The impact of statins on psychological wellbeing: a systematic review and meta-analysis

Statistical Power Analysis for the Behavioral Sciences

Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works

Statistical power analysis for the behavioral sciences

Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,406 · see citing works

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.

(2009) · PubMed Central · Cited by 44,859 · see citing works

Estimating the mean and variance from the median, range, and the size of a sample

Hozo, S. P., Djulbegovic, B., & Hozo, I. (2005) · BMC Medical Research Methodology · doi:10.1186/1471-2288-5-13 · Cited by 9,062 · see citing works

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

OLSSON, A. G., McMurray, J. J. V., Thorgeirsson, G., Spaulding, C. M., Slattery, J., Pyörälà, K., Færgeman, O., Wright, R. S., Berg, K. M., Wilhelmsen, L., et al. (1994) · The Lancet · Cited by 8,467 · see citing works

The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

Sacks, F. M., Pfeffer, M. A., Moye, L. A., Rouleau, J. L., Rutherford, J. D., Cole, T. G., Brown, L., Warnica, J. W., Arnold, J. M. O., Wun, C.-C., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610033351401 · Cited by 7,439 · see citing works

The brief symptom inventory: an introductory report.

Derogatis, L. R., & Melisaratos, N. (1983) · Psychological Medicine · doi:10.1017/s0033291700048017 · Cited by 6,650 · see citing works

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

(1998) · New England Journal of Medicine · doi:10.1056/nejm199811053391902 · Cited by 5,261 · see citing works

Statins for the primary prevention of cardiovascular disease

Taylor, F., Huffman, M. D., Macedo, A. F., Moore, T. H., Burke, M., Davey Smith, G., Ward, K., Ebrahim, S., & Gay, H. C. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004816.pub5 · Cited by 1,934 · see citing works

Variance imputation for overviews of clinical trials with continuous response

Follmann, D. A., Elliott, P., Suh, I., & Cutler, J. A. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90054-q · Cited by 1,391 · see citing works

The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials

Brugts, J. J., Yetgin, T., Hoeks, S. E., Gotto, A. M., Shepherd, J., Westendorp, R. G. J., de Craen, A. J. M., Knopp, R. H., Nakamura, H., Ridker, P., et al. (2009) · BMJ · doi:10.1136/bmj.b2376 · Cited by 792 · see citing works

Major Depression and Activation of The Inflammatory Response System

Maes, M. (1999) · Advances in Experimental Medicine and Biology · doi:10.1007/978-0-585-37970-8_2 · Cited by 617 · see citing works

Low serum cholesterol and suicide

Engelberg, H. (1992) · The Lancet · doi:10.1016/0140-6736(92)90609-7 · Cited by 513 · see citing works

In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias

Terrin, N. C., Schmid, C. H., & Lau, J. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.01.006 · Cited by 493 · see citing works

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M. (2012) · Inflammopharmacology · doi:10.1007/s10787-011-0111-7 · Cited by 325 · see citing works

THE EFFECT OF PRAVASTATIN ON CORONARY EVENTS AFTER MYOCARDIAL INFARCTION IN PATIENTS WITH AVERAGE CHOLESTEROL LEVELS

Acks, M. S., Arc, M., Feffer, A. P., Emuel, L., Oyé, A. M., Ouleau, J. E. L. R., Utherford, J. O. D. R., Ole, T. H. G. C., Rown, L. I. B., Arnica, J. W. A. W., et al. (1996) · Cited by 321 · see citing works

Statins for the primary prevention of cardiovascular disease

Taylor, F. C., Ward, K. J., Moore, T. H., Burke, M., Smith, G. D., Casas, J. P., & Ebrahim, S. B. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004816.pub4 · Cited by 305 · see citing works

Effects of lovastatin on cognitive function and psychological well-being

Muldoon, M. F., Barger, S. D., Ryan, C. M., Flory, J. D., Lehoczky, J. P., Matthews, K. A., & Manuck, S. B. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00353-3 · Cited by 290 · see citing works

