The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

American Journal of Pathology

(2015) · American Journal Of Pathology · doi:10.2353/ajpath · Cited by 4,961

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514

Neutrophils and immunity: challenges and opportunities

Nathan, C. (2006) · Nature reviews. Immunology · doi:10.1038/nri1785 · Cited by 2,971

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777

Immunoregulatory Feedback Between Interleukin-1 and Glucocorticoid Hormones

Besedovsky, H., del Rey, A., Sorkin, E., & Dinarello, C. A. (1986) · Science · doi:10.1126/science.3014662 · Cited by 1,519

Untitled work

Wyss-Coray (2006) · doi:10.1038/nm1484 · Cited by 1,284

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279

Anti-Inflammatory Action of Resveratrol in the Central Nervous System in Relation to Glucose Concentration—An In Vitro Study on a Blood–Brain Barrier Model

Komorowska, J., Wątroba, M., Bednarzak, M., Grabowska, A. D., & Szukiewicz, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063110 · Cited by 21

Administration of branched‐chain amino acids increases the susceptibility to lipopolysaccharide‐induced inflammation in young Wistar rats

Wessler, L. B., Ramos, V. D. M., Pasquali, M. A. D. B., Moreira, J. C. F., de Oliveira, J., Scaini, G., & STRECK, E. L. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.07.007 · Cited by 20

Evaluating the Effect of Interleukin-4 in the 3xTg Mouse Model of Alzheimer’s Disease

Dionisio-Santos, D. A., Behrouzi, A., Olschowka, J. A., & O’Banion, M. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00441 · Cited by 20

The in vivo functions of a histidine-rich protein Hpn in Helicobacter pylori: Linking gastric and Alzheimer’s diseases together?

Ge, R., & Sun, X. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.07.038 · Cited by 20

Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure

Çomaklı, S., Sevim, Ç., Kontadakis, G. A., Doğan, E., Taghizadehghalehjoughi, A., Özkaraca, M., Aschner, M., Νikolouzakis, Τ. Κ., & Tsatsakis, A. M. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.01.004 · Cited by 19

Short-term high-fat diet favors the appearances of apoptosis and gliosis by activation of ERK1/2/p38MAPK pathways in brain

Xu, C., Li, M., LiZhao, Chen, W.-G., & Wang, J. (2021) · Aging · doi:10.18632/aging.203607 · Cited by 18

Mitigating effects and mechanisms of Tai Chi on mild cognitive impairment in the elderly

Wang, X., Si, K., Gu, W., & Wang, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1028822 · Cited by 19

Inflammatory changes in the plasma and cerebrospinal fluid of patients with persistent pain and postpartum depression after elective Cesarean delivery: an exploratory prospective cohort study

Yurashevich, M., Cooter, M. L., Sims, S., Tan, H. S., Berger, M., Ji, R., & Habib, A. S. (2023) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-023-02603-2 · Cited by 18

Inflammasomes at the crossroads of traumatic brain injury and post-traumatic epilepsy

Javalgekar, M., Jupp, B., Vivash, L. E., O'Brien, T. J., Wright, D. K., Jones, N. C., & Ali, I. Y. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03167-8 · Cited by 19

Involvement of inflammasomes in the pathogenesis of Alzheimer's disease

Beder, N., Belkhelfa, M., & Leklou, H. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241283677 · Cited by 20

A novel IL-1RA-PEP fusion protein alleviates blood-brain barrier disruption after ischemia-reperfusion in male rats

Zhang, D., Jin, C., Zhang, Y.-T., Gan, X., Zou, M., Wang, Y., Fu, W., Xu, T., Xing, W., Xia, W., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1058-z · Cited by 19

Corticosterone and progesterone differentially regulate HPA axis and neuroimmune responses to stress in male rats

Hueston, C. M., & Terrence Deak, B. (2019) · Stress · doi:10.1080/10253890.2019.1678025 · Cited by 18

NLRP3 activation in endothelia promotes development of diabetes-associated atherosclerosis

Huang, D., Gao, W. Q., Zhong, X., & Ge, J. (2020) · Aging · doi:10.18632/aging.103666 · Cited by 18

Paeoniflorin exercise-mimetic potential regulates the Nrf2/HO-1/BDNF/CREB and APP/BACE-1/NF-κB/MAPK signaling pathways to reduce cognitive impairments and neuroinflammation in amnesic mouse model

Choi, J.-W., Im, J. Y., & Balakrishnan, R. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118299 · Cited by 19

Modulating neuroinflammation in neurodegeneration-related dementia: can microglial toll-like receptors pull the plug?

