LPS and TNF alpha modulate AMPA/NMDA receptor subunit expression and induce PGE2 and glutamate release in preterm fetal ovine mixed glial cultures
Open accessAbstract
BACKGROUND: White matter injury (WMI) is the major antecedent of cerebral palsy in premature infants, and is often associated with maternal infection and the fetal inflammatory response. The current study explores the therapeutic potential of glutamate receptor blockade or cyclooxygenase-2 (COX-2) inhibition for inflammatory WMI. METHODS: Using fetal ovine derived mixed glia cultures exposed to tumour necrosis factor-α (TNF-α) or lipopolysaccharide (LPS), the expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) and N-methyl D-aspartate (NMDA) glutamate receptors and their contribution to inflammation mediated pre-oligodendrocyte (OL) death was evaluated. The functional significance of TNF-α and COX-2 signalling in glutamate release in association with TNF-α and LPS exposure was also assessed. RESULTS: AMPA and NMDA receptors were expressed in primary mixed glial cultures on developing OLs, the main cell-type present in fetal white matter at a period of high risk for WMI. We show that glutamate receptor expression and configuration are regulated by TNF-α and LPS exposure, but AMPA and NMDA blockade, either alone or in combination, did not reduce pre-OL death. Furthermore, we demonstrate that glutamate and prostaglandin E2 (PGE2) release following TNF-α or LPS are mediated by a TNF-α-COX-2 dependent mechanism. CONCLUSIONS: Overall, these findings suggest that glial-localised glutamate receptors likely play a limited role in OL demise associated with chronic inflammation, but supports the COX-2 pathway as a potential therapeutic target for infection/inflammatory-mediated WMI.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple studies using different species document activation of microglia and astrocytes in response to maternal inflammation that leads to dysregulation in glutamate homeostasis.
“Multiple studies using different species of animals document an activation of microglia and astrocytes in response to maternal inflammation that leads to dysregulation in glutamate homeostasis (Roumier et al., 2008; Weaver-Mikaere et al., 2013; Zhang et al., 2016).”
From Neuroinflammation as a risk factor for attention deficit hyperactivity disorder (2019) · cites this paper as Weaver-Mikaere et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Epidemiology and causes of preterm birth
Goldenberg, R. L., Culhane, J. F., Iams, J. D., & Romero, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60074-4 · Cited by 7,801 · see citing works
Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,807 · see citing works
Quinoxalinediones: Potent Competitive Non-NMDA Glutamate Receptor Antagonists
Honoré, T., Davies, S. N., Drejer, J., Fletcher, E. J., Jacobsen, P., Lodge, D., & Nielsen, F. (1988) · Science · doi:10.1126/science.2899909 · Cited by 1,191 · see citing works
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
Bezzi, P., Carmignoto, G., Pasti, L., Vesce, S., Rossi, D., Rizzini, B. L., Pozzan, T., & Volterra, A. (1998) · Nature · doi:10.1038/34651 · Cited by 1,143 · see citing works
Neurobiology of Periventricular Leukomalacia in the Premature Infant
Volpe, J. J. (2001) · Pediatric Research · doi:10.1203/00006450-200111000-00003 · Cited by 945 · see citing works
NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
Káradóttir, R. T., Cavelier, P., Bergersen, L. H., & Attwell, D. (2005) · Nature · doi:10.1038/nature04302 · Cited by 773 · see citing works
Takeuchi, H., Jin, S., Wang, J., Zhang, G., Kawanokuchi, J., Kuno, R., Sonobe, Y., Mizuno, T., & Suzumura, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600504200 · Cited by 749 · see citing works
Can Adverse Neonatal Experiences Alter Brain Development and Subsequent Behavior?