Meta‐analysis combining parallel and cross‐over clinical trials. I: Continuous outcomes

Curtin, F., Altman, D. G., & Elbourne, D. R. (2002) · Statistics in Medicine · doi:10.1002/sim.1205 · Cited by 208 · see citing works

Serum cholesterol concentration and death from suicide in men: Paris prospective study I

Zureik, M., Courbon, D., & Ducimetière, P. (1996) · BMJ · doi:10.1136/bmj.313.7058.649 · Cited by 151 · see citing works

Long-term statin use and psychological well-being

Young‐Xu, Y., Chan, K. A., Liao, J. K., Ravid, S., & Blatt, C. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00785-x · Cited by 139 · see citing works

Lipid-Lowering Drugs and the Risk of Depression and Suicidal Behavior

Yang, C., Jick, S. S., & Jick, H. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.16.1926 · Cited by 116 · see citing works

Do cholesterol‐lowering agents affect brain activity? A comparison of simvastatin, pravastatin, and placebo in healthy volunteers.

Harrison, R., & Ashton, C. (1994) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1994.tb04268.x · Cited by 113 · see citing works

Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial

Hyyppä, M. T., Kronholm, E., Virtanen, A., Leino, A. E., & Jula, A. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00014-8 · Cited by 111 · see citing works

Clinical Implications of the Cytokine Hypothesis of Depression: The Association between Use of Statins and Aspirin and the Risk of Major Depression

Pasco, J. A., Jacka, F. N., Williams, L. J., Henry, M. J., Nicholson, G. C., Kotowicz, M. A., & Berk, M. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000319530 · Cited by 95 · see citing works

The HMG-CoA reductase inhibitor simvastatin inhibits IFN-gamma induced MHC class II expression in human vascular endothelial cells

Kwak, B. R., Mulhaupt, F., Veillard, N. R., & Granziano, P. (2001) · Swiss Medical Weekly · doi:10.4414/smw.2001.06144 · Cited by 94 · see citing works

The Use of Statins After a Cardiac Intervention Is Associated With Reduced Risk of Subsequent Depression

Stafford, L., & Berk, M. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05825blu · Cited by 93 · see citing works

Randomised placebo controlled trial of effect on mood of lowering cholesterol concentration

Wardle, J., Armitage, J., Collins, R., Wallendszus, K., KEECH, A. C., & Lawson, A. (1996) · BMJ · doi:10.1136/bmj.313.7049.75 · Cited by 89 · see citing works

Long-term Assessment of Psychological Well-being in a Randomized Placebo-Controlled Trial of Cholesterol Reduction With Pravastatin

Stewart, R. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.20.3144 · Cited by 86 · see citing works

Simvastatin Causes Changes in Affective Processes in Elderly Volunteers

Morales, K. H., Wittink, M. N., Datto, C. J., DiFilippo, S. D., Cary, M. S., TenHave, T. R., & Katz, I. R. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00542.x · Cited by 61 · see citing works

Statin Use and Risk of Depression in Patients With Coronary Heart Disease

Otte, C., Zhao, S., & Whooley, M. A. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m07038 · Cited by 61 · see citing works

Effects of treatment with lovastatin and pravastatin on daytime cognitive performance

Gengo, F. M., Cwudzinski, D., Kinkel, P. R., Block, G. A., Stauffer, L. A., & Lines, C. (1995) · Clinical Cardiology · doi:10.1002/clc.4960180406 · Cited by 53 · see citing works

The effects of statins on mood: a review of the literature

While, A., & Keen, L. (2010) · European Journal of Cardiovascular Nursing · doi:10.1016/j.ejcnurse.2010.08.008 · Cited by 49 · see citing works

HMG CoA reductase inhibitors and quality of life

Downs, J. R. (1993) · JAMA · doi:10.1001/jama.269.24.3107 · Cited by 36 · see citing works

Behavioral Implications of Lowering Cholesterol Levels: A Double-Blind Pilot Study

Ormiston, T., Wolkowitz, O. M., Reus, V. I., & Manfredi, F. (2003) · Psychosomatics · doi:10.1176/appi.psy.44.5.412 · Cited by 35 · see citing works

