Proteomic analysis of human vitreous humor
Open accessAbstract
BACKGROUND: The vitreous humor is a transparent, gelatinous mass whose main constituent is water. It plays an important role in providing metabolic nutrient requirements of the lens, coordinating eye growth and providing support to the retina. It is in close proximity to the retina and reflects many of the changes occurring in this tissue. The biochemical changes occurring in the vitreous could provide a better understanding about the pathophysiological processes that occur in vitreoretinopathy. In this study, we investigated the proteome of normal human vitreous humor using high resolution Fourier transform mass spectrometry. RESULTS: The vitreous humor was subjected to multiple fractionation techniques followed by LC-MS/MS analysis. We identified 1,205 proteins, 682 of which have not been described previously in the vitreous humor. Most proteins were localized to the extracellular space (24%), cytoplasm (20%) or plasma membrane (14%). Classification based on molecular function showed that 27% had catalytic activity, 10% structural activity, 10% binding activity, 4% cell and 4% transporter activity. Categorization for biological processes showed 28% participate in metabolism, 20% in cell communication and 13% in cell growth. The data have been deposited to the ProteomeXchange with identifier PXD000957. CONCLUSION: This large catalog of vitreous proteins should facilitate biomedical research into pathological conditions of the eye including diabetic retinopathy, retinal detachment and cataract.
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Ocular tissues, including the retina, shed intracellular proteins into adjacent intraocular fluid compartments such as vitreous fluid.
“proteomic studies of the eye reveal that ocular tissues, including the retina, shed intracellular proteins into adjacent intraocular fluid compartments (e.g., the vitreous fluid; Fig. 1a)20,26–28.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [28]
Vitreous fluid sequesters both intracellular and extracellular proteins shed from the retina and adjacent tissues.
“This tissue makes up 80% of the human eye by volume and sequesters both intracellular and extracellular proteins shed from the retina and adjacent tissues20,26–28.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [28]
Vitreous fluid makes up 80% of the human eye by volume.
“This tissue makes up 80% of the human eye by volume and sequesters both intracellular and extracellular proteins shed from the retina and adjacent tissues20,26–28.”
From Investigation of Cas9 Antibodies in the Human Eye (2022) · cites this paper as [28]
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Konson, A., Pradeep, S., D’Acunto, C. W., & Seger, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.151548 · Cited by 35 · see citing works
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Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860 · see citing works
Rappsilber, J., Mann, M., & Ishihama, Y. (2007) · Nature Protocols · doi:10.1038/nprot.2007.261 · Cited by 4,641 · see citing works
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works
Human Protein Reference Database--2009 update
Prasad, T. S. K., Goel, R., Kandasamy, K., Keerthikumar, S., Kumar, S., Mathivanan, S., Telikicherla, D., Raju, R., Shafreen, R. B., Venugopal, A., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn892 · Cited by 3,241 · see citing works
Self-citationProteomeXchange provides globally coordinated proteomics data submission and dissemination
Vizcaíno, J. A., Deutsch, E. W., Wang, R., Csordás, A., Reisinger, F., Ríos, D., Dianes, J. A., Sun, Z., Farrah, T., Bandeira, N., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2839 · Cited by 2,735 · see citing works
Human protein reference database--2006 update
Mishra, G. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj141 · Cited by 601 · see citing works
The human complement factor H: functional roles, genetic variations and disease associations
de Córdoba, S. R., Esparza-Gordillo, J., GOICOECHEADEJORGE, E., López‐Trascasa, M., & Sánchez‐Corral, P. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.02.005 · Cited by 572 · see citing works
Insulin-like growth factor binding proteins and their role in controlling IGF actions
Clemmons, D. R. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(96)00053-6 · Cited by 509 · see citing works
Role of insulin-like growth factor binding proteins in controlling IGF actions
Clemmons, D. R. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00024-0 · Cited by 396 · see citing works
Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases
Yoshimura, T., Sonoda, K., Sugahara, M., Mochizuki, Y., Enaida, H., Oshima, Y., Ueno, A., Hata, Y., Yoshida, H., & Ishibashi, T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008158 · Cited by 343 · see citing works
A rare penetrant mutation in CFH confers high risk of age-related macular degeneration
Raychaudhuri, S., Iartchouk, O., Chin, K., Tan, P. L., Tai, A. K., Ripke, S., Gowrisankar, S., Vemuri, S., Montgomery, K., Yu, Y., et al. (2011) · Nature Genetics · doi:10.1038/ng.976 · Cited by 323 · see citing works
Khanna, A. K., Meher, S., Prakash, S., Tiwary, S. K., Singh, U., Srivastava, A., & Dixit, V. K. (2013) · HPB Surgery · doi:10.1155/2013/367581 · Cited by 310 · see citing works
Fuchs, S., Nakazawa, M., Maw, M. A., Tamai, M., Oguchi, Y., & Gal, A. (1995) · Nature Genetics · doi:10.1038/ng0795-360 · Cited by 301 · see citing works
