The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Mechanisms of Degranulation in Neutrophils
Open accessAbstract
Neutrophils are critical inflammatory cells that cause tissue damage in a range of diseases and disorders. Being bone marrow-derived white blood cells, they migrate from the bloodstream to sites of tissue inflammation in response to chemotactic signals and induce inflammation by undergoing receptor-mediated respiratory burst and degranulation. Degranulation from neutrophils has been implicated as a major causative factor in pulmonary disorders, including severe asphyxic episodes of asthma. However, the mechanisms that control neutrophil degranulation are not well understood. Recent observations indicate that granule release from neutrophils depends on activation of intracellular signalling pathways, including β-arrestins, the Rho guanosine triphosphatase Rac2, soluble NSF attachment protein (SNAP) receptors, the src family of tyrosine kinases, and the tyrosine phosphatase MEG2. Some of these observations suggest that degranulation from neutrophils is selective and depends on nonredundant signalling pathways. This review focuses on new findings from the literature on the mechanisms that control the release of granule-derived mediators from neutrophils.
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Neutrophils at the crossroads of innate and adaptive immunity
Rosales, C. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mir0220-574rr · Cited by 372
ROS and glutathionylation balance cytoskeletal dynamics in neutrophil extracellular trap formation
Stojkov, D., Amini, P., Oberson, K., Sokollik, C., Duppenthaler, A., Simon, H.-U., & Yousefi, S. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201611168 · Cited by 142
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Stow, J. L., & Murray, R. Z. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.04.001 · Cited by 128
Phagocytosis: what’s on the menu?
Lancaster, C. E., Ho, C. Y., Hipolito, V. E. B., Botelho, R. J., & Terebiznik, M. R. (2019) · Biochemistry and Cell Biology · doi:10.1139/bcb-2018-0008 · Cited by 49
The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis
Baldewijns, S., Sillen, M., Palmans, I., Vandecruys, P., Van Dijck, P., & Demuyser, L. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.705779 · Cited by 44
Metadata
- Authors
- Lacy, P.
- Venue
- Allergy, Asthma & Clinical Immunology
- Published
- 2006-09
- Volume
- 2
- Issue
- 3
- Pages
- 98-108
- ISSN
- 1710-1484 (ISSN-L)
- 1710-1492
- OpenAlex
- W1999517476
- Cited by
- 473
- References
- 60
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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