Co-morbid cardiovascular disease and depression: sequence of disease onset is linked to mental but not physical self-rated health. Results from a cross-sectional, population-based study

O'Neil, A. E., Williams, E. D., Stevenson, C., Oldenburg, B. F., Berk, M., & Sanderson, K. A. (2011) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-011-0421-5 · Cited by 29 · see citing works

Lipid-Lowering Medication Use and Aggression Scores in Women: A Report from the NHLBI-Sponsored WISE Study

Olson, M. B., Kelsey, S. F., Matthews, K. A., Merz, C. N. B., Eteiba, W., McGorray, S. P., Cornell, C. E., Vido, D. A., & Muldoon, M. F. (2008) · Journal of Women s Health · doi:10.1089/jwh.2007.0379 · Cited by 28 · see citing works

Oxidative stress may be a common mechanism linking major depression and osteoporosis

Pasco, J. A., Nicholson, G. C., Ng, F., Henry, M. J., Williams, L. J., Kotowicz, M. A., Hodge, J. M., Dodd, S., Kapczinski, F. P., Gama, C. S., et al. (2008) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2008.00283.x · Cited by 25 · see citing works

HMG CoA Reductase Inhibitors and Quality of Life

Oster, G. (1993) · JAMA · doi:10.1001/jama.1993.03500240051020 · Cited by 6 · see citing works

Interpretation of the evidence for the efficacy and safety of statin therapy

Collins, R., Reith, C., Emberson, J., Armitage, J., Baigent, C., Blackwell, L., Blumenthal, R., Danesh, J., Smith, G. D., DeMets, D., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31357-5 · Cited by 1,857 · see citing works

Effect of Anti-inflammatory Treatment on Depression, Depressive Symptoms, and Adverse Effects: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Köhler, O., Benros, M. E., Nordentoft, M., Farkouh, M. E., Iyengar, R. L., Mors, O., & Krogh, J. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1611 · Cited by 941 · see citing works

Statin-Associated Side Effects

Thompson, P. D., Panza, G. A., Zaleski, A. L., & Taylor, B. A. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.02.071 · Cited by 756 · see citing works

Cognitive remission: a novel objective for the treatment of major depression?

Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works

Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis

Macedo, A. F., Taylor, F. C., Casas, J. P., Adler, A. J., Prieto‐Merino, D., & Ebrahim, S. B. J. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-51 · Cited by 183 · see citing works

Therapeutic Strategies for Treatment of Inflammation-related Depression

Adžić, M., Brkic, Z., Mitić, M., Francija, E., Jovicic, M. J., Radulović, J., & Marić, N. P. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170828163048 · Cited by 156 · see citing works

Oxidative/Nitrosative Stress and Immuno-inflammatory Pathways in Depression: Treatment Implications

Anderson, G., & Maes, M. H. J. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660738 · Cited by 147 · see citing works

Anti-inflammatory treatments for mood disorders: Systematic review and meta-analysis

Husain, M. I., Strawbridge, R., Stokes, P. R., & Young, A. H. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117725711 · Cited by 139 · see citing works

The renin–angiotensin system: a possible new target for depression

Vian, J., Pereira, C. L., Chavarria, V., Köhler, C. A., Stubbs, B., Quevedo, J., Kim, S., Carvalho, A. F., Berk, M., & Fernandes, B. S. (2017) · BMC Medicine · doi:10.1186/s12916-017-0916-3 · Cited by 132 · see citing works

The Integrative Management of Treatment-Resistant Depression: A Comprehensive Review and Perspectives

Carvalho, A. F., Berk, M., Hyphantis, T. N., & McIntyre, R. S. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000357500 · Cited by 123 · see citing works

Atherogenic index of plasma and atherogenic coefficient are increased in major depression and bipolar disorder, especially when comorbid with tobacco use disorder

Nunes, S. O. V., de Melo, de Castro, M. R. P., Barbosa, D. S., Vargas, H. O., Berk, M., & Maes, M. H. J. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.038 · Cited by 119 · see citing works