Tiwari, R. K., Moin, A., Rizvi, S. M. D., Shahid, S. M. A., & Bajpai, P. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00696-6 · Cited by 19

NLRP2 Is Overexpressed in Spinal Astrocytes at the Peak of Mechanical Pain Sensitivity during Complete Freund Adjuvant-Induced Persistent Pain

Ducza, L., Szűcs, P., Hegedűs, K., Bakk, E., Gajtkó, A., Wéber, I., & Holló, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111408 · Cited by 17

Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine

Sharma, S., Borski, C., Hanson, J. L., Garcia, M. A., Link, C. D., Hoeffer, C. A., Chatterjee, A., & Nagpal, P. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00365 · Cited by 15

Cognitive and inflammatory heterogeneity in severe mental illness: Translating findings from blood to brain

Sæther, L. S., Szabó, A., Akkouh, I. A., Haatveit, B. C., Mohn, C., Vaskinn, A., Aukrust, P., Ormerod, M. B. E. G., Steen, N. E., Melle, I. S., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.03.014 · Cited by 18

A New Use for an Old Treatment: Radiation Therapy and Alzheimer's Disease

Wilson, G. D., & Marples, B. (2016) · Radiation Research · doi:10.1667/rr14367.1 · Cited by 17

Side-Chain Immune Oxysterols Induce Neuroinflammation by Activating Microglia

Son, Y., Yeo, I.-J., Hong, J. T., Eo, S. K., Lee, D., & Kim, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015288 · Cited by 16

Microdose Lithium Treatment Reduced Inflammatory Factors and Neurodegeneration in Organotypic Hippocampal Culture of Old SAMP-8 Mice

Toricelli, M., Evangelista, S. R., Buck, H. S., & Viel, T. A. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00916-0 · Cited by 18

Hippocampal but Not Serum Cytokine Levels Are Altered by Traffic-Related Air Pollution in TgF344-AD and Wildtype Fischer 344 Rats in a Sex- and Age-Dependent Manner

Patten, K. T., Valenzuela, A. E., Wallis, C., Harvey, D. J., Bein, K. J., Wexler, A. S., Gorin, F. A., & Lein, P. J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.861733 · Cited by 17

Deoxynivalenol enhances IL-1ß expression in BV2 microglial cells through activation of the NF-κB pathway and the ASC/NLRP3 inflammasome

Molagoda, I. M. N., Lee, S., Jayasooriya, R. G. P. T., Jin, C.-Y., Choi, Y. H., & Kim, G. (2018) · EXCLI journal · doi:10.17179/excli2018-1974 · Cited by 16

The Neuroprotective Effect of Zingiber cassumunar Roxb. Extract on LPS‐Induced Neuronal Cell Loss and Astroglial Activation within the Hippocampus

Kongsui, R., Sriraksa, N., & Thongrong, S. (2020) · BioMed Research International · doi:10.1155/2020/4259316 · Cited by 16

Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer’s disease

Aparicio, N., Grande, M. T., Esteban, S. R. D. M., López, A., Ruiz‐Pérez, G., Amores, M., Vázquez, C., Martínez-Relimpio, A. M., Pazos, M. R., Cravatt, B. F., et al. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.009 · Cited by 16

Mind the Gap: Unraveling the Intricate Dance Between Alzheimer’s Disease and Related Dementias and Bone Health

Karnik, S. J., Margetts, T. J., Wang, H. S., Movilă, A., Oblak, A. L., Fehrenbacher, J. C., Kacena, M. A., & Plotkin, L. I. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00847-x · Cited by 15