Gao, B., Chen, X., Timothy, N. H., Aiello, L. P., & Feener, E. P. (2008) · Journal of Proteome Research · doi:10.1021/pr800112g · Cited by 250 · see citing works
Barnstable, C. J. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.05.002 · Cited by 240 · see citing works
Isolation and Molecular Cloning of Insulin-Like Growth Factor-Binding Protein-6
Shimasaki, S., Gao, L., Shimonaka, M., & LING, N. C. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-7-938 · Cited by 235 · see citing works
Effects of TGF-β2, BMP-4, and Gremlin in the Trabecular Meshwork: Implications for Glaucoma
Wordinger, R. J., Fleenor, D. L., Hellberg, P. E., Pang, I.-H., Tovar, T., Zode, G. S., Fuller, J. A., & Clark, A. F. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0296 · Cited by 226 · see citing works
Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis
Goel, R., Gowda, H., Pandey, A., & Prasad, T. S. K. (2011) · Molecular BioSystems · doi:10.1039/c1mb05340j · Cited by 212 · see citing works
Self-citationQuantitative proteomics using stable isotope labeling with amino acids in cell culture
Gowda, H., Molina, H., & Pandey, A. (2008) · Nature Protocols · doi:10.1038/nprot.2008.2 · Cited by 202 · see citing works
Self-citationProteogenomic Analysis of Mycobacterium tuberculosis By High Resolution Mass Spectrometry
Kelkar, D. S., Kumar, D., Kumar, P., Balakrishnan, L., Muthusamy, B., Yadav, A. K., Shrivastava, P., Marimuthu, A., Anand, S., Sundaram, H., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.011627 · Cited by 201 · see citing works
Self-citationGarcía‐Ramírez, M., Canals, F., Hernández, C., Colomé, N., Ferrer, C., Carrasco, E., García‐Arumí, J., & Simó, R. (2007) · Diabetologia · doi:10.1007/s00125-007-0627-y · Cited by 167 · see citing works
Human Proteinpedia enables sharing of human protein data
Mathivanan, S., Ahmed, M., Ahn, N. G., Hainard, A., Amanchy, R., Andrews, P., Bader, J. S., Balgley, B. M., Bantscheff, M., Bennett, K. L., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt0208-164 · Cited by 156 · see citing works
Self-citationZhang, J., Gerhardinger, C., & Lorenzi, M. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3499 · Cited by 151 · see citing works
Pepperberg, D. R., Okajima, T.-I. L., Wiggert, B., Ripps, H., Crouch, R. K., & Chader, G. J. (1993) · Molecular Neurobiology · doi:10.1007/bf02780609 · Cited by 149 · see citing works
Mapping the Type I Collagen-binding Site on Pigment Epithelium-derived Factor
Meyer, C., Notari, L., & Becerra, S. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208339200 · Cited by 147 · see citing works
The chemical morphology of the vitreous
Scott, J. E. (1992) · Eye · doi:10.1038/eye.1992.120 · Cited by 134 · see citing works
Chaerkady, R., Gowda, H., Nalli, A., Guček, M., Vivekanandan, P., Akhtar, J., Cole, R. N., Simmers, J. L., Schulick, R. D., Singh, S., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr800197z · Cited by 122 · see citing works
Self-citationInvolvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin
Zhuang, T., Chen, Q., Cho, M., Vishnivetskiy, S. A., Iverson, T. M., Gurevich, V. V., & Sanders, C. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215176110 · Cited by 111 · see citing works
Proteome Analysis of Human Vitreous Proteins
Yamane, K., Minamoto, A., Yamashita, H., Takamura, H., Miyamoto-Myoken, Y., Yoshizato, K., Nabetani, T., Tsugita, A., & Mishima, H. K. (2003) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m300038-mcp200 · Cited by 110 · see citing works
den Hollander, A. I., McGee, T. L., Ziviello, C., Banfi, S., Dryja, T. P., Gonzalez-Fernandez, F., Ghosh, D., & Berson, E. L. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-2497 · Cited by 109 · see citing works
Reardon, A., Goff, M. L., Briggs, M. D., McLeod, D., Sheehan, J. K., Thornton, D. J., & Bishop, P. N. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.2123 · Cited by 106 · see citing works
Extraction and characterization of the tissue forms of collagen types II and IX from bovine vitreous
Bishop, P. N., Crossman, M. V., McLeod, D., & Ayad, S. (1994) · Biochemical Journal · doi:10.1042/bj2990497 · Cited by 100 · see citing works
Profiling of vitreous proteomes from proliferative diabetic retinopathy and nondiabetic patients
Kim, T., Kim, S. J., Kim, K., Kang, U., Lee, C., Park, K. S., Yu, H. G., & Kim, Y. (2007) · PROTEOMICS · doi:10.1002/pmic.200700745 · Cited by 98 · see citing works
Proteomic analysis of vitreous from diabetic macular edema
Ouchi, M., West, K. A., Crabb, J. W., Kinoshita, S., & Kamei, M. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.01.020 · Cited by 96 · see citing works
Ceda, G. P., Fielder, P. J., Henzel, W. J., Louie, A., Donovan, S. M., Hoffman, A. R., & Rosenfeld, R. G. (1991) · Endocrinology · doi:10.1210/endo-128-6-2815 · Cited by 87 · see citing works
Nakanishi, T., Koyama, R., Ikeda, T., & Shimizu, A. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00078-8 · Cited by 82 · see citing works
Park, K., Jin, J., Hu, Y., Zhou, K., & Ma, J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.10.014 · Cited by 78 · see citing works
Deep Amino Acid Sequencing of Native Brain GABAA Receptors Using High-Resolution Mass Spectrometry
Chen, Z.-W., Fuchs, K., Sieghart, W., Townsend, R. R., & Evers, A. S. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.011445 · Cited by 77 · see citing works
Ortego, J., Escribano, J., Becerra, S. P., & Coca‐Prados, M. (1996) · PubMed · Cited by 74 · see citing works