Statins for the treatment of depression: A meta-analysis of randomized, double-blind, placebo-controlled trials

Salagre, E., Fernandes, B. S., Dodd, S., Brownstein, D. J., & Berk, M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.047 · Cited by 117 · see citing works

Call to action regarding the vascular‐bipolar link: A report from the Vascular Task Force of the International Society for Bipolar Disorders

Goldstein, B. I., Baune, B. T., Bond, D. J., Chen, P., Eyler, L. T., Fagiolini, A. M., Gomes, F. A., Hájek, T., Hatch, J. K., McElroy, S. L., et al. (2020) · Bipolar Disorders · doi:10.1111/bdi.12921 · Cited by 112 · see citing works

Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets

Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works

BIDIRECTIONAL PROSPECTIVE ASSOCIATIONS OF METABOLIC SYNDROME COMPONENTS WITH DEPRESSION, ANXIETY, AND ANTIDEPRESSANT USE

Hiles, S. A., Révész, D., Lamers, F., Giltay, E. J., & Penninx, B. W. J. H. (2016) · Depression and Anxiety · doi:10.1002/da.22512 · Cited by 103 · see citing works

Statins use and risk of depression: A systematic review and meta-analysis

Parsaik, A. K., Singh, B., M. Hassan, M., Singh, K., Mascarenhas, S. S., Williams, M. D., Lapid, M. I., Richardson, J. W., West, C. P., & Rummans, T. A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.11.026 · Cited by 100 · see citing works

Depression is a risk factor for incident coronary heart disease in women: An 18-year longitudinal study

O'Neil, A. E., Fisher, A. J., Kibbey, K. J., Jacka, F. N., Kotowicz, M. A., Williams, L. J., Stuart, A. L., Berk, M., Lewandowski, P. A., Taylor, C. B., et al. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.029 · Cited by 98 · see citing works

Statin use and risk of depression: a Swedish national cohort study

Redlich, C., Berk, M., Williams, L. J., Sundquist, J., Sundquist, K., & Li, X. (2014) · BMC Psychiatry · doi:10.1186/s12888-014-0348-y · Cited by 76 · see citing works

New drug candidates for depression – a nationwide population‐based study

Kessing, L. V., Rytgaard, H. C. W., Gerds, T. A., Berk, M., Ekstrøm, C. T., & Andersen, P. K. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12957 · Cited by 73 · see citing works

Intensive LDL-cholesterol lowering therapy and neurocognitive function

Banach, M., Rizzo, M., Nikolić, D., Howard, G., Howard, V. J., & Mikhailidis (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.11.001 · Cited by 66 · see citing works

In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major depressive disorder

Haghighi, M., Khodakarami, S., Jahangard, L., Ahmadpanah, M., Bajoghli, H., Holsboer-Trachsler, E., & Brand, S. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.07.018 · Cited by 65 · see citing works

Simvastatin prevents and ameliorates depressive behaviors via neuroinflammatory regulation in mice

Yu, X., Zhang, H., Dai, Y., Zhou, Z., Xu, R.-A., Hu, L., Zhang, C., Xu, H., An, Y., Tang, C., et al. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.11.086 · Cited by 61 · see citing works

Do statins have an effect on depressive symptoms? A systematic review and meta-analysis

Yatham, M. S., Yatham, K. S., Ravindran, A. V., & Sullivan, F. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.002 · Cited by 60 · see citing works

Statins for major depressive disorder: a systematic review and meta-analysis of randomized controlled trials

De Giorgi, R., De Crescenzo, F., Rizzo Pesci, N., Martens, M., Howard, W., Cowen, P. J., & Harmer, C. J. (2021) · PLOS ONE · doi:10.1371/journal.pone.0249409 · Cited by 52 · see citing works

Statins in the treatment of depression: Hype or hope?