Anand, K. J. S., & Scalzo, F. M. (2000) · Neonatology · doi:10.1159/000014197 · Cited by 615 · see citing works
Intrauterine infection and prematurity
Gonçalves, L. F., Chaiworapongsa, T., & Romero, R. J. (2002) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.10008 · Cited by 593 · see citing works
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury
Salter, M. G., & Fern, R. F. (2005) · Nature · doi:10.1038/nature04301 · Cited by 556 · see citing works
Werner, P., Pitt, D., & Raine, C. S. (2001) · Annals of Neurology · doi:10.1002/ana.1077 · Cited by 489 · see citing works
Vesicular release of glutamate from unmyelinated axons in white matter
Ziskin, J. L., Nishiyama, A., Rubio, M. E., Fukaya, M., & Bergles, D. E. (2007) · Nature Neuroscience · doi:10.1038/nn1854 · Cited by 476 · see citing works
Zou, J., & Crews, F. T. (2005) · Brain Research · doi:10.1016/j.brainres.2004.11.014 · Cited by 410 · see citing works
NBQX Attenuates Excitotoxic Injury in Developing White Matter
Follett, P. L., Rosenberg, P. A., Volpe, J. J., & Jensen, F. E. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09235.2000 · Cited by 389 · see citing works
Futaki, N., Yoshikawa, K., Hamasaka, Y., Arai, I., Higuchi, S., Iizuka, H., & Otomo, S. (1993) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(93)90018-s · Cited by 345 · see citing works
Glutamate‐mediated glial injury: Mechanisms and clinical importance
Matute, C., Domercq, M., & Sánchez‐Gómez, M. V. (2005) · Glia · doi:10.1002/glia.20275 · Cited by 330 · see citing works
Follett, P. L., Deng, W., Dai, W., Talos, D. M., Massillon, L. J., Rosenberg, P. A., Volpe, J. J., & Jensen, F. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0477-04.2004 · Cited by 314 · see citing works
Excitotoxicity in Perinatal Brain Injury
Johnston, M. V. (2005) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00526.x · Cited by 286 · see citing works
Cox-2-Selective Inhibitors: The New Super Aspirins
DeWitt, D. L. (1999) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23023-6 · Cited by 265 · see citing works
Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation
Barger, S. W., Goodwin, M. E., Porter, M. M., & Beggs, M. L. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04487.x · Cited by 255 · see citing works
Fetal Inflammatory Response and Brain Injury in the Preterm Newborn
Malaeb, S. N., & Dammann, O. (2009) · Journal of Child Neurology · doi:10.1177/0883073809338066 · Cited by 245 · see citing works
P2Y1 Receptor-evoked Glutamate Exocytosis from Astrocytes
Domercq, M., Brambilla, L., Pilati, E., Marchaland, J., Volterra, A., & Bezzi, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606429200 · Cited by 215 · see citing works
Deng, W., Rosenberg, P. A., Volpe, J. J., & Jensen, F. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1136624100 · Cited by 202 · see citing works
Leviton, A., Allred, E. N., Kuban, K., Hecht, J. L., Onderdonk, A. B., O’Shea, T. M., & Paneth, N. (2009) · Pediatric Research · doi:10.1203/pdr.0b013e3181bf5fab · Cited by 187 · see citing works
The Instrumented Fetal Sheep as a Model of Cerebral White Matter Injury in the Premature Infant
Back, S. A., Riddle, A., Dean, J. M., & Hohimer, A. R. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0108-y · Cited by 177 · see citing works
Manning, S. M., Talos, D. M., Zhou, C., Selip, D. B., Park, H.-K., Park, C., Volpe, J. J., & Jensen, F. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1702-08.2008 · Cited by 170 · see citing works
Molina‐Holgado, E., Vela, J. M., Arévalo‐Martín, Á., & Guaza, C. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01412.x · Cited by 162 · see citing works
Itoh, T., Beesley, J., Itoh, A., Cohen, A. S., Kavanaugh, B., Coulter, D. A., Grinspan, J. B., & Pleasure, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00866.x · Cited by 153 · see citing works
The interaction between MK-801 and receptors for : Functional consequences
Woodruff, G. N. (1987) · Neuropharmacology · doi:10.1016/0028-3908(87)90068-2 · Cited by 151 · see citing works
Antiepileptic drugs and brain development
Ikonomidou, C., & Turski, L. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.09.019 · Cited by 148 · see citing works
Production of Interleukin-10 by Mouse Glial Cells in Culture
Mizuno, T., Sawada, M., Marunouchi, T., & Suzumura, A. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2893 · Cited by 142 · see citing works
Mature myelin basic protein‐expressing oligodendrocytes are insensitive to kainate toxicity
