Inhibitory effect of sesquiterpene lactones and the sesquiterpene alcohol aromadendrane-4β,10α-diol on memory impairment in a mouse model of Alzheimer
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Alzheimer's disease (AD), a progressive neurodegenerative disorder of the aged brain with no known cause or cures, has become a major medical and social problem for industrialized countries. Cerebral deposition of amyloid-β peptide (Aβ) is a critical feature of AD. The use of medicinal plants as an alternative form of prevention, or even as a possible treatment of AD, is therefore interesting areas of research. Sesquiterpene lactones and a sesquiterpene alcohol are compounds found in H. brasiliense that have several anti-oxidative and anti-inflammatory effects. In the present study, we investigated whether these compounds have neuroprotective effects in an amyloid-β peptide-induced Alzheimer's disease mouse model. Mice were injected with Aβ1-42 peptide intracerebroventricularly and were subsequently injected (i.c.v.) with 1µg/site of IGM-A (15-acetoxy-isogermafurenolide), IGM-H (15-hydroxy-isogermafurenolide), PDA (Podoandin), EHP (1,2-epoxy-10α-hydroxy-podoandin), HDS (13-hydroxy-8,9-dehydroshizukanolide), and ARD (aromadendrane-4β,10α-diol). Seven days after treatments the animals had their memory tested in the inhibitory avoidance. After the behavioral testing of animals the brains were removed and subjected to biochemical tests for oxidative stress. The results showed that ARD, HDS and PDA significantly ameliorated the Aβ1-42 peptide-induced memory impairment in the passive avoidance task (P<0.05). In addition, GSH activity was increased while the TBARS levels were decreased by treatment with these compounds. These results suggest that these compounds inhibit the cognitive deficit of animals induced peptide amyloid and may be potential candidates for Alzheimer's disease therapy.
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The neuroprotective effects of the tested compounds were more correlated with the existence of the guaiane ring than with the presence of the lactone ring.
“However, the neuroprotective effects possessed by these tested compounds were found more correlated to the existence of the guaiane ring in comparison to the presence of the lactone ring for which mechanism of action is described by Michael-type nucleophilic addition.”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [140]
ARD, HDS, and PDA isolated from Hedyosmum brasiliense ameliorated Aβ peptide-induced memory impairment in passive avoidance models (p < 0.05).
“During the investigation, it was observed that aromadendrane-4β,10α-diol (ARD), 13-hydroxy-8,9-dehydroshizukanolide (HDS) and podoandin (PDA), efficiently ameliorated the Aβ peptide-induced memory impairment in models of the passive avoidance task (p < 0.05).”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [140]
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Emerging Drug Candidates from Plants
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- Authors
- Amoah, S. K. S., Dalla Vecchia, M. T., Pedrini, B., Carnhelutti, G. L., Gonçalves, A. E., dos Santos, D. A., Biavatti, M. W., & de Souza, M. M.
- Affiliations
- Universidade Federal de Santa Catarina (BR)
- Universidade do Vale do Itajaí (BR)
- Corresponding author
- Biavatti, Maique W.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 769
- Pages
- 195-202
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2224830186
- Cited by
- 40
- References
- 53
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 7 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 3 · 2017: 3 · 2016: 2
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universidade do Vale do Itajaí
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
- Universidade Federal de Santa Catarina
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Keywords
- Alzheimer's disease, sesquiterpene lactones, amyloid-beta 42, memory impairment, neuroprotection, oxidative stress, glutathione, lipid peroxidation, medicinal plants, cognitive impairment
- MeSH terms
- Alzheimer Disease, Animals, Avoidance Learning, Behavior, Animal, Brain, Disease Models, Animal, Male, Memory Disorders, Peptide Fragments, Sesquiterpenes, Amyloid beta-Peptides, Oxidative Stress, Plant Leaves, Neuroprotective Agents, Maze Learning, Magnoliopsida, Sesquiterpenes, Guaiane, Mice
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