Köhler‐Forsberg, O., Otte, C., Gold, S. M., & Østergaard, S. D. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107625 · Cited by 51 · see citing works

Statins in Depression: An Evidence-Based Overview of Mechanisms and Clinical Studies

Giorgi, R. D., Pesci, N. R., Quinton, A. M. G., Crescenzo, F. D., Cowen, P. J., & Harmer, C. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.702617 · Cited by 49 · see citing works

Toward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research

Maes, M. H. J., Nowak, G., Caso, J. R., Leza, J. C., Song, C., Kubera, M., Klein, H. C., Gałecki, P., Noto, C. D. S., Glaab, E., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9183-5 · Cited by 49 · see citing works

Total serum cholesterol, atherogenic indices and their longitudinal association with depressive symptoms among US adults

Beydoun, M. A., Beydoun, H. A., Dore, G. A., Kuczmarski, M. F., Evans, M. K., & Zonderman, A. B. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.4 · Cited by 45 · see citing works

Risk of neuropsychiatric adverse effects of lipid-lowering drugs: a mendelian randomization study

Alghamdi, J., Matou-Nasri, S., Alghamdi, F., Alghamdi, S., Alfadhel, M., & Padmanabhan, S. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy060 · Cited by 44 · see citing works

The use of statins for the treatment of depression in patients with acute coronary syndrome

Kim, S. W., Bae, K., Kim, J.-M., Shin, I., Hong, Y. J., Ahn, Y., Jeong, M. H., Berk, M., & Yoon, J. S. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.116 · Cited by 38 · see citing works

Obesity and Bipolar Disorder: Synergistic Neurotoxic Effects?

Liu, C. S., Carvalho, A. F., Mansur, R. B., & McIntyre, R. S. (2013) · Advances in Therapy · doi:10.1007/s12325-013-0067-7 · Cited by 36 · see citing works

Lovastatin for the adjunctive treatment of schizophrenia: A preliminary randomized double-blind placebo-controlled trial

Ghanizadeh, A. J., Rezaee, Z., Dehbozorgi, S., Berk, M., & Akhondzadeh, S. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.06.039 · Cited by 35 · see citing works

Longitudinal Study of Low Serum LDL Cholesterol and Depressive Symptom Onset in Postmenopause

Persons, J. E., Robinson, J. G., Coryell, W. H., Payne, M. E., & Fiedorowicz, J. G. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09505 · Cited by 34 · see citing works

Statins: Neurobiological underpinnings and mechanisms in mood disorders

Walker, A. J., Kim, Y., Borissiouk, I., Rehder, R., Dodd, S., Morris, G., Nierenberg, A. A., Maes, M., Fernandes, B. S., Dean, O. M., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.012 · Cited by 33 · see citing works

Update on Statin Treatment in Patients with Neuropsychiatric Disorders

Avan, R., Sahebnasagh, A., Hashemi, J., Monajati, M., Faramarzi, F., Henney, N. C., Montecucco, F., Jamialahmadi, T., & Sahebkar, A. (2021) · Life · doi:10.3390/life11121365 · Cited by 33 · see citing works

Statin and Aspirin Use and the Risk of Mood Disorders among Men

Williams, L. J., Pasco, J. A., Mohebbi, M., Jacka, F. N., Stuart, A. L., Venugopal, K., O’Neil, A., & Berk, M. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw008 · Cited by 32 · see citing works

Patterns of phytoplankton composition in coastal lakes differed by connectivity with the Baltic Sea

Obolewski, K., Glińska‐Lewczuk, K., Bąkowska, M., Szymańska, M., & Mrozińska, N. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.03.112 · Cited by 32 · see citing works

Post-Marketing Surveillance of Statins—A Descriptive Analysis of Psychiatric Adverse Reactions in EudraVigilance

Pop, G., Farcas, A. M., Butucă, A., Morgovan, C., Arseniu, A. M., Pumnea, M., Teodoru, M., & Gligor, F. G. (2022) · Pharmaceuticals · doi:10.3390/ph15121536 · Cited by 32 · see citing works

Do Statins Have Antidepressant Effects?