In-depth mass spectrometric mapping of the human vitreous proteome
Aretz, S., Krohne, T. U., Kammerer, K., Warnken, U. H., Hotz‐Wagenblatt, A., Bergmann, M., Stanzel, B. V., Kempf, T., Holz, F. G., Schnölzer, M., et al. (2013) · Proteome Science · doi:10.1186/1477-5956-11-22 · Cited by 73 · see citing works
Identifying targets of miR-143 using a SILAC-based proteomic approach
Yang, Y., Chaerkady, R., Kandasamy, K., Huang, T.-C., Selvan, L. N., Dwivedi, S. B., Kent, O., Mendell, J., & Pandey, A. (2010) · Molecular Biosystems · doi:10.1039/c004401f · Cited by 73 · see citing works
Self-citationNeumann, G. M., Marinaro, J. A., & Bach, L. A. (1998) · Biochemistry · doi:10.1021/bi972894e · Cited by 70 · see citing works
Immunolocalisation of opticin in the human eye
Ramesh, S. (2004) · British Journal of Ophthalmology · doi:10.1136/bjo.2003.031989 · Cited by 70 · see citing works
Simó, R. (2008) · Archives of Ophthalmology · doi:10.1001/archopht.126.8.1076 · Cited by 69 · see citing works
The ratio of VEGF/PEDF expression in bone marrow mesenchymal stem cells regulates neovascularization
Fan, W., Crawford, R., & Xiao, Y. (2011) · Differentiation · doi:10.1016/j.diff.2010.12.003 · Cited by 68 · see citing works
Support for the involvement of complement factor I in age-related macular degeneration
Ennis, S., Gibson, J., Cree, A. J., Collins, A. R., & Lotery, A. J. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.113 · Cited by 60 · see citing works
Comprehensive proteomic analysis of human bile
Barbhuiya, M. A., Sahasrabuddhe, N. A., Pinto, S. M., Muthusamy, B., Singh, T. D., Nanjappa, V., Keerthikumar, S., Delanghe, B., Gowda, H., Chaerkady, R., et al. (2011) · PROTEOMICS · doi:10.1002/pmic.201100197 · Cited by 57 · see citing works
Self-citationUltrastructure of the Hyaloid Vascular System
Jack, R. L. (1972) · Archives of Ophthalmology · doi:10.1001/archopht.1972.01000020557014 · Cited by 56 · see citing works
Human interstitial retinoid-binding protein
Liou, G. I., P, D., Yu, Y., Geng, L., Zhu, C., & Baehr, W. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83169-6 · Cited by 53 · see citing works
Identification and localization of major soluble vitreous proteins in human ocular tissue
Wu, C. W., Sauter, J. L., Johnson, P. K., Chen, C.-D., & Olsen, T. W. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.11.009 · Cited by 53 · see citing works
Clemmons, D. R., Busby, W. H., CLARKS, J. B., Parker, A., Duan, C., & NAM, T. J. (1998) · Endocrine Journal · doi:10.1507/endocrj.45.suppl_s1 · Cited by 45 · see citing works
Protein localization in the human eye and genetic screen of opticin
Friedman, J. S. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.11.1333 · Cited by 43 · see citing works
Characterizing the normal proteome of human ciliary body
Goel, R., Murthy, K. R., Manda, S. S., Pinto, S. M., Bhattacharjee, M., Kelkar, D. S., Madugundu, A. K., Dey, G., Mohan, S., Krishna, V., et al. (2013) · Clinical Proteomics · doi:10.1186/1559-0275-10-9 · Cited by 42 · see citing works
Self-citationRole of Insulin-Like Growth Factor Binding Protein 2 in Lung Adenocarcinoma
Migita, T., Narita, T., Asaka, R., Miyagi, E., Nagano, H., Nomura, K., Matsuura, M., Satoh, Y., Okumura, S., Nakagawa, K., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090500 · Cited by 41 · see citing works
Modulation of IGFBP2 mRNA Expression in White Adipose Tissue upon Aging and Obesity
Li, Z., & Picard, F. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1262854 · Cited by 39 · see citing works
David, D., Cardoso, J., Marques, B., Marques, R., Silva, E. D., Santos, H., & Boavida, M. G. (2003) · Genomics · doi:10.1016/s0888-7543(03)00046-6 · Cited by 37 · see citing works
Noma, H., Funatsu, H., Mimura, T., Eguchi, S., Shimada, K., & Hori, S. (2011) · Current Eye Research · doi:10.3109/02713683.2010.513090 · Cited by 37 · see citing works
Taniguchi, T., Adler, A. J., Mizuochi, T., Kochibe, N., & Kobata, A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36000-3 · Cited by 35 · see citing works
Distribution of Lead and Transthyretin in Human Eyes
Eichenbaum, J. W., & Zheng, W. (2000) · Journal of Toxicology Clinical Toxicology · doi:10.1081/clt-100100946 · Cited by 35 · see citing works
Clausen, R., Weller, M., Wiedemann, P., Heimann, K., Hilgers, R.-D., & Zilles, K. (1991) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/bf00170555 · Cited by 32 · see citing works
Friedman, J. S., Ducharme, R., Raymond, V., & Walter, M. A. (2000) · PubMed · Cited by 30 · see citing works
Type II collagen in the early embryonic chick cornea and vitreous: Immunoradiochemical evidence
Linsenmayer, T. F., Gibney, E. P., & Little, C. D. (1982) · Experimental Eye Research · doi:10.1016/0014-4835(82)90083-5 · Cited by 30 · see citing works
Uçmak, D., Akkurt, Z. M., Toprak, G., Yeşilova, Y., Turan, E., & Yıldız, İ. (2013) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2013.35615 · Cited by 29 · see citing works
Hyperphosphorylation and Association with RBP of the Intracellular Domain of Notch1
Foltz, D. R., & Nye, J. S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5421 · Cited by 28 · see citing works
Identification of IGFBP-6 as an effector of the tumor suppressor activity of SEMA3B
Koyama, N., Zhang, J., Huqun, Miyazawa, H., Tanaka, T., Su, X., & Hagiwara, K. (2008) · Oncogene · doi:10.1038/onc.2008.263 · Cited by 25 · see citing works
S-antigen specific T helper type 1 response is present in Behcet's disease.
