Control of blood glucose in type 2 diabetes without weight loss by modification of diet composition
Open accessAbstract
BACKGROUND: Over the past several years our research group has taken a systematic, comprehensive approach to determining the effects on body function (hormonal and non-hormonal) of varying the amounts and types of proteins, carbohydrates and fats in the diet. We have been particularly interested in the dietary management of type 2 diabetes. Our objective has been to develop a diet for people with type 2 diabetes that does not require weight loss, oral agents, or insulin, but that still controls the blood glucose concentration. Our overall goal is to enable the person with type 2 diabetes to control their blood glucose by adjustment in the composition rather than the amount of food in their diet. METHODS: This paper is a brief summary and review of our recent diet-related research, and the rationale used in the development of diets that potentially are useful in the treatment of diabetes. RESULTS: We determined that, of the carbohydrates present in the diet, absorbed glucose is largely responsible for the food-induced increase in blood glucose concentration. We also determined that dietary protein increases insulin secretion and lowers blood glucose. Fat does not significantly affect blood glucose, but can affect insulin secretion and modify the absorption of carbohydrates. Based on these data, we tested the efficacy of diets with various protein:carbohydrate:fat ratios for 5 weeks on blood glucose control in people with untreated type 2 diabetes. The results were compared to those obtained in the same subjects after 5 weeks on a control diet with a protein:carbohydrate:fat ratio of 15:55:30. A 30:40:30 ratio diet resulted in a moderate but significant decrease in 24-hour integrated glucose area and % total glycohemoglobin (%tGHb). A 30:20:50 ratio diet resulted in a 38% decrease in 24-hour glucose area, a reduction in fasting glucose to near normal and a decrease in %tGHb from 9.8% to 7.6%. The response to a 30:30:40 ratio diet was similar. CONCLUSION: Altering the diet composition could be a patient-empowering method of improving the hyperglycemia of type 2 diabetes without weight loss or pharmacologic intervention.
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A number of studies documented benefits of lower-carbohydrate diets on measures of metabolic health and medication use in patients with type 2 diabetes.
“A number of studies documented the benefits of lower-carbohydrate diets on measures of metabolic health and medication use in patients with T2D (6)(7)(8)(9)(10)(11) and for weight loss and improved metabolic health in healthy individuals (12).”
From A Lower-Carbohydrate, Higher-Fat Diet Reduces Abdominal and Intermuscular Fat and Increases Insulin Sensitivity in Adults at Risk of Type 2 Diabetes (2015) · cites this paper as [8]
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Cites
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011 · see citing works
Effect of Protein Ingestion on the Glucose and Insulin Response to a Standardized Oral Glucose Load
Nuttall, F. Q., Mooradian, A. D., Gannon, M. C., Billington, C. J., & Krezowski, P. A. (1984) · Diabetes Care · doi:10.2337/diacare.7.5.465 · Cited by 439 · see citing works
Self-citationGannon, M. C., & Nuttall, F. Q. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2375 · Cited by 428 · see citing works
Self-citationDecreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications
Donath, M. Y., & Halban, P. A. (2004) · Diabetologia · doi:10.1007/s00125-004-1336-4 · Cited by 427 · see citing works
An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes
Gannon, M. C., Nuttall, F. Q., Saeed, A., Jordan, K., & Hoover, H. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.734 · Cited by 404 · see citing works
Self-citationPATTERNS OF HORMONAL RELEASE AFTER GLUCOSE, PROTEIN, AND GLUCOSE PLUS PROTEIN
Rabinowitz, D. L., Merimee, T. J., MAFFEZZOLI, R. D., & Burgess, J. A. (1966) · The Lancet · doi:10.1016/s0140-6736(66)92767-x · Cited by 246 · see citing works
Effect of Amino Acids and Proteins on Insulin Secretion in Man
Fajans, S. S., Floyd, J. C., Knopf, R. F., & Conn, J. W. (1967) · Elsevier eBooks · doi:10.1016/b978-1-4831-9826-2.50017-9 · Cited by 223 · see citing works
Collier, G., & O'Dea, K. (1983) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/37.6.941 · Cited by 219 · see citing works
Insulin secretion in response to protein ingestion.
