Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and CMV UL130 originate from chemokines
Open accessAbstract
Herpesviridae is a large family of DNA viruses divided into three subfamilies: Alpha-, Beta- and Gammaherpesvirinae. The process of herpesvirus transmission is mediated by a range of proteins, one of which is glycoprotein L (gL). Based on our analysis of the solved structures of HSV2 and EBV gH/gL complexes, we propose that Alphaherpesvirinae and Gammaherpesvirinae glycoprotein L and Betaherpesvirinae UL130 originate from chemokines. Herpes simplex virus type 2 gL and human cytomegalovirus homolog (UL130) adopt a novel C chemokine-like fold, while Epstein-Barr virus gL mimics a CC chemokine structure. Hence, it is possible that gL interface with specific chemokine receptors during the transmission of Herpesviridae. We conclude that the further understanding of the function of viral chemokine-like proteins in Herpesviridae infection may lead to development of novel prophylactic and therapeutic treatment.
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Viral infection facilitates neurodegenerative disease development, such as Alzheimer's disease, Multiple Sclerosis and Parkinson's Disease.
“These evidences indicate that viral infection facilitates neurodegenerative disease development, as Alzheimer’s disease, Multiple Sclerosis and Parkinson’s Disease [140].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [140]
Experimental evidence supports that viral infection may evoke neuronal death, encephalopathy, myelin destruction and juvenile Parkinson's disease development; however, these studies did not include coronaviruses.
“Experimental evidence supports that viral infection may evoke neuronal death, encephalopathy, myelin destruction and juvenile Parkinson’s disease development; however, these studies did not include coronaviruses [140].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [140]
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- Authors
- Malkowska, M., Kokoszynska, K., Dymecka, M., Rychlewski, L., & Wyrwicz, L. S.
- Affiliations
- BioInfoBank Institute (PL)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- Corresponding author
- Wyrwicz, Lucjan S
- ORCID
- Wyrwicz, Lucjan S
- Venue
- Virology Journal
- Published
- 2013-01-02
- Volume
- 10
- Issue
- 1
- Pages
- 1-1
- ISSN
- 1743-422X (ISSN-L)
- PMC
- PMC3598415
- OpenAlex
- W2109736846
- Cited by
- 243
- References
- 27
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 6 · 2021: 49 · 2020: 22 · 2019: 16 · 2018: 17 · 2017: 46 · 2016: 29 · 2015: 15 · 2014: 13 · 2013: 6 · 2012: 1
- FWCI
- 15.16
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Virology Journal (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Narodowe Centrum Badań i Rozwoju
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Keywords
- glycoprotein L, Alphaherpesvirinae, Gammaherpesvirinae, herpes simplex virus type 2, Epstein-Barr virus, human cytomegalovirus, chemokine receptors, virus transmission, gH/gL complex, herpesvirus infection
- MeSH terms
- Amino Acid Sequence, Models, Molecular, Molecular Sequence Data, Protein Conformation, Viral Envelope Proteins, Sequence Alignment, Alphaherpesvirinae, Betaherpesvirinae, Gammaherpesvirinae, Chemokines, Evolution, Molecular
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