Zhao, C., Yang, P., He, H., Lin, X., Li, B., Zhou, H., Huang, X.-K., & Kijlstra, A. (2008) · Europe PMC (PubMed Central) · Cited by 20 · see citing works
Constituent monosaccharides and hexosamine concentration of diabetic human vitreous humour
Walker, F., & Patrick, R. S. (1967) · Experimental Eye Research · doi:10.1016/s0014-4835(67)80005-8 · Cited by 17 · see citing works
Huang, L., Li, W., Tang, W., Zhu, X., Ouyang, P., & Lu, G. (2012) · PubMed Central · Cited by 14 · see citing works
Ehrenborg, E., Zazzi, H., Bajalica‐Lagercrantz, S., Granqvist, M., Hillerbrand, U., Allander, S. V., Larsson, C., & Luthman, H. (1999) · Mammalian Genome · doi:10.1007/s003359901005 · Cited by 14 · see citing works
Oguchi Disease With Unusual Findings Associated With a Heterozygous Mutation in the SAG Gene
Fujinami, K. (2011) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2011.300 · Cited by 14 · see citing works
Constituent monosaccharides and hexosamine concentration of normal human vitreous humour
Walker, F., & Patrick, R. S. (1967) · Experimental Eye Research · doi:10.1016/s0014-4835(67)80035-6 · Cited by 13 · see citing works
Transthyretin (prealbumin) in eye structures and variation of vitreous-transthyretin in diseases.
Ramakrishnan, S., Sulochana, K. N., Parikh, S., & Punitham, R. (1999) · PubMed · Cited by 9 · see citing works
Identification of sialyl and galactosyl transferase activities in calf vitreous hyalocytes
Jacobson, B. M. (1984) · Current Eye Research · doi:10.3109/02713688409011749 · Cited by 8 · see citing works
Rod photoreceptors in the human retina synthesize and secrete interstitial retinol-binding protein.
Jg, H., Fliesler, S. J., Me, R., & Bridges, C. D. B. (1985) · PubMed · Cited by 7 · see citing works
Locke, J., & Morton, W. R. (1965) · PubMed · Cited by 6 · see citing works
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Pharmacokinetic aspects of retinal drug delivery
del Amo, E. M., Rimpelä, A.-K., Heikkinen, E., Kari, O. K., Ramsay, E., Lajunen, T., Schmitt, M., Pelkonen, L., Bhattacharya, M., Richardson, D., et al. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.12.001 · Cited by 693 · see citing works
Varela‐Fernández, R., Díaz-Tomé, V., Luaces-Rodríguez, A., Conde-Penedo, A., García‐Otero, X., Álvarez, A. L., Fernández‐Ferreiro, A., & Otero-Espinar, F. J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030269 · Cited by 363 · see citing works
Design, clinical translation and immunological response of biomaterials in regenerative medicine
Sadtler, K., Singh, A., Wolf, M. T., Wang, X., Pardoll, D. M., & Elisseeff, J. H. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.40 · Cited by 323 · see citing works
Biomarkers in Diabetic Retinopathy
Jenkins, A. J., Joglekar, M. V., Hardikar, A. A., KEECH, A. C., O'Neal, D. N., & Januszewski, A. S. (2015) · The Review of Diabetic Studies · doi:10.1900/rds.2015.12.159 · Cited by 317 · see citing works
Immune responses to injury and their links to eye disease
Stepp, M. A., & Menko, A. S. (2021) · Translational research · doi:10.1016/j.trsl.2021.05.005 · Cited by 199 · see citing works
Nawaz, M. I., Rezzola, S., Cancarini, A., Russo, A., Costagliola, C., Semeraro, F., & Presta, M. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.03.002 · Cited by 191 · see citing works
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Youngblood, H. A., Robinson, R. L., Sharma, A. K., & Sharma, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194755 · Cited by 181 · see citing works
Jacob, S., Nair, A. B., Shah, J., Gupta, S., Boddu, S. H. S., Sreeharsha, N., Joseph, A., Shinu, P., & Morsy, M. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030533 · Cited by 164 · see citing works
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Biswas, S., Thomas, A. A., Chen, S., Aref‐Eshghi, E., Feng, B., Gonder, J. R., Sadiković, B., & Chakrabarti, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-24907-w · Cited by 157 · see citing works
Application of lipid nanoparticles to ocular drug delivery
Battaglia, L., Serpe, L., Foglietta, F., Muntoni, E., Gallarate, M., del Pozo‐Rodríguez, A., & Solinís, M. Á. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1201059 · Cited by 152 · see citing works
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Seo, H., Chung, W. G., Kwon, Y. W., Kim, S., Hong, Y., Park, W., Kim, E., Lee, J., Lee, S., Kim, M., et al. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00290 · Cited by 152 · see citing works
Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review
Bévalot, F., Cartiser, N., Bottinelli, C., Fanton, L., & Guitton, J. (2015) · Forensic Toxicology · doi:10.1007/s11419-015-0294-5 · Cited by 141 · see citing works
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Loukovaara, S., Nurkkala, H., Tamene, F., Gucciardo, E., Liu, X., Repo, P. E., Lehti, K., & Varjosalo, M. T. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00900 · Cited by 129 · see citing works
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Skeie, J. M., Roybal, C. N., & Mahajan, V. B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0127567 · Cited by 93 · see citing works
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The Human Eye Proteome Project: Updates on an Emerging Proteome