Unravelling the neuroinflammatory links in depression: the potential of a lipopolysaccharide preclinical model

Pienaar, L., Baijnath, S., & Millen, A. M. E. (2024) · Discover Medicine · doi:10.1007/s44337-024-00114-7 · Cited by 16

There is no correlation between peripheral inflammation and cognitive status at diagnosis in Alzheimer’s disease

Julian, A., Dugast, E., Ragot, S., Krolak‐Salmon, P., Berrut, G., DANTOINE, T. F., Hommet, C., Hanon, O., Page, G., & Paccalin, M. (2015) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0332-5 · Cited by 16

TNFα Triggers an Augmented Inflammatory Response in Brain Neurons from Dahl Salt-Sensitive Rats Compared with Normal Sprague Dawley Rats

Gao, H., Bigalke, J. A., Jiang, E., Fan, Y., Chen, B., Chen, Q., & Shan, Z. J. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01056-9 · Cited by 15

IL-1R2 expression in human gastric cancer and its clinical significance

Yuan, M., Wang, L., Huang, H., Li, Y., Zheng, X. W., Shao, Q., & Jiang, J. (2021) · Bioscience Reports · doi:10.1042/bsr20204425 · Cited by 15

Metabolic syndrome as an independent risk factor for glaucoma: a nationally representative study

Lee, J., Kwon, Y., Kim, S., & Joung, B. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01151-5 · Cited by 14

Antioxidant and Anti-Inflammatory Effects of Bischofia javanica (Blume) Leaf Methanol Extracts through the Regulation of Nrf2 and TAK1

Lee, S., Ha, J., Park, J., Kang, E., Jeon, S.-H., Han, S. B., Ningsih, S. S., Paik, J. H., & Cho, S. (2021) · Antioxidants · doi:10.3390/antiox10081295 · Cited by 17

Plexin-A1 is required for Toll-like receptor-mediated microglial activation in the development of lipopolysaccharide-induced encephalopathy

Ito, T., Yoshida, K., Negishi, T., Miyajima, M., Takamatsu, H., Kikutani, H., Kumanogoh, A., & Yukawa, K. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1690 · Cited by 14

Structural Basis for LAR-RPTP-Mediated Synaptogenesis.

Won, S. Y., & Kim, H. M. (2018) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2018.0202 · Cited by 14

A 3D human iPSC-derived multi-cell type neurosphere system to model cellular responses to chronic amyloidosis

Wendt, S., Lin, A. J., Ebert, S. N., Brennan, D. J., Cai, W., Bai, Y., Kong, D. Y., Sorrentino, S., Groten, C. J., Lee, C., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03433-3 · Cited by 13

LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β1-42 Fibrils

Filippini, A., Salvi, V., Dattilo, V., Magri, C., Castrezzati, S., Veerhuis, R., Bosisio, D., Gennarelli, M., & Russo, I. (2023) · Biomolecules · doi:10.3390/biom13020307 · Cited by 13

Diagnostic methods and biomarkers for Alzheimer’s disease

Bagyinszky, E., Youn, Y. C., An, S. S. A., & Kim, S. (2014) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-014-0198-5 · Cited by 13

In Silico Investigation of Propolis Compounds as Potential Neuroprotective Agent

(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac126.82858306 · Cited by 13

cFLIP is critical for oligodendrocyte protection from inflammation

Tanner, D. C., Campbell, A., O’Banion, M. K., Noble, M., & Mayer-Pröschel, M. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2014.237 · Cited by 13

Sleep Deprivation Alters the Pituitary Stress Transcriptome in Male and Female Mice

Oyola, M. G., Shupe, E. A., Soltis, A. R., Sukumar, G., Páez-Pereda, M., Larco, D. O., Wilkerson, M. D., Rothwell, S. W., Dalgard, C. L., & Wu, T. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00676 · Cited by 14