Rosenberg, P. A., Dai, W., Gan, X. D., Ali, S., Fu, J. M., Back, S. A., Sanchez, R. M., Segal, M. M., Follett, P. L., Jensen, F. E., et al. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10472 · Cited by 135 · see citing works
Kim, J., Kondratyev, A. D., & Gale, K. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.126250 · Cited by 132 · see citing works
Kristensen, B. W., Noraberg, J., & Zimmer, J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02900-6 · Cited by 128 · see citing works
Araki, E., Forster, C. L., Dubinsky, J. M., Ross, M. E., & Iadecola, C. (2001) · Stroke · doi:10.1161/hs1001.096057 · Cited by 126 · see citing works
Expression of glutamate transporters in rat optic nerve oligodendrocytes
Domercq, M., Sánchez‐Gómez, M. V., Areso, P., & Matute, C. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00639.x · Cited by 124 · see citing works
; for the ELGAN Study Investigators, Leviton, A., Fichorova, R. N., O’Shea, T. M., Kuban, K., Paneth, N., Dammann, O., & Allred, E. N. (2012) · Pediatric Research · doi:10.1038/pr.2012.188 · Cited by 123 · see citing works
Back, S. A., Craig, A., Kayton, R. J., Luo, N. L., Meshul, C. K., Allcock, N., & Fern, R. F. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600344 · Cited by 105 · see citing works
Neuroprotective effects of topiramate after hypoxia–ischemia in newborn piglets
Schubert‐Bast, S., Brandl, U., Brodhun, M., Ulrich, C., Spaltmann, J., Fiedler, N., & Bauer, R. (2005) · Brain Research · doi:10.1016/j.brainres.2005.07.061 · Cited by 105 · see citing works
Simpson, K. L., Keelan, J. A., & Mitchell, M. D. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.12.5335 · Cited by 94 · see citing works
Self-citationMechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture
Rush, T., Liu, X. Q., Hjelmhaug, J., & Lobner, D. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.025 · Cited by 93 · see citing works
IL‐1β signalling in glial cells in wildtype and IL‐1RI deficient mice
Parker, L. C., Luheshi, G. N., Rothwell, N. J., & Pinteaux, E. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704715 · Cited by 90 · see citing works
McNaught, K. S. P., & Jenner, P. G. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00415-9 · Cited by 86 · see citing works
Lin, H., Wan, F.-J., Kang, B., Wu, C., & Tseng, C. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1218 · Cited by 84 · see citing works
Calcium dyshomeostasis in white matter pathology
Matute, C. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.12.004 · Cited by 81 · see citing works
Hirata, N., Yanagawa, Y., Ebihara, T., Seya, T., Uematsu, S., Akira, S., Hayashi, F., Iwabuchi, K., & Onoé, K. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.02.010 · Cited by 64 · see citing works
Weiss, J. H., Yin, H. Z., & Choi, D. W. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90494-4 · Cited by 60 · see citing works
Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function
Deng, W., Yue, Q., Rosenberg, P. A., Volpe, J. J., & Jensen, F. E. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03861.x · Cited by 58 · see citing works
Page, K. J., & Everitt, B. J. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01090.x · Cited by 56 · see citing works
Glutamate receptor‐mediated ischemic injury of premyelinated central axons
Alix, J. J. P., & Fern, R. F. (2009) · Annals of Neurology · doi:10.1002/ana.21767 · Cited by 55 · see citing works
Huang, W.-T., Niu, K., Chang, C.-K., Lin, M., & Chang, C. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.07.017 · Cited by 54 · see citing works
Carty, M. L., Wixey, J. A., Reinebrant, H. E., Gobe, G. C., Colditz, P. B., & Buller, K. M. (2011) · Brain Research · doi:10.1016/j.brainres.2011.06.001 · Cited by 52 · see citing works
Role of Glutamate Receptors in Periventricular Leukomalacia
Jensen, F. E. (2005) · Journal of Child Neurology · doi:10.1177/08830738050200120401 · Cited by 48 · see citing works
Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death
Carlson, N. G., Rojas, M. A., Redd, J. W., Tang, P., Wood, B., Hill, K. E., & ROSE, J. W. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-25 · Cited by 40 · see citing works
Högberg, H. T., & Bal‐Price, A. (2011) · Journal of Toxicology · doi:10.1155/2011/543512 · Cited by 32 · see citing works
Li, Y., Sameshima, H., Yamaguchi, M., & Ikenoue, T. (2005) · Journal of obstetrics and gynaecology research · doi:10.1111/j.1341-8076.2005.00266.x · Cited by 27 · see citing works
Cyclooxygenase-2 immunoreactivity in the ischemic neonatal human brain. An autopsy study.