Ahmad, M. T., Zhang, P., Dufresne, C. P., Ferrucci, L., & Semba, R. D. (2018) · PROTEOMICS · doi:10.1002/pmic.201700394 · Cited by 83 · see citing works
Vitreous Antioxidants, Degeneration, and Vitreo-Retinopathy: Exploring the Links
Ankamah, E., Sebag, J., Ng, E., & Nolan, J. M. (2019) · Antioxidants · doi:10.3390/antiox9010007 · Cited by 82 · see citing works
Proteomic Analysis of the Bovine and Human Ciliary Zonule
María, A., Wilmarth, P. A., David, L. L., & Bassnett, S. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20866 · Cited by 82 · see citing works
Minireview: Fibronectin in retinal disease
Miller, C. G., Budoff, G., Prenner, J. L., & Schwarzbauer, J. E. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216675245 · Cited by 77 · see citing works
Zhao, Y., Weber, S. R., Lease, J., Russo, M., Siedlecki, C. A., Xu, L., Chen, H., Wang, W., Ford, M., Simó, R., et al. (2018) · Translational Vision Science & Technology · doi:10.1167/tvst.7.3.6 · Cited by 76 · see citing works
Investigation of the global protein content from healthy human tears
Dor, M., Eperon, S., Lalive, P. H., Guex‐Crosier, Y., Hamedani, M., Salvisberg, C., & Turck, N. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.10.006 · Cited by 75 · see citing works
López-Contreras, A. K., Martínez-Ruíz, M. G., Olvera-Montaño, C., Robles-Rivera, R. R., Arévalo-Simental, D. E., Castellanos‐González, J. A., Hernández-Chávez, A., Huerta-Olvera, S. G., Cardona-Muñóz, E. G., & Rodríguez-Carrizález, A. D. (2020) · Antioxidants · doi:10.3390/antiox9090891 · Cited by 72 · see citing works
Updates on Biodegradable Formulations for Ocular Drug Delivery
Tsung, T., Chen, Y., & Lu, D. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030734 · Cited by 70 · see citing works
Employing Flow Cytometry to Extracellular Vesicles Sample Microvolume Analysis and Quality Control
Maia, J., Batista, S., Couto, N., Gregório, A. C., Bodo, C., Elzanowska, J., Moraes, M. C. S., & Costa‐Silva, B. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.593750 · Cited by 59 · see citing works
Balaiya, S., Zhou, Z., & Chalam, K. V. (2017) · Proteomics Insights · doi:10.1177/1178641816686078 · Cited by 59 · see citing works
The Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease
Schori, C., Trachsel, C., Grossmann, J., Zygoula, I., Barthelmes, D., & Grimm, C. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24122 · Cited by 57 · see citing works
Ocular Delivery of Therapeutic Proteins: A Review
Shastri, D. H., Silva, A. C., & Almeida, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010205 · Cited by 54 · see citing works
Vitreous humor in the pathologic scope: Insights from proteomic approaches
Monteiro, J. P., Santos, F. M., Rocha, A. S., Sousa, J. P. C., Queiroz, J. A., Passarinha, L. A., & Tomaz, C. T. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400133 · Cited by 54 · see citing works
Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases
Navarro‐Partida, J., Castro‐Castañeda, C. R., Cruz-Pavlovich, F. J. S., Aceves-Franco, L. A., Ori-Guy, T., & Santos, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050678 · Cited by 50 · see citing works
Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy
LeBlanc, M. E., Wang, W., Chen, X., Caberoy, N. B., Guo, F., Shen, C., Ji, Y., Tian, H., Wang, H., Chen, R., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161802 · Cited by 49 · see citing works
Kowalczuk, L., Matet, A., Dor, M., Bararpour, N., Daruich, A., Dirani, A., Béhar‐Cohen, F., Thomas, A., & Turck, N. (2018) · Translational Vision Science & Technology · doi:10.1167/tvst.7.1.3 · Cited by 43 · see citing works
The Quest of the Human Proteome and the Missing Proteins: Digging Deeper
Reddy, P. J., Ray, S., & Srivastava, S. (2015) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2015.0035 · Cited by 39 · see citing works
Bansal, R., & Gupta, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.610428 · Cited by 37 · see citing works
Glaucoma: Management and Future Perspectives for Nanotechnology-Based Treatment Modalities
Hoffy, N. M. E., Azim, E. A. A., Hathout, R. M., Fouly, M. A. K., & Elkheshen, S. A. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105648 · Cited by 34 · see citing works
Thermosensitive Nanocomposite Hydrogels for Intravitreal Delivery of Cefuroxime
Sapino, S., Peira, E., Chirio, D., Chindamo, G., Guglielmo, S., Oliaro‐Bosso, S., Barbero, R., Vercelli, C., Re, G., Brunella, V., et al. (2019) · Nanomaterials · doi:10.3390/nano9101461 · Cited by 33 · see citing works
Self-Healing Thermosensitive Hydrogel for Sustained Release of Dexamethasone for Ocular Therapy
Annala, A., Ilochonwu, B. C., Wilbie, D., Sadeghi, A., Hennink, W. E., & Vermonden, T. (2022) · ACS Polymers Au · doi:10.1021/acspolymersau.2c00038 · Cited by 32 · see citing works
Impaired vitreous composition and retinal pigment epithelium function in the FoxG1::LRP2 myopic mice
Cases, O., Obry, A., Ben-Yacoub, S., Augustin, S., Joseph, A., Toutirais, G., Simonutti, M., Christ, A., Cosette, P., & Kozyraki, R. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.03.022 · Cited by 32 · see citing works
