The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
The role of steroids in follicular growth
Open accessAbstract
The steroidogenic pathway within the ovary gives rise to progestins, androgens and oestrogens, all of which act via specific nuclear receptors to regulate reproductive function and maintain fertility. The role of progestins in follicular growth and development is limited, its action confined largely to ovulation, although direct effects on granulosa cell function have been reported. Consistent with these findings, progesterone receptor knockout mice are infertile because they cannot ovulate. Androgens have been shown to promote early follicular growth, but also to impede follicular development by stimulating atresia and apoptosis. The inability of androgens to transduce a signal in mice lacking androgen receptors culminates in reduced fertility. Oestrogens are known to exert effects on granulosa cell growth and differentiation in association with gonadotrophins. Studies with oestrogen receptor knockouts and oestrogen depleted mice have shown us that oestrogen is essential for folliculogenesis beyond the antral stage and is necessary to maintain the female phenotype of ovarian somatic cells. In summary, the action of steroids within the ovary is based on the developmental status of the follicle. In the absence of any single sex steroid, ovarian function and subsequently fertility, are compromised.
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PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment
Morgante, G., Darino, I., Spanò, A., Luisi, S., Luddi, A., Piomboni, P., Governini, L., & De Leo, V. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154509 · Cited by 95
High-fat high-sugar diet induces polycystic ovary syndrome in a rodent model†
Roberts, J. S., Perets, R. A., Sarfert, K. S., Bowman, J. J., Ozark, P. A., Whitworth, G. B., Blythe, S. N., & Toporikova, N. (2017) · Biology of Reproduction · doi:10.1095/biolreprod.116.142786 · Cited by 58
Wang, X., Wang, H., Liu, W., Zhang, Z., Zhang, Y., Zhang, W., Chen, Z., Xia, G., & Wang, C. (2018) · Clinical Science · doi:10.1042/cs20171394 · Cited by 30
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Metadata
- Authors
- Drummond, A. E.
- Venue
- Reproductive Biology and Endocrinology
- Published
- 2006-04-10
- Volume
- 4
- Issue
- 1
- Pages
- 16-16
- ISSN
- 1477-7827 (ISSN-L)
- OpenAlex
- W1708429683
- Cited by
- 366
- References
- 148
- FWCI
- 15.54
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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