The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Curcumin, inflammation, ageing and age-related diseases
Open accessAbstract
A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy between April 7 and 8th 2009. Here the lecture by Sikora with some input from the chairpersons Scapagnini and Barbagallo is summarized. Ageing is manifested by the decreasing health status and increasing probability to acquire age-related disease such as cancer, Alzheimer's disease, atherosclerosis, metabolic disorders and others. They are likely caused by low grade inflammation driven by oxygen stress and manifested by the increased level of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-alpha, encoded by genes activated by the transcription factor NF-kappaB. It is believed that ageing is plastic and can be slowed down by caloric restriction as well as by some nutraceuticals. Accordingly, slowing down ageing and postponing the onset of age-related diseases might be achieved by blocking the NF-kappaB-dependent inflammation. In this review we consider the possibility of the spice curcumin, a powerful antioxidant and anti-inflammatory agent possibly capable of improving the health status of the elderly.
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Cites
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Neuroprotective effects of curcumin
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The molecular inflammatory process in aging
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Puzzles, promises and a cure for ageing
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“Cellular participants in low-grade inflammatory status not only include cells of the immune sytem but also other ones which have undergone genotoxic stress-induced senescence and secrete many inflammatory cytokines, to the so-called senescence-associated secretory phenotype (SASP) [9].”
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Cited by
Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?
He, Y., Yue, Y., Zheng, X., Zhang, K., Chen, S., & Du, Z. (2015) · Molecules · doi:10.3390/molecules20059183 · Cited by 608
Sirtuins, a promising target in slowing down the ageing process
Grabowska, W., Sikora, E., & Bielak-Zmijewska, A. (2017) · Biogerontology · doi:10.1007/s10522-017-9685-9 · Cited by 470
Self-citationDominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433
Self-citationShen, C., Jiang, J., Yang, L., Wang, D., & Zhu, W. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13631 · Cited by 344
Functional foods based on extracts or compounds derived from mushrooms
Reis, F. S., Martins, A., Vasconcelos, M. H., Morales, P., & Ferreira, I. C. F. R. (2017) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2017.05.010 · Cited by 267
Metadata
- Authors
- Sikora, E., Scapagnini, G., & Barbagallo, M.
- Venue
- Immunity & Ageing
- Published
- 2010-01-17
- Volume
- 7
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1742-4933 (ISSN-L)
- OpenAlex
- W2142839021
- Cited by
- 164
- References
- 8
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
