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Cited by 112Adipokines, Inflammation, and Metabolic DiseasesGut microbiota and healthExercise and Physiological Responses

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects

Open access
Lira, Fabio S, Rosa, Jose C, Pimentel, Gustavo D, Souza, Hélio A, Caperuto, Erico C, Carnevali, Luiz C, Seelaender, Marília, Damaso, Ana R, Oyama, Lila M, de Mello, Marco T, Santos, Ronaldo V·2010·Lipids in Health and Disease
DOI 10.1186/1476-511x-9-82PMC PMC2922209
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Abstract

INTRODUCTION: A sedentary lifestyle increases the risk of developing cardiovascular disease, obesity, and diabetes. This phenomenon is supported by recent studies suggesting a chronic, low-grade inflammation status. Endotoxin derived from gut flora may be key to the development of inflammation by stimulating the secretion of inflammatory factors. This study aimed to examine plasma inflammatory markers and endotoxin levels in individuals with a sedentary lifestyle and/or in highly trained subjects at rest. METHODS: Fourteen male subjects (sedentary lifestyle n = 7; highly trained subjects n = 7) were recruited. Blood samples were collected after an overnight fast (approximately 12 h). The plasmatic endotoxin, plasminogen activator inhibitor type-1 (PAI-1), monocyte chemotactic protein-1 (MCP1), ICAM/CD54, VCAM/CD106 and lipid profile levels were determined. RESULTS: Endotoxinemia was lower in the highly trained subject group relative to the sedentary subjects (p < 0.002). In addition, we observed a positive correlation between endotoxin and PAI-1 (r = 0.85, p < 0.0001), endotoxin and total cholesterol (r = 0.65; p < 0.01), endotoxin and LDL-c (r = 0.55; p < 0.049) and endotoxin and TG levels (r = 0.90; p < 0.0001). The plasma levels of MCP-1, ICAM/CD54 and VCAM/CD106 did not differ. CONCLUSION: These results indicate that a lifestyle associated with high-intensity and high-volume exercise induces favorable changes in chronic low-grade inflammation markers and may reduce the risk for diseases such as obesity, diabetes and cardiovascular diseases.

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Figure 1 Correlation between Enddotoxin and PAI-1 (Figure 1a), Endotoxin and total cholesterol (Figure 1b), Enddotoxin and LDL-c (Figure 1c) and Enddotoxin and TG leves (Figure 1d).
Figure 1 Correlation between Enddotoxin and PAI-1 (Figure 1a), Endotoxin and total cholesterol (Figure 1b), Enddotoxin and LDL-c (Figure 1c) and Enddotoxin and TG leves (Figure 1d).CC BY · PubMed Central

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Research works printed but not linked: 1

  1. Friedewald WT, Levy RI, Fredrickson DS: Estimation Of The Concentration Of LDL-Cholesterol In Plasma, Without Use Of The Ultracentrifuge. Clin Clem. 1972, 18: 499-502.

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Metadata

Authors
Lira, F. S., Rosa, J. C., Pimentel, G. D., Souza, H. A., Caperuto, E. C., Carnevali, L. C., Seelaender, M., Damaso, A. R., Oyama, L. M., de Mello, M. T., & Santos, R. V.
Affiliations
  • Universidade Federal de São Paulo (BR)
  • Universidade de São Paulo (BR)
Corresponding author
Santos, Ronaldo V
ORCID
Venue
Lipids in Health and Disease
Publisher
Springer Science and Business Media LLC
Published
2010-08-04
Volume
9
Issue
1
Pages
82-82
ISSN
1476-511X (ISSN-L)
DOI
10.1186/1476-511x-9-82
PMC
PMC2922209
OpenAlex
W2147866514
Cited by
112
References
22
Citations by year
2026: 5 · 2025: 4 · 2024: 9 · 2023: 6 · 2022: 10 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 3 · 2017: 10 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 4 · 2012: 12
FWCI
4.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Lipids in Health and Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
  • Americanae (AECID Library) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo (08/03533-1)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Keywords
endotoxemia, sedentary lifestyle, highly trained athletes, low-grade inflammation, gut microbiota, plasminogen activator inhibitor-1, MCP-1, lipid profile, serum cholesterol, triglycerides, cardiovascular risk, obesity, diabetes mellitus
MeSH terms
Adult, Bicycling, Endotoxins, Humans, Hypercholesterolemia, Lipids, Male, Hypertriglyceridemia, Biomarkers, Exercise, Plasminogen Activator Inhibitor 1, Intercellular Adhesion Molecule-1, Inflammation Mediators, Chemokine CCL2, Vascular Cell Adhesion Molecule-1, Endotoxemia, Young Adult, Athletes, Sedentary Behavior

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