The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Multiple functions of microsomal triglyceride transfer protein
Open accessAbstract
Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles. Its role as an essential chaperone for the biosynthesis of apolipoprotein B (apoB)-containing triglyceride-rich lipoproteins was established after the realization that abetalipoproteinemia patients carry mutations in the MTTP gene resulting in the loss of its lipid transfer activity. Now it is known that it also plays a role in the biosynthesis of CD1, glycolipid presenting molecules, as well as in the regulation of cholesterol ester biosynthesis. In this review, we will provide a historical perspective about the identification, purification and characterization of MTP, describe methods used to measure its lipid transfer activity, and discuss tissue expression and function. Finally, we will review the role MTP plays in the assembly of apoB-lipoprotein, the regulation of cholesterol ester synthesis, biosynthesis of CD1 proteins and propagation of hepatitis C virus. We will also provide a brief overview about the clinical potentials of MTP inhibition.
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Cites
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
Cuchel, M., Bloedon, L. T., Szapary, P. O., Kolansky, D. M., Wolfe, M. L., Sarkis, A., Millar, J. S., Ikewaki, K., Siegelman, E. S., Gregg, R. E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061189 · Cited by 580
Samaha, F. F., McKenney, J., Bloedon, L. T., Sasiela, W. J., & Rader, D. J. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1250 · Cited by 220
Cited by
Cuchel, M., Bruckert, E., Ginsberg, H. N., Raal, F. J., Santos, R. D., Hegele, R. A., Kuivenhoven, J. A., Nordestgaard, B. G., Descamps, O. S., Steinhagen-Thiessen, E., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu274 · Cited by 1,057
Cuchel, M., Raal, F. J., Hegele, R. A., Al-Rasadi, K., Arca, M., Averna, M., Bruckert, E., Freiberger, T., Gaudet, D., Harada-Shiba, M., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad197 · Cited by 359
Soh, J., Iqbal, J., Queiroz, J., Fernandez-Hernando, C., & Hussain, M. M. (2013) · Nature Medicine · doi:10.1038/nm.3200 · Cited by 301
Self-citationChen, Y., Du, X., Kuppa, A., Feitosa, M. F., Bielak, L. F., O’Connell, J. R., Musani, S. K., Guo, X., Kahali, B., Chen, V. L., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01497-6 · Cited by 215
Sołtysik, K., Ohsaki, Y., Tatematsu, T., Cheng, J., & Fujimoto, T. (2019) · Nature Communications · doi:10.1038/s41467-019-08411-x · Cited by 132
Metadata
- Authors
- Hussain, M. M., Rava, P., Walsh, M., Rana, M., & Iqbal, J.
- Venue
- Nutrition & Metabolism
- Published
- 2012
- Volume
- 9
- Issue
- 1
- Pages
- 14
- ISSN
- 1743-7075 (ISSN-L)
- OpenAlex
- W2121549194
- Cited by
- 261
- References
- 2
- FWCI
- 17.65
- Type
- journal article
- Language
- en
- Open access
- gold
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- Hussain, M. M., Rava, P., Walsh, M., Rana, M., & Iqbal, J. (2012). Multiple functions of microsomal triglyceride transfer protein. Nutrition & Metabolism. https://doi.org/10.1186/1743-7075-9-14
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