The DOI matches its Crossref record; 191 of the 191 references it cites were found in a registry or an index.
Connexins: a myriad of functions extending beyond assembly of gap junction channels
Open accessAbstract
Connexins constitute a large family of trans-membrane proteins that allow intercellular communication and the transfer of ions and small signaling molecules between cells. Recent studies have revealed complex translational and post-translational mechanisms that regulate connexin synthesis, maturation, membrane transport and degradation that in turn modulate gap junction intercellular communication. With the growing myriad of connexin interacting proteins, including cytoskeletal elements, junctional proteins, and enzymes, gap junctions are now perceived, not only as channels between neighboring cells, but as signaling complexes that regulate cell function and transformation. Connexins have also been shown to form functional hemichannels and have roles altogether independent of channel functions, where they exert their effects on proliferation and other aspects of life and death of the cell through mostly-undefined mechanisms. This review provides an updated overview of current knowledge of connexins and their interacting proteins, and it describes connexin modulation in disease and tumorigenesis.
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Cites
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Cited by
Kanady, J. D., Dellinger, M. T., Munger, S. J., Witte, M. H., & Simon, A. M. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.04.004 · Cited by 184
Protein–Protein Interactions with Connexin 43: Regulation and Function
Sorgen, P. L., Trease, A. J., Spagnol, G., Delmar, M., & Nielsen, M. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051428 · Cited by 106
Choudhury, S. P., Bano, S., Sen, S., Suchal, K., Kumar, S., Nikolajeff, F., Dey, S. K., & Sharma, V. (2022) · npj Parkinson's Disease · doi:10.1038/s41531-022-00324-9 · Cited by 52
Metadata
- Authors
- Dbouk, H. A., Mroue, R. M., El-Sabban, M. E., & Talhouk, R. S.
- Venue
- Cell Communication and Signaling
- Published
- 2009-03-12
- Volume
- 7
- Issue
- 1
- Pages
- 4-4
- ISSN
- 1478-811X (ISSN-L)
- OpenAlex
- W2162569984
- Cited by
- 265
- References
- 191
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
