A quantitative comparison of regional myocardial motion in mice, rabbits and humans using in-vivo phase contrast CMR
Open accessAbstract
BACKGROUND: Genetically manipulated animals like mice or rabbits play an important role in the exploration of human cardiovascular diseases. It is therefore important to identify animal models that closely mimic physiological and pathological human cardiac function. METHODS: In-vivo phase contrast cardiovascular magnetic resonance (CMR) was used to measure regional three-directional left ventricular myocardial motion with high temporal resolution in mice (N=18), rabbits (N=8), and humans (N=20). Radial, long-axis, and rotational myocardial velocities were acquired in left ventricular basal, mid-ventricular, and apical short-axis locations. RESULTS: Regional analysis revealed different patterns of motion: 1) In humans and rabbits, the apex showed slower radial velocities compared to the base. 2) Significant differences within species were seen in the pattern of long-axis motion. Long-axis velocities during systole were fairly homogeneously distributed in mice, whereas humans showed a dominant component in the lateral wall and rabbits in the base. 3) Rotational velocities and twist showed the most distinct patterns in both temporal evolution and relative contribution of base, mid-ventricle and apex, respectively. Interestingly, a marked difference in rotational behavior during early-systole was found in mice, which exhibited clockwise rotation in all slice locations compared to counter-clockwise rotation in rabbits and humans. CONCLUSIONS: Phase contrast CMR revealed subtle, but significantly different regional myocardial motion patterns in mice, rabbits and humans. This finding has to be considered when investigating myocardial motion pattern in small animal models of heart disease.
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Myocardial function in intact rabbits can be assessed with established in vivo quantitative and imaging techniques such as echocardiography, hemodynamic catheterization, electrocardiography, and cardiac MRI.
“various in vivo quantitative and imaging techniques such as echocardiography (Pogwizd, Qi, Yuan, Samarel, & Bers, 1999), hemodynamic cardiac catheterization (Mahaffey, Raya, Pennock, Morkin, & Goldman, 1995; A. S. Shah, et al., 2000), electrocardiography (Pogwizd, et al., 1999), and cardiac magnetic resonance imaging (Jung, et al., 2012) are well established and are routinely performed in rabbits.”
From Small and large animal models in cardiac contraction research: advantages and disadvantages (2014) · cites this paper as Jung, et al., 2012
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Small and large animal models in cardiac contraction research: advantages and disadvantages
Milani-Nejad, N., & Janssen, P. M. L. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.007 · Cited by 484 · see citing works
- Authors
- Jung, B., Odening, K. E., Dall'Armellina, E., Föll, D., Menza, M., Markl, M., & Schneider, J. E.
- Affiliations
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Northwestern University (US)
- University of Oxford (GB)
- Corresponding author
- Jung, Bernd
- Venue
- Journal of Cardiovascular Magnetic Resonance
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 14
- Issue
- 1
- Pages
- 90
- ISSN
- 1097-6647 (ISSN-L)
- PMC
- PMC3579745
- OpenAlex
- W2136308957
- Cited by
- 44
- References
- 42
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 6 · 2017: 7 · 2016: 10 · 2015: 3 · 2014: 4 · 2013: 3
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Cardiovascular Magnetic Resonance (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Wellcome Trust (090532)
- British Heart Foundation (BS/06/001, FS/11/50/29038, RG/l01002J28)
- Deutscher Akademischer Austauschdienst
- Bundesministerium für Bildung und Forschung (01EV0706)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- regional myocardial motion, left ventricular function, myocardial rotation, radial velocity, animal models of heart disease, mice, rabbits, human comparison, species differences
- MeSH terms
- Adult, Animals, Biomechanical Phenomena, Humans, Mice, Inbred C57BL, Predictive Value of Tests, Rabbits, Reference Values, Rotation, Species Specificity, Time Factors, Ventricular Function, Left, Magnetic Resonance Imaging, Cine, Mice
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