Floyd, J. C., Fajans, S. S., Conn, J. W., Knopf, R. F., & Rull, J. A. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105455 · Cited by 202 · see citing works
Gannon, M. C., Nuttall, F. Q., Neil, B. J., & Westphal, S. A. (1988) · Metabolism · doi:10.1016/0026-0495(88)90072-8 · Cited by 200 · see citing works
Self-citationCollier, G. R., McLean, A., & O’Dea, K. (1984) · Diabetologia · doi:10.1007/bf00252263 · Cited by 181 · see citing works
The effect of protein ingestion on the metabolic response to oral glucose in normal individuals
Krezowski, P. A., Nuttall, F. Q., Gannon, M. C., & Bartosh, N. (1986) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/44.6.847 · Cited by 142 · see citing works
Self-citationDietary Fiber in the Management of Diabetes
Nuttall, F. Q. (1993) · Diabetes · doi:10.2337/diab.42.4.503 · Cited by 129 · see citing works
Self-citationFloyd, J. C., Fajans, S. S., Knope, R. F., & Conn, J. W. (1963) · Journal of Clinical Investigation · doi:10.1172/jci104857 · Cited by 110 · see citing works
Effect of Protein Ingestion on the Glucose Appearance Rate in People with Type 2 Diabetes1
Gannon, M. C., Nuttall, J. A., Damberg, G., Gupta, V., & Nuttall, F. Q. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7263 · Cited by 105 · see citing works
Self-citationEffect of Protein Ingestion on the Glucose Appearance Rate in People with Type 2 Diabetes
Gannon, M. C. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.3.1040 · Cited by 92 · see citing works
Self-citationInsulin Response to Ingested Protein in Diabetes
Berger, S., & Vongaraya, N. (1966) · Diabetes · doi:10.2337/diab.15.5.303 · Cited by 78 · see citing works
Metabolic response of people with type 2 diabetes to a high protein diet
Nuttall, F. Q., & Gannon, M. C. (2004) · Nutrition & Metabolism · doi:10.1186/1743-7075-1-6 · Cited by 71 · see citing works
Self-citationGannon, M. C., Nuttall, F. Q., Westphal, S. A., & Seaquist, E. R. (1993) · Journal of the American College of Nutrition · doi:10.1080/07315724.1993.10718280 · Cited by 67 · see citing works
Self-citationGannon, M., Nuttall, F., Westphal, S., Fang, S., & Ercan-Fang, N. G. (1998) · Diabetes Care · doi:10.2337/diacare.21.10.1619 · Cited by 61 · see citing works
Self-citationGannon, M., Nuttall, F., Krezowski, P., Billington, C., & Parker, S. (1986) · Diabetologia · doi:10.1007/bf00873217 · Cited by 61 · see citing works
Self-citationInsulin and Glucose Responses to Various Starch-Containing Foods in Type II Diabetic Subjects
Krezowski, P. A., Nuttall, F. Q., Gannon, M. C., Billington, C. J., & Parker, S. (1987) · Diabetes Care · doi:10.2337/diacare.10.2.205 · Cited by 61 · see citing works
Self-citationGlucose appearance rate following protein ingestion in normal subjects.