Olczak, M., Poniatowski, Ł. A., Niderla‐Bielińska, J., Kwiatkowska, M., Chutorański, D., Tarka, S., & Wierzba‐Bobrowicz, T. (2019) · Forensic Science International · doi:10.1016/j.forsciint.2019.05.010 · Cited by 32 · see citing works
Filippelli, M., Campagna, G., Vito, P., Zotti, T., Ventre, L., Rinaldi, M., Bartollino, S., dell’Omo, R., & Costagliola, C. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.592274 · Cited by 32 · see citing works
Srividya, G., Jain, M., Mahalakshmi, K., Gayathri, S., Raman, R., & Angayarkanni, N. (2018) · Eye · doi:10.1038/eye.2017.285 · Cited by 31 · see citing works
Luaces-Rodríguez, A., González‐Barcia, M., Blanco‐Teijeiro, M. J., Gil‐Martínez, M., González, F., Gómez‐Ulla, F., Lamas, M. J., Otero-Espinar, F. J., & Fernández‐Ferreiro, A. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10020066 · Cited by 30 · see citing works
Investigation of Cas9 Antibodies in the Human Eye
Toral, M. A., Charlesworth, C. T., Ng, B., Chemudupati, T., Homma, S., Nakauchi, H., Bassuk, A. G., Porteus, M. H., & Mahajan, V. B. (2022) · Nature Communications · doi:10.1038/s41467-022-28674-1 · Cited by 28 · see citing works
Identification of vitreous proteins in retinopathy of prematurity
Sugioka, K., Saito, A., Kusaka, S., Kuniyoshi, K., & Shimomura, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.067 · Cited by 27 · see citing works
Lindberg, G. C. J., Longoni, A., Lim, K. S., Rosenberg, A. J. W. P., Hooper, G. J., Gawlitta, D., & Woodfield, T. B. F. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.022 · Cited by 27 · see citing works
Proteomic Study of Aqueous Humor and Its Application in the Treatment of Neovascular Glaucoma
Yu, M., Xie, F., Liu, X., Sun, H., Guo, Z., Liu, X., Li, W., Sun, W., Wang, Y., & He, C. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.587677 · Cited by 26 · see citing works
Confalonieri, F., Josifovska, N., Boix‐Lemonche, G., Stene‐Johansen, I., Bragadóttir, R., Lumi, X., & Petrovski, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043342 · Cited by 26 · see citing works
Extracellular vesicles: an emerging player in retinal homeostasis
Chatterjee, A., & Singh, R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1059141 · Cited by 25 · see citing works
Proteomic Analysis of Vitreous Humor in Retinal Vein Occlusion
Reich, M., Dacheva, I., Nobl, M., Siwy, J., Schanstra, J. P., Mullen, W., Koch, F., Kopitz, J., Kretz, F. T. A., Auffarth, G. U., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158001 · Cited by 25 · see citing works
Choi, G., An, S. H., Choi, J., Rho, M. S., Park, W. C., Jeong, W. J., & Chi, H. J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2023.122459 · Cited by 24 · see citing works
Yu, F., Lam, T. C., Liu, L., Chun, R. K. M., Cheung, J. K.-W., Li, K. K., & To, C. H. (2017) · Scientific Reports · doi:10.1038/s41598-017-12650-7 · Cited by 24 · see citing works
Ocular delivery of solid lipid nanoparticles
Battaglia, L., Gallarate, M., Serpe, L., Foglietta, F., Muntoni, E., del Pozo‐Rodríguez, A., & Solinís, M. Á. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813687-4.00007-4 · Cited by 24 · see citing works
iTRAQ Quantitative Proteomic Analysis of Vitreous from Patients with Retinal Detachment
Santos, F. M., Gaspar, L. M., Ciordia, S., Rocha, A. S., Sousa, J. C. E., Paradela, A., Passarinha, L. A., & Tomaz, C. T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041157 · Cited by 23 · see citing works
Asif, M., Rehman, F. U., Rashid, Z., Hussain, A., Mirza, A., & Qureshi, W. S. (2025) · IEEE Access · doi:10.1109/access.2025.3583647 · Cited by 21 · see citing works
Replacing the vitreous body with hydrogels: Rationale and strategies
Schulz, A., Keskar, M., Swindle‐Reilly, K. E., Junge, V., Parikh, B. H., Su, X., Liu, Z., & Seah, I. Y. J. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101389 · Cited by 21 · see citing works
System-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy
Shaik, A. A., Qiu, B., Lai, S. L., Cheung, N., Tan, G. S. W., Neo, S. P., Tan, A., Cheung, C. M. G., Hong, W., Wong, T. Y., et al. (2022) · Theranostics · doi:10.7150/thno.72947 · Cited by 21 · see citing works
Fang, J., Wang, H., Niu, T., Shi, X., Xing, X., Qu, Y., Liu, Y., Liu, X., Xiao, Y., Dou, T., et al. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00007 · Cited by 21 · see citing works
Choosing preclinical study models of diabetic retinopathy: key problems for consideration
Mi, X.-S., Yuan, T., Zhong, J., Ding, Y., & So, K. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s72797 · Cited by 20 · see citing works
Morro, B., Doherty, M. K., Balseiro, P., Handeland, S. O., MacKenzie, S. A., Sveier, H., & Albalat, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227003 · Cited by 19 · see citing works
Hollmann, A. K., Dammann, I., Wemheuer, W. M., Wemheuer, W., Chilla, A., Tipold, A., Schulz‐Schaeffer, W., Beck, J., Schütz, E., & Brenig, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180665 · Cited by 18 · see citing works
Proteomic Analysis of Embryonic and Young Human Vitreous
Yee, K. M. P., Feener, E. P., Madigan, M. C., JACKSON, N. J., Gao, B., Ross‐Cisneros, F. N., Provis, J. M., Aiello, L. P., Sadun, A. A., & Sebag, J. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16809 · Cited by 18 · see citing works
