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Cited by 301Obstructive Sleep Apnea ResearchBlood Pressure and Hypertension StudiesSleep and related disorders

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

The effect of antihypertensive agents on sleep apnea: protocol for a randomized controlled trial

Open access
Cichelero, Fábio Tremea, Martinez, Denis, Fuchs, Sandra Costa, Gus, Miguel, Moreira, Leila Beltrami, Fuchs, Flávio Danni·2014·Trials
DOI 10.1186/1745-6215-15-1PMC PMC3892032
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Abstract

Background: Obstructive sleep apnea (OSA) and hypertension are well-known cardiovascular risk factors. Their control could reduce the burden of heart disease across populations. Several drugs are used to control hypertension, but the only consistently effective treatment of OSA is continuous positive airway pressure. The identification of a drug capable of improving OSA and hypertension simultaneously would provide a novel approach in the treatment of both diseases. Methods/Design: This is a randomized double-blind clinical trial, comparing the use of chlorthalidone with amiloride versus amlodipine as a first drug option in patients older than 40 years of age with stage I hypertension (140 to 159/90 to 99 mmHg) and moderate OSA (15 to 30 apneas/hour of sleep). The primary outcomes are the variation of the number of apneas per hour and blood pressure measured by ambulatory blood pressure monitoring. The secondary outcomes are adverse events, somnolence scale (Epworth), ventilatory parameters and C reactive protein levels. The follow-up will last 8 weeks. There will be 29 participants per group. The project has been approved by the ethics committee of our institution. Discussion: The role of fluid retention in OSA has been known for several decades. The use of diuretics are well established in treating hypertension but have never been appropriately tested for sleep apnea. As well as testing the efficacy of these drugs, this study will help to understand the mechanisms that link hypertension and sleep apnea and their treatment. Trial registration: ClinicalTrials.gov: NCT01896661

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Figure 1 Flow chart of selection, interventions and outcomes.CC BY · PubMed Central

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Research works printed but not linked: 1

  1. Balk EM, Moorthy D, Obadan NO, Patel K, Ip S, Chung M, Bannuru RR, Kitsios GD, Sen S, Iovin RC: Diagnosis and Treatment of Obstructive Sleep Apnea in Adults. 2011, Rockville, MD: AHRQ Comparative Effectiveness Reviews

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Metadata

Authors
Cichelero, F. T., Martinez, D., Fuchs, S. C., Gus, M., Moreira, L. B., & Fuchs, F. D.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • Hospital de Clínicas de Porto Alegre (BR)
Corresponding author
Fuchs, Flávio Danni
ORCID
Venue
Trials
Publisher
Springer Science and Business Media LLC
Published
2014-01-02
Volume
15
Issue
1
Pages
1-1
ISSN
1745-6215 (ISSN-L)
DOI
10.1186/1745-6215-15-1
PMC
PMC3892032
OpenAlex
W2168495171
Cited by
301
References
34
Citations by year
2026: 1 · 2025: 13 · 2024: 11 · 2023: 7 · 2022: 17 · 2021: 44 · 2020: 31 · 2019: 31 · 2018: 32 · 2017: 57 · 2016: 35 · 2015: 13 · 2014: 8
FWCI
25.11
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Trials (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (publishedVersion, other-oa)
  • Lume (Universidade Federal do Rio Grande do Sul) (submittedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
Funders
  • Hospital de Clínicas de Porto Alegre
  • Fundação Instituto de Pesquisas Econômicas
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
obstructive sleep apnea, hypertension, antihypertensive drugs, chlorthalidone, amiloride, amlodipine, diuretics, fluid retention, apnea-hypopnea index, ambulatory blood pressure monitoring, C-reactive protein, cardiovascular risk factors
MeSH terms
Adult, Antihypertensive Agents, Blood Pressure, Calcium Channel Blockers, Chlorthalidone, Clinical Protocols, Diuretics, Double-Blind Method, Drug Therapy, Combination, Humans, Hypertension, Research Design, Sleep, Sleep Apnea Syndromes, Time Factors, Treatment Outcome, Polysomnography, Amlodipine, Blood Pressure Monitoring, Ambulatory

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