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Cosinor-based rhythmometry

Open access
Cornelissen, Germaine·2014·Theoretical Biology and Medical Modelling

Abstract

A brief overview is provided of cosinor-based techniques for the analysis of time series in chronobiology. Conceived as a regression problem, the method is applicable to non-equidistant data, a major advantage. Another dividend is the feasibility of deriving confidence intervals for parameters of rhythmic components of known periods, readily drawn from the least squares procedure, stressing the importance of prior (external) information. Originally developed for the analysis of short and sparse data series, the extended cosinor has been further developed for the analysis of long time series, focusing both on rhythm detection and parameter estimation. Attention is given to the assumptions underlying the use of the cosinor and ways to determine whether they are satisfied. In particular, ways of dealing with non-stationary data are presented. Examples illustrate the use of the different cosinor-based methods, extending their application from the study of circadian rhythms to the mapping of broad time structures (chronomes).

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Metadata

Authors
Cornelissen, G.
Venue
Theoretical Biology and Medical Modelling
Published
2014-04-11
Volume
11
Issue
1
Pages
16-16
ISSN
1742-4682 (ISSN-L)
OpenAlex
W2098342740
Cited by
811
References
3
FWCI
9.19
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Cosinor-based rhythmometry. https://app.cochat.ai/papers/10.1186/1742-4682-11-16
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Cornelissen, G. (2014). Cosinor-based rhythmometry. Theoretical Biology and Medical Modelling. https://doi.org/10.1186/1742-4682-11-16

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.