Differential Expression of Vitreous Proteins in Young and Mature New Zealand White Rabbits
Liu, Y., Bouhenni, R., Dufresne, C. P., Semba, R. D., & Edward, D. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153560 · Cited by 17 · see citing works
Robinson, R. L., Youngblood, H. A., Iyer, H., Bloom, J., Lee, T. J., Chang, L. Y., Lukowski, Z. L., Zhi, W., Sharma, A. K., & Sharma, S. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.11.2 · Cited by 17 · see citing works
Khan, S., Wai, C., & Ho, E. A. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01756-x · Cited by 16 · see citing works
Early posterior vitreous detachment is associated with LAMA5 dominant mutation
Napolitano, F., Iorio, V. D., Iorio, G. D., Melone, M. A. B., Gianfrancesco, F., Simonelli, F., Esposito, T., Testa, F., & Sampaolo, S. (2018) · Ophthalmic Genetics · doi:10.1080/13816810.2018.1558261 · Cited by 16 · see citing works
Subbannayya, Y., Pinto, S. M., Mohanty, V., Dagamajalu, S., Prasad, T. S. K., & Murthy, K. R. (2020) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2019.0190 · Cited by 16 · see citing works
Self-citationAnalytical Strategy for MS-Based Thanatochemistry to Estimate Postmortem Interval
Aiello, D., Lucà, F., Siciliano, C., Frati, P., Fineschi, V., Rongo, R., & Napoli, A. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c01038 · Cited by 16 · see citing works
Naru, J., Aggarwal, R., Singh, U., Mohanty, A. K., Bansal, D., Mangat, N. K., Kakkar, N., & Agnihotri, N. (2016) · Tumor Biology · doi:10.1007/s13277-016-5162-3 · Cited by 16 · see citing works
Movsas, T. Z., Wong, K. Y., Ober, M. D., Sigler, R. E., Lei, Z. M., & Muthusamy, A. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.049 · Cited by 16 · see citing works
Identification of unique proteins in vitreous fluid of patients with noninfectious uveitis
Kasudhan, K. S., Sarkar, S., Gupta, V., Gupta, A., & Chakraborti, A. (2018) · Acta Ophthalmologica · doi:10.1111/aos.13801 · Cited by 14 · see citing works
Immune Inhibitor A Metalloproteases Contribute to Virulence in Bacillus Endophthalmitis
Livingston, E. T., Mursalin, M. H., Coburn, P. S., Astley, R., Miller, F. C., Amayem, O., Lereclus, D., & Callegan, M. C. (2021) · Infection and Immunity · doi:10.1128/iai.00201-21 · Cited by 14 · see citing works
Joshi, K., & Patil, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801814-9.00009-x · Cited by 14 · see citing works
Guo, H., Li, J., & Lu, P. (2023) · BMC Ophthalmology · doi:10.1186/s12886-023-03237-0 · Cited by 13 · see citing works
Murthy, K. R., Dammalli, M., Pinto, S. M., Murthy, K. B., Nirujogi, R. S., Madugundu, A. K., Dey, G., Subbannayya, Y., Mishra, U. K., Nair, B. G., et al. (2016) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2016.0100 · Cited by 13 · see citing works
Self-citationProteomic profiling of human intraschisis cavity fluid
Sudha, D., Kohansal-Nodehi, M., Kovuri, P., Manda, S. S., Neriyanuri, S., Gopal, L., Bhende, P., Chidambaram, S., & Arunachalam, J. P. (2017) · Clinical Proteomics · doi:10.1186/s12014-017-9148-y · Cited by 13 · see citing works
Self-citationProteomic profile of vitreous in patients with tubercular uveitis
Bansal, R., Khan, M. M., Dasari, S., Verma, I., Goodlett, D. R., Manes, N. P., Nita‐Lazar, A., Sharma, S. P., Kumar, A., Singh, N., et al. (2020) · Tuberculosis · doi:10.1016/j.tube.2020.102036 · Cited by 13 · see citing works
Peptidomimetics Therapeutics for Retinal Disease
Parsons, D., Hyeon, L. S., Sun, Y. J., Velez, G., Bassuk, A. G., Smith, M. A., & Mahajan, V. B. (2021) · Biomolecules · doi:10.3390/biom11030339 · Cited by 13 · see citing works
Gharbiya, M., Albanese, G. M., Plateroti, A. M., Marcelli, M., Marenco, M., & Lambìase, A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051411 · Cited by 12 · see citing works
Dammalli, M., Murthy, K. R., Pinto, S. M., Murthy, K. B., Nirujogi, R. S., Madugundu, A. K., Dey, G., Nair, B. G., Gowda, H., & Prasad, T. S. K. (2017) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2016.0170 · Cited by 12 · see citing works
Self-citationKundu, S., Kumari, G., & Srinivasarao, D. A. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00068h · Cited by 11 · see citing works
Bindal, S., & Gupta, R. (2016) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2016.1188314 · Cited by 11 · see citing works
Neutralisation of adeno-associated virus transduction by human vitreous humour
Andrzejewski, S., Moyle, P. M., Stringer, B. W., Steel, J. C., & Layton, C. J. (2021) · Gene Therapy · doi:10.1038/s41434-020-0162-8 · Cited by 10 · see citing works
Ankamah, E., Green, M., Roche, W., Ng, E., Welge‐Lüßen, U., Kaercher, T., & Nolan, J. M. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.12.19 · Cited by 10 · see citing works
Komatsu, H., Usui, Y., Tsubota, K., Fujii, R., Yamaguchi, T., Maruyama, K., Wakita, R., Asakage, M., Shimizu, H., Yamakawa, N., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11133606 · Cited by 10 · see citing works
Bindal, S., Dagar, V. K., Saini, M., Khasa, Y. P., & Gupta, R. (2018) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2018.05.004 · Cited by 10 · see citing works