Köhler-Forsberg, O., Gasse, C., Berk, M., & Østergaard, S. D. (2017) · CNS Drugs · doi:10.1007/s40263-017-0422-3 · Cited by 31 · see citing works

New drug candidates for bipolar disorder—A nation‐wide population‐based study

Kessing, L. V., Rytgaard, H. C. W., Gerds, T. A., Berk, M., Ekstrøm, C. T., & Andersen, P. K. (2019) · Bipolar Disorders · doi:10.1111/bdi.12772 · Cited by 31 · see citing works

Clinical profile of statin intolerance in the phase 3 GAUSS-2 Study

Cho, L., Rocco, M., Colquhoun, D., Sullivan, D., Rosenson, R. S., Dent, R., Xue, A., Scott, R., Wasserman, S. M., & Stroes, E. (2016) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-016-6655-4 · Cited by 30 · see citing works

Atorvastatin ameliorates depressive behaviors and neuroinflammatory in streptozotocin-induced diabetic mice

Hai-Na, Z., Xu-Ben, Y., Cong-Rong, T., Yan-Cheng, C., Fan, Y., Lei-Mei, X., Ruo-Lan, S., Ye-Zi, Ye-Xuan, W., & Jing, L. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05406-w · Cited by 29 · see citing works

2019 Taiwan Society of Lipids and Atherosclerosis expert consensus statement on statin intolerance

Chien, S.-C., Chen, P.-S., Huang, Y., Tang, S., Li, Y.-H., & Yeh, H. (2018) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.11.017 · Cited by 26 · see citing works

Statins, mood, sleep, and physical function: a systematic review

Swiger, K. J., Manalac, R. J., Blaha, M. J., Blumenthal, R. S., & Martin, S. S. (2014) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-014-1758-y · Cited by 20 · see citing works

Hyperlipidemia and statins use for the risk of new-onset anxiety/depression in patients with head and neck cancer: A population-based study

Huang, C., Lin, L., Tien, H.-C., Que, J., Ting, W. C., Chen, P., Wu, H.-M., Ho, C., Wang, J., Wang, R.-H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174574 · Cited by 19 · see citing works

Exploring the role of serum lipid profile and neutrophil-to-lymphocyte ratio in violent suicide attempters: a cross sectional study

Capuzzi, E., Caldiroli, A., Capellazzi, M., Tagliabue, I., Auxilia, A. M., Ghilardi, G. I., Buoli, M., & Clerici, M. (2020) · CNS Spectrums · doi:10.1017/s1092852920002199 · Cited by 18 · see citing works

The effect of atorvastatin on cognition and mood in bipolar disorder and unipolar depression patients: A secondary analysis of a randomized controlled trial

Soh, J. F., Almadani, A. H., Beaulieu, S., Rajji, T. K., Mulsant, B. H., Su, C., Renaud, S., Mucsi, I., Torres-Platas, S. G., LEVINSON, A. J., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.013 · Cited by 17 · see citing works

Impact of Vitamin D Deficiency on Mental Health in University Students: A Cross-Sectional Study

Almuqbil, M. S., Almadani, M. E., Albraiki, S. A., Alamri, A. M., Alshehri, A., Alghamdi, A., Alshehri, S., & Asdaq, S. M. B. (2023) · Healthcare · doi:10.3390/healthcare11142097 · Cited by 15 · see citing works

Simvastatin prevents morphine-induced tolerance and dependence in mice

Pajohanfar, N. S., Mohebbi, E., Hosseini–Bandegharaei, A., Amin, M., Vaseghi, G., & Amin, B. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.054 · Cited by 15 · see citing works

Autoantibodies are not Predictive Markers for the Development of Depressive Symptoms in a Population-Based Cohort of Older Adults

Iseme, R. A., McEvoy, M., Kelly, B. J., Agnew, L. L., Attia, J., Walker, F. R., Oldmeadow, C. J., & Boyle, M. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.06.006 · Cited by 12 · see citing works

Revisiting the J shaped curve, exploring the association between cardiovascular risk factors and concurrent depressive symptoms in patients with cardiometabolic disease: Findings from a large cross-sectional study

