The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model
Open accessAbstract
BACKGROUND: Experimental studies provide evidence that inhaled nanoparticles may translocate over the airspace epithelium and cause increased cellular inflammation. Little is known, however, about the dependence of particle size or material on translocation characteristics, inflammatory response and intracellular localization. RESULTS: Using a triple cell co-culture model of the human airway wall composed of epithelial cells, macrophages and dendritic cells we quantified the entering of fine (1 mum) and nano-sized (0.078 mum) polystyrene particles by laser scanning microscopy. The number distribution of particles within the cell types was significantly different between fine and nano-sized particles suggesting different translocation characteristics. Analysis of the intracellular localization of gold (0.025 mum) and titanium dioxide (0.02-0.03 mum) nanoparticles by energy filtering transmission electron microscopy showed differences in intracellular localization depending on particle composition. Titanium dioxide nanoparticles were detected as single particles without membranes as well as in membrane-bound agglomerations. Gold nanoparticles were found inside the cells as free particles only. The potential of the different particle types (different sizes and different materials) to induce a cellular response was determined by measurements of the tumour necrosis factor-alpha in the supernatants. We measured a 2-3 fold increase of tumour necrosis factor-alpha in the supernatants after applying 1 mum polystyrene particles, gold nanoparticles, but not with polystyrene and titanium dioxide nanoparticles. CONCLUSION: Quantitative laser scanning microscopy provided evidence that the translocation and entering characteristics of particles are size-dependent. Energy filtering transmission electron microscopy showed that the intracellular localization of nanoparticles depends on the particle material. Both particle size and material affect the cellular responses to particle exposure as measured by the generation of tumour necrosis factor-alpha.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J. (2004) · Circulation · doi:10.1161/01.cir.0000108927.80044.7f · Cited by 2,592
Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage
Li, N., Sioutas, C., Cho, A., Schmitz, D., Misra, C., Sempf, J., Wang, M., Oberley, T., Froines, J., & Nel, A. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6000 · Cited by 2,097
Nanomedicine: current status and future prospects
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029
Limbach, L. K., Li, Y., Grass, R. N., Brunner, T. J., Hintermann, M. A., Muller, M., Gunther, D., & Stark, W. J. (2005) · Environmental Science & Technology · doi:10.1021/es051043o · Cited by 779 · cited 1×
“Other studies have shown vesicles containing mostly large aggregates of TiO2 in A549 cells [45] or membrane-bound ceria NP agglomerates in human lung fibroblasts [46].”
Cited by
Nanoplastic Affects Growth of S. obliquus and Reproduction of D. magna
Besseling, E., Wang, B., Lürling, M., & Koelmans, A. A. (2014) · Environmental Science & Technology · doi:10.1021/es503001d · Cited by 1,138
Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine
Sousa de Almeida, M., Susnik, E., Drasler, B., Taladriz-Blanco, P., Petri-Fink, A., & Rothen-Rutishauser, B. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01127d · Cited by 1,079
Self-citationRivera Gil, P., Oberdörster, G., Elder, A., Puntes, V., & Parak, W. J. (2010) · ACS Nano · doi:10.1021/nn1025687 · Cited by 314
Blank, F., Gerber, P., Rothen-Rutishauser, B., Sakulkhu, U., Salaklang, J., De Peyer, K., Gehr, P., Nicod, L. P., Hofmann, H., Geiser, T., et al. (2011) · Nanotoxicology · doi:10.3109/17435390.2010.541293 · Cited by 97
Self-citationTham, R., & Schikowski, T. (2021) · Journal of Alzheimer’s Disease · doi:10.3233/jad-200813 · Cited by 29
Metadata
- Authors
- Rothen-Rutishauser, B., Mühlfeld, C., Blank, F., Musso, C., & Gehr, P.
- Venue
- Particle and Fibre Toxicology
- Published
- 2007
- Volume
- 4
- Issue
- 1
- Pages
- 9
- ISSN
- 1743-8977 (ISSN-L)
- OpenAlex
- W2169542790
- Cited by
- 202
- References
- 4
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. https://app.cochat.ai/papers/10.1186/1743-8977-4-9
- The paper
- Rothen-Rutishauser, B., Mühlfeld, C., Blank, F., Musso, C., & Gehr, P. (2007). Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Particle and Fibre Toxicology. https://doi.org/10.1186/1743-8977-4-9
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
