The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps
Open accessAbstract
BACKGROUND: Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation. METHODS: Pharmacological inhibitors were used to block PKC activity in neutrophils harvested from healthy donor blood. RESULTS: Pan PKC inhibition with Ro-31-8220 (p<0.001), conventional PKC inhibition with Go 6976 (p<0.001) and specific PKCβ inhibition with LY333531 (p<0.01) blocked NET formation in response to PMA. Inhibition of novel and atypical PKC had no effect. LY333531 blocked NET induction by the diacylglycerol analogue OAG (conventional PKC activator) (p<0.001). CONCLUSIONS: Conventional PKCs have a prominent role in NET formation. Furthermore PKCβ is the major isoform implicated in NET formation.
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Cites
Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Novel cell death program leads to neutrophil extracellular traps
Fuchs, T. A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Brinkmann, V., & Zychlinsky, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606027 · Cited by 3,197
Neutrophils and immunity: challenges and opportunities
Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971
Beneficial suicide: why neutrophils die to make NETs
Brinkmann, V., & Zychlinsky, A. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1710 · Cited by 937
NETs: a new strategy for using old weapons
Papayannopoulos, V., & Zychlinsky, A. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.011 · Cited by 634 · cited 1×
“The beneficial anti-microbial effects of NET formation have been described in several studies [4,20-25].”
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Cited by
Neutrophil extracellular traps in homeostasis and disease
Wang, H., Kim, S. J., Lei, Y., Wang, S., Wang, H., Huang, H., Zhang, H., & Tsung, A. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01933-x · Cited by 537
Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
(DeCOI), G. C.-1. O. I., Aschenbrenner, A. C., Mouktaroudi, M., Krämer, B., Oestreich, M., Antonakos, N., Nuesch-Germano, M., Gkizeli, K., Bonaguro, L., Reusch, N., et al. (2021) · Genome Medicine · doi:10.1186/s13073-020-00823-5 · Cited by 255
Zawrotniak, M., Bartnicka, D., & Rapala-Kozik, M. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111511 · Cited by 41
Methods for Quantifying Neutrophil Extracellular Traps on Biomaterials
Fetz, A. E., King, W. E., Minden-Birkenmaier, B. A., & Bowlin, G. L. (2022) · Methods in Molecular Biology · doi:10.1007/978-1-0716-1811-0_38 · Cited by 7
Metadata
- Authors
- Gray, R. D., Lucas, C. D., MacKellar, A., Li, F., Hiersemenzel, K., Haslett, C., Davidson, D. J., & Rossi, A. G.
- Venue
- Journal of Inflammation
- Published
- 2013
- Volume
- 10
- Issue
- 1
- Pages
- 12
- ISSN
- 1476-9255 (ISSN-L)
- OpenAlex
- W2144492890
- Cited by
- 166
- References
- 5
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gray, R. D., Lucas, C. D., MacKellar, A., Li, F., Hiersemenzel, K., Haslett, C., Davidson, D. J., & Rossi, A. G. (2013). Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps. Journal of Inflammation. https://doi.org/10.1186/1476-9255-10-12
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
