Cited by 565Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsInflammasome and immune disorders

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The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

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Shaftel, Solomon S, Griffin, W Sue T, O'Banion, M Kerry·2008·Journal of Neuroinflammation

DOI 10.1186/1742-2094-5-7PMC PMC2335091

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Abstract

Elevation of the proinflammatory cytokine Interleukin-1 (IL-1) is an integral part of the local tissue reaction to central nervous system (CNS) insult. The discovery of increased IL-1 levels in patients following acute injury and in chronic neurodegenerative disease laid the foundation for two decades of research that has provided important details regarding IL-1's biology and function in the CNS. IL-1 elevation is now recognized as a critical component of the brain's patterned response to insults, termed neuroinflammation, and of leukocyte recruitment to the CNS. These processes are believed to underlie IL-1's function in the setting of acute brain injury, where it has been ascribed potential roles in repair as well as in exacerbation of damage. Explorations of IL-1's role in chronic neurodegenerative disease have mainly focused on Alzheimer disease (AD), where indirect evidence has implicated it in disease pathogenesis. However, recent observations in animal models challenge earlier assumptions that IL-1 elevation and resulting neuroinflammatory processes play a purely detrimental role in AD, and prompt a need for new characterizations of IL-1 function. Potentially adaptive functions of IL-1 elevation in AD warrant further mechanistic studies, and provide evidence that enhancement of these effects may help to alleviate the pathologic burden of disease.

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Figure 1 A schematic depiction of potential roles of IL-1 in AD.CC BY · PubMed Central

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Authors: Shaftel, S. S., Griffin, W. S. T., & O'Banion, M. K.
Affiliations: University of Rochester Medicine (US)
University of Arkansas for Medical Sciences (US)
ORCID: Griffin, W Sue T
Venue: Journal of Neuroinflammation
Publisher: Springer Science and Business Media LLC
Published: 2008-02-26
Volume: 5
Issue: 1
Pages: 7-7
ISSN: 1742-2094 (ISSN-L)
DOI: 10.1186/1742-2094-5-7
PMC: PMC2335091
OpenAlex: W2015186493
Cited by: 565
References: 158
Citations by year: 2026: 22 · 2025: 49 · 2024: 47 · 2023: 55 · 2022: 36 · 2021: 43 · 2020: 42 · 2019: 34 · 2018: 23 · 2017: 28 · 2016: 21 · 2015: 30 · 2014: 27 · 2013: 32 · 2012: 25
FWCI: 1.46
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Journal of Neuroinflammation (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R21NS048522)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: interleukin-1, neuroinflammation, Alzheimer's disease, inflammatory cytokines, acute brain injury, neurodegenerative diseases, leukocyte recruitment
MeSH terms: Alzheimer Disease, Animals, Central Nervous System, Encephalitis, Humans, Interleukin-1, Leukocytes

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The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective

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