Toti, P., Felice, C. D., Schürfeld, K., Stumpo, M., Bartolommei, S., Lombardi, A., Petraglia, F., & Buonocore, G. (2001) · PubMed · Cited by 23 · see citing works
Molina‐Holgado, F., Toulmond, S., & Rothwell, N. J. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00344-1 · Cited by 22 · see citing works
Ong, W., Leong, S. K., Garey, L. J., & Reynolds, R. (1996) · Experimental Brain Research · doi:10.1007/bf00229137 · Cited by 20 · see citing works
Simpson, K. L. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.12.4332 · Cited by 17 · see citing works
Pitfalls in the Quest of Neuroprotectants for the Perinatal Brain
Gressèns, P., Verche, V. L., Fraser, M., Rousset, C. I., Schwendimann, L., Bennet, L., George, S. A., Wang, X., Mallard, C. E., Tilley, B. C., et al. (2011) · Developmental Neuroscience · doi:10.1159/000333109 · Cited by 14 · see citing works
Self-citationDean, J. M., Fraser, M., Shelling, A. N., Bennet, L., George, S. A., Shaikh, S. B., Scheepens, A., & Gunn, A. J. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.05.026 · Cited by 11 · see citing works
Self-citationWeaver-Mikaere, L., Gibbons, H. M., Silva, D. D., & Fraser, M. (2012) · Developmental Neuroscience · doi:10.1159/000338039 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Neuroinflammation as a risk factor for attention deficit hyperactivity disorder
Dunn, G. A., Nigg, J. T., & Sullivan, E. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.005 · Cited by 299 · see citing works
Emerging Roles of miRNAs in Brain Development and Perinatal Brain Injury
Cho, K. H. T., Xu, B., Blenkiron, C., & Fraser, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00227 · Cited by 114 · see citing works
Self-citationOlmo, I. G., Carvalho, T. G., Costa, V. V., Alves‐Silva, J., Ferrari, C. Z., Izidoro‐Toledo, T. C., da Silva, J., Teixeira, A. L., Souza, D. G., Marques, J. T., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01016 · Cited by 96 · see citing works
Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus
Gussenhoven, R., Westerlaken, R. J. J., Ophelders, D. R. M. G., Jobe, A. H., Kemp, M. W., Kallapur, S. G., Zimmermann, L. J. I., Sangild, P. T., Pankratova, S., Gressèns, P., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1149-x · Cited by 80 · see citing works
Glia: A major player in glutamate–GABA dysregulation‐mediated neurodegeneration
Sood, A., Kumari, P., Fernandes, V., Khatri, D. K., & Singh, S. B. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24977 · Cited by 60 · see citing works
An integrated cytokine and kynurenine network as the basis of neuroimmune communication
Stone, T. W., Clanchy, F. I. L., Huang, Y., Chiang, N., Darlington, L. G., & Williams, R. O. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1002004 · Cited by 54 · see citing works
Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway
Balzano, T., Arenas, Y. M., Dadsetan, S., Forteza, J., Gil‐Perotín, S., Cubas-Núñez, L., Casanova, B., Gracià, F., Varela-Andrés, N., Montoliu, C., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01746-z · Cited by 52 · see citing works
Coquenlorge, S., Van Landeghem, L., Jaulin, J., Cenac, N., Vergnolle, N., Duchalais, E., Neunlist, M., & Rolli-Derkinderen, M. (2016) · Scientific Reports · doi:10.1038/srep25203 · Cited by 48 · see citing works
Stone, T. W., & Williams, R. O. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16015 · Cited by 43 · see citing works
Li, H., Zhou, J., Wei, X., Chen, R., Geng, J., Zheng, R., Chai, J., Li, F., & Jiang, S. (2016) · Scientific Reports · doi:10.1038/srep27914 · Cited by 36 · see citing works
Dhillon, S. K., Gunn, A. J., Jung, Y., Mathai, S., Bennet, L., & Fraser, M. (2015) · Developmental Neuroscience · doi:10.1159/000433422 · Cited by 30 · see citing works
Self-citationNeuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease
Chavda, V. K., Singh, K., Patel, V., Mishra, M., & Mishra, A. K. (2022) · Brain Sciences · doi:10.3390/brainsci12010075 · Cited by 29 · see citing works
Tumour Necrosis Factor in Neuroplasticity, Neurogenesis and Alcohol Use Disorder
Cooper, I. A., Beecher, K., Chehrehasa, F., Belmer, A., & Bartlett, S. E. (2020) · Brain Plasticity · doi:10.3233/bpl-190095 · Cited by 28 · see citing works