The E. coli CNF1 as a Pioneering Therapy for the Central Nervous System Diseases

Travaglione, S., Loizzo, S., Ballan, G., Fiorentini, C., & Fabbri, A. (2014) · Toxins · doi:10.3390/toxins6010270 · Cited by 14

Correction: CNF1 Increases Brain Energy Level, Counteracts Neuroinflammatory Markers and Rescues Cognitive Deficits in a Murine Model of Alzheimer's Disease

Loizzo, S., Rimondini, R., Travaglione, S., Fabbri, A., Guidotti, M., Ferri, A., Campana, G., & Fiorentini, C. (2013) · PLoS ONE · doi:10.1371/annotation/8da0f878-fcab-4f65-bad0-c5bdda8181ed · Cited by 13

Interlacing the relevance of caspase activation in the onset and progression of Alzheimer’s disease

Dhage, P. A., Sharbidre, A. A., & Magdum, S. M. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.11.008 · Cited by 12

Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice

Schenck, J. K., Paredes, C. C., Pushkarsky, T., Wang, Y., Miller, R. H., & Bukrinsky, M. (2024) · Life Science Alliance · doi:10.26508/lsa.202402879 · Cited by 13

Therapeutic potential of chrysin in regulation of interleukin-17 signaling in a repeated intranasal amyloid-beta-induced Alzheimer's disease model

Gautam, A. S., Panda, E. S., Balki, S., Pandey, S. K., Tiwari, A., & Singh, R. K. (2024) · Food & Function · doi:10.1039/d4fo05278a · Cited by 13

Cytokines as Neuromodulators: Insights From Experimental Studies With Humans and Nonhuman Primates

Martins, D., & Harrison, N. A. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.06.037 · Cited by 16

Excessive Expression of Microglia/Macrophage and Proinflammatory Mediators in Olfactory Bulb and Olfactory Dysfunction After Stroke

Yeh, C., Chuang, T., Lan, M., Chin, Y., Wang, W., & Lin, Y.-Y. (2019) · In Vivo · doi:10.21873/invivo.11683 · Cited by 12

NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease‐like pathology in mice by targeting protein phosphatase magnesium‐dependent 1A phosphatase

Lv, J., Shen, X., Shen, X.-Y., Zhao, S., Xu, R., Yan, Q., Lu, J., Zhu, D., Zhao, Y., Dong, J., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.7945 · Cited by 12

Enduring effects of an unhealthy diet during adolescence on systemic but not neurobehavioural measures in adult rats

Nicolas, S., Ó’Léime, C. S., Hoban, A. E., Hueston, C. M., Cryan, J. F., & Nolan, Y. M. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1796041 · Cited by 12

Expression of proteins linked to Alzheimer’s disease in C6 rat glioma cells under the action of lipopolysaccharide (LPS), nimesulide, resveratrol and citalopram

Martínez-Díaz, J. A., Hernández‐Aguilar, M. E., Rojas-Durán, F., Herrera‐Covarrubias, D., García, L. I., Mestizo-Gutiérrez, S. L., & Aranda-Abreu, G. E. (2020) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2020-0091 · Cited by 12

Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females

Wang, T., Mao, Z., Shang, Y., Merlini, S., Vitali, F., Wiegand, J. L., & Brinton, R. D. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1632877 · Cited by 12

Intermittent hypoxia: linkage between OSAS and epilepsy

Ma, Y., & Wu, Q. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1230313 · Cited by 11

miRNA‐211‐5p inhibition enhances the protective effect of hucMSC‐derived exosome in Aβ1‐40‐induced SH‐SY5Y cells by increasing NEP expression

Chen, H., Huang, Z., Lei, A., Yu, X., Shen, M., & Wu, D. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23624 · Cited by 12

Radiotherapy for non-cancer diseases: benefits and long-term risks

Thariat, J., Little, M. P., Zablotska, L. B., Samson, P. P., O’Banion, M. K., Leuraud, K., Bergom, C. R., Girault, G., Azimzadeh, O., Bouffler, S. D., et al. (2024) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2295966 · Cited by 14

Emerging functions and therapeutic targets of IL‐38 in central nervous system diseases

