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Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina

Open access
Kubicek, Christian P, Mikus, Marianna, Schuster, André, Schmoll, Monika, Seiboth, Bernhard·2009·Biotechnology for Biofuels

Abstract

Hypocrea jecorina (= Trichoderma reesei) is the main industrial source of cellulases and hemicellulases used to depolymerise plant biomass to simple sugars that are converted to chemical intermediates and biofuels, such as ethanol. Cellulases are formed adaptively, and several positive (XYR1, ACE2, HAP2/3/5) and negative (ACE1, CRE1) components involved in this regulation are now known. In addition, its complete genome sequence has been recently published, thus making the organism susceptible to targeted improvement by metabolic engineering. In this review, we summarise current knowledge about how cellulase biosynthesis is regulated, and outline recent approaches and suitable strategies for facilitating the targeted improvement of cellulase production by genetic engineering.

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Metadata

Authors
Kubicek, C. P., Mikus, M., Schuster, A., Schmoll, M., & Seiboth, B.
Venue
Biotechnology for Biofuels
Published
2009
Volume
2
Issue
1
Pages
19
ISSN
1754-6834 (ISSN-L)
OpenAlex
W2082324597
Cited by
423
References
2
FWCI
13.00
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina. https://app.cochat.ai/papers/10.1186/1754-6834-2-19
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Kubicek, C. P., Mikus, M., Schuster, A., Schmoll, M., & Seiboth, B. (2009). Metabolic engineering strategies for the improvement of cellulase production by Hypocrea jecorina. Biotechnology for Biofuels. https://doi.org/10.1186/1754-6834-2-19

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