Jani, B., Cavanagh, J., Barry, S., Der, G., Sattar, N. A., & Mair, F. S. (2014) · BMC Cardiovascular Disorders · doi:10.1186/1471-2261-14-139 · Cited by 12 · see citing works

Major Depressive Disorder (MDD) and Antidepressant Medication Are Overrepresented in High-Dose Statin Treatment

Leutner, M., Matzhold, C., Kautzky, A., Kaleta, M., Stefan Thurner, A., Klimek, P., & Kautzky‐Willer, A. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.608083 · Cited by 11 · see citing works

‘You feel like you haven’t got any control’: A qualitative study of side effects from medicines

O’Donovan, B., Rodgers, R. M., Cox, A. R., & Krska, J. (2019) · Journal of Patient Safety and Risk Management · doi:10.1177/2516043518821499 · Cited by 11 · see citing works

Depression in the Context of Medical Disorders: New Pharmacological Pathways Revisited

Lang, U. E., & Walter, M. (2017) · Neurosignals · doi:10.1159/000482001 · Cited by 9 · see citing works

Health-related quality of life and its associated factors among patients with angina in Jordan

Jarab, A. S., Almousa, A., Rababa’h, A. M., Mukattash, T. L., & Farha, R. K. A. (2019) · Quality of Life Research · doi:10.1007/s11136-019-02383-7 · Cited by 8 · see citing works

Effects of High-Dose Statin Therapy on Cognitive Functions and Quality of Life in Very High Cardiovascular Risk Patients

Kobalava, Z. D., Вадимовна, В. С., & Vorobyeva, M. (2017) · Kardiologiia · doi:10.18087/cardio.2017.9.10024 · Cited by 7 · see citing works

Síntomas conductuales y psiquiátricos en neurología cognitiva

Bayón, A. R., & Sampedro, F. G. (2015) · Neurología · doi:10.1016/j.nrl.2015.01.003 · Cited by 6 · see citing works

Is There a Link Between Cholesterol Level and the Risk of Developing Depression?

Broncel, M., & Serejko-Banaś, K. E. (2016) · Open Medicine Journal · doi:10.2174/1874220301603010352 · Cited by 5 · see citing works

Huffman and colleagues' response to Abramson and colleagues' article on statins in low risk people

Huffman, M. D., Taylor, F. C., & Ebrahim, S. B. J. (2014) · BMJ · doi:10.1136/bmj.g1520 · Cited by 5 · see citing works

The risk of developing cardiovascular disease in bipolar disorder. Biological factors and therapy

Mosolov, S. N., & Fedorova, E. Y. (2022) · Terapevticheskii arkhiv · doi:10.26442/00403660.2022.04.201455 · Cited by 4 · see citing works

Statin use is associated with reduced depressive symptoms in Europeans, but increased symptoms in ethnic minorities in the UK: an observational study

Williams, E. D., Eastwood, S. V., Tillin, T., Stewart, R. J., Chaturvedi, N., & Hughes, A. D. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12599 · Cited by 4 · see citing works

Behavioural and psychiatric symptoms in cognitive neurology

Bayón, A. R., & Sampedro, F. G. (2017) · Neurología (English Edition) · doi:10.1016/j.nrleng.2015.01.003 · Cited by 3 · see citing works

The association of statin use with the risk of anxiety: a systematic review and meta-analysis

Yan, Y., Deng, S., Li, Y., Fu, J., Gong, H., Zhang, H., & Zhang, F. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1769044 · Cited by 2 · see citing works

Exploring repositioning opportunities and side-effects of statins: a Mendelian randomization study of HMG-CoA reductase inhibition with 55 complex traitsPreprint

So, H., Chau, C. K., & Zhao, K. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/170241 · Cited by 2 · see citing works

Differential associations of various depression-related phenotypes with cardiometabolic risks: Identification of shared genetic factors and implications for drug repositioningPreprint

Wong, B. C., Chau, C. K., Ao, F., Mo, C., Wong, S., Wong, Y. H., & So, H. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/140590 · Cited by 2 · see citing works