Gao, Y., Cai, L., Wu, Y., Jiang, M., Zhang, Y., Ren, W., Song, Y., Li, L., Lei, Z., Wu, Y., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14550 · Cited by 11

Epistasis analysis links immune cascades and cerebral amyloidosis

Initiative, A. D. N., Benedet, A. L., Labbe, A., Lemay, P., Zimmer, E. R., Pascoal, T. A., Leuzy, A., Mathotaarachchi, S. S., Mohades, S., Shin, M., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0436-z · Cited by 13

Ethanolic extract of Sophora japonica flower buds alleviates cognitive deficits induced by scopolamine in mice

Bui, T. T., & Nguyen, H. T. (2017) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-017-0286-6 · Cited by 11

Effects of Microglial Cytokines on Alzheimer’s Disease-Related Phenomena

Ji, Y., Wang, X., Kalicki, C. H., Menta, B. W., Baumgardner, M., Koppel, S. J., Weidling, I. W., Ortiz, J. P., Wilkins, H., & Swerdlow, R. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180820 · Cited by 12

Cadmium-induced gut dysbiosis precedes the onset of hippocampus-dependent learning and memory deficits in mice

Wang, H., Lim, J. J., Gu, H., Xia, Z., & Cui, J. Y. (2025) · Toxicology · doi:10.1016/j.tox.2025.154265 · Cited by 11

Differential neuroprotective effect of curcuminoid formulations in aluminum chloride–induced Alzheimer’s disease

Shabbir, A., Rehman, K., Akash, M. S. H., Akbar, M., Chaudhary, Z., Panichayupakaranant, P., & Shah, M. A. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-20593-4 · Cited by 10

Neuroinflammation to neurodegeneration: Boulevard of broken nerves

Attiq, A., Afzal, S., Raman, H., & Ahmad, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115015 · Cited by 12

Plasma Cytokines Profile in Subjects with Alzheimer’s Disease: Interleukin 1 Alpha as a Candidate for Target Therapy

Mahdavi, M., Karima, S., Rajaei, S., Aghamolaii, V., Ghahremani, H., Ataeia, R., Tehrani, H. S., Baram, S. M., Tafakhori, A., Lima, B. S., et al. (2021) · Galen Medical Journal · doi:10.31661/gmj.v10i0.1974 · Cited by 10

Neuroinflammation in Tinnitus

Adcock, K. S., & Vanneste, S. (2022) · Current Otorhinolaryngology Reports · doi:10.1007/s40136-022-00411-8 · Cited by 10

Cytokine Profiling in Aqueous Humor of Glaucoma Patients and in Retinas from an Ex Vivo Glaucoma Animal Model

Tang, J., Sun, M., Feng, Y., Prokosch, V., Cui, H., & Liu, H. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2901029 · Cited by 10

Stabilized Low-n Amyloid-β Oligomers Induce Robust Novel Object Recognition Deficits Associated with Inflammatory, Synaptic, and GABAergic Dysfunction in the Rat

Watremez, W., Jackson, J. D., Almari, B., McLean, S. L., Grayson, B., Neill, J. C., Fischer, N., Allouche, A., Koziel, V., Pillot, T., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170489 · Cited by 13

Co-Localization of DNA i-Motif-Forming Sequences and 5-Hydroxymethyl-cytosines in Human Embryonic Stem Cells

Bhavsar-Jog, Y. P., Dornshuld, E. V., Brooks, T. A., Tschumper, G. S., & Wadkins, R. M. (2019) · Molecules · doi:10.3390/molecules24193619 · Cited by 10

Impact of Phthalates and Parabens on the Neurobehavioral and Reproductive Function: A Review

Yesumanipreethi, S., Magadalenal, N. N., & Inbaraj, R. (2021) · Proceedings of the Zoological Society · doi:10.1007/s12595-021-00408-z · Cited by 7

In Vitro Blood-Brain Barrier Models for Neuroinfectious Diseases: A Narrative Review

