The risk of developing cardiovascular disease in bipolar disorder. Biological factors and therapy
Open accessAbstract
BACKGROUND: Bipolar disorder (BD) is one of the most common mental disorders characterized by alternating episodes of mania/hypomania and depression, as well as the possibility of developing mixed conditions. Correct and timely diagnosis of BD is important due to the presence of a high suicidal risk and a high predisposition to the development of cardiovascular disease (CVD). The risk of CVD is higher in ВD than in other mental disorders. MATERIALS AND METHODS: A sample assessment was made of current studies focusing on the vascular-bipolar link. The search was carried out in the PubMed and eLIBRARY databases for the following keywords: bipolar disorder, psychopharmacology, cardiovascular disease, biological mediators. RESULTS: There are several biological factors which explain the close association and common pathogenetic mechanisms of BD and CVD. The most interesting of them are inflammation, oxidative stress, and brain-derived neurotrophic factor. Neuroimaging methods have shown similar structural brain changes in people with BD and with CVD. There is some evidence of the efficacy of statins and angiotensin-converting enzyme inhibitors in reducing cardio-vascular risk factors in BD patients. CONCLUSION: The predisposition of patients of BD to CVD is beyond doubt. It is necessary to consider the peculiarities of the course of BD and conduct active monitoring and preventive measures to reduce the risk of developing life-threatening CVDs. Further research focused on the pathogenetic relationship between BD and CVD could provide more insight into this area.
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Smoking is the most relevant biological mediator of comorbid cardiovascular disease in people with bipolar disorder.
“This mechanism also makes smoking the most relevant biological mediator of co-morbid cardiovascular disease in people with BD (38).”
From The detrimental effects of smoking on the course and outcome in adults with bipolar disorder—A narrative review (2023) · cites this paper as [38]
The section on inflammation, oxidative stress and BDNF (p. 580–581) discusses biological links between bipolar disorder and cardiovascular disease, but does not identify smoking as a mediator or rank it above other factors. Searches for курение (smoking), tobacco and nicotine found no passage in our copy addressing that claim. (LLM, conf=0.75)
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- АВП -антипсихотики II поколения БР -биполярное расстройство ДИ -доверительный интервал ИАПФ -ингибиторы ангиотензинпревращающего фермента ИЛ -интерлейкин ИМТ -индекс массы тела МРТ -магнитно-резонансная томография ОШ -отношение шансов РДР -рекуррентное депрессивное расстройство РКИ -рандомизированное клиническое исследование СРС -стандартизованное различие средних при 95% доверительном интервале ССЗ -сердечно-сосудистые заболевания ССФР -сердечно-сосудистые факторы риска ЦК -церебральный кровоток BDNF -нейротрофический фактор головного мозга ES -размер эффекта Список сокращений https://doi.org/10.26442/00403660.2022.04.201455 REVIEW ТЕРАПЕВТИЧЕСКИЙАРХИВ.2022;94(4):579-583. TERAPEVTICHESKIIARKHIV.2022;94(4):579-583. 583 · DOI
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“This mechanism also makes smoking the most relevant biological mediator of co-morbid cardiovascular disease in people with BD (38).”
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- Authors
- Mosolov, S. N., & Fedorova, E. Y.
- Affiliations
- Russian Medical Academy of Continuous Professional Education (RU)
- Federal Medical Research Centre for Psychiatry and Narcology (RU)
- Venue
- Terapevticheskii arkhiv
- Publisher
- Consilium Medicum
- Published
- 2022-05-26
- Volume
- 94
- Issue
- 4
- Pages
- 579-583
- ISSN
- 0040-3660 (ISSN-L)
- 2309-5342
- OpenAlex
- W4281554349
- Cited by
- 4
- References
- 48
- Citations by year
- 2024: 2 · 2023: 2
- FWCI
- 0.65
- Type
- journal article
- Language
- ru
- Open access
- diamond
- doi.org
- Licence
- Locations
- Terapevticheskii arkhiv (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- bipolar disorder, cardiovascular disease, inflammation, oxidative stress, brain-derived neurotrophic factor, neuroimaging, statins, ACE inhibitors, cardiovascular risk factors, psychopharmacology
- MeSH terms
- Angiotensin-Converting Enzyme Inhibitors, Biological Factors, Bipolar Disorder, Cardiovascular Diseases, Humans, Risk Factors, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Brain-Derived Neurotrophic Factor
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