If my cholesterol is…then I foresee…: patient accounts of uncertainty

Drummond, D. K. (2017) · Qualitative Research in Medicine & Healthcare · doi:10.4081/qrmh.2017.7006 · Cited by 1 · see citing works

The Relationships Between Sleep Disturbances, Depression, Inflammatory Markers, and Sexual Trauma in Female Veterans

Marcolongo, E. M. (2014) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1 · see citing works

The inflammation hypothesis of depression: cross sectional associations, temporal relationships and the confounds of comorbidity

Hiles, S. A. (2014) · NOVA (University of Newcastle Australia)

NEW THERAPEUTIC TARGETS FOR BIPOLAR DISORDER

Carvalho, A. F. (2014) · Debates em Psiquiatria · doi:10.25118/2236-918x-4-2-3

What is the potential of statins in the treatment of depression?

Viloria, N. D. U., & Berk, M. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1743685

Atorvastatin prevents depressive behavior improving the sphingolipid metabolism and triggering neurovascular coupling via Apolipoprotein EPreprint

Su, D., Song, Y., Liao, Z., Liu, Y., Liao, L., Zhang, Z., Zhu, G., Yang, M., luo, X., & Ai, Z. (2022) · doi:10.22541/au.165157026.67760952/v1

Association of Cognitive Function, Depression, and Quality of Sleep with Statins among Oldest-Old Individuals

Regalla, S. S., Anaika, G., Reddy, B. M., Sharma, P. K., & Ganguly, E. (2022) · Journal of The Indian Academy of Geriatrics · doi:10.4103/jiag.jiag_34_21

Rosuvastatin ameliorates anxiety but impairs skeletal muscle performance by malondialdehyde and calcium depletion in high fat diet-fed swiss albino mice

Abi, I., Matthias, S. O., & Saater, E. M. (2024) · Journal of African Association of Physiological Sciences · doi:10.4314/jaaps.v11i2.1

Associations between statin use and depressive disorders and suicidal behaviour

Roztocka, A., Radziszewski, K., Osiński, P., Szlęzak, Z. A., Kulinek, A. J., & Stefaniak, I. (2025) · Psychiatria i Psychologia Kliniczna · doi:10.15557/pipk.2025.0017

Response to letter to the editor on methodological and biological considerations for interpreting statin–depression associations

Peng, T.-R., Tsai, P.-Y., & Lee, J.-A. (2025) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2025.12.015

Low-density lipoprotein (LDL) in serum and measures of well-being

Koshino, A., & Hara, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-28842-5.00017-x

Association between beta-blocker and statin use and mental health in patients following pulmonary embolism: a prospective cohort study

Sabljo, D., Fischer, S., Berghaus, T. M., Linseisen, J., Meisinger, C., & Schmitz, T. (2026) · BMC Psychology · doi:10.1186/s40359-026-05187-w

Statins for the treatment of depression: A meta-analysis of randomized, double-blind, placebo-controlled trials

Salagre, E., Fernandes, B. S., Dodd, S., Brownstein, D. J., & Berk, M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.04.047 · Cited by 117 · see citing works

Do statins have an effect on depressive symptoms? A systematic review and meta-analysis

Yatham, M. S., Yatham, K. S., Ravindran, A. V., & Sullivan, F. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.002 · Cited by 60 · see citing works

The impact of statins on psychological wellbeing: 12A systematic review and meta-analysis

(12318020), A. O., (14469369), L. S., (13691701), C. R., (13288359), K. S., Jacka, F. N., Williams, L., (13077054), J. P., & Berk, M. (2024) · Figshare

Statins cholesterol lowering and mental health: a review

Pazarlis, P., Katsigiannopoulos, K., Bolimou, S., Ioakimidou, A., Papazisis, G., Xidopoulos, G., Vasiliadis, P., Dampalis, A., Milousis, A., & Antonoglou, C. (2006) · Annals of General Psychiatry · doi:10.1186/1744-859x-5-s1-s251

The Effect of Statins as Adjunctive Therapy for Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Junior, A. D. V. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.22820634