Badawi, A. H. J., Mohamad, N. A., Stanslas, J., Kirby, B. P., Neela, V. K., Ramasamy, R., & Basri, H. (2023) · Current Neuropharmacology · doi:10.2174/1570159x22666231207114346 · Cited by 13

Exploring the role of interleukin-1β and interleukin-6 in the pathophysiology of obsessive-compulsive disorder

Sarmin, N., Roknuzzaman, A. S. M., Sarker, R., Mamun-or-Rashid, Hasan, A., Qusar, M. S., Kabir, E. R., Islam, M. R., & Mahmud, Z. A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0306125 · Cited by 10

Primary cortical cell tri-culture to study effects of amyloid-β on microglia function and neuroinflammatory response

Kim, H., Le, B., Goshi, N., Zhu, K., Grodzki, A. C., Lein, P. J., Zhao, M., & Şeker, E. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241291142 · Cited by 11

Therapeutic Effects of TianDiJingWan on the Aβ25–35-Induced Alzheimer’s Disease Model Rats

Li, Z., Tong, Q., Xu, H., Hu, L., Zhao, R., Zhou, F., Pan, W., & Zhou, L. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/307350 · Cited by 9

P2X7-dependent constitutive Interleukin-1β release from pyramidal neurons of the normal mouse hippocampus: Evidence for a role in maintenance of the innate seizure threshold

Dutta, S. S., Andonova, A. A., Wöellert, T., Hewett, S. J., & Hewett, J. A. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105689 · Cited by 9

Intrahippocampal injection of IL ‐1β upregulates Siah1‐mediated degradation of synaptophysin by activation of the ERK signaling in male rat

Zhou, Q., Lin, L., Li, H., Li, Y., Liu, N., Wang, H., Jiang, S., Li, Q., Chen, Z., Lin, Y., et al. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25170 · Cited by 9

Are IL-1 family cytokines important in management of sickle cell disease in Sub-Saharan Africa patients?

Siransy, L. K., Dassé, R., Adou, H., Kouacou, P., Kouamenan, S., Sékongo, Y. M., Yeboah, R., Memel, C., Assi-Sahoin, A., Salimata, M., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.954054 · Cited by 9

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Li, F., Oh, I. Y., Kumar, S., Eteleeb, A. M., Gupta, A., Buchser, W., Xiong, C., Cole, S. F., McDade, E., Karch, C. M. M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.19.508592 · Cited by 9

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Olğun, Y., Poyraz, C. A., Bozluolçay, M., Konukoğlu, D., & Poyraz, B. Ç. (2024) · Current Alzheimer Research · doi:10.2174/0115672050313419240520051751 · Cited by 9

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Coats, S. R., Su, T., Miller, Z. L., King, A. J., Ortiz, J. L. J., Reddy, A., Alaei, S. R., & Jain, S. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkae050 · Cited by 9

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Rahmani, N., Mohammadi, M., Manaheji, H. S., Maghsoudi, N., Katinger, H. W. D., Baniasadi, M., & Zaringhalam, J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113576 · Cited by 8

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Patsouris, V., Blecharz-Lang, K. G., Nieminen-Kelhä, M., Schneider, U. C., & Vajkoczy, P. (2023) · Neurocritical Care · doi:10.1007/s12028-023-01770-w · Cited by 8

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Chamaa, F., Bitar, L., Darwish, B., Saadé, N. E., & Abou-Kheir, W. G. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.12.013 · Cited by 8

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Irani, M. A., & Ejtehadi, M. R. (2020) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2020.1841027 · Cited by 8

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Caruso, G., Fresta, C. G., Fidilio, A., Lazzara, F., Musso, N., Cardaci, V., Drago, F., Caraci, F., & Bucolo, C. (2023) · Molecules · doi:10.3390/molecules28083324 · Cited by 9

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Komorowska, J., Wątroba, M., Bednarzak, M., Grabowska, A. D., & Szukiewicz, D. (2023) · Medical Science Monitor · doi:10.12659/msm.941044 · Cited by 8