Cytokine regulation by modulation of the NMDA receptor on astrocytes
Sühs, K., Gudi, V., Eckermann, N., Fairless, R., Pul, R., Skripuletz, T., & Stangel, M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.07.016 · Cited by 27 · see citing works
Anaparti, V., Pascoe, C. D., Jha, A., Mahood, T. H., Ilarraza, R., Unruh, H. W., Moqbel, R., & Halayko, A. J. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00382.2015 · Cited by 23 · see citing works
Anti-Inflammatory Therapies for Treatment of Inflammation-Related Preterm Brain Injury
Prasad, J. D., Gunn, K. C., Davidson, J. O., Galinsky, R., Graham, S. E., Berry, M. J., Bennet, L., Gunn, A. J., & Dean, J. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084008 · Cited by 23 · see citing works
Self-citationHan, W.-M., Hao, X.-B., Hong, Y., Zhao, S., Chen, X.-C., Wang, R., Wang, Y., & Li, G. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01362-9 · Cited by 20 · see citing works
Cho, K. H. T., Wassink, G., Galinsky, R., Xu, B., Mathai, S., Dhillon, S. K., van den Heuij, L. G., Davidson, J. O., Weaver-Mikaere, L., Bennet, L., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45872-y · Cited by 18 · see citing works
Self-citationErdoğan, M. A., Nesil, P., Altuntas, I., Şirin, C., Uyanıkgil, Y., & Erbaş, O. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.07.013 · Cited by 15 · see citing works
Yang, Y., Su, Y., Wu, P.-L., Yang, C.-H., Yang, Y. S. H., Suen, J., & Yang, S. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/9797146 · Cited by 13 · see citing works
Potential neuroprotective strategies for perinatal infection and inflammation
Ranchhod, S. M., Gunn, K. C., Fowke, T. M., Davidson, J. O., Lear, C. A., Bai, J., Bennet, L., Mallard, C. E., Gunn, A. J., & Dean, J. M. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.02.006 · Cited by 11 · see citing works
Self-citationCui, J., Yu, S., Li, Y., Li, P., & Liu, F. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3331 · Cited by 11 · see citing works
Ćwiklińska, A., Przewodowska, D., Koziorowski, D., & Szlufik, S. (2024) · Cancers · doi:10.3390/cancers16244235 · Cited by 8 · see citing works
Ismailova, A. U., Ichetkina, K., Shults, M. R., Shults, A. S., Kurilova, E. A., & Tuchina, O. P. (2025) · Genes and Cells · doi:10.17816/gc655664 · Cited by 2 · see citing works
Cho, K. H. T., Zeng, N., Anekal, P. V., Xu, B., & Fraser, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-63770-6 · Cited by 2 · see citing works
Self-citationOriaifo, S. E. (2015) · International Research Journal of Medicine and Medical Sciences · doi:10.14303/jmms.2015.116 · Cited by 1 · see citing works
Antenatal inflammatory insults and preterm brain injury
Gussenhoven, R. (2019) · doi:10.26481/dis.20191216rg
Targeting oligodendrocytes in developmental neurotoxicity: A systematic literature review
Mohammed, V., Persson, C., Awoga, R. A., & Forsby, A. (2026) · NeuroToxicology · doi:10.1016/j.neuro.2026.103557
- Authors
- Weaver-Mikaere, L., Gunn, A. J., Mitchell, M. D., Bennet, L., & Fraser, M.
- Affiliations
- University of Auckland (NZ)
- Corresponding author
- Fraser, Mhoyra
- Venue
- Journal of Neuroinflammation
- Published
- 2013-12
- Volume
- 10
- Issue
- 1
- Pages
- 153-153
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC3878505
- OpenAlex
- W2151415982
- Cited by
- 29
- References
- 62
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 3
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by)
- Funders
- Kelliher Charitable Trust
- Health Research Council of New Zealand
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
- Keywords
- white matter injury, cerebral palsy, preterm infants, glutamate receptors, AMPA receptors, NMDA receptor, oligodendrocyte death, lipopolysaccharide, TNF-α, cyclooxygenase-2, prostaglandin E2, glutamate release, fetal brain, glial inflammation, maternal infection
- MeSH terms
- Animals, Brain Injuries, Cells, Cultured, Disease Models, Animal, Encephalitis, Fetus, Immunohistochemistry, Lipopolysaccharides, Neuroglia, Radioimmunoassay, Sheep, Tumor Necrosis Factor-alpha, Blotting, Western, Dinoprostone, Receptors, N-Methyl-D-Aspartate, Receptors, Glutamate, Receptors, AMPA, Glutamic Acid, Cyclooxygenase 2, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