Khan, M. A. I., Gannon, M. C., & Nuttall, F. Q. (1992) · Journal of the American College of Nutrition · doi:10.1080/07315724.1992.10718270 · Cited by 53 · see citing works
Self-citationModern Methods in the Diagnosis and Treatment of Glycosuria and-Diabetes
(1928) · Journal of The Royal Naval Medical Service · doi:10.1136/jrnms-14-141 · Cited by 47 · see citing works
Gannon, M. C., Ercan-Fang, N. G., Westphal, S. A., & Nuttall, F. Q. (1993) · Diabetes Care · doi:10.2337/diacare.16.6.874 · Cited by 47 · see citing works
Self-citationErcan, N., Nuttall, F. Q., Gannon, M. C., Redmon, J. B., & Sheridan, K. J. (1993) · Metabolism · doi:10.1016/0026-0495(93)90151-d · Cited by 42 · see citing works
Self-citationMay, J. M., & Williams, R. H. (1978) · Diabetes · doi:10.2337/diab.27.8.849 · Cited by 40 · see citing works
THE METABOLIC RELATIONSHIP OF THE PROTEINS TO GLUCOSE
Janney, N. W. (1915) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)88247-3 · Cited by 32 · see citing works
Effect of Protein Meals on Plasma Insulin in Mildly Diabetic Patients
Fajans, S. S., Floyd, J. C., Pek, S., et al. (1969) · Diabetes · doi:10.2337/diab.18.8.523 · Cited by 27 · see citing works
The metabolic response to various doses of fructose in type II diabetic subjects
Nuttall, F. Q., Gannon, M. C., Burmeister, L. A., Lane, J. T., & Pyzdrowski, K. L. (1992) · Metabolism · doi:10.1016/0026-0495(92)90210-2 · Cited by 23 · see citing works
Self-citationObservations on the decay of glycated hemoglobin HbA1c in diabetic patients
Rech, M. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1211430 · Cited by 13 · see citing works
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Feinman, R. D., Pogozelski, W. K., Astrup, A., Bernstein, R. K., Fine, E. J., Westman, E. C., Accurso, A., Frassetto, L., Gower, B. A., McFarlane, S. I., et al. (2015) · Nutrition · doi:10.1016/j.nut.2014.06.011 · Cited by 912 · see citing works
Forsythe, C. E., Phinney, S. D., Fernandez, M. L., Quann, E. E., Wood, R. J., Bibus, D. M., Kraemer, W. J., Feinman, R. D., & Volek, J. S. (2008) · Lipids · doi:10.1007/s11745-007-3132-7 · Cited by 371 · see citing works
Lindeberg, S., Jönsson, T., Granfeldt, Y., Borgstrand, E., Soffman, J., Sjöström, K., & Ahrén, B. (2007) · Diabetologia · doi:10.1007/s00125-007-0716-y · Cited by 273 · see citing works
Jönsson, T., Granfeldt, Y., Ahrén, B., Branell, U.-C., Pålsson, G., Hansson, A., Söderström, M., & Lindeberg, S. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-35 · Cited by 273 · see citing works
Accurso, A., Bernstein, R. K., Dahlqvist, A., Draznin, B., Feinman, R. D., Fine, E. J., Gleed, A., Jacobs, D. B., Larson, G., Lustig, R. H., et al. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-9 · Cited by 263 · see citing works
Davis, N. J., Tomuta, N., Schechter, C., Isasi, C. R., Segal-Isaacson, C. J., Stein, D., Zonszein, J., & Wylie-Rosett, J. (2009) · Diabetes Care · doi:10.2337/dc08-2108 · Cited by 256 · see citing works
Saslow, L. R., Kim, S., Daubenmier, J. J., Moskowitz, J. T., Phinney, S. D., Goldman, V., Murphy, E. J., Cox, R. M., Moran, P., & Hecht, F. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091027 · Cited by 221 · see citing works
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Noakes, T. D., & Windt, J. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096491 · Cited by 178 · see citing works
Gower, B. A., & Goss, A. M. (2015) · The Journal of Nutrition · doi:10.3945/jn.114.195065 · Cited by 98 · see citing works
Pearce, K. L., Noakes, M., Keogh, J., & Clifton, P. M. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.638 · Cited by 80 · see citing works
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- Authors
- Gannon, M. C., & Nuttall, F. Q.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Gannon, Mary C
- ORCID
- Gannon, Mary C
- Venue
- Nutrition & Metabolism
- Published
- 2006-03-23
- Volume
- 3
- Issue
- 1
- Pages
- 16-16
- ISSN
- 1743-7075 (ISSN-L)
- PMC
- PMC1475800
- OpenAlex
- W2149839409
- Cited by
- 134
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 6
- FWCI
- 5.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrition & Metabolism (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- American Diabetes Association
- U.S. Department of Veterans Affairs
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, glycemic control, diet composition, carbohydrate absorption, insulin secretion, glycohemoglobin, hyperglycemia, dietary management of diabetes
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