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Herman, A. P., Krawczyńska, A., Bochenek, J., Haziak, K., Antushevich, H., Herman, A., & Tomaszewska-Zaremba, D. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2012.10.003 · Cited by 8

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MUSHTAQ, S., Hanif, U., Shah, M. A., Ali, N. M., Chauhdary, Z., Qasim, M., MUNEEB, M., CHAUDHARY, M., & Marium, D. A. R. (2023) · Notulae Botanicae Horti Agrobotanici Cluj-Napoca · doi:10.15835/nbha51313228 · Cited by 7

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Yang, I., Kuan, C., Zhang, S., Chen, Z., Li, C.-H., Liang, Y., Kuo, W., Chang, C., Lin, J., Hsieh, H., et al. (2024) · European Polymer Journal · doi:10.1016/j.eurpolymj.2024.113151 · Cited by 7

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Smirnova, M. I., & Quan, N. (2025) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2025.100123 · Cited by 8

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Kurmi, S., Doshi, G., & Parab, S. B. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273377780250505115039 · Cited by 7

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Sharifi, H., Nayebi, A. M., & Farajnia, S. (2013) · Europe PMC (PubMed Central) · Cited by 7

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Taoro‐González, L., Arenas, Y. M., Cabrera‐Pastor, A., & Felipo, V. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1387-z · Cited by 7

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Sheikh, W. G. E., Sleem, B., Kobeissy, F. H., & Bizri, M. (2023) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2023.100064 · Cited by 10

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Hoozemans, J. J. M. (2014) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000243 · Cited by 8

Role of phosphodiesterase inhibitor Ibudilast in morphine-induced hippocampal injury

Zhaleh, M., Panahi, M., Broujerdnia, M. G., Ghorbani, R., Angali, K. A., & Saki, G. (2013) · Journal of Injury and Violence Research · doi:10.5249/jivr.v6i2.497 · Cited by 7

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Dias, P., Freiberger, V., Ventura, L., Bragagnolo, D., Dutra, M. L., Horewicz, V. V., & Comim, C. M. (2019) · BioMed Research International · doi:10.1155/2019/9573248 · Cited by 8

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Kim, H. S., Jang, J. M., Yun, S. Y., Zhou, D., Piao, Y., Ha, H. C., Back, M. J., Shin, I. C., & Kim, D. K. (2019) · In Vivo · doi:10.21873/invivo.11684 · Cited by 7

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Cuervo-Zanatta, D., Pérez-Grijalva, B., González-Magaña, E., Hernández-Acosta, J., Murugesan, S., García-Mena, J., & Perez‐Cruz, C. (2021) · Studies in natural products chemistry · doi:10.1016/b978-0-12-819489-8.00019-3 · Cited by 7

Deer Bone Oil Extract Suppresses Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Cells

Choi, H., Im, S., Park, Y., Hong, K., & Suh, H. J. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00952 · Cited by 6

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Morisaki, M., Rezaali, F., Lau, L. C., Boche, D., Khandaker, G. M., Turecki, G., & Sinclair, L. I. (2025) · PLoS ONE · doi:10.1371/journal.pone.0320561 · Cited by 6

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Ali, M., Timsina, J., Xu, Y., Chen, Y., Gong, K., Western, D., Heo, G., Liu, M., Budde, J., Pottier, C. P., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.02.035 · Cited by 9

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Cheng, W., Lee, X.-Z., Lai, M. S., Ho, J. Y. S., & Chang, R. C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1469737 · Cited by 7

Journal of Neuroinflammation BioMed Central Review The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

Shaftel, S. S., Sue, W., Griffin, T., & O’Banion, M. K. (2008)

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O’Banion, M. K., Matousek, S. B., Shaftel, S. S., Kyrkanides, S., & Olschowka, J. A. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.745

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Wang, H., & Wang, X. (2017) · InTech eBooks · doi:10.5772/intechopen.69067 · Cited by 4

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Spulber, S. D., & Schultzberg, M. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.015 · Cited by 36

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Resch, S. N. (2015) · CUNY Academic Works (City University of New York) · Cited by 1