, allylcysteines and other sulphur-containing compounds have long been known for their antioxidant properties.
“Alliin, allicin, allyl sulphides, allylcysteines and other sulphur-containing compounds have long been known for their antioxidant properties [202].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [202]
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Green-fabricated MgO nanoparticles: A potent antimicrobial and anticancer agent
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Fusarium proliferatum causing dry rot of stored garlic in Slovakia
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Cracking the Sulfur Code: Garlic Bioactive Molecules as Multi-Target Blueprints for Drug Discovery
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Effects of Nostoc sp. inoculation on the yield and quality of a medicinal plant, Allium sativum
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Medicinal Plants: Therapeutic Potential, Safety, and Toxicity
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In Vitro Colonic Fermentation of (Poly)phenols and Organosulfur Compounds of Fresh and Black Garlic
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Role of Gasotransmitters in Inflammatory Edema
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Functional flavor agents: enhancing health benefits and consumer preferences
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Optimization and storage study of garlic (Allium sativum) incorporated herbal multi-millet sev snack
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Effect of Garlic Extract on the Erythrocyte as a Simple Model Cell
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Tunisian Nephroprotective Plants: A Review
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Penicillium Species Associated with Postharvest Blue Mold Rots of Garlic in Serbia
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Bioactive Phytochemicals from Garlic (Allium sativum L.) By-Products
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Insights into garlic (Allium Sativum)’s nutrigenomics-associated fly-repellent potency in cattle
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Garlic as a Potential Nominee in Functional Food Industry
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Smart Bags and Smartphone for On-The-Spot Detection of Bleached Garlic
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- Authors
- Ansary, J., Forbes-Hernández, T. Y., Gil, E., Cianciosi, D., Zhang, J., Elexpuru-Zabaleta, M., Simal-Gandara, J., Giampieri, F., & Battino, M.
- Affiliations
- Marche Polytechnic University (IT)
- Universidade de Vigo (ES)
- Nutrition and Food Science Group, Department of Biochemistry, Genetics and Immunology, Faculty of Biology, University of Vigo, 36310 Vigo, Spain
- Dipartimento di Scienze Cliniche e Molecolari, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy
- Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Science, University of Vigo, Ourense Campus, E-32004 Ourense, Spain
- Jiangsu University (CN)
- Corresponding author
- Giampieri, Francesca
- Battino, Maurizio
- ORCID
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2020-07-15
- Volume
- 9
- Issue
- 7
- Pages
- 619
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC7402177
- OpenAlex
- W3042652083
- Cited by
- 217
- References
- 156
- Citations by year
- 2026: 30 · 2025: 32 · 2024: 45 · 2023: 47 · 2022: 29 · 2021: 28 · 2020: 4 · 2015: 2
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Investigo repository of University of Vigo (University of Vigo) (submittedVersion, other-oa)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion, other-oa)
- Investigo Institutional repository of UVigo (Universidade de Vigo) (submittedVersion, cc-by)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
- Keywords
- garlic, organosulfur compounds, polyphenols, nutraceuticals, garlic extract, oxidative stress, inflammation, cancer prevention, cardiovascular disease, metabolic disorders, diabetes mellitus, blood pressure, skin health, bone health, bioavailability, drug interactions, human intervention studies
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