Mohanty, V., Subbannayya, Y., Najar, M. A., Pinto, S. M., Kasaragod, S., Hilda, K., Bhuvaragavan, S., Singh, K. K., Dalal, S., Manikkoth, S., et al. (2019) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2018.0185 · Cited by 10 · see citing works
Self-citationUslubas, I., Kanlı, A., Kasap, M., Akpınar, G., & Karabas, L. V. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2020.108425 · Cited by 10 · see citing works
Dabigatran inhibits intravitreal thrombin activity
Bastiaans, J., Mulder, V. C., van Meurs, J. C., Nijenhuis, M. S.-T., Neelen, C., van Hagen, P. M., & Dik, W. A. (2017) · Acta Ophthalmologica · doi:10.1111/aos.13630 · Cited by 9 · see citing works
Sustainable hydrogels from slaughterhouse waste: Vitreous humor for tissue engineering applications
Corridon, P. R., Fahmy, M. J., Arjemandi, M., Alkaabi, H., Alameri, S. K., Purohit, S. D., Trucco, D., & Ricotti, L. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.144897 · Cited by 8 · see citing works
Upreti, A., Padula, S. L., Tangeman, J. A., Wagner, B. D., O’Connell, M. J., Jaquish, T. J., Palko, R. K., Mantz, C. J., Anand, D., Lovicu, F. J., et al. (2023) · Cells · doi:10.3390/cells12030501 · Cited by 8 · see citing works
Jiménez-López, R., Martín-Chaves, L., Gutiérrez-García, Á. M., Carmona-Segovia, A. D. M., Mora-Ordóñez, B., García, A. M. S., Fernández-Romero, L., Murri, M., Sanchez‐Quintero, M. J., García, G. B., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1631334 · Cited by 7 · see citing works
Gaspar, L. M., Santos, F. M., Albuquerque, T., Sousa, J. P. C., Passarinha, L. A., & Tomaz, C. T. (2017) · Journal of Chromatography B · doi:10.1016/j.jchromb.2017.07.049 · Cited by 7 · see citing works
LC-MS/MS Analysis Elucidates a Daily Rhythm in Orexin A Concentration in the Rat Vitreous Body
Chrobok, Ł., Bajkacz, S., Klich, J. D., & Lewandowski, M. H. (2021) · Molecules · doi:10.3390/molecules26165036 · Cited by 7 · see citing works
Mohanty, V., Pinto, S. M., Subbannayya, Y., Najar, M. A., Murthy, K. B., Prasad, T. S. K., & Murthy, K. R. (2020) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2020.0020 · Cited by 7 · see citing works
Self-citationAngayarkanni, N., Coral, K., Devi, S. R. B., & Saijyothi, A. V. (2016) · Springer eBooks · doi:10.1007/978-3-319-25498-2_5 · Cited by 6 · see citing works
Validation of the i-STAT®1 Analyzer for Postmortem Vitreous Humor Electrolytes and Glucose Analysis
Monzon, L. R., Pearring, S., Miller, C., & Vargas, J. R. (2017) · Journal of Analytical Toxicology · doi:10.1093/jat/bkx084 · Cited by 6 · see citing works
Vasileiou, K., Nikolaou, P., Dona, A., Papadodima, S. A., Athanaselis, S., Spiliopoulou, C., & Papoutsis, I. I. (2025) · Journal of Analytical Toxicology · doi:10.1093/jat/bkae088 · Cited by 5 · see citing works
Vitreous Humor Proteomic Profile in Patients With Vitreoretinal Lymphoma
Komatsu, H., Usui, Y., Tsubota, K., Fujii, R., Yamaguchi, T., Maruyama, K., Wakita, R., Asakage, M., Hamada, K., Yamakawa, N., et al. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.15.2 · Cited by 5 · see citing works
Brighenti, T., Neri, G., Mazzola, M., Tomè, G., Scalfati, M., Peroni, D., Belli, R., Zampedri, E., Tebaldi, T., Borello, U., et al. (2024) · Clinical Proteomics · doi:10.1186/s12014-024-09515-3 · Cited by 5 · see citing works
Proteomanalyse unverdünnter Glaskörperflüssigkeit bei Patienten mit einem Venenastverschluss
Dacheva, I., Reich, M., Nobl, M., Ceglowska, K., Wasiak, J., Siwy, J., Zürbig, P., Mischak, H., Koch, F., Kopitz, J., et al. (2017) · Der Ophthalmologe · doi:10.1007/s00347-017-0469-z · Cited by 5 · see citing works
Peng, H., & Hulleman, J. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163855 · Cited by 5 · see citing works
- Authors
- Murthy, K. R., Goel, R., Subbannayya, Y., Jacob, H. K., Murthy, P. R., Manda, S. S., Patil, A. H., Sharma, R., Sahasrabuddhe, N. A., Parashar, A., Nair, B. G., Krishna, V., Prasad, T. K., Gowda, H., & Pandey, A.
- Affiliations
- Institute of Bioinformatics (IN)
- Kuvempu University (IN)
- Pondicherry University (IN)
- National Institute of Mental Health and Neurosciences (IN)
- Armed Forces Medical College (IN)
- Amrita Vishwa Vidyapeetham (IN)
- Johns Hopkins University (US)
- Corresponding author
- Murthy, Krishna R
- ORCID
- Venue
- Clinical Proteomics
- Published
- 2014-07-14
- Volume
- 11
- Issue
- 1
- Pages
- 29-29
- ISSN
- 1542-6416 (ISSN-L)
- 1559-0275
- PMC
- PMC4106660
- OpenAlex
- W2164518567
- Cited by
- 145
- References
- 76
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 14 · 2023: 12 · 2022: 9 · 2021: 10 · 2020: 21 · 2019: 8 · 2018: 18 · 2017: 15 · 2016: 14 · 2015: 6 · 2014: 2
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Clinical Proteomics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Department of Biotechnology, Ministry of Science and Technology, India
- University Grants Commission
- The Wellcome Trust DBT India Alliance
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Physical Sciences › Chemistry › Spectroscopy › Mass Spectrometry Techniques and Applications
- Keywords
- vitreous humor, vitreous proteome, vitreoretinopathy, vitreous proteins, extracellular proteins, protein function classification, diabetic retinopathy, retinal detachment, cataract
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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